Published in Proc Natl Acad Sci U S A on November 12, 2008
Antibody recognition of a highly conserved influenza virus epitope. Science (2009) 11.26
Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins. PLoS Pathog (2010) 3.89
HIV-1 and influenza antibodies: seeing antigens in new ways. Nat Immunol (2009) 2.80
Influenza hemagglutinin and neuraminidase membrane glycoproteins. J Biol Chem (2010) 2.65
Structures of influenza A proteins and insights into antiviral drug targets. Nat Struct Mol Biol (2010) 2.31
Induction of unnatural immunity: prospects for a broadly protective universal influenza vaccine. Nat Med (2010) 1.90
Structures of receptor complexes of a North American H7N2 influenza hemagglutinin with a loop deletion in the receptor binding site. PLoS Pathog (2010) 1.69
Attacking the flu: neutralizing antibodies may lead to 'universal' vaccine. Nat Med (2009) 1.49
Reliable B cell epitope predictions: impacts of method development and improved benchmarking. PLoS Comput Biol (2012) 1.44
Continuing challenges in influenza. Ann N Y Acad Sci (2014) 1.43
Novel inhibitors of influenza virus fusion: structure-activity relationship and interaction with the viral hemagglutinin. J Virol (2010) 1.42
A new common mutation in the hemagglutinin of the 2009 (H1N1) influenza A virus. PLoS Curr (2010) 1.37
Complement-dependent lysis of influenza a virus-infected cells by broadly cross-reactive human monoclonal antibodies. J Virol (2011) 1.21
Emerging antiviral targets for influenza A virus. Trends Pharmacol Sci (2009) 1.18
Structural analysis of the hemagglutinin from the recent 2013 H7N9 influenza virus. J Virol (2013) 1.15
Intersubunit interactions modulate pH-induced activation of membrane fusion by the Junin virus envelope glycoprotein GPC. J Virol (2009) 1.15
Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein. Proc Natl Acad Sci U S A (2009) 1.14
Increased acid stability of the hemagglutinin protein enhances H5N1 influenza virus growth in the upper respiratory tract but is insufficient for transmission in ferrets. J Virol (2013) 1.13
Structure and receptor complexes of the hemagglutinin from a highly pathogenic H7N7 influenza virus. J Virol (2012) 1.13
Influenza virus-mediated membrane fusion: determinants of hemagglutinin fusogenic activity and experimental approaches for assessing virus fusion. Viruses (2012) 1.07
Capturing a fusion intermediate of influenza hemagglutinin with a cholesterol-conjugated peptide, a new antiviral strategy for influenza virus. J Biol Chem (2011) 1.06
Recent progress in structure-based anti-influenza drug design. Drug Discov Today (2012) 1.06
New small molecule entry inhibitors targeting hemagglutinin-mediated influenza a virus fusion. J Virol (2013) 1.04
Free-energy simulations reveal that both hydrophobic and polar interactions are important for influenza hemagglutinin antibody binding. Biophys J (2012) 1.02
RNA Viruses: ROS-Mediated Cell Death. Int J Cell Biol (2014) 1.01
Innate immune evasion strategies of influenza viruses. Future Microbiol (2010) 1.00
Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines. Protein Cell (2012) 0.98
Influenza A virus entry inhibitors targeting the hemagglutinin. Viruses (2013) 0.95
Characteristics of human infection with avian influenza viruses and development of new antiviral agents. Acta Pharmacol Sin (2013) 0.94
New-generation screening assays for the detection of anti-influenza compounds targeting viral and host functions. Antiviral Res (2013) 0.92
Influenza virus-membrane fusion triggered by proton uncaging for single particle studies of fusion kinetics. Anal Chem (2012) 0.91
Complex networks govern coiled-coil oligomerization--predicting and profiling by means of a machine learning approach. Mol Cell Proteomics (2011) 0.91
Inhibition of influenza H7 hemagglutinin-mediated entry. PLoS One (2013) 0.90
Epidemiology of the influenza A virus H5N1 subtype and memory of immunity to the H2N2 subtype. MBio (2012) 0.90
A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junín hemorrhagic fever arenavirus. J Biol Chem (2010) 0.89
Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines. Protein Cell (2010) 0.89
Intracytoplasmic trapping of influenza virus by a lipophilic derivative of aglycoristocetin. J Virol (2012) 0.88
A multi-scale analysis of influenza A virus fitness trade-offs due to temperature-dependent virus persistence. PLoS Comput Biol (2013) 0.88
Molecular mechanism of respiratory syncytial virus fusion inhibitors. Nat Chem Biol (2015) 0.88
Structure and receptor binding preferences of recombinant hemagglutinins from avian and human H6 and H10 influenza A virus subtypes. J Virol (2015) 0.87
Inhibition of influenza A virus (H1N1) fusion by benzenesulfonamide derivatives targeting viral hemagglutinin. PLoS One (2011) 0.86
Compounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza. Part I: Influenza life-cycle and currently available drugs. J Prev Med Hyg (2014) 0.86
Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry. Viruses (2015) 0.86
Molecular Characterizations of Surface Proteins Hemagglutinin and Neuraminidase from Recent H5Nx Avian Influenza Viruses. J Virol (2016) 0.84
Influenza B-cells protective epitope characterization: a passkey for the rational design of new broad-range anti-influenza vaccines. Viruses (2012) 0.84
Structure and receptor binding specificity of hemagglutinin H13 from avian influenza A virus H13N6. J Virol (2013) 0.83
How influenza virus is locked out of the cell. Proc Natl Acad Sci U S A (2008) 0.83
The breadth of cross sub-type neutralisation activity of a single domain antibody to influenza hemagglutinin can be increased by antibody valency. PLoS One (2014) 0.82
Options and obstacles for designing a universal influenza vaccine. Viruses (2014) 0.82
Influenza hemagglutinin (HA) stem region mutations that stabilize or destabilize the structure of multiple HA subtypes. J Virol (2015) 0.82
Compounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza. Part II: Future compounds against influenza virus. J Prev Med Hyg (2014) 0.81
Structural and functional analysis of surface proteins from an A(H3N8) influenza virus isolated from New England harbor seals. J Virol (2014) 0.80
Design and synthesis of benzenesulfonamide derivatives as potent anti-influenza hemagglutinin inhibitors. ACS Med Chem Lett (2011) 0.79
H1N1, but not H3N2, influenza A virus infection protects ferrets from H5N1 encephalitis. J Virol (2013) 0.78
Antiviral activity of stachyflin on influenza A viruses of different hemagglutinin subtypes. Virol J (2013) 0.78
Identification of a specific region in the e1 fusion protein involved in zinc inhibition of semliki forest virus fusion. J Virol (2012) 0.78
Characterization of potent fusion inhibitors of influenza virus. PLoS One (2015) 0.77
The hemagglutinin of the influenza A(H1N1)pdm09 is mutating towards stability. Adv Appl Bioinform Chem (2014) 0.77
Mutagenesis studies of the H5 influenza hemagglutinin stem loop region. J Biol Chem (2014) 0.77
Seasonal influenza vaccination is the strongest correlate of cross-reactive antibody responses in migratory bird handlers. MBio (2014) 0.77
A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hemagglutinin Protein. ACS Infect Dis (2014) 0.76
Identification of Novel Fusion Inhibitors of Influenza A Virus by Chemical Genetics. J Virol (2015) 0.76
Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol. Proc Natl Acad Sci U S A (2016) 0.76
Small-Molecule Fusion Inhibitors Bind the pH-Sensing Stable Signal Peptide-GP2 Subunit Interface of the Lassa Virus Envelope Glycoprotein. J Virol (2016) 0.75
Molecular-level simulation of pandemic influenza glycoproteins. Methods Mol Biol (2012) 0.75
A new in vitro hemagglutinin inhibitor screening system based on a single-vesicle fusion assay. Sci Rep (2016) 0.75
Viral glycoproteins: biological role and application in diagnosis. Virusdisease (2016) 0.75
Computational approach for predicting the conserved B-cell epitopes of hemagglutinin H7 subtype influenza virus. Exp Ther Med (2016) 0.75
Exploration of binding and inhibition mechanism of a small molecule inhibitor of influenza virus H1N1 hemagglutinin by molecular dynamics simulation. Sci Rep (2017) 0.75
Inhibition of endosomal fusion activity of influenza virus by Rheum tanguticum (da-huang). Sci Rep (2016) 0.75
Identification and Characterization of Influenza Virus Entry Inhibitors through Dual Myxovirus High-Throughput Screening. J Virol (2016) 0.75
Novel hemagglutinin-based influenza virus inhibitors. J Thorac Dis (2013) 0.75
A New Strategy to Reduce Influenza Escape: Detecting Therapeutic Targets Constituted of Invariance Groups. Viruses (2017) 0.75
Investigation of the network of preferred interactions in an artificial coiled-coil association using the peptide array technique. Beilstein J Org Chem (2012) 0.75
A Combinatorial approach: To design inhibitory molecules on Hemagglutinin protein of H1N1 virus (Swine Flu). Bioinformation (2013) 0.75
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
Phaser crystallographic software. J Appl Crystallogr (2007) 108.34
PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr D Biol Crystallogr (2002) 53.61
Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature (1981) 24.17
Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin. Annu Rev Biochem (2000) 19.03
Structure of influenza haemagglutinin at the pH of membrane fusion. Nature (1994) 14.61
The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype). Cell (1982) 12.44
Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls. J Virol (2005) 10.77
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability. Nat Protoc (2007) 9.92
Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature (1993) 8.62
Viral membrane fusion. Nat Struct Mol Biol (2008) 8.54
Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity. Nature (1983) 8.28
The molecular basis of the specific anti-influenza action of amantadine. EMBO J (1985) 7.08
X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs. Proc Natl Acad Sci U S A (2001) 5.92
Automated analysis of interatomic contacts in proteins. Bioinformatics (1999) 5.60
N- and C-terminal residues combine in the fusion-pH influenza hemagglutinin HA(2) subunit to form an N cap that terminates the triple-stranded coiled coil. Proc Natl Acad Sci U S A (1999) 3.90
Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J Am Chem Soc (1997) 3.69
Selection of influenza virus mutants in experimentally infected volunteers treated with oseltamivir. J Infect Dis (2001) 3.69
Oseltamivir (Tamiflu) and its potential for use in the event of an influenza pandemic. J Antimicrob Chemother (2005) 3.53
The M2 proton channels of influenza A and B viruses. J Biol Chem (2005) 3.49
Epidemiology of HIV/AIDS--United States, 1981-2005. MMWR Morb Mortal Wkly Rep (2006) 3.31
Antiviral agents active against influenza A viruses. Nat Rev Drug Discov (2006) 3.12
Influenza virus carrying neuraminidase with reduced sensitivity to oseltamivir carboxylate has altered properties in vitro and is compromised for infectivity and replicative ability in vivo. Antiviral Res (2002) 3.07
A revision of the system of nomenclature for influenza viruses: a WHO memorandum. Bull World Health Organ (1980) 2.86
H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes. Virology (2004) 2.67
Structure of influenza virus haemagglutinin complexed with a neutralizing antibody. Nature (1995) 2.55
Emergence and transmission of influenza A viruses resistant to amantadine and rimantadine. Curr Top Microbiol Immunol (1992) 2.38
Combination chemotherapy, a potential strategy for reducing the emergence of drug-resistant influenza A variants. Antiviral Res (2006) 2.11
Analysis of residues near the fusion peptide in the influenza hemagglutinin structure for roles in triggering membrane fusion. Virology (2007) 1.83
Amantadine selection of a mutant influenza virus containing an acid-stable hemagglutinin glycoprotein: evidence for virus-specific regulation of the pH of glycoprotein transport vesicles. Proc Natl Acad Sci U S A (1991) 1.79
Influenza-virus-liposome lipid mixing is leaky and largely insensitive to the material properties of the target membrane. Biochemistry (1996) 1.57
Inhibition of the fusion-inducing conformational change of influenza hemagglutinin by benzoquinones and hydroquinones. Biochemistry (1993) 1.51
Phylogenetic trees: visualizing, customizing and detecting incongruence. Bioinformatics (2005) 1.38
Structure-based identification of an inducer of the low-pH conformational change in the influenza virus hemagglutinin: irreversible inhibition of infectivity. J Virol (1997) 1.29
Ligand binding affinity determined by temperature-dependent circular dichroism: cyclin-dependent kinase 2 inhibitors. Anal Biochem (2005) 1.06
Structure-activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine. Bioorg Med Chem Lett (2002) 0.96
Structure of an unliganded simian immunodeficiency virus gp120 core. Nature (2005) 8.30
A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins. Science (2011) 7.86
Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature (2006) 7.56
Printed covalent glycan array for ligand profiling of diverse glycan binding proteins. Proc Natl Acad Sci U S A (2004) 7.55
Role of the polycomb protein EED in the propagation of repressive histone marks. Nature (2009) 6.62
The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature (2006) 6.00
Regulation of p53 activity through lysine methylation. Nature (2004) 5.78
Structure of mammalian AMPK and its regulation by ADP. Nature (2011) 4.27
Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature (2003) 4.00
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants. Nature (2008) 3.79
Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature (2007) 3.26
H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes. EMBO J (2002) 2.69
Influenza hemagglutinin and neuraminidase membrane glycoproteins. J Biol Chem (2010) 2.65
Specificity and mechanism of the histone methyltransferase Pr-Set7. Genes Dev (2005) 2.50
Receptor binding by an H7N9 influenza virus from humans. Nature (2013) 2.33
Single-particle kinetics of influenza virus membrane fusion. Proc Natl Acad Sci U S A (2008) 2.32
Crystal structure and functional analysis of the histone methyltransferase SET7/9. Cell (2002) 2.27
Variation and infectivity neutralization in influenza. Immunology (2006) 2.23
X-ray structure of the hemagglutinin of a potential H3 avian progenitor of the 1968 Hong Kong pandemic influenza virus. Virology (2003) 2.23
Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin. Proc Natl Acad Sci U S A (2012) 2.18
The motor complex of Plasmodium falciparum: phosphorylation by a calcium-dependent protein kinase. J Biol Chem (2008) 2.14
Determining the structure of an unliganded and fully glycosylated SIV gp120 envelope glycoprotein. Structure (2005) 2.13
Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS. Nat Struct Mol Biol (2009) 2.08
Key features of the interaction between Pcf11 CID and RNA polymerase II CTD. Nat Struct Mol Biol (2005) 2.07
Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957. Proc Natl Acad Sci U S A (2009) 1.98
Genetics of influenza viruses. Annu Rev Genet (2002) 1.88
AMP-activated protein kinase: nature's energy sensor. Nat Chem Biol (2011) 1.85
Analysis of residues near the fusion peptide in the influenza hemagglutinin structure for roles in triggering membrane fusion. Virology (2007) 1.83
SET domains and histone methylation. Curr Opin Struct Biol (2003) 1.72
AMP-activated protein kinase: also regulated by ADP? Trends Biochem Sci (2011) 1.71
Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation. Proc Natl Acad Sci U S A (2003) 1.68
Influenza a viruses with mutations in the m1 helix six domain display a wide variety of morphological phenotypes. J Virol (2005) 1.67
Influenza HA subtypes demonstrate divergent phenotypes for cleavage activation and pH of fusion: implications for host range and adaptation. PLoS Pathog (2013) 1.64
Structural bases for the interaction of frataxin with the central components of iron-sulphur cluster assembly. Nat Commun (2010) 1.56
Dual acylation of the 45 kDa gliding-associated protein (GAP45) in Plasmodium falciparum merozoites. Mol Biochem Parasitol (2006) 1.53
Receptor binding by a ferret-transmissible H5 avian influenza virus. Nature (2013) 1.43
ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase. Cell Metab (2011) 1.37
Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A. Biochemistry (2002) 1.36
Effect of proteolytic processing at two distinct sites on shape and aggregation of an anchorless fusion protein of human respiratory syncytial virus and fate of the intervening segment. Virology (2002) 1.34
Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein. Proc Natl Acad Sci U S A (2010) 1.34
Acetate kinase: not just a bacterial enzyme. Trends Microbiol (2006) 1.33
Antibiotic recognition by binuclear metallo-beta-lactamases revealed by X-ray crystallography. J Am Chem Soc (2005) 1.30
Composition and functions of the influenza fusion peptide. Protein Pept Lett (2009) 1.27
Structure of a Mycobacterium tuberculosis NusA-RNA complex. EMBO J (2005) 1.25
MgF(3)(-) as a transition state analog of phosphoryl transfer. Chem Biol (2002) 1.25
Comparison of the receptor binding properties of contemporary swine isolates and early human pandemic H1N1 isolates (Novel 2009 H1N1). Virology (2011) 1.22
The MTIP-myosin A complex in blood stage malaria parasites. J Mol Biol (2005) 1.20
Unbiased cold denaturation: low- and high-temperature unfolding of yeast frataxin under physiological conditions. J Am Chem Soc (2007) 1.17
A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses. J Virol (2012) 1.15
Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism. Biochemistry (2002) 1.14
H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis. PLoS Pathog (2012) 1.13
Thermostability of the human respiratory syncytial virus fusion protein before and after activation: implications for the membrane-fusion mechanism. J Gen Virol (2004) 1.13
Studies of structural changes in the M2 proton channel of influenza A virus by tryptophan fluorescence. Virus Res (2004) 1.12
Novel H7N9 influenza virus shows low infectious dose, high growth rate, and efficient contact transmission in the guinea pig model. J Virol (2013) 1.09
Reading, writing and editing methylated lysines on histone tails: new insights from recent structural studies. Curr Opin Struct Biol (2010) 1.08
Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase. Nat Commun (2010) 1.08
Functional glycomic analysis of human milk glycans reveals the presence of virus receptors and embryonic stem cell biomarkers. J Biol Chem (2012) 1.07
Molecular basis of FIR-mediated c-myc transcriptional control. Nat Struct Mol Biol (2010) 1.07
Full-length influenza hemagglutinin HA2 refolds into the trimeric low-pH-induced conformation. Biochemistry (2004) 1.07
Functional characterization of the propeptide of Plasmodium falciparum subtilisin-like protease-1. J Biol Chem (2003) 1.07
Plasticity of influenza haemagglutinin fusion peptides and their interaction with lipid bilayers. Biophys J (2004) 1.06
The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection. J Immunol (2007) 1.03
Subtle manipulation of egg sex ratio in birds. Proc Biol Sci (2003) 1.02
Temperature jump kinetic study of the stability of apo-calmodulin. Biophys Chem (2002) 1.02
Bacterial IscU is a well folded and functional single domain protein. Eur J Biochem (2004) 1.02
Analysis of influenza virus hemagglutinin receptor binding mutants with limited receptor recognition properties and conditional replication characteristics. J Virol (2011) 1.01
Avian influenza viruses infect primary human bronchial epithelial cells unconstrained by sialic acid α2,3 residues. PLoS One (2011) 1.01
An elastically tethered viscous load imposes a regular gait on the motion of myosin-V. Simulation of the effect of transient force relaxation on a stochastic process. J R Soc Interface (2006) 1.01
In vivo T-box transcription factor profiling reveals joint regulation of embryonic neuromesodermal bipotency. Cell Rep (2013) 1.00
Suramin and suramin analogues inhibit merozoite surface protein-1 secondary processing and erythrocyte invasion by the malaria parasite Plasmodium falciparum. J Biol Chem (2003) 0.99
KH domains with impaired nucleic acid binding as a tool for functional analysis. Nucleic Acids Res (2012) 0.98