Published in J Med Chem on December 11, 2008
MASP-1, a promiscuous complement protease: structure of its catalytic region reveals the basis of its broad specificity. J Immunol (2009) 1.25
A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations. J Biol Chem (2005) 1.23
C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease. J Biol Chem (2007) 1.08
Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: structure of the active catalytic region of C1r. Mol Immunol (2007) 1.05
Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins. Nucleic Acids Res (2006) 1.02
Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]-L-deprenyl using whole hemisphere autoradiography. Neurochem Int (2010) 1.00
Directed evolution reveals the binding motif preference of the LC8/DYNLL hub protein and predicts large numbers of novel binders in the human proteome. PLoS One (2011) 0.98
Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase. Nucleic Acids Res (2010) 0.95
Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2. J Biol Chem (2012) 0.94
Structural evidence for non-canonical binding of Ca2+ to a canonical EF-hand of a conventional myosin. J Biol Chem (2005) 0.92
Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway. J Biol Chem (2013) 0.91
Enzyme:substrate hydrogen bond shortening during the acylation phase of serine protease catalysis. Biochemistry (2006) 0.88
Extended intermolecular interactions in a serine protease-canonical inhibitor complex account for strong and highly specific inhibition. J Mol Biol (2005) 0.88
The structure of the complex of calmodulin with KAR-2: a novel mode of binding explains the unique pharmacology of the drug. J Biol Chem (2004) 0.86
Human prorenin structure sheds light on a novel mechanism of its autoinhibition and on its non-proteolytic activation by the (pro)renin receptor. J Mol Biol (2012) 0.85
The acylaminoacyl peptidase from Aeropyrum pernix K1 thought to be an exopeptidase displays endopeptidase activity. J Mol Biol (2007) 0.85
A self-compartmentalizing hexamer serine protease from Pyrococcus horikoshii: substrate selection achieved through multimerization. J Biol Chem (2013) 0.82
Three dimensional structures of S189D chymotrypsin and D189S trypsin mutants: the effect of polarity at site 189 on a protease-specific stabilization of the substrate-binding site. J Mol Biol (2003) 0.82
Structure and enzymatic mechanism of a moonlighting dUTPase. Acta Crystallogr D Biol Crystallogr (2013) 0.82
Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors. Bioorg Med Chem Lett (2010) 0.82
Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors. Bioorg Med Chem Lett (2011) 0.81
Rapidly progressing fatal reperfusion syndrome caused by acute critical ischemia of the lower limb. Cardiovasc Pathol (2013) 0.80
Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases. FEBS Lett (2010) 0.80
Purification, crystallization and preliminary X-ray analysis of human mannose-binding lectin-associated serine protease-1 (MASP-1) catalytic region. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.79
Structural and kinetic contributions of the oxyanion binding site to the catalytic activity of acylaminoacyl peptidase. J Struct Biol (2008) 0.79
Characterization of a novel acylaminoacyl peptidase with hexameric structure and endopeptidase activity. Biochim Biophys Acta (2009) 0.79
Crystallization and preliminary crystallographic analysis of dUTPase from the φ11 helper phage of Staphylococcus aureus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.78
Structure and mechanism of calmodulin binding to a signaling sphingolipid reveal new aspects of lipid-protein interactions. FASEB J (2010) 0.77
Lipophilicity of aminopyridazinone regioisomers. J Agric Food Chem (2003) 0.76
Structure-based design and optimization of potent renin inhibitors on 5- or 7-azaindole-scaffolds. Bioorg Med Chem Lett (2011) 0.76
In vitro formation of selegiline-N-oxide as a metabolite of selegiline in human, hamster, mouse, rat, guinea-pig, rabbit and dog. Eur J Drug Metab Pharmacokinet (2004) 0.75
Alcohol-O,O'-dibenzoyl-(2R,3R)-tartaric acid complexes. Chirality (2004) 0.75
Ring transformation of unsaturated N-bridgehead fused pyrimidin-4(3H)-ones: role of repulsive electrostatic nonbonded interaction. J Org Chem (2010) 0.75
[Postconditioning can reduce long-term lung injury after lower limb ischemia-reperfusion]. Magy Seb (2013) 0.75
[Light- and temperature-induced degradation of fumagillin]. Acta Pharm Hung (2003) 0.75
[Long ischemic period of the lower limb--study of skeletal muscle viability in experimental animal models]. Magy Seb (2010) 0.75
A novel orally active inhibitor of HLE. Eur J Med Chem (2003) 0.75
[The multidrug resistance modulators heterocondensed quinazolones]. Acta Pharm Hung (2003) 0.75
Interaction of SSR161421, a novel specific adenosine A(3) receptor antagonist with adenosine A(3) receptor agonists both in vitro and in vivo. Eur J Pharmacol (2012) 0.75
[Effect of postconditioning in major vascular operations on rats]. Magy Seb (2009) 0.75
Suzuki-Miyaura cross-coupling reactions of halo derivatives of 4H-pyrido[1,2-a]pyrimidin-4-ones. Org Biomol Chem (2011) 0.75
Drotaverine interacts with the L-type Ca(2+) channel in pregnant rat uterine membranes. Eur J Pharmacol (2002) 0.75
1,5-Hydride shift in Wolff-Kishner reduction of (20R)-3beta,20, 26-trihydroxy-27-norcholest-5-en-22-one: synthetic, quantum chemical, and NMR studies. Steroids (2002) 0.75
An experimental and theoretical study of reaction mechanisms between nitriles and hydroxylamine. Org Biomol Chem (2014) 0.75
[Acute and critical ischemia of the lower limb]. Orv Hetil (2010) 0.75
Modeling rate-controlling solvent effects. The pericyclic meisenheimer rearrangement of N-propargylmorpholine N-oxide. J Am Chem Soc (2005) 0.75