Published in J Biol Chem on April 30, 2013
Expression, purification, crystallization and preliminary X-ray diffraction analysis of acylpeptide hydrolase from Deinococcus radiodurans. Acta Crystallogr F Struct Biol Commun (2014) 0.75
A Porphyromonas gingivalis Periplasmic Novel Exopeptidase, Acylpeptidyl Oligopeptidase, Releases N-Acylated Di- and Tripeptides from Oligopeptides. J Biol Chem (2016) 0.75
EstDZ3: A New Esterolytic Enzyme Exhibiting Remarkable Thermostability. Front Microbiol (2016) 0.75
A short history of SHELX. Acta Crystallogr A (2007) 7339.18
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
XDS. Acta Crystallogr D Biol Crystallogr (2010) 67.46
MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2009) 53.36
GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. J Chem Theory Comput (2008) 34.90
SFCHECK: a unified set of procedures for evaluating the quality of macromolecular structure-factor data and their agreement with the atomic model. Acta Crystallogr D Biol Crystallogr (1999) 19.57
The Buccaneer software for automated model building. 1. Tracing protein chains. Acta Crystallogr D Biol Crystallogr (2006) 18.18
Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations. J Comput Chem (2004) 17.97
Protein folding and misfolding. Nature (2003) 14.92
Towards automated crystallographic structure refinement with phenix.refine. Acta Crystallogr D Biol Crystallogr (2012) 11.31
Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation. Proc Natl Acad Sci U S A (2002) 4.66
Amyloid formation by globular proteins under native conditions. Nat Chem Biol (2009) 3.72
Structural basis of anticodon loop recognition by glutaminyl-tRNA synthetase. Nature (1991) 3.21
Exploring the sequence determinants of amyloid structure using position-specific scoring matrices. Nat Methods (2010) 2.74
Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis. Cell (1998) 2.08
Implementation of the CHARMM Force Field in GROMACS: Analysis of Protein Stability Effects from Correction Maps, Virtual Interaction Sites, and Water Models. J Chem Theory Comput (2010) 2.00
Prevention of amyloid-like aggregation as a driving force of protein evolution. EMBO Rep (2007) 1.78
The prolyl oligopeptidase family. Cell Mol Life Sci (2002) 1.65
The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism. Proc Natl Acad Sci U S A (2003) 1.62
Protein misfolding and aggregation: new examples in medicine and biology of the dark side of the protein world. Biochim Biophys Acta (2004) 1.60
Structural investigation of the cofactor-free chloroperoxidases. J Mol Biol (1998) 1.59
Deficiency of acylpeptide hydrolase in small-cell lung carcinoma cell lines. J Lab Clin Med (1992) 1.58
Crystal structure of haloalkane dehalogenase: an enzyme to detoxify halogenated alkanes. EMBO J (1991) 1.56
Crystal structure of a conserved protease that binds DNA: the bleomycin hydrolase, Gal6. Science (1995) 1.34
Crystal structure of carboxylesterase from Pseudomonas fluorescens, an alpha/beta hydrolase with broad substrate specificity. Structure (1997) 1.29
Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity. Proc Natl Acad Sci U S A (2005) 1.27
Refined structure of dienelactone hydrolase at 1.8 A. J Mol Biol (1990) 1.23
Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation. Protein Sci (2004) 1.23
Structure, function and biological relevance of prolyl oligopeptidase. Curr Protein Pept Sci (2008) 1.18
The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold. Biochem Biophys Res Commun (2003) 1.16
Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality. J Pharmacol Exp Ther (2001) 1.13
Identification of acylpeptide hydrolase as a sensitive site for reaction with organophosphorus compounds and a potential target for cognitive enhancing drugs. Mol Pharmacol (2000) 1.10
Structure of proline iminopeptidase from Xanthomonas campestris pv. citri: a prototype for the prolyl oligopeptidase family. EMBO J (1998) 1.05
Amyloid formation of a protein in the absence of initial unfolding and destabilization of the native state. Biophys J (2005) 1.03
The DNF15S2 locus at 3p21 is transcribed in normal lung and small cell lung cancer. Genomics (1989) 1.01
Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber. EMBO J (2010) 1.00
Enantioselectivity of haloalkane dehalogenases and its modulation by surface loop engineering. Angew Chem Int Ed Engl (2010) 0.98
Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation. PLoS One (2011) 0.95
Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism. EMBO J (2002) 0.93
Induced-fit mechanism for prolyl endopeptidase. J Biol Chem (2010) 0.92
Structure and catalysis of acylaminoacyl peptidase: closed and open subunits of a dimer oligopeptidase. J Biol Chem (2010) 0.90
Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum. J Mol Biol (2002) 0.90
The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor. J Mol Biol (2008) 0.90
The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase. Oncogene (1991) 0.89
Flexibility of prolyl oligopeptidase: molecular dynamics and molecular framework analysis of the potential substrate pathways. Proteins (2005) 0.89
The unusual extended C-terminal helix of the peroxisomal α/β-hydrolase Lpx1 is involved in dimer contacts but dispensable for dimerization. J Struct Biol (2011) 0.88
The acylaminoacyl peptidase from Aeropyrum pernix K1 thought to be an exopeptidase displays endopeptidase activity. J Mol Biol (2007) 0.85
Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor. J Biol Chem (2010) 0.83
Protein aggregation determinants from a simplified model: cooperative folders resist aggregation. Protein Sci (2005) 0.83
Atomic resolution crystal structures and quantum chemistry meet to reveal subtleties of hydroxynitrile lyase catalysis. J Biol Chem (2008) 0.82
Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett (2009) 0.82
The conserved N-terminal helix of acylpeptide hydrolase from archaeon Aeropyrum pernix K1 is important for its hyperthermophilic activity. Biochim Biophys Acta (2008) 0.82
Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV. J Mol Biol (2005) 0.81
Electrostatic effects and binding determinants in the catalysis of prolyl oligopeptidase. Site specific mutagenesis at the oxyanion binding site. J Biol Chem (2002) 0.80
Weak activity of haloalkane dehalogenase LinB with 1,2,3-trichloropropane revealed by X-Ray crystallography and microcalorimetry. Appl Environ Microbiol (2007) 0.80
Characterization of a novel acylaminoacyl peptidase with hexameric structure and endopeptidase activity. Biochim Biophys Acta (2009) 0.79
Structural and kinetic contributions of the oxyanion binding site to the catalytic activity of acylaminoacyl peptidase. J Struct Biol (2008) 0.79
Truncated prolyl oligopeptidase from Pyrococcus furiosus. Proteins (2007) 0.78
The beta-propeller domain of the trilobed protease from Pyrococcus furiosus reveals an open Velcro topology. Acta Crystallogr D Biol Crystallogr (2007) 0.78
MASP-1, a promiscuous complement protease: structure of its catalytic region reveals the basis of its broad specificity. J Immunol (2009) 1.25
A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations. J Biol Chem (2005) 1.23
Structure, function and biological relevance of prolyl oligopeptidase. Curr Protein Pept Sci (2008) 1.18
The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions. J Mol Biol (2004) 1.16
C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease. J Biol Chem (2007) 1.08
Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: structure of the active catalytic region of C1r. Mol Immunol (2007) 1.05
Detection and characterisation of Giardia and Cryptosporidium in Hungarian raw, surface and sewage water samples by IFT, PCR and sequence analysis of the SSUrRNA and GDH genes. Int J Hyg Environ Health (2008) 1.04
Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins. Nucleic Acids Res (2006) 1.02
Role of phosphate chain mobility of MgATP in completing the 3-phosphoglycerate kinase catalytic site: binding, kinetic, and crystallographic studies with ATP and MgATP. Biochemistry (2004) 1.00
Directed evolution reveals the binding motif preference of the LC8/DYNLL hub protein and predicts large numbers of novel binders in the human proteome. PLoS One (2011) 0.98
Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase. Nucleic Acids Res (2010) 0.95
Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2. J Biol Chem (2012) 0.94
Structural evidence for non-canonical binding of Ca2+ to a canonical EF-hand of a conventional myosin. J Biol Chem (2005) 0.92
Concerted structural changes in the peptidase and the propeller domains of prolyl oligopeptidase are required for substrate binding. J Mol Biol (2004) 0.92
Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway. J Biol Chem (2013) 0.91
Structure and catalysis of acylaminoacyl peptidase: closed and open subunits of a dimer oligopeptidase. J Biol Chem (2010) 0.90
A combined electronegativity equalization and electrostatic potential fit method for the determination of atomic point charges. J Comput Chem (2007) 0.89
Flexibility of prolyl oligopeptidase: molecular dynamics and molecular framework analysis of the potential substrate pathways. Proteins (2005) 0.89
Unclosed beta-propellers display stable structures: implications for substrate access to the active site of prolyl oligopeptidase. J Mol Biol (2005) 0.88
Enzyme:substrate hydrogen bond shortening during the acylation phase of serine protease catalysis. Biochemistry (2006) 0.88
Extended intermolecular interactions in a serine protease-canonical inhibitor complex account for strong and highly specific inhibition. J Mol Biol (2005) 0.88
The structure of the complex of calmodulin with KAR-2: a novel mode of binding explains the unique pharmacology of the drug. J Biol Chem (2004) 0.86
Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase. Biochimie (2012) 0.86
The acylaminoacyl peptidase from Aeropyrum pernix K1 thought to be an exopeptidase displays endopeptidase activity. J Mol Biol (2007) 0.85
Fluorescence resonance energy transfer (FRET) peptides and cycloretro-inverso peptides derived from bradykinin as substrates and inhibitors of prolyl oligopeptidase. Peptides (2007) 0.85
How can the mood stabilizer VPA limit both mania and depression? Mol Cell Neurosci (2005) 0.85
Triosephosphate isomerase deficiency: consequences of an inherited mutation at mRNA, protein and metabolic levels. Biochem J (2005) 0.85
The unusual catalytic triad of poliovirus protease 3C. Biochemistry (2003) 0.85
His507 of acylaminoacyl peptidase stabilizes the active site conformation, not the catalytic intermediate. FEBS Lett (2004) 0.83
Three dimensional structures of S189D chymotrypsin and D189S trypsin mutants: the effect of polarity at site 189 on a protease-specific stabilization of the substrate-binding site. J Mol Biol (2003) 0.82
Structure and enzymatic mechanism of a moonlighting dUTPase. Acta Crystallogr D Biol Crystallogr (2013) 0.82
Homology modelling and protein structure based functional analysis of five cucumovirus coat proteins. J Mol Graph Model (2005) 0.82
Crystallographic and thiol-reactivity studies on the complex of pig muscle phosphoglycerate kinase with ATP analogues: correlation between nucleotide binding mode and helix flexibility. Biochemistry (2002) 0.81
Modeling-based characterization of the elicitor function of amino acid 461 of Cucumber mosaic virus 1a protein in the hypersensitive response. Virology (2006) 0.80
Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases. FEBS Lett (2010) 0.80
Properties of the prolyl oligopeptidase homologue from Pyrococcus furiosus. FEBS Lett (2006) 0.80
Characterization of a novel acylaminoacyl peptidase with hexameric structure and endopeptidase activity. Biochim Biophys Acta (2009) 0.79
The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity. Biochim Biophys Acta (2012) 0.79
Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase. J Biol Chem (2002) 0.79
Structural and kinetic contributions of the oxyanion binding site to the catalytic activity of acylaminoacyl peptidase. J Struct Biol (2008) 0.79
Purification, crystallization and preliminary X-ray analysis of human mannose-binding lectin-associated serine protease-1 (MASP-1) catalytic region. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.79
GAP43 shows partial co-localisation but no strong physical interaction with prolyl oligopeptidase. Biochim Biophys Acta (2010) 0.78
Role of the oxyanion binding site and subsites S1 and S2 in the catalysis of oligopeptidase B, a novel target for antimicrobial chemotherapy. Biochemistry (2002) 0.78
Truncated prolyl oligopeptidase from Pyrococcus furiosus. Proteins (2007) 0.78
C-29 ecdysteroids from Ajuga reptans var. reptans. J Nat Prod (2009) 0.78
Crystallization and preliminary crystallographic analysis of dUTPase from the φ11 helper phage of Staphylococcus aureus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.78
Increase of SARS-CoV 3CL peptidase activity due to macromolecular crowding effects in the milieu composition. Biol Chem (2010) 0.77
Structure and mechanism of calmodulin binding to a signaling sphingolipid reveal new aspects of lipid-protein interactions. FASEB J (2010) 0.77
Multicoordinate driven method for approximating enzymatic reaction paths: automatic definition of the reaction coordinate using a subset of chemical coordinates. J Phys Chem A (2006) 0.77
Kosmotropic salt activation and substrate specificity of poliovirus protease 3C. Biochemistry (2006) 0.77
Four spatial points that define enzyme families. Biochem Biophys Res Commun (2009) 0.76
Compatibility of the movement protein and the coat protein of cucumoviruses is required for cell-to-cell movement. J Gen Virol (2004) 0.76
Lipophilicity of aminopyridazinone regioisomers. J Agric Food Chem (2003) 0.76
Crystallization and preliminary crystallographic analysis of porcine acylaminoacyl peptidase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.75
Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules. J Med Chem (2008) 0.75