Published in Biol Chem on January 01, 2009
Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med (2012) 2.01
Selenoprotein P-expression, functions, and roles in mammals. Biochim Biophys Acta (2009) 1.83
Differential functions of ApoER2 and very low density lipoprotein receptor in Reelin signaling depend on differential sorting of the receptors. J Biol Chem (2009) 1.08
Selenoprotein P regulates 1-(4-Chlorophenyl)-benzo-2,5-quinone-induced oxidative stress and toxicity in human keratinocytes. Free Radic Biol Med (2013) 0.89
Isoform-specific binding of selenoprotein P to the β-propeller domain of apolipoprotein E receptor 2 mediates selenium supply. J Biol Chem (2014) 0.79
Transcriptomics of maternal and fetal membranes can discriminate between gestational-age matched preterm neonates with and without cognitive impairment diagnosed at 18-24 months. PLoS One (2015) 0.78
Canonical and Non-canonical Reelin Signaling. Front Cell Neurosci (2016) 0.77
Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell (1999) 5.52
Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron (2005) 3.25
Reelin, lipoprotein receptors and synaptic plasticity. Nat Rev Neurosci (2006) 2.95
Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis. Annu Rev Nutr (2005) 2.33
Deletion of selenoprotein P alters distribution of selenium in the mouse. J Biol Chem (2003) 2.27
Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fed. J Neurosci (2007) 1.41
Apolipoprotein E receptor-2 (ApoER2) mediates selenium uptake from selenoprotein P by the mouse testis. J Biol Chem (2007) 1.36
Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity. J Neurosci (2006) 1.26
Infertile spermatozoa of c-ros tyrosine kinase receptor knockout mice show flagellar angulation and maturational defects in cell volume regulatory mechanisms. Biol Reprod (1999) 1.19
Essential role of the apolipoprotein E receptor-2 in sperm development. J Biol Chem (2003) 1.19
Acquisition of volume regulatory response of sperm upon maturation in the epididymis and the role of the cytoplasmic droplet. Microsc Res Tech (2003) 1.17
Neurodegeneration in mice resulting from loss of functional selenoprotein P or its receptor apolipoprotein E receptor 2. J Neuropathol Exp Neurol (2008) 1.16
Selenoprotein P is required for mouse sperm development. Biol Reprod (2005) 1.15
Altered hippocampus synaptic function in selenoprotein P deficient mice. Mol Neurodegener (2006) 1.13
ApoE receptor 2 controls neuronal survival in the adult brain. Curr Biol (2006) 1.08
The coiled tail of the round-headed spermatozoa appears during epididymal passage in GOPC-deficient mice. Arch Histol Cytol (2004) 0.89
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst (2005) 13.00
Suppression of aging in mice by the hormone Klotho. Science (2005) 8.11
LRP: role in vascular wall integrity and protection from atherosclerosis. Science (2003) 3.89
Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers? Trends Mol Med (2004) 3.44
Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron (2005) 3.25
Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci U S A (2002) 3.03
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes. J Biol Chem (2010) 2.72
Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. J Biol Chem (2002) 2.67
All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proc Natl Acad Sci U S A (2007) 2.59
Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron (2007) 2.55
TDP-43 is a developmentally regulated protein essential for early embryonic development. J Biol Chem (2009) 2.40
Reelin activates SRC family tyrosine kinases in neurons. Curr Biol (2003) 2.29
Deletion of selenoprotein P alters distribution of selenium in the mouse. J Biol Chem (2003) 2.27
Effectiveness of selenium supplements in a low-selenium area of China. Am J Clin Nutr (2005) 2.13
Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med (2012) 2.01
Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia. J Biol Chem (2011) 1.88
Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta. J Biol Chem (2002) 1.88
Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J Biol Chem (2002) 1.83
Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. Mol Cell Biol (2004) 1.81
Acute selenium toxicity associated with a dietary supplement. Arch Intern Med (2010) 1.78
Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2. J Clin Invest (2010) 1.77
Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae. J Biol Chem (2002) 1.74
Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. J Clin Invest (2007) 1.73
Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo. PLoS One (2009) 1.67
Receptor clustering is involved in Reelin signaling. Mol Cell Biol (2004) 1.66
Neurological dysfunction occurs in mice with targeted deletion of the selenoprotein P gene. J Nutr (2004) 1.66
Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration. EMBO J (2006) 1.66
Reelin modulates NMDA receptor activity in cortical neurons. J Neurosci (2005) 1.65
TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor. Mol Cell Biol (2010) 1.64
Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination. J Biol Chem (2003) 1.63
Lrp4 modulates extracellular integration of cell signaling pathways in development. PLoS One (2008) 1.60
Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis. Arterioscler Thromb Vasc Biol (2008) 1.58
Reelin protects against amyloid β toxicity in vivo. Sci Signal (2015) 1.57
ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling. Proc Natl Acad Sci U S A (2010) 1.57
Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia. J Biol Chem (2003) 1.56
Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. Hum Mol Genet (2005) 1.56
Interaction of reelin signaling and Lis1 in brain development. Nat Genet (2003) 1.56
A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility. Nat Cell Biol (2003) 1.54
Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development. EMBO J (2006) 1.51
Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase. J Biol Chem (2003) 1.48
Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes. Structure (2003) 1.48
Human apolipoprotein E isoforms differentially affect bone mass and turnover in vivo. J Bone Miner Res (2013) 1.47
Apolipoprotein E induces antiinflammatory phenotype in macrophages. Arterioscler Thromb Vasc Biol (2011) 1.47
Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure. J Biol Chem (2002) 1.47
Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling. J Biol Chem (2009) 1.45
Reelin signaling directly affects radial glia morphology and biochemical maturation. Development (2003) 1.44
LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome. PLoS One (2007) 1.44
Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration. J Biol Chem (2012) 1.43
The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development. J Neurosci (2004) 1.42
Identical phenotypes of CatSper1 and CatSper2 null sperm. J Biol Chem (2005) 1.40
Gamma-secretase limits the inflammatory response through the processing of LRP1. Sci Signal (2008) 1.38
LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome. Am J Hum Genet (2010) 1.37
LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling. J Biol Chem (2008) 1.36
Apolipoprotein E receptor-2 (ApoER2) mediates selenium uptake from selenoprotein P by the mouse testis. J Biol Chem (2007) 1.36
TDP-43 aggregation in neurodegeneration: are stress granules the key? Brain Res (2012) 1.35
Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells. J Biol Chem (2008) 1.34
Reelin signaling antagonizes beta-amyloid at the synapse. Proc Natl Acad Sci U S A (2009) 1.32
Apolipoprotein E receptors are required for reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1. J Biol Chem (2004) 1.31
Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity. J Neurosci (2006) 1.26
The modular adaptor protein autosomal recessive hypercholesterolemia (ARH) promotes low density lipoprotein receptor clustering into clathrin-coated pits. J Biol Chem (2005) 1.25
The selenium-rich C-terminal domain of mouse selenoprotein P is necessary for the supply of selenium to brain and testis but not for the maintenance of whole body selenium. J Biol Chem (2007) 1.22
Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia. J Clin Invest (2007) 1.22
Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta). J Biol Chem (2005) 1.21
Essential role of the apolipoprotein E receptor-2 in sperm development. J Biol Chem (2003) 1.19
Extracellular glutathione peroxidase (Gpx3) binds specifically to basement membranes of mouse renal cortex tubule cells. Am J Physiol Renal Physiol (2009) 1.17
Emerging topics in Reelin function. Eur J Neurosci (2010) 1.17
Trypanosoma cruzi utilizes the host low density lipoprotein receptor in invasion. PLoS Negl Trop Dis (2011) 1.17
Neurodegeneration in mice resulting from loss of functional selenoprotein P or its receptor apolipoprotein E receptor 2. J Neuropathol Exp Neurol (2008) 1.16
Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P. J Immunol (2008) 1.16
Selenoprotein P is required for mouse sperm development. Biol Reprod (2005) 1.15
Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin α5β1. Neuron (2012) 1.14
Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Cancer Res (2012) 1.13
Altered hippocampus synaptic function in selenoprotein P deficient mice. Mol Neurodegener (2006) 1.13
All regions of mouse brain are dependent on selenoprotein P for maintenance of selenium. J Nutr (2007) 1.13
Functions of lipoprotein receptors in neurons. J Lipid Res (2003) 1.11
Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. PLoS Biol (2011) 1.11
Defective splicing of Megf7/Lrp4, a regulator of distal limb development, in autosomal recessive mulefoot disease. Genomics (2006) 1.10
Genetic modulation of tau phosphorylation in the mouse. J Neurosci (2003) 1.09
LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS One (2009) 1.09
Combined deficiency of vitamins E and C causes paralysis and death in guinea pigs. Am J Clin Nutr (2003) 1.09
A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC). Proc Natl Acad Sci U S A (2007) 1.08
ApoE receptor 2 controls neuronal survival in the adult brain. Curr Biol (2006) 1.08
Mutations in VLDLR as a cause for autosomal recessive cerebellar ataxia with mental retardation (dysequilibrium syndrome). J Child Neurol (2009) 1.08
Insulin-secreting beta-cell dysfunction induced by human lipoproteins. J Biol Chem (2003) 1.08
Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis. PLoS One (2013) 1.07
Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family. Biol Chem (2010) 1.07
Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission. Neuron (2013) 1.07
Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. J Biol Chem (2012) 1.06
Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice. J Comp Neurol (2003) 1.06
Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol Cell Biol (2004) 1.05
"Devolution" of bipedality. Proc Natl Acad Sci U S A (2008) 1.05
Signaling through LRP1: Protection from atherosclerosis and beyond. Biochem Pharmacol (2010) 1.03
Smooth muscle LDL receptor-related protein-1 inactivation reduces vascular reactivity and promotes injury-induced neointima formation. Arterioscler Thromb Vasc Biol (2009) 1.03
Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation. J Neurosci (2010) 1.02
Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. J Neurosci (2013) 1.01
Reelin induces EphB activation. Cell Res (2013) 1.01
Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. J Neurosci (2004) 1.00
An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. J Clin Invest (2014) 0.99