Published in Proc Natl Acad Sci U S A on January 16, 2007
The biology of infertility: research advances and clinical challenges. Nat Med (2008) 4.62
The Concise Guide to PHARMACOLOGY 2013/14: ion channels. Br J Pharmacol (2013) 3.03
KSper, a pH-sensitive K+ current that controls sperm membrane potential. Proc Natl Acad Sci U S A (2007) 1.77
The control of male fertility by spermatozoan ion channels. Annu Rev Physiol (2011) 1.74
Male infertility caused by spermiogenic defects: lessons from gene knockouts. Mol Cell Endocrinol (2009) 1.64
Fertilization: a sperm's journey to and interaction with the oocyte. J Clin Invest (2010) 1.53
Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa. Proc Natl Acad Sci U S A (2011) 1.43
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Advances in male contraception. Endocr Rev (2008) 1.39
As the world grows: contraception in the 21st century. J Clin Invest (2008) 1.37
The role of Hv1 and CatSper channels in sperm activation. J Physiol (2010) 1.33
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Probing neurochemical structure and function of retinal ON bipolar cells with a transgenic mouse. J Comp Neurol (2008) 1.27
Ion channels that control fertility in mammalian spermatozoa. Int J Dev Biol (2008) 1.23
LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel. Proc Natl Acad Sci U S A (2011) 1.22
Ion channels, phosphorylation and mammalian sperm capacitation. Asian J Androl (2011) 1.21
Human male infertility caused by mutations in the CATSPER1 channel protein. Am J Hum Genet (2009) 1.19
A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun (2011) 1.16
Ancestral Ca2+ signaling machinery in early animal and fungal evolution. Mol Biol Evol (2011) 1.12
A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein. Biol Reprod (2009) 1.10
Mouse sperm K+ currents stimulated by pH and cAMP possibly coded by Slo3 channels. Biochem Biophys Res Commun (2009) 1.08
A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC). Proc Natl Acad Sci U S A (2007) 1.08
Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice. J Clin Invest (2010) 1.06
Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient. Proc Natl Acad Sci U S A (2013) 1.05
Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. PLoS One (2008) 1.05
Two distinct Ca(2+) signaling pathways modulate sperm flagellar beating patterns in mice. Biol Reprod (2011) 1.04
Rediscovering sperm ion channels with the patch-clamp technique. Mol Hum Reprod (2011) 1.03
Genetic male infertility and mutation of CATSPER ion channels. Eur J Hum Genet (2010) 1.03
Mouse models in male fertility research. Asian J Androl (2010) 1.01
New frontiers in nonhormonal male contraception. Contraception (2010) 1.00
Egg coat proteins activate calcium entry into mouse sperm via CATSPER channels. Biol Reprod (2009) 0.99
Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Cell (2014) 0.98
Rethinking the relationship between hyperactivation and chemotaxis in mammalian sperm. Biol Reprod (2010) 0.97
OAZ-t/OAZ3 is essential for rigid connection of sperm tails to heads in mouse. PLoS Genet (2009) 0.97
Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation. PLoS One (2009) 0.97
Behavioral mechanism during human sperm chemotaxis: involvement of hyperactivation. PLoS One (2011) 0.96
The BSA-induced Ca2+ influx during sperm capacitation is CATSPER channel-dependent. Reprod Biol Endocrinol (2009) 0.96
Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility. Mol Reprod Dev (2011) 0.95
Odorant receptor-mediated sperm activation in disease vector mosquitoes. Proc Natl Acad Sci U S A (2014) 0.93
Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa. J Gen Physiol (2013) 0.92
Roles of the oviduct in mammalian fertilization. Reproduction (2012) 0.92
ATP-activated P2X2 current in mouse spermatozoa. Proc Natl Acad Sci U S A (2011) 0.91
Mendelian genetics of male infertility. Ann N Y Acad Sci (2010) 0.90
SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility. Proc Natl Acad Sci U S A (2015) 0.90
Drosophila sperm swim backwards in the female reproductive tract and are activated via TRPP2 ion channels. PLoS One (2011) 0.89
A nonsense mutation in TMEM95 encoding a nondescript transmembrane protein causes idiopathic male subfertility in cattle. PLoS Genet (2014) 0.89
Molecular and functional characterization of voltage-gated sodium channels in human sperm. Reprod Biol Endocrinol (2009) 0.88
Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. Science (2016) 0.87
Biphasic role of calcium in mouse sperm capacitation signaling pathways. J Cell Physiol (2015) 0.87
Mathematical modeling of calcium signaling during sperm hyperactivation. Mol Hum Reprod (2011) 0.86
Expression and secretion of plasma membrane Ca2+-ATPase 4a (PMCA4a) during murine estrus: association with oviductal exosomes and uptake in sperm. PLoS One (2013) 0.85
p,p'-DDE activates CatSper and compromises human sperm function at environmentally relevant concentrations. Hum Reprod (2013) 0.84
Ion channels and calcium signaling in motile cilia. Elife (2015) 0.84
Testicular expression of Adora3i2 in Adora3 knockout mice reveals a role of mouse A3Ri2 and human A3Ri3 adenosine receptors in sperm. J Biol Chem (2010) 0.84
Ca2+ ionophore A23187 can make mouse spermatozoa capable of fertilizing in vitro without activation of cAMP-dependent phosphorylation pathways. Proc Natl Acad Sci U S A (2013) 0.84
Early evolution of the eukaryotic Ca2+ signaling machinery: conservation of the CatSper channel complex. Mol Biol Evol (2014) 0.84
The CatSper channel controls chemosensation in sea urchin sperm. EMBO J (2014) 0.83
Structural and regulatory evolution of cellular electrophysiological systems. Evol Dev (2009) 0.83
Up-regulation of CatSper genes family by selenium. Reprod Biol Endocrinol (2009) 0.83
Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility. J Biol Chem (2010) 0.82
Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view. Cell Calcium (2014) 0.82
Sodium influx induced by external calcium chelation decreases human sperm motility. Hum Reprod (2011) 0.81
Calcium influx and male fertility in the context of the sperm proteome: an update. Biomed Res Int (2014) 0.81
Sperm BerserKers. Elife (2013) 0.80
Loss of calcium in human spermatozoa via EPPIN, the semenogelin receptor. Biol Reprod (2012) 0.80
CABYR isoforms expressed in late steps of spermiogenesis bind with AKAPs and ropporin in mouse sperm fibrous sheath. Reprod Biol Endocrinol (2010) 0.80
A clinical appraisal of the genetic basis in unexplained male infertility. J Hum Reprod Sci (2013) 0.80
The evolutionary history of sarco(endo)plasmic calcium ATPase (SERCA). PLoS One (2012) 0.80
The voltage-gated sodium channel nav1.8 is expressed in human sperm. PLoS One (2013) 0.79
Major regulatory mechanisms involved in sperm motility. Asian J Androl (2015) 0.78
Involvement of Transient Receptor Potential Vanilloid (TRPV) 4 in mouse sperm thermotaxis. J Reprod Dev (2016) 0.78
From damage response to action potentials: early evolution of neural and contractile modules in stem eukaryotes. Philos Trans R Soc Lond B Biol Sci (2016) 0.78
Coupling biochemistry and hydrodynamics captures hyperactivated sperm motility in a simple flagellar model. J Theor Biol (2011) 0.78
Panax ginseng induces the expression of CatSper genes and sperm hyperactivation. Asian J Androl (2014) 0.77
Impact of glycosylation on the unimpaired functions of the sperm. Clin Exp Reprod Med (2015) 0.77
Sperm are promiscuous and CatSper is to blame…. EMBO J (2012) 0.77
Molecular and cellular mechanisms of sperm-oocyte interactions opinions relative to in vitro fertilization (IVF). Int J Mol Sci (2014) 0.77
Structural evolution of CatSper1 in rodents is influenced by sperm competition, with effects on sperm swimming velocity. BMC Evol Biol (2014) 0.77
Regulation of fertilization in male rats by CatSper2 knockdown. Asian J Androl (2011) 0.77
Microarray-Based Comparisons of Ion Channel Expression Patterns: Human Keratinocytes to Reprogrammed hiPSCs to Differentiated Neuronal and Cardiac Progeny. Stem Cells Int (2013) 0.76
Roles of intracellular cyclic AMP signal transduction in the capacitation and subsequent hyperactivation of mouse and boar spermatozoa. J Reprod Dev (2013) 0.76
Odyssey of the spermatozoon. Asian J Androl (2015) 0.76
Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids. Proc Natl Acad Sci U S A (2017) 0.76
Progesterone Accelerates the Completion of Sperm Capacitation and Activates CatSper Channel in Spermatozoa from the Rhesus Macaque. Biol Reprod (2015) 0.75
Analysis of the correlation of CATSPER single nucleotide polymorphisms (SNPs) with idiopathic asthenospermia. J Assist Reprod Genet (2015) 0.75
Male contraception - a molecular approach. Indian J Community Med (2010) 0.75
The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex. ACS Chem Biol (2015) 0.75
Molecular cloning, spatial and temporal expression analysis of CatSper genes in the Chinese Meishan pigs. Reprod Biol Endocrinol (2011) 0.75
The control of male fertility by spermatid-specific factors: searching for contraceptive targets from spermatozoon's head to tail. Cell Death Dis (2016) 0.75
Factors and pathways involved in capacitation: how are they regulated? Oncotarget (2016) 0.75
Construction of a catsper1 DNA vaccine and its antifertility effect on male mice. PLoS One (2015) 0.75
Dose-dependent effects of cisplatin on the severity of testicular injury in Sprague Dawley rats: reactive oxygen species and endoplasmic reticulum stress. Drug Des Devel Ther (2016) 0.75
CatSperζ regulates the structural continuity of sperm Ca(2+) signaling domains and is required for normal fertility. Elife (2017) 0.75
Physiology and Evolution of Voltage-Gated Calcium Channels in Early Diverging Animal Phyla: Cnidaria, Placozoa, Porifera and Ctenophora. Front Physiol (2016) 0.75
Wrath of the wraiths of CatSper3 and CatSper4. Proc Natl Acad Sci U S A (2007) 0.75
Progress in ciliary ion channel physiology. J Gen Physiol (2016) 0.75
The Catsper channel and its roles in male fertility: a systematic review. Reprod Biol Endocrinol (2017) 0.75
Expression of uncharacterized male germ cell-specific genes and discovery of novel sperm-tail proteins in mice. PLoS One (2017) 0.75
A sperm ion channel required for sperm motility and male fertility. Nature (2001) 4.43
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Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature (2006) 2.63
A voltage-gated ion channel expressed specifically in spermatozoa. Proc Natl Acad Sci U S A (2001) 2.37
CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proc Natl Acad Sci U S A (2003) 2.34
Sperm guidance in mammals - an unpaved road to the egg. Nat Rev Mol Cell Biol (2006) 2.24
Hyperactivated sperm motility driven by CatSper2 is required for fertilization. Proc Natl Acad Sci U S A (2003) 2.07
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Mouse models of male infertility. Nat Rev Genet (2002) 1.86
Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3. Nat Cell Biol (2001) 1.81
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A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility. Nat Cell Biol (2003) 1.54
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Evidence for the involvement of calmodulin in mouse sperm capacitation. Biol Reprod (2000) 0.95
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An introduction to TRP channels. Annu Rev Physiol (2006) 7.52
The mitochondrial calcium uniporter is a highly selective ion channel. Nature (2004) 6.97
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet (2005) 5.53
TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A (2007) 5.27
Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell (2006) 5.03
A voltage-gated proton-selective channel lacking the pore domain. Nature (2006) 4.89
Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol (2004) 4.19
Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. Science (2009) 3.96
The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol (2002) 3.63
TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature (2002) 3.55
Progesterone activates the principal Ca2+ channel of human sperm. Nature (2011) 3.18
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature (2012) 2.97
Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel. Cell (2010) 2.73
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature (2006) 2.63
The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron (2003) 2.61
Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science (2008) 2.59
Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci (2006) 2.58
The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Neuron (2006) 2.50
Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J Neurosci (2004) 2.41
Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. Circ Res (2005) 2.40
EMRE is an essential component of the mitochondrial calcium uniporter complex. Science (2013) 2.39
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell (2012) 2.35
CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proc Natl Acad Sci U S A (2003) 2.34
TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell (2010) 2.32
Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria. Cell (2012) 2.29
Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J Biol Chem (2003) 2.29
A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proc Natl Acad Sci U S A (2009) 2.16
Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. J Neurosci (2005) 2.09
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev (2003) 2.05
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell (2012) 2.03
Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A (2007) 1.99
SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron (2004) 1.97
Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci U S A (2010) 1.96
TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci (2003) 1.95
The cation selectivity filter of the bacterial sodium channel, NaChBac. J Gen Physiol (2002) 1.94
A superfamily of voltage-gated sodium channels in bacteria. J Biol Chem (2003) 1.84
Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proc Natl Acad Sci U S A (2009) 1.80
TRP ion channels in the nervous system. Curr Opin Neurobiol (2004) 1.78
KSper, a pH-sensitive K+ current that controls sperm membrane potential. Proc Natl Acad Sci U S A (2007) 1.77
TRPM1 forms ion channels associated with melanin content in melanocytes. Sci Signal (2009) 1.75
The control of male fertility by spermatozoan ion channels. Annu Rev Physiol (2011) 1.74
Essential role for TRPC5 in amygdala function and fear-related behavior. Cell (2009) 1.72
TRPA1 contributes to cold hypersensitivity. J Neurosci (2010) 1.68
Activity of the mitochondrial calcium uniporter varies greatly between tissues. Nat Commun (2012) 1.64
International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol Rev (2005) 1.63
Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Proc Natl Acad Sci U S A (2009) 1.60
A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility. Nat Cell Biol (2003) 1.54
Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury. Nat Med (2003) 1.54
Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol (2009) 1.51
Rheotaxis guides mammalian sperm. Curr Biol (2013) 1.47
Real-time imaging of nuclear permeation by EGFP in single intact cells. Biophys J (2003) 1.46
The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat Neurosci (2012) 1.45
CatSperbeta, a novel transmembrane protein in the CatSper channel complex. J Biol Chem (2007) 1.43
Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors. Mol Pain (2009) 1.42
Identical phenotypes of CatSper1 and CatSper2 null sperm. J Biol Chem (2005) 1.40
MCU encodes the pore conducting mitochondrial calcium currents. Elife (2013) 1.39
CACNA1H mutations in autism spectrum disorders. J Biol Chem (2006) 1.35
The role of Hv1 and CatSper channels in sperm activation. J Physiol (2010) 1.33
The channel kinase, TRPM7, is required for early embryonic development. Proc Natl Acad Sci U S A (2011) 1.29
The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus. Proc Natl Acad Sci U S A (2004) 1.28
Phenotyping sensory nerve endings in vitro in the mouse. Nat Protoc (2009) 1.27
A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biol (2004) 1.26
Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A (2013) 1.25
Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport. EMBO J (2006) 1.25
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Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A (2011) 1.19
Role of the C-terminal domain in the structure and function of tetrameric sodium channels. Nat Commun (2013) 1.19
TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. Proc Natl Acad Sci U S A (2008) 1.17
A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun (2011) 1.16