Published in Nat Struct Mol Biol on November 16, 2008
HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol (2010) 7.16
Converging concepts of protein folding in vitro and in vivo. Nat Struct Mol Biol (2009) 5.47
Mechanism of folding chamber closure in a group II chaperonin. Nature (2010) 2.85
4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement. Proc Natl Acad Sci U S A (2010) 2.17
Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1. Cell (2014) 1.82
The molecular architecture of the eukaryotic chaperonin TRiC/CCT. Structure (2012) 1.80
Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity. Mol Cell (2013) 1.72
Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure. Structure (2011) 1.71
The ribosome as a hub for protein quality control. Mol Cell (2013) 1.53
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Cell (2014) 1.52
Allostery in the Hsp70 chaperone proteins. Top Curr Chem (2013) 1.52
Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease. PLoS Biol (2010) 1.47
Subunit order of eukaryotic TRiC/CCT chaperonin by cross-linking, mass spectrometry, and combinatorial homology modeling. Proc Natl Acad Sci U S A (2012) 1.36
The structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCT. Cell (2014) 1.31
The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins. EMBO J (2011) 1.30
Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin. Nat Struct Mol Biol (2010) 1.26
Dual action of ATP hydrolysis couples lid closure to substrate release into the group II chaperonin chamber. Cell (2011) 1.25
p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling. J Biol Chem (2009) 1.16
Effects of oxidative stress on behavior, physiology, and the redox thiol proteome of Caenorhabditis elegans. Antioxid Redox Signal (2010) 1.16
Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle. EMBO J (2011) 1.12
Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl. Proc Natl Acad Sci U S A (2010) 1.09
TRiC's tricks inhibit huntingtin aggregation. Elife (2013) 1.02
A gradient of ATP affinities generates an asymmetric power stroke driving the chaperonin TRIC/CCT folding cycle. Cell Rep (2012) 0.97
Disruption of the chaperonin containing TCP-1 function affects protein networks essential for rod outer segment morphogenesis and survival. Mol Cell Proteomics (2010) 0.96
Association of the influenza virus RNA polymerase subunit PB2 with the host chaperonin CCT. J Virol (2010) 0.96
Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT. Proc Natl Acad Sci U S A (2012) 0.95
The Mechanism and Function of Group II Chaperonins. J Mol Biol (2015) 0.93
Multistate proteomics analysis reveals novel strategies used by a hibernator to precondition the heart and conserve ATP for winter heterothermy. Physiol Genomics (2011) 0.93
Fidelity of cotranslational protein targeting by the signal recognition particle. Annu Rev Biophys (2014) 0.91
Cytosolic chaperones mediate quality control of higher-order septin assembly in budding yeast. Mol Biol Cell (2015) 0.91
A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1. Cell Rep (2014) 0.91
Structural and biochemical characterization of the childhood cataract-associated R76S mutant of human γD-crystallin. Biochemistry (2012) 0.90
Programmed cell death protein 5 interacts with the cytosolic chaperonin containing tailless complex polypeptide 1 (CCT) to regulate β-tubulin folding. J Biol Chem (2013) 0.90
Barcoding heat shock proteins to human diseases: looking beyond the heat shock response. Dis Model Mech (2014) 0.90
The group II chaperonin Mm-Cpn binds and refolds human γD crystallin. Protein Sci (2011) 0.90
Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex. Mol Cell Biol (2013) 0.90
Modulation of STAT3 folding and function by TRiC/CCT chaperonin. PLoS Biol (2014) 0.88
Interactions of subunit CCT3 in the yeast chaperonin CCT/TRiC with Q/N-rich proteins revealed by high-throughput microscopy analysis. Proc Natl Acad Sci U S A (2012) 0.87
The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction. J Biol Chem (2011) 0.86
CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proc Natl Acad Sci U S A (2013) 0.85
A two-step mechanism for the folding of actin by the yeast cytosolic chaperonin. J Biol Chem (2010) 0.85
Improved Peak Detection and Deconvolution of Native Electrospray Mass Spectra from Large Protein Complexes. J Am Soc Mass Spectrom (2015) 0.85
Functional Subunits of Eukaryotic Chaperonin CCT/TRiC in Protein Folding. J Amino Acids (2011) 0.84
Caenorhabditis elegans chaperonin CCT/TRiC is required for actin and tubulin biogenesis and microvillus formation in intestinal epithelial cells. Mol Biol Cell (2014) 0.83
Molecular and genetic analysis of the Drosophila model of fragile X syndrome. Results Probl Cell Differ (2012) 0.83
Molecular pathways undergoing dramatic transcriptomic changes during tumor development in the human colon. BMC Cancer (2012) 0.83
Overexpression of chaperonin containing TCP1, subunit 3 predicts poor prognosis in hepatocellular carcinoma. World J Gastroenterol (2015) 0.82
The calcium-dependent interaction between S100B and the mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplasmic processing of ATAD3A. Mol Cell Biol (2010) 0.82
Interactions between the actin filament capping and severing protein gelsolin and the molecular chaperone CCT: evidence for nonclassical substrate interactions. Cell Stress Chaperones (2010) 0.82
A human CCT5 gene mutation causing distal neuropathy impairs hexadecamer assembly in an archaeal model. Sci Rep (2014) 0.81
Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae. Genetics (2012) 0.81
Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced Activity. Front Mol Biosci (2016) 0.81
Essential role of the chaperonin CCT in rod outer segment biogenesis. Invest Ophthalmol Vis Sci (2014) 0.80
Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis. Int J Mol Sci (2015) 0.79
Controlling the cortical actin motor. Protoplasma (2012) 0.79
Opportunities and challenges for molecular chaperone modulation to treat protein-conformational brain diseases. Neurotherapeutics (2013) 0.79
Proteomic analysis reveals CCT is a target of Fragile X mental retardation protein regulation in Drosophila. Dev Biol (2010) 0.78
Integration of two ancestral chaperone systems into one: the evolution of eukaryotic molecular chaperones in light of eukaryogenesis. Mol Biol Evol (2013) 0.78
Proteomics of rimmed vacuoles define new risk allele in inclusion body myositis. Ann Neurol (2016) 0.77
The molecular chaperone TRiC/CCT binds to the Trp-Asp 40 (WD40) repeat protein WDR68 and promotes its folding, protein kinase DYRK1A binding, and nuclear accumulation. J Biol Chem (2014) 0.77
Group II archaeal chaperonin recognition of partially folded human γD-crystallin mutants. Protein Sci (2014) 0.77
Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO. J Biol Chem (2015) 0.76
Resistance to Inhibitors of Cholinesterase 3 (Ric-3) Expression Promotes Selective Protein Associations with the Human α7-Nicotinic Acetylcholine Receptor Interactome. PLoS One (2015) 0.76
Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM. Nat Struct Mol Biol (2016) 0.76
Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions. Biophys J (2016) 0.75
Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan. Nat Commun (2016) 0.75
Role of CCT chaperonin in the disassembly of mitotic checkpoint complexes. Proc Natl Acad Sci U S A (2017) 0.75
The molecular chaperone CCT modulates the activity of the actin filament severing and capping protein gelsolin in vitro. Cell Stress Chaperones (2015) 0.75
Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy. Sci Rep (2017) 0.75
Effect of Inulin on Proteome Changes Induced by Pathogenic Lipopolysaccharide in Human Colon. PLoS One (2017) 0.75
Silencing P2X7 receptor downregulates the expression of TCP-1 involved in lymphoma lymphatic metastasis. Oncotarget (2015) 0.75
Regulation of GPCR expression through an interaction with CCT7, a subunit of the CCT/TRiC complex. Mol Biol Cell (2016) 0.75
Replacement of GroEL in Escherichia coli by the Group II Chaperonin from the Archaeon Methanococcus maripaludis. J Bacteriol (2016) 0.75
Co-translational mechanisms of quality control of newly synthesized polypeptides. Translation (Austin) (2014) 0.75
Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex. PLoS Pathog (2016) 0.75
Chaperone-client interactions: non-specificity engenders multi-functionality. J Biol Chem (2017) 0.75
A simple method for displaying the hydropathic character of a protein. J Mol Biol (1982) 150.65
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol (2001) 66.87
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science (1999) 36.25
Protein secondary structure prediction based on position-specific scoring matrices. J Mol Biol (1999) 33.07
Lethality and centrality in protein networks. Nature (2001) 29.64
Global analysis of protein activities using proteome chips. Science (2001) 13.74
Protein aggregation and neurodegenerative disease. Nat Med (2004) 9.51
MIPS: analysis and annotation of proteins from whole genomes. Nucleic Acids Res (2004) 8.58
Contact order, transition state placement and the refolding rates of single domain proteins. J Mol Biol (1998) 8.51
Pathways of chaperone-mediated protein folding in the cytosol. Nat Rev Mol Cell Biol (2004) 6.45
Folding of newly translated proteins in vivo: the role of molecular chaperones. Annu Rev Biochem (2001) 5.74
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution. J Mol Med (Berl) (2003) 5.15
Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli. Cell (2005) 4.78
Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones. Nature (1994) 4.75
Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation. Proc Natl Acad Sci U S A (2002) 4.66
Improvement of an "In-Gel" digestion procedure for the micropreparation of internal protein fragments for amino acid sequencing. Anal Biochem (1995) 4.49
The SWISS-MODEL Repository of annotated three-dimensional protein structure homology models. Nucleic Acids Res (2004) 4.30
TCP1 complex is a molecular chaperone in tubulin biogenesis. Nature (1992) 3.52
Saccharomyces genome database: underlying principles and organisation. Brief Bioinform (2004) 3.46
Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits. EMBO J (1992) 3.33
Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets. Trends Cell Biol (2004) 3.18
Hsp90: chaperoning signal transduction. J Cell Physiol (2001) 3.13
Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure. Nature (2005) 2.99
Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT. Cell (1998) 2.94
The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev (2001) 2.76
Two families of chaperonin: physiology and mechanism. Annu Rev Cell Dev Biol (2007) 2.63
Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesis. J Biol Chem (2005) 2.61
The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions. Nat Cell Biol (2006) 2.58
Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state. Nat Cell Biol (2006) 2.37
Systems analyses reveal two chaperone networks with distinct functions in eukaryotic cells. Cell (2006) 2.30
Distribution of protein folds in the three superkingdoms of life. Genome Res (1999) 2.29
Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC. Mol Cell (1999) 2.20
Copper ion inducible and repressible promoter systems in yeast. Methods Enzymol (1999) 2.17
Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers. Mol Cell (2006) 2.16
In vivo newly translated polypeptides are sequestered in a protected folding environment. EMBO J (1999) 2.08
A yeast TCP-1-like protein is required for actin function in vivo. Proc Natl Acad Sci U S A (1994) 1.86
The CCT chaperonin promotes activation of the anaphase-promoting complex through the generation of functional Cdc20. Mol Cell (2003) 1.81
Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins. Nat Struct Mol Biol (2007) 1.67
Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding. Mol Cell (2003) 1.66
Chaperonin-mediated folding in the eukaryotic cytosol proceeds through rounds of release of native and nonnative forms. Cell (1997) 1.65
The Hsp70 and TRiC/CCT chaperone systems cooperate in vivo to assemble the von Hippel-Lindau tumor suppressor complex. Mol Cell Biol (2003) 1.62
Global aggregation of newly translated proteins in an Escherichia coli strain deficient of the chaperonin GroEL. Proc Natl Acad Sci U S A (2006) 1.58
Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. Genes Dev (2002) 1.53
Cytoplasmic chaperonin containing TCP-1: structural and functional characterization. Biochemistry (1997) 1.39
Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. Mol Cell Biol (1998) 1.39
Myosin II folding is mediated by a molecular chaperonin. J Biol Chem (1999) 1.36
The interaction of the chaperonin tailless complex polypeptide 1 (TCP1) ring complex (TRiC) with ribosome-bound nascent chains examined using photo-cross-linking. J Cell Biol (2000) 1.25
Individual subunits of the eukaryotic cytosolic chaperonin mediate interactions with binding sites located on subdomains of beta-actin. J Biol Chem (2000) 1.21
Recent advances in producing and selecting functional proteins by using cell-free translation. Curr Opin Biotechnol (1998) 1.21
Cytosolic chaperonin protects folding intermediates of Gbeta from aggregation by recognizing hydrophobic beta-strands. Proc Natl Acad Sci U S A (2006) 1.20
Crystal structure of the CCTgamma apical domain: implications for substrate binding to the eukaryotic cytosolic chaperonin. J Mol Biol (2002) 1.18
Local secondary structure content predicts folding rates for simple, two-state proteins. J Mol Biol (2003) 1.17
Type D retrovirus Gag polyprotein interacts with the cytosolic chaperonin TRiC. J Virol (2001) 1.14
The cytosolic class II chaperonin CCT recognizes delineated hydrophobic sequences in its target proteins. Biochemistry (1999) 1.13
The substrate recognition mechanisms in chaperonins. J Mol Recognit (2004) 1.13
ATP-dependent protein refolding activity in reticulocyte lysate. Evidence for the participation of different chaperone components. FEBS Lett (1993) 1.06
Experimental evaluation of topological parameters determining protein-folding rates. Proc Natl Acad Sci U S A (2002) 1.05
Expression cloning in the test tube. Science (1997) 1.02
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet (2009) 58.77
The transcriptional landscape of the yeast genome defined by RNA sequencing. Science (2008) 48.99
Functional profiling of the Saccharomyces cerevisiae genome. Nature (2002) 36.10
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
A draft sequence of the rice genome (Oryza sativa L. ssp. japonica). Science (2002) 21.26
Landscape of transcription in human cells. Nature (2012) 20.18
GENCODE: the reference human genome annotation for The ENCODE Project. Genome Res (2012) 19.19
Global identification of human transcribed sequences with genome tiling arrays. Science (2004) 17.85
A map of the interactome network of the metazoan C. elegans. Science (2004) 15.60
Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell (2012) 12.32
A Bayesian networks approach for predicting protein-protein interactions from genomic data. Science (2003) 12.07
Genomic analysis of regulatory network dynamics reveals large topological changes. Nature (2004) 9.32
ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res (2012) 9.13
Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell (2012) 8.41
The minimum information required for reporting a molecular interaction experiment (MIMIx). Nat Biotechnol (2007) 8.24
Subcellular localization of the yeast proteome. Genes Dev (2002) 7.93
Global analysis of protein phosphorylation in yeast. Nature (2005) 7.46
Divergence of transcription factor binding sites across related yeast species. Science (2007) 7.10
Comparing protein abundance and mRNA expression levels on a genomic scale. Genome Biol (2003) 6.98
CNVnator: an approach to discover, genotype, and characterize typical and atypical CNVs from family and population genome sequencing. Genome Res (2011) 6.97
The transcriptional activity of human Chromosome 22. Genes Dev (2003) 6.82
Biochemical and genetic analysis of the yeast proteome with a movable ORF collection. Genes Dev (2005) 6.14
Relating whole-genome expression data with protein-protein interactions. Genome Res (2002) 5.78
The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics. PLoS Comput Biol (2007) 5.63
Relating three-dimensional structures to protein networks provides evolutionary insights. Science (2006) 5.50
Millions of years of evolution preserved: a comprehensive catalog of the processed pseudogenes in the human genome. Genome Res (2003) 5.49
Annotation transfer between genomes: protein-protein interologs and protein-DNA regulogs. Genome Res (2004) 5.26
A cis-regulatory map of the Drosophila genome. Nature (2011) 4.80
Misfolded proteins partition between two distinct quality control compartments. Nature (2008) 4.75
AlleleSeq: analysis of allele-specific expression and binding in a network framework. Mol Syst Biol (2011) 4.71
New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis. Genes Dev (2007) 4.62
Structure and evolution of transcriptional regulatory networks. Curr Opin Struct Biol (2004) 4.48
Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Res (2008) 4.08
Distribution of NF-kappaB-binding sites across human chromosome 22. Proc Natl Acad Sci U S A (2003) 3.89
Global landscape of HIV-human protein complexes. Nature (2011) 3.70
The serine protease TMPRSS6 is required to sense iron deficiency. Science (2008) 3.70
Pseudogene.org: a comprehensive database and comparison platform for pseudogene annotation. Nucleic Acids Res (2006) 3.62
Classification of human genomic regions based on experimentally determined binding sites of more than 100 transcription-related factors. Genome Biol (2012) 3.61
Genomic analysis of essentiality within protein networks. Trends Genet (2004) 3.52
Genomic analysis of the hierarchical structure of regulatory networks. Proc Natl Acad Sci U S A (2006) 3.51
Modeling ChIP sequencing in silico with applications. PLoS Comput Biol (2008) 3.48
GATA-1 binding sites mapped in the beta-globin locus by using mammalian chIp-chip analysis. Proc Natl Acad Sci U S A (2002) 3.41
Structured digital abstract makes text mining easy. Nature (2007) 3.38
Defining functional DNA elements in the human genome. Proc Natl Acad Sci U S A (2014) 3.35
Systematic analysis of transcribed loci in ENCODE regions using RACE sequencing reveals extensive transcription in the human genome. Genome Biol (2008) 3.34
Dynamic transcriptomes during neural differentiation of human embryonic stem cells revealed by short, long, and paired-end sequencing. Proc Natl Acad Sci U S A (2010) 3.28
Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae. Genes Dev (2002) 3.27
Multi-species microarrays reveal the effect of sequence divergence on gene expression profiles. Genome Res (2005) 3.23
Efficient yeast ChIP-Seq using multiplex short-read DNA sequencing. BMC Genomics (2009) 3.22
Printable ion-gel gate dielectrics for low-voltage polymer thin-film transistors on plastic. Nat Mater (2008) 3.22
Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets. Trends Cell Biol (2004) 3.18
The Centers for Mendelian Genomics: a new large-scale initiative to identify the genes underlying rare Mendelian conditions. Am J Med Genet A (2012) 3.12
Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells. Nature (2012) 3.09
Getting connected: analysis and principles of biological networks. Genes Dev (2007) 3.03
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med (2015) 3.00
Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches. Cell (2007) 2.95
Analyzing protein function on a genomic scale: the importance of gold-standard positives and negatives for network prediction. Curr Opin Microbiol (2004) 2.92
HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. Mol Cell (2010) 2.91
Close association of RNA polymerase II and many transcription factors with Pol III genes. Proc Natl Acad Sci U S A (2010) 2.90
Transcribed processed pseudogenes in the human genome: an intermediate form of expressed retrosequence lacking protein-coding ability. Nucleic Acids Res (2005) 2.89
Molecular fossils in the human genome: identification and analysis of the pseudogenes in chromosomes 21 and 22. Genome Res (2002) 2.89
PubNet: a flexible system for visualizing literature derived networks. Genome Biol (2005) 2.89
Identification and analysis of over 2000 ribosomal protein pseudogenes in the human genome. Genome Res (2002) 2.88
Mechanism of folding chamber closure in a group II chaperonin. Nature (2010) 2.85
PseudoPipe: an automated pseudogene identification pipeline. Bioinformatics (2006) 2.85
Patterns of nucleotide substitution, insertion and deletion in the human genome inferred from pseudogenes. Nucleic Acids Res (2003) 2.85
Mapping accessible chromatin regions using Sono-Seq. Proc Natl Acad Sci U S A (2009) 2.83
The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans. Dev Cell (2005) 2.81
Systematic functional prioritization of protein posttranslational modifications. Cell (2012) 2.78
Modeling gene expression using chromatin features in various cellular contexts. Genome Biol (2012) 2.76
Genomics. Defining genes in the genomics era. Science (2003) 2.73
Normal mode analysis of macromolecular motions in a database framework: developing mode concentration as a useful classifying statistic. Proteins (2002) 2.72
Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection. Nature (2011) 2.71
MAPK target networks in Arabidopsis thaliana revealed using functional protein microarrays. Genes Dev (2008) 2.66
DNA replication-timing analysis of human chromosome 22 at high resolution and different developmental states. Proc Natl Acad Sci U S A (2004) 2.66
Understanding transcriptional regulation by integrative analysis of transcription factor binding data. Genome Res (2012) 2.66
Major molecular differences between mammalian sexes are involved in drug metabolism and renal function. Dev Cell (2004) 2.65
Bridging structural biology and genomics: assessing protein interaction data with known complexes. Trends Genet (2002) 2.65
The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions. Nat Cell Biol (2006) 2.58
Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways. Cell (2005) 2.55
Robotic cloning and Protein Production Platform of the Northeast Structural Genomics Consortium. Methods Enzymol (2005) 2.54
Comparative analysis of processed pseudogenes in the mouse and human genomes. Trends Genet (2004) 2.51
Tilescope: online analysis pipeline for high-density tiling microarray data. Genome Biol (2007) 2.48
Genome-wide identification of binding sites defines distinct functions for Caenorhabditis elegans PHA-4/FOXA in development and environmental response. PLoS Genet (2010) 2.46
Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network. Genome Biol (2009) 2.43
TOS9 regulates white-opaque switching in Candida albicans. Eukaryot Cell (2006) 2.42
Target hub proteins serve as master regulators of development in yeast. Genes Dev (2006) 2.39
Large-scale analysis of pseudogenes in the human genome. Curr Opin Genet Dev (2004) 2.38
Genomic analysis of gene expression relationships in transcriptional regulatory networks. Trends Genet (2003) 2.38
Personal genome sequencing: current approaches and challenges. Genes Dev (2010) 2.38
Conformational changes associated with protein-protein interactions. Curr Opin Struct Biol (2004) 2.37
Analysis of proteome dynamics in the mouse brain. Proc Natl Acad Sci U S A (2010) 2.37
Issues in the analysis of oligonucleotide tiling microarrays for transcript mapping. Trends Genet (2005) 2.36
Assessing the limits of genomic data integration for predicting protein networks. Genome Res (2005) 2.33