The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals.

PubWeight™: 1.85‹?› | Rank: Top 3%

🔗 View Article (PMC 2612020)

Published in BMC Mol Biol on November 18, 2008

Authors

Rebecca S LaRue1, Stefán R Jónsson, Kevin A T Silverstein, Mathieu Lajoie, Denis Bertrand, Nadia El-Mabrouk, Isidro Hötzel, Valgerdur Andrésdóttir, Timothy P L Smith, Reuben S Harris

Author Affiliations

1: Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Beckman Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA. rsh@umn.edu

Articles citing this

APOBEC3 proteins mediate the clearance of foreign DNA from human cells. Nat Struct Mol Biol (2010) 3.61

Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction. Nucleic Acids Res (2010) 2.96

Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1. J Virol (2011) 2.50

Evolutionary conflicts between viruses and restriction factors shape immunity. Nat Rev Immunol (2012) 2.10

Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism. Proc Natl Acad Sci U S A (2011) 1.98

Guidelines for naming nonprimate APOBEC3 genes and proteins. J Virol (2008) 1.86

Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces. Structure (2010) 1.65

The APOBEC3 family of retroelement restriction factors. Curr Top Microbiol Immunol (2013) 1.46

Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities. J Virol (2010) 1.40

Genetic editing of HBV DNA by monodomain human APOBEC3 cytidine deaminases and the recombinant nature of APOBEC3G. PLoS One (2009) 1.39

Lentiviral Vif degrades the APOBEC3Z3/APOBEC3H protein of its mammalian host and is capable of cross-species activity. J Virol (2010) 1.35

The range of human APOBEC3H sensitivity to lentiviral Vif proteins. J Virol (2010) 1.34

Intrinsic immunity against retrotransposons by APOBEC cytidine deaminases. Front Microbiol (2013) 1.33

AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity. Nat Struct Mol Biol (2009) 1.31

APOBECs and virus restriction. Virology (2015) 1.27

APOBEC3B and AID have similar nuclear import mechanisms. J Mol Biol (2012) 1.22

Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo. J Virol (2011) 1.18

A single amino acid in human APOBEC3F alters susceptibility to HIV-1 Vif. J Biol Chem (2010) 1.17

Crystal structure of the DNA cytosine deaminase APOBEC3F: the catalytically active and HIV-1 Vif-binding domain. Structure (2013) 1.13

Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet. J Biol Chem (2008) 1.12

The role of cytidine deaminases on innate immune responses against human viral infections. Biomed Res Int (2013) 1.11

AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity. Nucleic Acids Res (2009) 1.09

Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination. Cell Cycle (2013) 1.07

The localization of APOBEC3H variants in HIV-1 virions determines their antiviral activity. J Virol (2010) 1.05

Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons. Nucleic Acids Res (2011) 1.04

An ancient history of gene duplications, fusions and losses in the evolution of APOBEC3 mutators in mammals. BMC Evol Biol (2012) 1.02

Suppression of APOBEC3-mediated restriction of HIV-1 by Vif. Front Microbiol (2014) 1.00

Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity. PLoS Genet (2014) 1.00

Productive replication of Vif-chimeric HIV-1 in feline cells. J Virol (2010) 0.99

Endogenous APOBEC3A DNA cytosine deaminase is cytoplasmic and nongenotoxic. J Biol Chem (2013) 0.99

Restriction of equine infectious anemia virus by equine APOBEC3 cytidine deaminases. J Virol (2009) 0.98

Infection barriers to successful xenotransplantation focusing on porcine endogenous retroviruses. Clin Microbiol Rev (2012) 0.97

A novel role for APOBEC3: susceptibility to sexual transmission of murine acquired immunodeficiency virus (mAIDS) is aggravated in APOBEC3 deficient mice. Retrovirology (2012) 0.96

Model structure of APOBEC3C reveals a binding pocket modulating ribonucleic acid interaction required for encapsidation. Proc Natl Acad Sci U S A (2009) 0.94

APOBEC3 cytidine deaminases in double-strand DNA break repair and cancer promotion. Cancer Res (2013) 0.92

Differential virus restriction patterns of rhesus macaque and human APOBEC3A: implications for lentivirus evolution. Virology (2011) 0.92

The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization. Structure (2015) 0.92

Reduced APOBEC3H variant anti-viral activities are associated with altered RNA binding activities. PLoS One (2012) 0.92

Polymorphism in human APOBEC3H affects a phenotype dominant for subcellular localization and antiviral activity. J Virol (2011) 0.91

AID/APOBEC deaminases and cancer. Oncoscience (2015) 0.89

Leveraging APOBEC3 proteins to alter the HIV mutation rate and combat AIDS. Future Virol (2009) 0.89

AID and APOBECs span the gap between innate and adaptive immunity. Front Microbiol (2014) 0.87

Are viruses inhibited by APOBEC3 molecules from their host species? PLoS Pathog (2009) 0.87

Core-binding factor subunit beta is not required for non-primate lentiviral Vif-mediated APOBEC3 degradation. J Virol (2014) 0.86

A computational analysis of the structural determinants of APOBEC3's catalytic activity and vulnerability to HIV-1 Vif. Virology (2014) 0.86

Identification of two APOBEC3F splice variants displaying HIV-1 antiviral activity and contrasting sensitivity to Vif. J Biol Chem (2010) 0.86

Intrinsic restriction activity by AID/APOBEC family of enzymes against the mobility of retroelements. Mob Genet Elements (2011) 0.85

Running loose or getting lost: how HIV-1 counters and capitalizes on APOBEC3-induced mutagenesis through its Vif protein. Viruses (2012) 0.85

Signals in APOBEC3F N-terminal and C-terminal deaminase domains each contribute to encapsidation in HIV-1 virions and are both required for HIV-1 restriction. J Biol Chem (2012) 0.84

Retroviral restriction and dependency factors in primates and carnivores. Vet Immunol Immunopathol (2011) 0.83

Prototype foamy virus Bet impairs the dimerization and cytosolic solubility of human APOBEC3G. J Virol (2013) 0.83

Transcriptional regulation of APOBEC3 antiviral immunity through the CBF-β/RUNX axis. Sci Adv (2015) 0.83

Nuclear Magnetic Resonance Structure of the APOBEC3B Catalytic Domain: Structural Basis for Substrate Binding and DNA Deaminase Activity. Biochemistry (2016) 0.82

Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity. Cell Rep (2015) 0.82

Molecular basis of the attenuated phenotype of human APOBEC3B DNA mutator enzyme. Nucleic Acids Res (2015) 0.82

Cellular restriction factors of feline immunodeficiency virus. Viruses (2011) 0.81

Sequence and structural determinants of human APOBEC3H deaminase and anti-HIV-1 activities. Retrovirology (2015) 0.80

Determinants of FIV and HIV Vif sensitivity of feline APOBEC3 restriction factors. Retrovirology (2016) 0.80

Immunogenetics of small ruminant lentiviral infections. Viruses (2014) 0.80

Degradation of the cancer genomic DNA deaminase APOBEC3B by SIV Vif. Oncotarget (2015) 0.80

Evolution of orthologous tandemly arrayed gene clusters. BMC Bioinformatics (2011) 0.80

Footprint of APOBEC3 on the genome of human retroelements. J Virol (2013) 0.79

Restriction of porcine endogenous retrovirus by porcine APOBEC3 cytidine deaminases. J Virol (2011) 0.79

Natural Polymorphisms and Oligomerization of Human APOBEC3H Contribute to Single-stranded DNA Scanning Ability. J Biol Chem (2015) 0.79

D316 is critical for the enzymatic activity and HIV-1 restriction potential of human and rhesus APOBEC3B. Virology (2013) 0.78

Retroviral infections in sheep and goats: small ruminant lentiviruses and host interaction. Viruses (2013) 0.77

Correlation of APOBEC3 in tumor tissues with clinico-pathological features and survival from hepatocellular carcinoma after curative hepatectomy. Int J Clin Exp Med (2015) 0.77

Host restriction of lentiviruses and viral countermeasures: APOBEC3 and Vif. Viruses (2013) 0.77

Understanding restriction factors and intrinsic immunity: insights and lessons from the primate lentiviruses. Future Virol (2015) 0.76

How Active Are Porcine Endogenous Retroviruses (PERVs)? Viruses (2016) 0.76

A naturally occurring bovine APOBEC3 confers resistance to bovine lentiviruses: implication for the co-evolution of bovids and their lentiviruses. Sci Rep (2016) 0.75

Immunization against small ruminant lentiviruses. Viruses (2013) 0.75

Opossum APOBEC1 is a DNA mutator with retrovirus and retroelement restriction activity. Sci Rep (2017) 0.75

Evolutionary Paradigms from Ancient and Ongoing Conflicts between the Lentiviral Vif Protein and Mammalian APOBEC3 Enzymes. PLoS Pathog (2016) 0.75

Articles cited by this

MrBayes 3: Bayesian phylogenetic inference under mixed models. Bioinformatics (2003) 130.85

Clustal W and Clustal X version 2.0. Bioinformatics (2007) 126.47

WebLogo: a sequence logo generator. Genome Res (2004) 59.58

T-Coffee: A novel method for fast and accurate multiple sequence alignment. J Mol Biol (2000) 57.88

PAML: a program package for phylogenetic analysis by maximum likelihood. Comput Appl Biosci (1997) 45.07

Human-mouse alignments with BLASTZ. Genome Res (2003) 35.49

The Jalview Java alignment editor. Bioinformatics (2004) 21.74

Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21

The delayed rise of present-day mammals. Nature (2007) 15.98

A molecular timescale for vertebrate evolution. Nature (1998) 13.92

Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. Nature (2003) 13.24

DNA deamination mediates innate immunity to retroviral infection. Cell (2003) 12.10

Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. Science (2003) 10.79

The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA. Nature (2003) 10.76

Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif. Cell (2003) 9.48

A composite estimate of primate phylogeny. Philos Trans R Soc Lond B Biol Sci (1995) 8.72

High frequency retrotransposition in cultured mammalian cells. Cell (1996) 8.60

PAL2NAL: robust conversion of protein sequence alignments into the corresponding codon alignments. Nucleic Acids Res (2006) 8.36

Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature (2007) 7.91

An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. Genomics (2002) 7.10

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. Genes Dev (1988) 6.08

HIV-1 accessory proteins--ensuring viral survival in a hostile environment. Cell Host Microbe (2008) 5.90

Genome analysis of the platypus reveals unique signatures of evolution. Nature (2008) 5.74

Inhibition of hepatitis B virus replication by APOBEC3G. Science (2004) 5.15

RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators. Mol Cell (2002) 5.14

Retroviral restriction by APOBEC proteins. Nat Rev Immunol (2004) 5.00

Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity. Curr Biol (2005) 4.98

Intrinsic immunity: a front-line defense against viral attack. Nat Immunol (2004) 4.95

APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo. Curr Biol (2004) 4.89

GARD: a genetic algorithm for recombination detection. Bioinformatics (2006) 4.88

Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G. PLoS Biol (2004) 4.76

Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. Proc Natl Acad Sci U S A (1987) 4.61

Gepard: a rapid and sensitive tool for creating dotplots on genome scale. Bioinformatics (2007) 4.45

The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements. Annu Rev Immunol (2008) 4.27

Cellular inhibitors of long interspersed element 1 and Alu retrotransposition. Proc Natl Acad Sci U S A (2006) 3.76

Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors. J Virol (2006) 3.63

APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons. Curr Biol (2006) 3.57

Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases. Mol Biol Evol (2004) 3.57

APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication. J Biol Chem (2004) 3.56

APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses. Nature (2005) 3.53

Complementary function of the two catalytic domains of APOBEC3G. Virology (2005) 3.45

APOBEC3 proteins inhibit human LINE-1 retrotransposition. J Biol Chem (2006) 3.30

Phylogenetic analysis using PHYLIP. Methods Mol Biol (2000) 3.27

Retrovirus restriction factors. Mol Cell (2004) 2.95

APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism. J Biol Chem (2006) 2.86

Antiretroelement activity of APOBEC3H was lost twice in recent human evolution. Cell Host Microbe (2008) 2.85

Population stratification of a common APOBEC gene deletion polymorphism. PLoS Genet (2007) 2.85

Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity. J Exp Med (2006) 2.83

Extensive editing of both hepatitis B virus DNA strands by APOBEC3 cytidine deaminases in vitro and in vivo. Proc Natl Acad Sci U S A (2005) 2.68

Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC family. J Virol (2006) 2.63

The retroviral hypermutation specificity of APOBEC3F and APOBEC3G is governed by the C-terminal DNA cytosine deaminase domain. J Biol Chem (2005) 2.62

Biochemical activities of highly purified, catalytically active human APOBEC3G: correlation with antiviral effect. J Virol (2006) 2.58

Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes. Proc Natl Acad Sci U S A (1988) 2.58

Reconstitution of an infectious human endogenous retrovirus. PLoS Pathog (2007) 2.52

Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H. J Virol (2006) 2.40

Role of APOBEC3 in genetic diversity among endogenous murine leukemia viruses. PLoS Genet (2007) 2.33

APOBEC3 inhibits mouse mammary tumour virus replication in vivo. Nature (2007) 2.28

Inhibition of a yeast LTR retrotransposon by human APOBEC3 cytidine deaminases. Curr Biol (2005) 2.21

Base-By-Base: single nucleotide-level analysis of whole viral genome alignments. BMC Bioinformatics (2004) 2.15

Rapid evolution of primate antiviral enzyme APOBEC3G. Hum Mol Genet (2004) 2.03

Interferon-inducible expression of APOBEC3 editing enzymes in human hepatocytes and inhibition of hepatitis B virus replication. Hepatology (2006) 2.03

APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast. Proc Natl Acad Sci U S A (2005) 2.00

Guidelines for naming nonprimate APOBEC3 genes and proteins. J Virol (2008) 1.86

Foamy virus Bet proteins function as novel inhibitors of the APOBEC3 family of innate antiretroviral defense factors. J Virol (2005) 1.84

All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition. Nucleic Acids Res (2007) 1.79

Restriction of an extinct retrovirus by the human TRIM5alpha antiviral protein. Science (2007) 1.76

Anti-viral protein APOBEC3G is induced by interferon-alpha stimulation in human hepatocytes. Biochem Biophys Res Commun (2006) 1.76

Resistance of human T cell leukemia virus type 1 to APOBEC3G restriction is mediated by elements in nucleocapsid. Proc Natl Acad Sci U S A (2007) 1.73

Human cytidine deaminase APOBEC3H restricts HIV-1 replication. J Biol Chem (2008) 1.68

Functions, structure, and read-through alternative splicing of feline APOBEC3 genes. Genome Biol (2008) 1.63

Extensive mutagenesis experiments corroborate a structural model for the DNA deaminase domain of APOBEC3G. FEBS Lett (2007) 1.62

Antiretroviral activity and Vif sensitivity of rhesus macaque APOBEC3 proteins. J Virol (2007) 1.56

Phylogenies constrained by the crossover process as illustrated by human hemoglobins and a thirteen-cycle, eleven-amino-acid repeat in human apolipoprotein A-I. Genetics (1977) 1.55

Differential inhibition of long interspersed element 1 by APOBEC3 does not correlate with high-molecular-mass-complex formation or P-body association. J Virol (2007) 1.53

Murine retrovirus escapes from murine APOBEC3 via two distinct novel mechanisms. Curr Biol (2006) 1.53

Hypermutation of an ancient human retrovirus by APOBEC3G. J Virol (2008) 1.50

Evolutionarily conserved and non-conserved retrovirus restriction activities of artiodactyl APOBEC3F proteins. Nucleic Acids Res (2006) 1.46

Conserved footprints of APOBEC3G on Hypermutated human immunodeficiency virus type 1 and human endogenous retrovirus HERV-K(HML2) sequences. J Virol (2008) 1.36

The innate antiretroviral factor APOBEC3G does not affect human LINE-1 retrotransposition in a cell culture assay. J Biol Chem (2004) 1.36

The intrinsic antiretroviral factor APOBEC3B contains two enzymatically active cytidine deaminase domains. Virology (2007) 1.33

A porcine BAC library with tenfold genome coverage: a resource for physical and genetic map integration. Mamm Genome (2001) 1.26

Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization. J Virol (2008) 1.24

Duplication and inversion history of a tandemly repeated genes family. J Comput Biol (2007) 1.22

The betaretrovirus Mason-Pfizer monkey virus selectively excludes simian APOBEC3G from virion particles. J Virol (2006) 1.17

Induction of antiviral cytidine deaminases does not explain the inhibition of hepatitis B virus replication by interferons. J Virol (2007) 1.13

Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C). Hum Reprod (2006) 1.09

Porcine gene discovery by normalized cDNA-library sequencing and EST cluster assembly. Mamm Genome (2002) 1.05

The restriction of zoonotic PERV transmission by human APOBEC3G. PLoS One (2007) 1.04

Inhibition of alpharetrovirus replication by a range of human APOBEC3 proteins. J Virol (2007) 1.03

Sp1 and Sp3 regulate basal transcription of the human APOBEC3G gene. Nucleic Acids Res (2007) 0.97

Greedy method for inferring tandem duplication history. Bioinformatics (2003) 0.85

Inferring ancestral gene orders for a family of tandemly arrayed genes. J Comput Biol (2008) 0.84

Conservation within artiodactyls of an AATA interrupt in the IGF-I microsatellite for 19-35 million years. Mol Biol Evol (2000) 0.79

Articles by these authors

SNP discovery and allele frequency estimation by deep sequencing of reduced representation libraries. Nat Methods (2008) 8.26

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature (2002) 7.12

Development and characterization of a high density SNP genotyping assay for cattle. PLoS One (2009) 7.06

Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature (2009) 5.90

The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G. Curr Biol (2003) 5.58

Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines. Cancer Res (2012) 5.50

APOBEC3B is an enzymatic source of mutation in breast cancer. Nature (2013) 5.18

The Medicago genome provides insight into the evolution of rhizobial symbioses. Nature (2011) 4.94

APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo. Curr Biol (2004) 4.89

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. Nat Genet (2012) 4.82

Reducing assembly complexity of microbial genomes with single-molecule sequencing. Genome Biol (2013) 4.55

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science (2009) 4.16

Evidence for APOBEC3B mutagenesis in multiple human cancers. Nat Genet (2013) 3.94

APOBEC3 proteins mediate the clearance of foreign DNA from human cells. Nat Struct Mol Biol (2010) 3.61

Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo. J Mol Biol (2004) 3.59

A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat Biotechnol (2009) 3.44

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature (2012) 3.23

Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction. Nucleic Acids Res (2010) 2.96

Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration. J Virol (2007) 2.95

APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism. J Biol Chem (2006) 2.86

The draft genome of sweet orange (Citrus sinensis). Nat Genet (2012) 2.81

Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G. Nature (2008) 2.80

Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection. Nature (2011) 2.71

The retroviral hypermutation specificity of APOBEC3F and APOBEC3G is governed by the C-terminal DNA cytosine deaminase domain. J Biol Chem (2005) 2.62

Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1. J Virol (2011) 2.50

LoFreq: a sequence-quality aware, ultra-sensitive variant caller for uncovering cell-population heterogeneity from high-throughput sequencing datasets. Nucleic Acids Res (2012) 2.46

Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics. Expert Rev Mol Med (2010) 2.43

Immunity through DNA deamination. Trends Biochem Sci (2003) 2.39

Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states. BMC Cancer (2009) 2.32

Extensive somatic L1 retrotransposition in colorectal tumors. Genome Res (2012) 2.29

The DNA deaminase activity of human APOBEC3G is required for Ty1, MusD, and human immunodeficiency virus type 1 restriction. J Virol (2008) 2.21

APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast. Proc Natl Acad Sci U S A (2005) 2.00

SNP discovery in swine by reduced representation and high throughput pyrosequencing. BMC Genet (2008) 1.92

Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals. Genome Res (2002) 1.91

Guidelines for naming nonprimate APOBEC3 genes and proteins. J Virol (2008) 1.86

Single nucleotide polymorphism discovery in rainbow trout by deep sequencing of a reduced representation library. BMC Genomics (2009) 1.81

Selection and use of SNP markers for animal identification and paternity analysis in U.S. beef cattle. Mamm Genome (2002) 1.79

TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer. Proc Natl Acad Sci U S A (2013) 1.77

Computational identification and characterization of novel genes from legumes. Plant Physiol (2004) 1.67

Central cell-derived peptides regulate early embryo patterning in flowering plants. Science (2014) 1.66

Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces. Structure (2010) 1.65

An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model. J Mol Biol (2009) 1.62

Extensive mutagenesis experiments corroborate a structural model for the DNA deaminase domain of APOBEC3G. FEBS Lett (2007) 1.62

APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis. J Virol (2010) 1.58

Discovery and profiling of bovine microRNAs from immune-related and embryonic tissues. Physiol Genomics (2006) 1.58

Evolution of HIV-1 isolates that use a novel Vif-independent mechanism to resist restriction by human APOBEC3G. Curr Biol (2008) 1.51

Transcript analysis of early nodulation events in Medicago truncatula. Plant Physiol (2005) 1.49

The APOBEC3 family of retroelement restriction factors. Curr Top Microbiol Immunol (2013) 1.46

Evolutionarily conserved and non-conserved retrovirus restriction activities of artiodactyl APOBEC3F proteins. Nucleic Acids Res (2006) 1.46

APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma. Cancer Res (2013) 1.43

Pillars article: AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature. 2002. 418: 99-103. J Immunol (2015) 1.38

Atomic force microscopy studies provide direct evidence for dimerization of the HIV restriction factor APOBEC3G. J Biol Chem (2010) 1.38

Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A. J Biol Chem (2012) 1.38

MicroRNA transcriptome profiles during swine skeletal muscle development. BMC Genomics (2009) 1.35

Role for Msh5 in the regulation of Ig class switch recombination. Proc Natl Acad Sci U S A (2007) 1.35

Isolation of an active Lv1 gene from cattle indicates that tripartite motif protein-mediated innate immunity to retroviral infection is widespread among mammals. J Virol (2006) 1.35

Lentiviral Vif degrades the APOBEC3Z3/APOBEC3H protein of its mammalian host and is capable of cross-species activity. J Virol (2010) 1.35

Whole-genome reconstruction and mutational signatures in gastric cancer. Genome Biol (2012) 1.33

Animal-to-animal variation in fecal microbial diversity among beef cattle. Appl Environ Microbiol (2010) 1.33

Molecular basis for negative regulation of the glucagon receptor. Proc Natl Acad Sci U S A (2012) 1.33

Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n. PLoS Pathog (2012) 1.29

First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G. ACS Chem Biol (2012) 1.28

Engineered proteins detect spontaneous DNA breakage in human and bacterial cells. Elife (2013) 1.28

Vif proteins of human and simian immunodeficiency viruses require cellular CBFβ to degrade APOBEC3 restriction factors. J Virol (2011) 1.25

Virulence-associated and antibiotic resistance genes of microbial populations in cattle feces analyzed using a metagenomic approach. J Microbiol Methods (2010) 1.25

Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization. J Virol (2008) 1.24

Prion gene sequence variation within diverse groups of U.S. sheep, beef cattle, and deer. Mamm Genome (2003) 1.23

APOBEC3B and AID have similar nuclear import mechanisms. J Mol Biol (2012) 1.22

MtDB: a database for personalized data mining of the model legume Medicago truncatula transcriptome. Nucleic Acids Res (2003) 1.22

Duplication and inversion history of a tandemly repeated genes family. J Comput Biol (2007) 1.22

Association, effects and validation of polymorphisms within the NCAPG - LCORL locus located on BTA6 with feed intake, gain, meat and carcass traits in beef cattle. BMC Genet (2011) 1.22

Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance. AIDS Rev (2006) 1.21

Reduced lentivirus susceptibility in sheep with TMEM154 mutations. PLoS Genet (2012) 1.20

A single amino acid in human APOBEC3F alters susceptibility to HIV-1 Vif. J Biol Chem (2010) 1.17

APOBEC3G enhances lymphoma cell radioresistance by promoting cytidine deaminase-dependent DNA repair. Blood (2012) 1.15

Beta-2-microglobulin haplotypes in U.S. beef cattle and association with failure of passive transfer in newborn calves. Mamm Genome (2004) 1.13

Crystal structure of the DNA cytosine deaminase APOBEC3F: the catalytically active and HIV-1 Vif-binding domain. Structure (2013) 1.13

MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells. Mol Immunol (2005) 1.13

A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer. Proc Natl Acad Sci U S A (2012) 1.12

Prevalence of the prion protein gene E211K variant in U.S. cattle. BMC Vet Res (2008) 1.12

Long-term restriction by APOBEC3F selects human immunodeficiency virus type 1 variants with restored Vif function. J Virol (2010) 1.12

Prion gene haplotypes of U.S. cattle. BMC Genet (2006) 1.10

AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity. Nucleic Acids Res (2009) 1.09

Gene family evolution by duplication, speciation, and loss. J Comput Biol (2008) 1.09

Phylogeny of Shiga toxin-producing Escherichia coli O157 isolated from cattle and clinically ill humans. Mol Biol Evol (2012) 1.09

Evaluation of a new high-dimensional miRNA profiling platform. BMC Med Genomics (2009) 1.08

Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination. Cell Cycle (2013) 1.07

Linkage mapping bovine EST-based SNP. BMC Genomics (2005) 1.07

Elevated APOBEC3B correlates with poor outcomes for estrogen-receptor-positive breast cancers. Horm Cancer (2014) 1.07

Competition of Escherichia coli DNA polymerases I, II and III with DNA Pol IV in stressed cells. PLoS One (2010) 1.07

Porcine gene discovery by normalized cDNA-library sequencing and EST cluster assembly. Mamm Genome (2002) 1.05

Association of a bovine prion gene haplotype with atypical BSE. PLoS One (2008) 1.04

The restriction of zoonotic PERV transmission by human APOBEC3G. PLoS One (2007) 1.04