Expanding functions of lipoprotein receptors.

Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med (2012) 2.01

Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo. PLoS One (2009) 1.67

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain. J Neurochem (2010) 1.47

Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease. Cold Spring Harb Perspect Med (2012) 1.32

Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease. J Alzheimers Dis (2013) 1.07

Apolipoprotein E receptors in the nervous system. Curr Opin Lipidol (2009) 1.01

LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease. Front Physiol (2012) 0.96

Hepatic deficiency of low density lipoprotein receptor-related protein-1 reduces high density lipoprotein secretion and plasma levels in mice. J Biol Chem (2011) 0.96

Exploitation of lipid components by viral and host proteins for hepatitis C virus infection. Front Microbiol (2012) 0.92

Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β is an early biomarker for mild cognitive impairment preceding Alzheimer's disease. J Alzheimers Dis (2011) 0.91

Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo. PLoS One (2010) 0.90

Neuroprotection and regeneration by extracellular metallothionein via lipoprotein-receptor-related proteins. J Biol Inorg Chem (2011) 0.90

Up-regulation of ATP binding cassette transporter A1 expression by very low density lipoprotein receptor and apolipoprotein E receptor 2. J Biol Chem (2011) 0.87

Differential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptor. J Biol Chem (2011) 0.85

Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities. Pharmacol Ther (2012) 0.85

Bone and the regulation of global energy balance. J Intern Med (2015) 0.84

Lrp4: A novel modulator of extracellular signaling in craniofacial organogenesis. Am J Med Genet A (2010) 0.84

Factor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising "Hot-Spot" Lysine Residues. J Biol Chem (2015) 0.79

A Subregion of Reelin Suppresses Lipoprotein-Induced Cholesterol Accumulation in Macrophages. PLoS One (2015) 0.78

LRP1b shows restricted expression in human tissues and binds to several extracellular ligands, including fibrinogen and apoE-carrying lipoproteins. Atherosclerosis (2011) 0.78

The very low density lipoprotein receptor attenuates house dust mite-induced airway inflammation by suppressing dendritic cell-mediated adaptive immune responses. J Immunol (2014) 0.78

SorLA in glia: shared subcellular distribution patterns with caveolin-1. Cell Mol Neurobiol (2011) 0.77

Genes associated with Alzheimer's disease: an overview and current status. Clin Interv Aging (2016) 0.76

Characterization of lipophorin receptor (LpR) mediating the binding of high density lipophorin (HDLp) in the silkworm, Bombyx mori. J Insect Sci (2011) 0.75

Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron (2007) 6.60

NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders. Nat Rev Neurosci (2007) 6.26

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell (1999) 5.52

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A (2005) 4.34

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron (2004) 4.29

Reelin and brain development. Nat Rev Neurosci (2003) 3.97

Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron (1999) 3.70

LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. Physiol Rev (2008) 3.46

Lrp4 is a receptor for Agrin and forms a complex with MuSK. Cell (2008) 3.29

Reelin is a ligand for lipoprotein receptors. Neuron (1999) 3.26

Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron (2005) 3.25

LRP4 serves as a coreceptor of agrin. Neuron (2008) 2.98

Reelin, lipoprotein receptors and synaptic plasticity. Nat Rev Neurosci (2006) 2.95

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J Biol Chem (1998) 2.71

Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. J Biol Chem (2002) 2.67

Lipoprotein receptors in the nervous system. Annu Rev Biochem (2001) 2.61

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J Biol Chem (2000) 2.59

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron (2007) 2.55

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell (1995) 2.37

LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction. Development (2006) 2.22

Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. J Biol Chem (2000) 2.00

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1. J Biol Chem (2007) 1.88

Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta. J Biol Chem (2002) 1.88

Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. Mol Cell Biol (2004) 1.81

Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation. J Neurosci (2000) 1.72

The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A (2000) 1.65

Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. Hum Mol Genet (2005) 1.56

The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2. J Biol Chem (2000) 1.52

The FE65 proteins and Alzheimer's disease. J Neurosci Res (2008) 1.51

Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development. EMBO J (2006) 1.51

Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus. J Neurosci (2006) 1.45

Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein. J Biol Chem (2005) 1.36

Apolipoprotein E-containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1. J Neurosci (2007) 1.33

Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration. EMBO J (2008) 1.26

LRP in amyloid-beta production and metabolism. Ann N Y Acad Sci (2006) 1.17

Mutations in the gene encoding the low-density lipoprotein receptor LRP4 cause abnormal limb development in the mouse. Genomics (2006) 1.16

Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor. J Biol Chem (2005) 1.11

Defective splicing of Megf7/Lrp4, a regulator of distal limb development, in autosomal recessive mulefoot disease. Genomics (2006) 1.10

Genetic modulation of tau phosphorylation in the mouse. J Neurosci (2003) 1.09

LDL receptor relatives at the crossroad of endocytosis and signaling. Cell Mol Life Sci (2003) 1.09

ApoE receptor 2 controls neuronal survival in the adult brain. Curr Biol (2006) 1.08

Congenital syndactyly in cattle: four novel mutations in the low density lipoprotein receptor-related protein 4 gene (LRP4). BMC Genet (2007) 1.06

Thrombospondins use the VLDL receptor and a nonapoptotic pathway to inhibit cell division in microvascular endothelial cells. Mol Biol Cell (2007) 1.03

A mechanism for SRC kinase-dependent signaling by noncatalytic receptors. Biochemistry (2008) 1.00

Reelin down-regulation in mice and psychosis endophenotypes. Neurosci Biobehav Rev (2006) 0.99

Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP. Brain Res Mol Brain Res (2001) 0.99

Identification of a doublet missense substitution in the bovine LRP4 gene as a candidate causal mutation for syndactyly in Holstein cattle. Genomics (2006) 0.98

The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene. Biochim Biophys Acta (2008) 0.98

Requirement of JIP scaffold proteins for NMDA-mediated signal transduction. Genes Dev (2007) 0.97

Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55

Role of the Arabidopsis glucose sensor HXK1 in nutrient, light, and hormonal signaling. Science (2003) 5.41

RPE65 is the isomerohydrolase in the retinoid visual cycle. Proc Natl Acad Sci U S A (2005) 4.61

Production of offspring from a germline stem cell line derived from neonatal ovaries. Nat Cell Biol (2009) 4.11

Plasma soluble urokinase receptor levels are increased but do not distinguish primary from secondary focal segmental glomerulosclerosis. Kidney Int (2013) 3.97

A unique short-chain dehydrogenase/reductase in Arabidopsis glucose signaling and abscisic acid biosynthesis and functions. Plant Cell (2002) 3.60

Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron (2005) 3.25

MicroRNA-mediated control of oligodendrocyte differentiation. Neuron (2010) 3.24

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci (2009) 3.18

Reelin promoter hypermethylation in schizophrenia. Proc Natl Acad Sci U S A (2005) 3.12

High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation. Med Oncol (2010) 3.06

MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2. Cancer Res (2011) 3.03

Reelin, lipoprotein receptors and synaptic plasticity. Nat Rev Neurosci (2006) 2.95

Breast-feeding and risk for childhood obesity: does maternal diabetes or obesity status matter? Diabetes Care (2006) 2.93

Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease. Blood (2009) 2.91

Modeling electronic discharge summaries as a simple temporal constraint satisfaction problem. J Am Med Inform Assoc (2004) 2.88

A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64

Central and autonomic nervous system interaction is altered by short-term meditation. Proc Natl Acad Sci U S A (2009) 2.45

Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res (2006) 2.37

Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet (2012) 2.26

Toxicity of atmospheric aerosols on marine phytoplankton. Proc Natl Acad Sci U S A (2009) 2.25

Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease. Blood (2008) 2.24

Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality. Clin Nutr (2012) 2.17

A dynamic gene expression atlas covering the entire life cycle of rice. Plant J (2009) 2.15

Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology (2007) 2.11

Retracted The autoimmune regulator (Aire) controls iNKT cell development and maturation. Nat Med (2006) 2.07

Insulin resistance in children with primary nephrotic syndrome and normal renal function. Pediatr Nephrol (2012) 2.03

Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of Eastern China. J Rheumatol (2008) 2.00

Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J Biol Chem (2005) 1.98

Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations. Blood (2012) 1.98

Sample size calculations for evaluating a diagnostic test when the gold standard is missing at random. Stat Med (2010) 1.96

DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes. Mol Pharmacol (2006) 1.95

Primate-specific microRNA-637 inhibits tumorigenesis in hepatocellular carcinoma by disrupting signal transducer and activator of transcription 3 signaling. Hepatology (2011) 1.93

Initial Evaluation of [(18)F]DCFPyL for Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer. Mol Imaging Biol (2015) 1.90

The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. PLoS Genet (2010) 1.90

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response. J Biol Chem (2002) 1.87

A regulatory toolbox of MiniPromoters to drive selective expression in the brain. Proc Natl Acad Sci U S A (2010) 1.85

Studying Chinese suicide with proxy-based data: reliability and validity of the methodology and instruments in China. J Nerv Ment Dis (2003) 1.84

Bcl-2 upregulation induced by miR-21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa-2 pancreatic cancer cells. Arch Med Res (2011) 1.83

Aberrant regulation of planar cell polarity in polycystic kidney disease. J Am Soc Nephrol (2010) 1.81

Undisclosed antiretroviral drug use in a multinational clinical trial (HIV Prevention Trials Network 052). J Infect Dis (2013) 1.77

Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. Hum Mol Genet (2012) 1.77

Genetically altered mice to evaluate glutathione homeostasis in health and disease. Free Radic Biol Med (2004) 1.76

Obesity induces signs of premature cardiac aging in younger patients: the role of mitochondria. J Am Coll Cardiol (2011) 1.76

Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells. Stem Cells (2010) 1.75

Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. J Clin Invest (2007) 1.73

ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets. Stem Cells (2012) 1.70

Müller cell-derived VEGF is a significant contributor to retinal neovascularization. J Pathol (2009) 1.69

Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell (2013) 1.66

Plasma miRNAs Effectively Distinguish Patients With Pancreatic Cancer From Controls: A Multicenter Study. Ann Surg (2016) 1.66

Small RNAs have a large impact: circulating microRNAs as biomarkers for human diseases. RNA Biol (2012) 1.64

Interactions of perilipin-5 (Plin5) with adipose triglyceride lipase. J Biol Chem (2010) 1.64

Are there differences between women's and men's antidepressant responses? Am J Psychiatry (2002) 1.64

Genetic composition of yield heterosis in an elite rice hybrid. Proc Natl Acad Sci U S A (2012) 1.63

Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application. Pharmacol Rev (2012) 1.62

Hydrogen sulfide treatment promotes glucose uptake by increasing insulin receptor sensitivity and ameliorates kidney lesions in type 2 diabetes. Antioxid Redox Signal (2013) 1.60

Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from Toll-like receptor 3. J Exp Med (2009) 1.60

Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel. Am J Physiol Cell Physiol (2012) 1.60

A crucial role for Olig2 in white matter astrocyte development. Development (2007) 1.60

Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice. Nephrol Dial Transplant (2008) 1.56

Overexpression of phosphorylated mammalian target of rapamycin predicts lymph node metastasis and prognosis of chinese patients with gastric cancer. Clin Cancer Res (2009) 1.56

Atmospheric iron deposition: global distribution, variability, and human perturbations. Ann Rev Mar Sci (2009) 1.56

The hydrogen sulfide donor NaHS promotes angiogenesis in a rat model of hind limb ischemia. Antioxid Redox Signal (2010) 1.54

Pretreatment of formula or expressed breast milk with sodium polystyrene sulfonate (Kayexalate(®)) as a treatment for hyperkalemia in infants with acute or chronic renal insufficiency. J Ren Nutr (2013) 1.53

Evidence-based obstetrics in four hospitals in China: An observational study to explore clinical practice, women's preferences and provider's views. BMC Pregnancy Childbirth (2001) 1.52

Decreased connexin 43 and increased fibrosis in atrial regions susceptible to complex fractionated atrial electrograms. Cardiology (2009) 1.49

Crystallographic studies of Xe and Kr binding within the large internal cavity of cytochrome ba3 from Thermus thermophilus: structural analysis and role of oxygen transport channels in the heme-Cu oxidases. Biochemistry (2008) 1.49

Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors. Blood (2006) 1.48

Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis. PLoS Genet (2011) 1.47

Efficacy of catheter ablation and surgical CryoMaze procedure in patients with long-lasting persistent atrial fibrillation and rheumatic heart disease: a randomized trial. Eur Heart J (2010) 1.47

Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE. Invest Ophthalmol Vis Sci (2002) 1.46

Modifications of superoxide dismutase (SOD1) in human erythrocytes: a possible role in amyotrophic lateral sclerosis. J Biol Chem (2009) 1.46

Peregrine and saker falcon genome sequences provide insights into evolution of a predatory lifestyle. Nat Genet (2013) 1.45

Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling. J Biol Chem (2009) 1.45

Immortalization of pancreatic stellate cells as an in vitro model of pancreatic fibrosis: deactivation is induced by matrigel and N-acetylcysteine. Lab Invest (2005) 1.43

Repetitive element-mediated recombination as a mechanism for new gene origination in Drosophila. PLoS Genet (2007) 1.42

The cytochrome ba3 oxygen reductase from Thermus thermophilus uses a single input channel for proton delivery to the active site and for proton pumping. Proc Natl Acad Sci U S A (2009) 1.42

Intraretinal leakage and oxidation of LDL in diabetic retinopathy. Invest Ophthalmol Vis Sci (2008) 1.42

Porous boron nitride nanosheets for effective water cleaning. Nat Commun (2013) 1.42

Abdominal aorta aneurysms in children: single-center experience of six patients. Ann Thorac Surg (2011) 1.41

Activating enhancer-binding protein-2β nucleolar localization predicts poor survival after stage I non-small cell lung cancer resection. Ann Thorac Surg (2011) 1.41

Controlled surface modification of boron nitride nanotubes. Nanotechnology (2011) 1.41

Community-wide assessment of protein-interface modeling suggests improvements to design methodology. J Mol Biol (2011) 1.40

Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: structural characterization. J Med Chem (2008) 1.39

Physiological mechanisms underlying OsNAC5-dependent tolerance of rice plants to abiotic stress. Planta (2011) 1.39

Rapamycin prevents early steps of the development of diabetic nephropathy in rats. Am J Nephrol (2007) 1.39

Two point mutations of RPE65 from patients with retinal dystrophies decrease the stability of RPE65 protein and abolish its isomerohydrolase activity. J Biol Chem (2006) 1.38

Concern microRNA-218 Inhibits Oxygen-induced Retinal Neovascularization via Reducing the Expression of Roundabout 1. Chin Med J (Engl) (2016) 1.38

Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway. J Biol Chem (2006) 1.38

Survey of access to gastroenterology in Canada: the SAGE wait times program. Can J Gastroenterol (2010) 1.37

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS. Blood (2012) 1.36

RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle. J Biol Chem (2005) 1.36

LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling. J Biol Chem (2008) 1.36

Bias associated with mining electronic health records. J Biomed Discov Collab (2011) 1.36

Characterization and purification of Saccharomyces cerevisiae RNase MRP reveals a new unique protein component. J Biol Chem (2005) 1.36

A novel cryoprotection scheme for enhancing the diffraction of crystals of recombinant cytochrome ba3 oxidase from Thermus thermophilus. Acta Crystallogr D Biol Crystallogr (2005) 1.36

Involvement of microRNA-93, a new regulator of PTEN/Akt signaling pathway, in regulation of chemotherapeutic drug cisplatin chemosensitivity in ovarian cancer cells. FEBS Lett (2012) 1.35

Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii. J Immunol (2009) 1.35

Overexpression of Grb2/HER2 signaling in Chinese gastric cancer: their relationship with clinicopathological parameters and prognostic significance. J Cancer Res Clin Oncol (2009) 1.34

Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J Biol Chem (2008) 1.34