Published in Biochem Soc Trans on December 01, 2008
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Molecular anatomy of a trafficking organelle. Cell (2006) 11.47
Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution. Science (2008) 8.04
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Anatomy and dynamics of a supramolecular membrane protein cluster. Science (2007) 3.75
Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein. Proc Natl Acad Sci U S A (2005) 3.48
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Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR. Proc Natl Acad Sci U S A (2005) 3.37
A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo. Cancer Cell (2010) 3.05
NMR structure determination for larger proteins using backbone-only data. Science (2010) 3.00
Rosetta predictions in CASP5: successes, failures, and prospects for complete automation. Proteins (2003) 2.77
Structure of the human voltage-dependent anion channel. Proc Natl Acad Sci U S A (2008) 2.69
Ligand docking and binding site analysis with PyMOL and Autodock/Vina. J Comput Aided Mol Des (2010) 2.67
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Membrane protein sequestering by ionic protein-lipid interactions. Nature (2011) 2.40
Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR. Nature (2006) 2.34
Effect of sodium chloride on a lipid bilayer. Biophys J (2003) 2.24
Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel. Biochemistry (2008) 2.22
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Structure and mechanism of the reversible photoswitch of a fluorescent protein. Proc Natl Acad Sci U S A (2005) 2.21
Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs. Nat Struct Biol (2002) 2.21
Sequential N- to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles. EMBO J (2006) 2.19
Mechanoenzymatics of titin kinase. Proc Natl Acad Sci U S A (2008) 2.17
Generalized correlation for biomolecular dynamics. Proteins (2006) 2.17
β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons. Ann Neurol (2013) 2.10
Free modeling with Rosetta in CASP6. Proteins (2005) 2.10
Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit. Proc Natl Acad Sci U S A (2011) 2.10
Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models. EMBO J (2009) 2.09
g_membed: Efficient insertion of a membrane protein into an equilibrated lipid bilayer with minimal perturbation. J Comput Chem (2010) 2.08
Atomic model of the type III secretion system needle. Nature (2012) 2.02
Determination of membrane protein structure and dynamics by magic-angle-spinning solid-state NMR spectroscopy. J Am Chem Soc (2005) 2.02
Predicting free energy changes using structural ensembles. Nat Methods (2009) 1.93
Nanoseconds molecular dynamics simulation of primary mechanical energy transfer steps in F1-ATP synthase. Nat Struct Biol (2002) 1.92
De novo high-resolution protein structure determination from sparse spin-labeling EPR data. Structure (2008) 1.84
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. Science (2014) 1.81
The mechanism of proton exclusion in the aquaporin-1 water channel. J Mol Biol (2003) 1.80
Defining long-range order and local disorder in native alpha-synuclein using residual dipolar couplings. J Am Chem Soc (2005) 1.75
Scrutinizing molecular mechanics force fields on the submicrosecond timescale with NMR data. Biophys J (2010) 1.75
Force spectroscopy of single biomolecules. Chemphyschem (2002) 1.73
Mechanically induced titin kinase activation studied by force-probe molecular dynamics simulations. Biophys J (2004) 1.70
Mechanism of selectivity in aquaporins and aquaglyceroporins. Proc Natl Acad Sci U S A (2008) 1.67
The dynamics and energetics of water permeation and proton exclusion in aquaporins. Curr Opin Struct Biol (2005) 1.65
Model-free analysis of protein backbone motion from residual dipolar couplings. J Am Chem Soc (2002) 1.65
Myelin basic protein-diverse conformational states of an intrinsically unstructured protein and its roles in myelin assembly and multiple sclerosis. Micron (2004) 1.62
A ligand-induced switch in the periplasmic domain of sensor histidine kinase CitA. J Mol Biol (2008) 1.61
Structural polymorphism of 441-residue tau at single residue resolution. PLoS Biol (2009) 1.61
Single-molecule FRET measures bends and kinks in DNA. Proc Natl Acad Sci U S A (2008) 1.58
Structure and function of water channels. Curr Opin Struct Biol (2002) 1.55
Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions. J Biol Chem (2005) 1.54
A concept for rapid protein-structure determination by solid-state NMR spectroscopy. Angew Chem Int Ed Engl (2005) 1.53
Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system. ACS Chem Neurosci (2010) 1.52
Computational methods in drug discovery. Pharmacol Rev (2013) 1.51
RosettaEPR: an integrated tool for protein structure determination from sparse EPR data. J Struct Biol (2010) 1.50
Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease. Proc Natl Acad Sci U S A (2005) 1.50
Multistep binding of divalent cations to phospholipid bilayers: a molecular dynamics study. Angew Chem Int Ed Engl (2004) 1.50
Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation. J Am Chem Soc (2007) 1.49
The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli. J Biol Chem (2003) 1.48
Full correlation analysis of conformational protein dynamics. Proteins (2008) 1.47
Quaternary ammonium compounds as water channel blockers. Specificity, potency, and site of action. J Biol Chem (2006) 1.46
Weak long-range correlated motions in a surface patch of ubiquitin involved in molecular recognition. J Am Chem Soc (2011) 1.45
Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol (2010) 1.45
Kinetics, statistics, and energetics of lipid membrane electroporation studied by molecular dynamics simulations. Biophys J (2008) 1.43
Energy barriers and driving forces in tRNA translocation through the ribosome. Nat Struct Mol Biol (2013) 1.41
NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation. EMBO J (2004) 1.41
Crystal structure of a yeast aquaporin at 1.15 angstrom reveals a novel gating mechanism. PLoS Biol (2009) 1.41
Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation. Nat Struct Mol Biol (2011) 1.41
Interaction of urea with amino acids: implications for urea-induced protein denaturation. J Am Chem Soc (2007) 1.39
CASP6 assessment of contact prediction. Proteins (2005) 1.39
Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment. Nat Struct Mol Biol (2013) 1.38
Structural models for the KCNQ1 voltage-gated potassium channel. Biochemistry (2007) 1.38
Crystallographic ab initio protein structure solution below atomic resolution. Nat Methods (2009) 1.38
Protein conformational flexibility from structure-free analysis of NMR dipolar couplings: quantitative and absolute determination of backbone motion in ubiquitin. Angew Chem Int Ed Engl (2009) 1.38
Water permeation through gramicidin A: desformylation and the double helix: a molecular dynamics study. Biophys J (2002) 1.37
A model for the solution structure of the rod arrestin tetramer. Structure (2008) 1.37
Structural properties of pore-forming oligomers of alpha-synuclein. J Am Chem Soc (2009) 1.36
A structural link between inactivation and block of a K+ channel. Nat Struct Mol Biol (2008) 1.36
Protein refolding is required for assembly of the type three secretion needle. Nat Struct Mol Biol (2010) 1.36
Determination of the structures of symmetric protein oligomers from NMR chemical shifts and residual dipolar couplings. J Am Chem Soc (2011) 1.35
A thorough dynamic interpretation of residual dipolar couplings in ubiquitin. J Biomol NMR (2006) 1.34
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol (2013) 1.34
Protein thermostability calculations using alchemical free energy simulations. Biophys J (2010) 1.33