PubRank

Jacqueline A Lees

Author PubWeight™ 59.06‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Sibling rivalry in the E2F family. Nat Rev Mol Cell Biol 2002 7.64
2 p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell 2007 4.01
3 Many ribosomal protein genes are cancer genes in zebrafish. PLoS Biol 2004 3.99
4 E2Fs regulate adipocyte differentiation. Dev Cell 2002 2.71
5 Life and death decisions by the E2F transcription factors. Curr Opin Cell Biol 2007 2.66
6 Rb regulates fate choice and lineage commitment in vivo. Nature 2010 2.60
7 Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1. Cancer Cell 2012 2.04
8 Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage. Proc Natl Acad Sci U S A 2008 1.98
9 Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Genes Dev 2004 1.97
10 DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. Genes Dev 2006 1.96
11 Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion. Proc Natl Acad Sci U S A 2008 1.90
12 Proapoptotic function of the retinoblastoma tumor suppressor protein. Cancer Cell 2009 1.73
13 Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations. Proc Natl Acad Sci U S A 2008 1.63
14 E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas. Mol Cell Biol 2003 1.50
15 E2F4 loss suppresses tumorigenesis in Rb mutant mice. Cancer Cell 2002 1.48
16 A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes Dev 2010 1.47
17 Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss. Mol Cell 2003 1.47
18 Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo. Mol Cell Biol 2002 1.44
19 The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development. Mol Cancer Res 2008 1.43
20 The retinoblastoma protein induces apoptosis directly at the mitochondria. Genes Dev 2013 1.28
21 Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish. Dev Dyn 2009 1.27
22 E2f4 is required for normal development of the airway epithelium. Dev Biol 2007 1.11
23 Selective requirements for E2f3 in the development and tumorigenicity of Rb-deficient chimeric tissues. Mol Cell Biol 2007 1.07
24 Cell cycle genes are the evolutionarily conserved targets of the E2F4 transcription factor. PLoS One 2007 1.07
25 Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers. Proc Natl Acad Sci U S A 2010 0.96
26 Zebrafish Hagoromo mutants up-regulate fgf8 postembryonically and develop neuroblastoma. Mol Cancer Res 2009 0.96
27 E2F3 plays an essential role in cardiac development and function. Cell Cycle 2008 0.94
28 The role of E2F4 in adipogenesis is independent of its cell cycle regulatory activity. Proc Natl Acad Sci U S A 2003 0.93
29 E2f6 and Bmi1 cooperate in axial skeletal development. Dev Dyn 2008 0.89
30 Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects. Proc Natl Acad Sci U S A 2009 0.86
31 Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery. PLoS Genet 2013 0.84
32 Disruption of calvarial ossification in E2f4 mutant embryos correlates with increased proliferation and progenitor cell populations. Cell Cycle 2010 0.82
33 E2F4 cooperates with pRB in the development of extra-embryonic tissues. Dev Biol 2009 0.82
34 pRB and E2F4 play distinct cell-intrinsic roles in fetal erythropoiesis. Cell Cycle 2010 0.80