PubRank

Diethard Mattanovich

Author PubWeight™ 77.12‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Microbial production of organic acids: expanding the markets. Trends Biotechnol 2008 2.88
2 Protein folding and conformational stress in microbial cells producing recombinant proteins: a host comparative overview. Microb Cell Fact 2008 1.89
3 Effects of gene dosage, promoters, and substrates on unfolded protein stress of recombinant Pichia pastoris. Biotechnol Bioeng 2004 1.64
4 Engineering of Pichia pastoris for improved production of antibody fragments. Biotechnol Bioeng 2006 1.58
5 The effect of temperature on the proteome of recombinant Pichia pastoris. J Proteome Res 2009 1.53
6 Recombinant protein production in yeasts. Mol Biotechnol 2005 1.38
7 Novel insights into the unfolded protein response using Pichia pastoris specific DNA microarrays. BMC Genomics 2008 1.36
8 Adaptive laboratory evolution -- principles and applications for biotechnology. Microb Cell Fact 2013 1.29
9 A multi-level study of recombinant Pichia pastoris in different oxygen conditions. BMC Syst Biol 2010 1.28
10 Pichia pastoris: protein production host and model organism for biomedical research. Future Microbiol 2013 1.19
11 Hypoxic fed-batch cultivation of Pichia pastoris increases specific and volumetric productivity of recombinant proteins. Biotechnol Bioeng 2008 1.19
12 Divergent genetic control of protein solubility and conformational quality in Escherichia coli. J Mol Biol 2007 1.18
13 Versatile modeling and optimization of fed batch processes for the production of secreted heterologous proteins with Pichia pastoris. Microb Cell Fact 2006 1.18
14 Identification and characterisation of novel Pichia pastoris promoters for heterologous protein production. J Biotechnol 2010 1.13
15 Differential gene expression in recombinant Pichia pastoris analysed by heterologous DNA microarray hybridisation. Microb Cell Fact 2004 1.13
16 Transcriptomics-based identification of novel factors enhancing heterologous protein secretion in yeasts. Appl Environ Microbiol 2007 1.12
17 Macromolecular and elemental composition analysis and extracellular metabolite balances of Pichia pastoris growing at different oxygen levels. Microb Cell Fact 2009 1.11
18 Induction without methanol: novel regulated promoters enable high-level expression in Pichia pastoris. Microb Cell Fact 2013 1.09
19 Directed gene copy number amplification in Pichia pastoris by vector integration into the ribosomal DNA locus. FEMS Yeast Res 2009 1.09
20 Monitoring of transcriptional regulation in Pichia pastoris under protein production conditions. BMC Genomics 2007 1.09
21 A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris. PLoS One 2011 1.08
22 Intracellular pH distribution in Saccharomyces cerevisiae cell populations, analyzed by flow cytometry. Appl Environ Microbiol 2005 1.08
23 Genome-scale metabolic model of methylotrophic yeast Pichia pastoris and its use for in silico analysis of heterologous protein production. Biotechnol J 2010 1.07
24 Improvement of lactic acid production in Saccharomyces cerevisiae by cell sorting for high intracellular pH. Appl Environ Microbiol 2006 1.06
25 Biochemistry of microbial itaconic acid production. Front Microbiol 2013 1.06
26 Unconventional microbial systems for the cost-efficient production of high-quality protein therapeutics. Biotechnol Adv 2012 1.05
27 Biosynthesis of vitamin C by yeast leads to increased stress resistance. PLoS One 2007 1.03
28 Effect of increased expression of protein disulfide isomerase and heavy chain binding protein on antibody secretion in a recombinant CHO cell line. Biotechnol Prog 2005 1.03
29 Production of recombinant proteins and metabolites in yeasts: when are these systems better than bacterial production systems? Appl Microbiol Biotechnol 2010 1.02
30 The response to unfolded protein is involved in osmotolerance of Pichia pastoris. BMC Genomics 2010 1.02
31 The secretory pathway: exploring yeast diversity. FEMS Microbiol Rev 2013 1.01
32 Overexpression of the riboflavin biosynthetic pathway in Pichia pastoris. Microb Cell Fact 2008 0.99
33 In Pichia pastoris, growth rate regulates protein synthesis and secretion, mating and stress response. Biotechnol J 2014 0.99
34 Six novel constitutive promoters for metabolic engineering of Aspergillus niger. Appl Microbiol Biotechnol 2012 0.98
35 The impact of oxygen on the transcriptome of recombinant S. cerevisiae and P. pastoris - a comparative analysis. BMC Genomics 2011 0.97
36 Oxidative protein folding and unfolded protein response elicit differing redox regulation in endoplasmic reticulum and cytosol of yeast. Free Radic Biol Med 2012 0.96
37 Monitoring intracellular redox conditions in the endoplasmic reticulum of living yeasts. FEMS Microbiol Lett 2010 0.96
38 Lactate production yield from engineered yeasts is dependent from the host background, the lactate dehydrogenase source and the lactate export. Microb Cell Fact 2006 0.95
39 Targeting enzymes to the right compartment: metabolic engineering for itaconic acid production by Aspergillus niger. Metab Eng 2013 0.95
40 Protein trafficking, ergosterol biosynthesis and membrane physics impact recombinant protein secretion in Pichia pastoris. Microb Cell Fact 2011 0.95
41 Genome sequence of the ruminal bacterium Megasphaera elsdenii. J Bacteriol 2011 0.94
42 Yeast systems biotechnology for the production of heterologous proteins. FEMS Yeast Res 2009 0.94
43 Engineering of protein folding and secretion-strategies to overcome bottlenecks for efficient production of recombinant proteins. Antioxid Redox Signal 2014 0.93
44 Assessing viability and cell-associated product of recombinant protein producing Pichia pastoris with flow cytometry. J Biotechnol 2003 0.93
45 Quo vadis? The challenges of recombinant protein folding and secretion in Pichia pastoris. Appl Microbiol Biotechnol 2015 0.91
46 Modeling and measuring intracellular fluxes of secreted recombinant protein in Pichia pastoris with a novel 34S labeling procedure. Microb Cell Fact 2011 0.91
47 Antibody production with yeasts and filamentous fungi: on the road to large scale? Biotechnol Lett 2006 0.91
48 16 years research on lactic acid production with yeast - ready for the market? Biotechnol Genet Eng Rev 2010 0.91
49 1,3-Propanediol production from glycerol with Lactobacillus diolivorans. Bioresour Technol 2012 0.90
50 Systems metabolic engineering, industrial biotechnology and microbial cell factories. Microb Cell Fact 2012 0.90
51 High level expression of a promising anti-idiotypic antibody fragment vaccine against HIV-1 in Pichia pastoris. J Biotechnol 2007 0.90
52 Cloning, disruption and protein secretory phenotype of the GAS1 homologue of Pichia pastoris. FEMS Microbiol Lett 2006 0.87
53 Intracellular interactome of secreted antibody Fab fragment in Pichia pastoris reveals its routes of secretion and degradation. Appl Microbiol Biotechnol 2012 0.87
54 Identification and deletion of the major secreted protein of Pichia pastoris. Appl Microbiol Biotechnol 2012 0.86
55 Influence of growth temperature on the production of antibody Fab fragments in different microbes: a host comparative analysis. Biotechnol Prog 2010 0.86
56 Pichia pastoris secretes recombinant proteins less efficiently than Chinese hamster ovary cells but allows higher space-time yields for less complex proteins. Biotechnol J 2014 0.86
57 Engineering of bottlenecks in Rhizopus oryzae lipase production in Pichia pastoris using the nitrogen source-regulated FLD1 promoter. N Biotechnol 2009 0.85
58 Genome-scale analysis of library sorting (GALibSo): Isolation of secretion enhancing factors for recombinant protein production in Pichia pastoris. Biotechnol Bioeng 2010 0.85
59 Bacterial expression and refolding of human trypsinogen. J Biotechnol 2004 0.84
60 Repressible promoters - a novel tool to generate conditional mutants in Pichia pastoris. Microb Cell Fact 2013 0.84
61 U13C cell extract of Pichia pastoris--a powerful tool for evaluation of sample preparation in metabolomics. J Sep Sci 2012 0.83
62 Engineering of biotin-prototrophy in Pichia pastoris for robust production processes. Metab Eng 2010 0.83
63 Optimization of recombinant protein expression level in Escherichia coli by flow cytometry and cell sorting. Biotechnol Bioeng 2002 0.83
64 The lipidome and proteome of microsomes from the methylotrophic yeast Pichia pastoris. Biochim Biophys Acta 2014 0.82
65 Pichia pastoris Aft1--a novel transcription factor, enhancing recombinant protein secretion. Microb Cell Fact 2014 0.81
66 Accurate quantification of the redox-sensitive GSH/GSSG ratios in the yeast Pichia pastoris by HILIC-MS/MS. Anal Bioanal Chem 2012 0.80
67 Reverse engineering of protein secretion by uncoupling of cell cycle phases from growth. Biotechnol Bioeng 2011 0.80
68 Integrative omics analysis. A study based on Plasmodium falciparum mRNA and protein data. BMC Syst Biol 2014 0.80
69 Interlaboratory comparison for quantitative primary metabolite profiling in Pichia pastoris. Anal Bioanal Chem 2013 0.79
70 From rumen to industry. Microb Cell Fact 2012 0.79
71 Sample preparation workflow for the liquid chromatography tandem mass spectrometry based analysis of nicotinamide adenine dinucleotide phosphate cofactors in yeast. J Sep Sci 2014 0.79
72 Recombinant protein production in yeasts. Methods Mol Biol 2004 0.78
73 Induction and measurement of UPR and osmotic stress in the yeast Pichia pastoris. Methods Enzymol 2011 0.78
74 Recombinant protein production in the new Millennium. Microb Cell Fact 2007 0.76
75 Microbial production of 1,3-propanediol. Recent Pat Biotechnol 2008 0.76
76 Identification of microRNAs specific for high producer CHO cell lines using steady-state cultivation. Appl Microbiol Biotechnol 2014 0.76
77 The scientific impact of microbial cell factories. Microb Cell Fact 2008 0.75
78 Recombinant protein production 6: a comparative view on host physiology. N Biotechnol 2011 0.75
79 Corrigendum: Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. Nat Commun 2016 0.75
80 Organic acids from lignocellulose: Candida lignohabitans as a new microbial cell factory. J Ind Microbiol Biotechnol 2015 0.75
81 Recombinant protein production 6 (Vienna, February 2011). N Biotechnol 2011 0.75
82 Mass spectrometry based analysis of nucleotides, nucleosides, and nucleobases--application to feed supplements. Anal Bioanal Chem 2012 0.75
83 Genetic engineering of Lactobacillus diolivorans. FEMS Microbiol Lett 2013 0.75