Epigenetics and obesity.

Epigenetics and cardiovascular disease. Nat Rev Cardiol (2010) 1.68

Epigenetic control in rheumatoid arthritis synovial fibroblasts. Nat Rev Rheumatol (2009) 1.32

Perinatal environment and its influences on metabolic programming of offspring. Physiol Behav (2010) 1.29

Global DNA methylation is associated with insulin resistance: a monozygotic twin study. Diabetes (2011) 1.24

Impact of diabetes on cardiovascular disease: an update. Int J Hypertens (2013) 1.13

The genetics of obesity. Curr Diab Rep (2010) 1.11

Microvesicles/exosomes as potential novel biomarkers of metabolic diseases. Diabetes Metab Syndr Obes (2012) 1.01

Genomic imprinting in diabetes. Genome Med (2010) 0.97

Early origins of adult disease: approaches for investigating the programmable epigenome in humans, nonhuman primates, and rodents. ILAR J (2012) 0.89

DNA sequence polymorphisms within the bovine guanine nucleotide-binding protein Gs subunit alpha (Gsα)-encoding (GNAS) genomic imprinting domain are associated with performance traits. BMC Genet (2011) 0.81

Genetic & epigenetic approach to human obesity. Indian J Med Res (2014) 0.79

Multiple conditions: exploring literature from the consumer perspective in Australia. Health Expect (2012) 0.78

Variation in ultraviolet radiation and diabetes: evidence of an epigenetic effect that modulates diabetics' lifespan. Clin Epigenetics (2013) 0.78

Epigenomic elements analyses for promoters identify ESRRG as a new susceptibility gene for obesity-related traits. Int J Obes (Lond) (2016) 0.75

Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells. Stem Cells Int (2017) 0.75

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18

Chromatin modifications and their function. Cell (2007) 55.98

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16

DNA methylation patterns and epigenetic memory. Genes Dev (2002) 33.83

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A (1996) 29.54

The large-scale organization of metabolic networks. Nature (2000) 27.57

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet (2003) 25.57

The mammalian epigenome. Cell (2007) 18.13

Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A (2005) 15.46

Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04

Genome regulation by polycomb and trithorax proteins. Cell (2007) 11.96

Next-generation sequencing transforms today's biology. Nat Methods (2007) 11.93

Genomic imprinting: parental influence on the genome. Nat Rev Genet (2001) 11.50

Environmental epigenomics and disease susceptibility. Nat Rev Genet (2007) 11.02

Phenotypic plasticity and the epigenetics of human disease. Nature (2007) 10.37

Beyond the sequence: cellular organization of genome function. Cell (2007) 10.32

Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol (2003) 9.30

Epigenetic inheritance at the agouti locus in the mouse. Nat Genet (1999) 9.14

Perceptions of epigenetics. Nature (2007) 8.43

Noncoding RNAs and gene silencing. Cell (2007) 5.99

Genomic imprinting in mammalian development: a parental tug-of-war. Trends Genet (1991) 5.95

The emerging epidemic of obesity in developing countries. Int J Epidemiol (2005) 5.48

Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring. J Nutr (2002) 4.97

A census of mammalian imprinting. Trends Genet (2005) 4.84

Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. FASEB J (1998) 4.62

ChIP-seq: welcome to the new frontier. Nat Methods (2007) 4.56

Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect (2006) 4.46

Waddington's canalization revisited: developmental stability and evolution. Proc Natl Acad Sci U S A (2002) 4.01

Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19. Am J Hum Genet (2002) 3.93

Neomorphic agouti mutations in obese yellow mice. Nat Genet (1994) 3.92

Genome organization, function, and imprinting in Prader-Willi and Angelman syndromes. Annu Rev Genomics Hum Genet (2001) 3.92

Relaxation of imprinted genes in human cancer. Nature (1993) 3.86

Computational and experimental identification of novel human imprinted genes. Genome Res (2007) 3.50

Gametic imprinting in mammals. Science (1995) 3.49

Metastable epialleles in mammals. Trends Genet (2002) 3.36

Differential effects of culture on imprinted H19 expression in the preimplantation mouse embryo. Biol Reprod (2000) 3.33

Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour. Nature (1993) 3.24

Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57. Nat Genet (2008) 3.06

Imprinting in Prader-Willi and Angelman syndromes. Trends Genet (1998) 2.85

Changes in gene expression foreshadow diet-induced obesity in genetically identical mice. PLoS Genet (2006) 2.80

Genome-wide prediction of imprinted murine genes. Genome Res (2005) 2.76

Diabetes and obesity: the twin epidemics. Nat Med (2006) 2.72

Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene. Proc Natl Acad Sci U S A (1998) 2.71

Mechanisms of imprinting of the Prader-Willi/Angelman region. Am J Med Genet A (2008) 2.68

Large offspring syndrome in cattle and sheep. Rev Reprod (1998) 2.64

Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation. Proc Natl Acad Sci U S A (2006) 2.63

Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus. Hum Mol Genet (2006) 2.60

Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: association with aberrant phenotypes. Development (1998) 2.60

Beckwith-Wiedemann syndrome and assisted reproduction technology (ART). J Med Genet (2003) 2.48

Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations. Br J Nutr (2007) 2.48

Maternal nutrition and fetal development. J Nutr (2004) 2.31

Selective loss of imprinting in the placenta following preimplantation development in culture. Development (2004) 2.23

In vitro fertilization may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCN1OT gene. Am J Hum Genet (2003) 2.21

Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians. Nat Genet (2008) 2.20

The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding. Nat Genet (2004) 2.13

Resourceful imprinting. Nature (2004) 2.10

Limited evolutionary conservation of imprinting in the human placenta. Proc Natl Acad Sci U S A (2006) 2.08

Genomic imprinting in mammals: emerging themes and established theories. PLoS Genet (2006) 1.99

Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes. Biol Reprod (2001) 1.97

Maternal effects as the cause of parent-of-origin effects that mimic genomic imprinting. Genetics (2008) 1.88

Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life? Br J Nutr (2007) 1.85

Mutations of the Gs alpha-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis. Proc Natl Acad Sci U S A (1990) 1.82

Epigenetic deregulation of imprinting in congenital diseases of aberrant growth. Bioessays (2006) 1.75

Parental imprinting and human disease. Annu Rev Genet (1996) 1.72

Epigenetic variation illustrated by DNA methylation patterns of the fragile-X gene FMR1. Hum Mol Genet (1997) 1.70

Deletion of the NESP55 differentially methylated region causes loss of maternal GNAS imprints and pseudohypoparathyroidism type Ib. Nat Genet (2004) 1.68

Manipulations of mouse embryos prior to implantation result in aberrant expression of imprinted genes on day 9.5 of development. Hum Mol Genet (2007) 1.67

Alternative Gnas gene products have opposite effects on glucose and lipid metabolism. Proc Natl Acad Sci U S A (2005) 1.59

Type 2 (non-insulin-dependent) diabetes--an epidemiological overview. Diabetologia (1982) 1.55

Beckwith-Wiedemann syndrome and IVF: a case-control study. Am J Hum Genet (2004) 1.54

Possible genomic imprinting of three human obesity-related genetic loci. Am J Hum Genet (2005) 1.54

Genomic imprinting, growth control and the allocation of nutritional resources: consequences for postnatal life. Curr Opin Endocrinol Diabetes Obes (2007) 1.54

Transient neonatal diabetes, a disorder of imprinting. J Med Genet (2002) 1.51

Nutritional epigenomics of metabolic syndrome: new perspective against the epidemic. Diabetes (2005) 1.48

The thrifty epigenotype: an acquired and heritable predisposition for obesity and diabetes? Bioessays (2008) 1.47

Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of type 2 diabetes and BMI in Pima Indians. Diabetes (2001) 1.44

Molecular barcodes detect redundancy and contamination in hairpin-bisulfite PCR. Nucleic Acids Res (2004) 1.44

Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size. Am J Physiol Endocrinol Metab (2004) 1.42

A maternal hypomethylation syndrome presenting as transient neonatal diabetes mellitus. Hum Genet (2006) 1.35

A mouse model of albright hereditary osteodystrophy generated by targeted disruption of exon 1 of the Gnas gene. Endocrinology (2005) 1.34

Physiological functions of the imprinted Gnas locus and its protein variants Galpha(s) and XLalpha(s) in human and mouse. J Endocrinol (2008) 1.32

Genomic imprinting effects on adult body composition in mice. Proc Natl Acad Sci U S A (2008) 1.31

In vivo methylation patterns of the leptin promoter in human and mouse. Epigenetics (2006) 1.29

Assisted reproductive technology in Europe, 2003. Results generated from European registers by ESHRE. Hum Reprod (2007) 1.28

A maternal epimutation of GNAS leads to Albright osteodystrophy and parathyroid hormone resistance. J Clin Endocrinol Metab (2008) 1.27

Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance. FASEB J (2008) 1.24

Minireview: pharmacogenetics and beyond: the interaction of therapeutic response, beta-cell physiology, and genetics in diabetes. Endocrinology (2006) 1.22

Genetic linkage and imprinting effects on body mass index in children and young adults. Eur J Hum Genet (2003) 1.21

Characterization of the extra-large G protein alpha-subunit XLalphas. II. Signal transduction properties. J Biol Chem (2000) 1.18

Is personalized medicine finally arriving? Nat Biotechnol (2008) 1.16

Assessment of genetic linkage and parent-of-origin effects on obesity. J Clin Endocrinol Metab (2006) 1.14

Satiety dysfunction in Prader-Willi syndrome demonstrated by fMRI. J Neurol Neurosurg Psychiatry (2005) 1.13

RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes. EMBO J (2007) 1.12

Encoding PCR products with batch-stamps and barcodes. Biochem Genet (2007) 1.11

In-utero overgrowth in ruminants following embryo culture: lessons from mice and a warning to men. Hum Reprod (2000) 1.10

Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of birth weight. Hum Genet (2002) 1.09

What will whole genome searches for susceptibility genes for common complex disease offer to clinical practice? J Intern Med (2008) 1.07

Epigenetic deregulation of genomic imprinting in human disorders and following assisted reproduction. Birth Defects Res C Embryo Today (2005) 1.05