Published in Cell on February 23, 2007
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18
The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99
RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex. Cell (2009) 11.12
Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. Cell (2008) 9.02
Epigenome-wide association studies for common human diseases. Nat Rev Genet (2011) 7.96
Epigenetic modifications and human disease. Nat Biotechnol (2010) 7.29
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell (2010) 6.94
Control of the embryonic stem cell state. Cell (2011) 6.89
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Small RNAs in transcriptional gene silencing and genome defence. Nature (2009) 5.98
Noncoding transcription by RNA polymerase Pol IVb/Pol V mediates transcriptional silencing of overlapping and adjacent genes. Cell (2008) 5.78
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Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci U S A (2010) 4.73
Pimet, the Drosophila homolog of HEN1, mediates 2'-O-methylation of Piwi- interacting RNAs at their 3' ends. Genes Dev (2007) 4.68
MicroRNA-directed transcriptional gene silencing in mammalian cells. Proc Natl Acad Sci U S A (2008) 4.16
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. Genes Dev (2010) 4.00
Reiterated WG/GW motifs form functionally and evolutionarily conserved ARGONAUTE-binding platforms in RNAi-related components. Genes Dev (2007) 3.75
ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes. PLoS One (2010) 3.15
Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing. Proc Natl Acad Sci U S A (2008) 3.03
TRAMP-mediated RNA surveillance prevents spurious entry of RNAs into the Schizosaccharomyces pombe siRNA pathway. Nat Struct Mol Biol (2008) 2.98
Retracted RNAi-dependent and independent control of LINE1 accumulation and mobility in mouse embryonic stem cells. PLoS Genet (2013) 2.91
Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Dev (2009) 2.73
RNA interference guides histone modification during the S phase of chromosomal replication. Curr Biol (2008) 2.72
Gene silencing mechanisms mediated by Aubergine piRNA complexes in Drosophila male gonad. RNA (2007) 2.55
Lid2 is required for coordinating H3K4 and H3K9 methylation of heterochromatin and euchromatin. Cell (2008) 2.42
Regulation and function of DNA methylation in plants and animals. Cell Res (2011) 2.41
The evolution of RNAi as a defence against viruses and transposable elements. Philos Trans R Soc Lond B Biol Sci (2009) 2.35
Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline. Nucleic Acids Res (2007) 2.22
An effector of RNA-directed DNA methylation in arabidopsis is an ARGONAUTE 4- and RNA-binding protein. Cell (2009) 2.16
Arabidopsis FIERY1, XRN2, and XRN3 are endogenous RNA silencing suppressors. Plant Cell (2007) 2.11
Rice MicroRNA effector complexes and targets. Plant Cell (2009) 1.93
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Mitotic bookmarking of genes: a novel dimension to epigenetic control. Nat Rev Genet (2010) 1.76
RNA-directed DNA methylation requires an AGO4-interacting member of the SPT5 elongation factor family. EMBO Rep (2009) 1.75
Transcription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterochromatin on lytic promoters. J Virol (2009) 1.65
Maternal noncoding transcripts antagonize the targeting of DNA elimination by scanRNAs in Paramecium tetraurelia. Genes Dev (2008) 1.60
Proliferation-dependent and cell cycle regulated transcription of mouse pericentric heterochromatin. J Cell Biol (2007) 1.59
A two-dimensional mutate-and-map strategy for non-coding RNA structure. Nat Chem (2011) 1.58
RNA and transcriptional modulation of gene expression. Cell Cycle (2007) 1.56
Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway. RNA (2009) 1.55
Epigenetic principles and mechanisms underlying nervous system functions in health and disease. Prog Neurobiol (2008) 1.53
Association of large intergenic noncoding RNA expression with disease activity and organ damage in systemic lupus erythematosus. Arthritis Res Ther (2015) 1.49
Small RNA-directed epigenetic natural variation in Arabidopsis thaliana. PLoS Genet (2008) 1.43
The polycomb complex protein mes-2/E(z) promotes the transition from developmental plasticity to differentiation in C. elegans embryos. Dev Cell (2009) 1.43
siRNA and miRNA processing: new functions for Cajal bodies. Curr Opin Genet Dev (2008) 1.42
DXZ4 chromatin adopts an opposing conformation to that of the surrounding chromosome and acquires a novel inactive X-specific role involving CTCF and antisense transcripts. Genome Res (2008) 1.40
Silent chromatin at the middle and ends: lessons from yeasts. EMBO J (2009) 1.36
Mapping epigenetic mutations in fission yeast using whole-genome next-generation sequencing. Genome Res (2009) 1.36
Characterization of the contradictory chromatin signatures at the 3' exons of zinc finger genes. PLoS One (2011) 1.34
Large-scale field application of RNAi technology reducing Israeli acute paralysis virus disease in honey bees (Apis mellifera, Hymenoptera: Apidae). PLoS Pathog (2010) 1.29
The progeny of Arabidopsis thaliana plants exposed to salt exhibit changes in DNA methylation, histone modifications and gene expression. PLoS One (2012) 1.28
Regulation of heterochromatin assembly on unpaired chromosomes during Caenorhabditis elegans meiosis by components of a small RNA-mediated pathway. PLoS Genet (2009) 1.28
Mapping the genome landscape using tiling array technology. Curr Opin Plant Biol (2007) 1.28
RNA polymerase V functions in Arabidopsis interphase heterochromatin organization independently of the 24-nt siRNA-directed DNA methylation pathway. Mol Plant (2009) 1.28
Computational identification and functional predictions of long noncoding RNA in Zea mays. PLoS One (2012) 1.25
Wheat hybridization and polyploidization results in deregulation of small RNAs. Genetics (2011) 1.22
Genome-wide analysis of plant nat-siRNAs reveals insights into their distribution, biogenesis and function. Genome Biol (2012) 1.20
siRNA-mediated methylation of Arabidopsis telomeres. PLoS Genet (2010) 1.18
Centromere size and position in Candida albicans are evolutionarily conserved independent of DNA sequence heterogeneity. Mol Genet Genomics (2007) 1.16
RNA-directed DNA methylation and demethylation in plants. Sci China C Life Sci (2009) 1.14
Epigenetics: definition, mechanisms and clinical perspective. Semin Reprod Med (2009) 1.14
Long antisense non-coding RNAs and their role in transcription and oncogenesis. Cell Cycle (2010) 1.11
A transcriptomic analysis of human centromeric and pericentric sequences in normal and tumor cells. Nucleic Acids Res (2009) 1.07
RNA turnover and chromatin-dependent gene silencing. Chromosoma (2008) 1.05
Epigenetic histone modifications of human transposable elements: genome defense versus exaptation. Mob DNA (2010) 1.04
The epigenome of evolving Drosophila neo-sex chromosomes: dosage compensation and heterochromatin formation. PLoS Biol (2013) 1.03
Small RNAs in the animal gonad: guarding genomes and guiding development. Int J Biochem Cell Biol (2010) 1.03
Heterochromatin, small RNA and post-fertilization dysgenesis in allopolyploid and interploid hybrids of Arabidopsis. New Phytol (2010) 1.02
Conserved DNA methylation patterns in healthy blood cells and extensive changes in leukemia measured by a new quantitative technique. Epigenetics (2012) 1.02
A novel epigenetic phenotype associated with the most aggressive pathway of bladder tumor progression. J Natl Cancer Inst (2010) 1.02
Differential interactions of the autonomous pathway RRM proteins and chromatin regulators in the silencing of Arabidopsis targets. PLoS One (2008) 1.00
Non-coding RNAs, epigenetic memory and the passage of information to progeny. RNA Biol (2009) 1.00
Identification and characterization of Dicer-like, Argonaute and RNA-dependent RNA polymerase gene families in maize. Plant Cell Rep (2011) 1.00
Spatial and temporal plasticity of chromatin during programmed DNA-reorganization in Stylonychia macronuclear development. Epigenetics Chromatin (2008) 1.00
Molecular and enzymatic profiles of mammalian DNA methyltransferases: structures and targets for drugs. Curr Med Chem (2010) 0.99
IDN2 and its paralogs form a complex required for RNA-directed DNA methylation. PLoS Genet (2012) 0.99
Distorted sex ratios: a window into RNAi-mediated silencing. PLoS Biol (2007) 0.99
Transcriptional activity of transposable elements in maize. BMC Genomics (2010) 0.99
Epigenetic regulation in plants. Cold Spring Harb Perspect Biol (2014) 0.98
Transcriptional regulation of neuronal differentiation: the epigenetic layer of complexity. Biochim Biophys Acta (2008) 0.98
Paramutation: the tip of an epigenetic iceberg? Trends Genet (2009) 0.97
Two GW repeat proteins interact with Tetrahymena thermophila argonaute and promote genome rearrangement. Mol Cell Biol (2009) 0.97
The Caenorhabditis elegans rsd-2 and rsd-6 genes are required for chromosome functions during exposure to unfavorable environments. Genetics (2008) 0.97
RNA-dependent RNA polymerase is required for enhancer-mediated transcriptional silencing associated with paramutation at the maize p1 gene. Genetics (2008) 0.96
Invasion of the Arabidopsis genome by the tobacco retrotransposon Tnt1 is controlled by reversible transcriptional gene silencing. Plant Physiol (2008) 0.96
Control of flowering and cell fate by LIF2, an RNA binding partner of the polycomb complex component LHP1. PLoS One (2011) 0.95
Heterochromatin protein 1 (HP1) proteins do not drive pericentromeric cohesin enrichment in human cells. PLoS One (2009) 0.95
Mapping key features of transcriptional regulatory circuitry in embryonic stem cells. Cold Spring Harb Symp Quant Biol (2008) 0.93
Genomic SELEX: a discovery tool for genomic aptamers. Methods (2010) 0.93
Paramutation: epigenetic instructions passed across generations. Genetics (2008) 0.93
Characterization of the Small RNA Transcriptome of the Marine Coccolithophorid, Emiliania huxleyi. PLoS One (2016) 0.90
RNA-directed DNA methylation: mechanisms and functions. Plant Signal Behav (2010) 0.89
Epigenetics and obesity. Pharmacogenomics (2008) 0.89
The mechanisms of radiation-induced bystander effect. J Biomed Phys Eng (2014) 0.89
NCBI Epigenomics: what's new for 2013. Nucleic Acids Res (2012) 0.89
Highly potent and specific siRNAs against E6 or E7 genes of HPV16- or HPV18-infected cervical cancers. Cancer Gene Ther (2010) 0.87
Evolution of serum albumin intron-1 is shaped by a 5' truncated non-long terminal repeat retrotransposon in western Palearctic water frogs (Neobatrachia). Mol Phylogenet Evol (2009) 0.86
Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression. Mol Cancer (2015) 0.85
On the epigenetics of vascular regulation and disease. Clin Epigenetics (2012) 0.85
The B73 maize genome: complexity, diversity, and dynamics. Science (2009) 18.73
Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science (2002) 17.04
Criteria for annotation of plant MicroRNAs. Plant Cell (2008) 7.49
The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol (2003) 6.90
Epigenetic reprogramming and small RNA silencing of transposable elements in pollen. Cell (2009) 6.05
Vernalization requires epigenetic silencing of FLC by histone methylation. Nature (2004) 5.77
Understanding mechanisms of novel gene expression in polyploids. Trends Genet (2003) 4.90
Dependence of heterochromatic histone H3 methylation patterns on the Arabidopsis gene DDM1. Science (2002) 4.49
Epigenetic natural variation in Arabidopsis thaliana. PLoS Biol (2007) 4.29
RNA polymerase II is required for RNAi-dependent heterochromatin assembly. Science (2005) 3.94
Spatially restricted microRNA directs leaf polarity through ARGONAUTE1. Nature (2004) 3.92
The developmental role of microRNA in plants. Curr Opin Plant Biol (2005) 3.81
RNA interference is required for normal centromere function in fission yeast. Chromosome Res (2003) 3.46
Maize genome sequencing by methylation filtration. Science (2003) 3.31
RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond. Nat Rev Genet (2013) 3.17
Arabidopsis TFL2/LHP1 specifically associates with genes marked by trimethylation of histone H3 lysine 27. PLoS Genet (2007) 3.11
Specification of leaf polarity in Arabidopsis via the trans-acting siRNA pathway. Curr Biol (2006) 3.04
Oil palm genome sequence reveals divergence of interfertile species in Old and New worlds. Nature (2013) 2.58
ASYMMETRIC LEAVES1 reveals knox gene redundancy in Arabidopsis. Development (2002) 2.55
Control of female gamete formation by a small RNA pathway in Arabidopsis. Nature (2010) 2.53
Argonaute slicing is required for heterochromatic silencing and spreading. Science (2006) 2.48
Reprogramming of DNA methylation in pollen guides epigenetic inheritance via small RNA. Cell (2012) 2.29
Sorghum genome sequencing by methylation filtration. PLoS Biol (2005) 2.02
Kismeth: analyzer of plant methylation states through bisulfite sequencing. BMC Bioinformatics (2008) 2.01
Global effects on gene expression in fission yeast by silencing and RNA interference machineries. Mol Cell Biol (2005) 1.98
S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription. Mol Cell (2007) 1.84
Differential regulation of strand-specific transcripts from Arabidopsis centromeric satellite repeats. PLoS Genet (2005) 1.83
RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II. Nature (2011) 1.79
The maize methylome influences mRNA splice sites and reveals widespread paramutation-like switches guided by small RNA. Genome Res (2013) 1.78
Differential methylation of genes and repeats in land plants. Genome Res (2005) 1.77
The oil palm SHELL gene controls oil yield and encodes a homologue of SEEDSTICK. Nature (2013) 1.72
Epigenomic consequences of immortalized plant cell suspension culture. PLoS Biol (2008) 1.68
Genes and transposons are differentially methylated in plants, but not in mammals. Genome Res (2003) 1.66
MicroRNA-targeted and small interfering RNA-mediated mRNA degradation is regulated by argonaute, dicer, and RNA-dependent RNA polymerase in Arabidopsis. Plant Cell (2006) 1.54
Phyllotactic pattern and stem cell fate are determined by the Arabidopsis homeobox gene BELLRINGER. Development (2003) 1.49
The role of ARGONAUTE1 (AGO1) in meristem formation and identity. Dev Biol (2005) 1.45
A functional phylogenomic view of the seed plants. PLoS Genet (2011) 1.44
Ribonuclease activity of Dis3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function. PLoS One (2007) 1.41
Three PIGGYBACK genes that specifically influence leaf patterning encode ribosomal proteins. Development (2008) 1.32
Detailed analysis of a contiguous 22-Mb region of the maize genome. PLoS Genet (2009) 1.29
Identification of novel high-frequency DNA methylation changes in breast cancer. PLoS One (2007) 1.22
The development of an Arabidopsis model system for genome-wide analysis of polyploidy effects. Biol J Linn Soc Lond (2004) 1.22
CENP-B preserves genome integrity at replication forks paused by retrotransposon LTR. Nature (2010) 1.17
Arabidopsis thaliana chromosome 4 replicates in two phases that correlate with chromatin state. PLoS Genet (2010) 1.16
Endogenous TasiRNAs mediate non-cell autonomous effects on gene regulation in Arabidopsis thaliana. PLoS One (2009) 1.14
MicroRNA activity in the Arabidopsis male germline. J Exp Bot (2011) 1.11
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Gene enrichment in plant genomic shotgun libraries. Curr Opin Plant Biol (2003) 1.02
The fission yeast Jmj2 reverses histone H3 Lysine 4 trimethylation. J Biol Chem (2007) 1.01
Computational identification and analysis of novel sugarcane microRNAs. BMC Genomics (2012) 1.00
ABAP1 is a novel plant Armadillo BTB protein involved in DNA replication and transcription. EMBO J (2008) 0.99
Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication. Science (2014) 0.97
Global expression changes resulting from loss of telomeric DNA in fission yeast. Genome Biol (2004) 0.95
RNA-directed DNA methylation regulates parental genomic imprinting at several loci in Arabidopsis. Development (2013) 0.94
Genome-wide transposon tagging reveals location-dependent effects on transcription and chromatin organization in Arabidopsis. Plant J (2008) 0.94
RNA interference and heterochromatin assembly. Cold Spring Harb Perspect Biol (2011) 0.93
Finding the right template: RNA Pol IV, a plant-specific RNA polymerase. Mol Cell (2005) 0.92
Comparing low coverage random shotgun sequence data from Brassica oleracea and Oryza sativa genome sequence for their ability to add to the annotation of Arabidopsis thaliana. Genome Res (2005) 0.92
Genome reprogramming and small interfering RNA in the Arabidopsis germline. Curr Opin Genet Dev (2011) 0.91
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Genome-wide identification of microRNA and siRNA responsive to endophytic beneficial diazotrophic bacteria in maize. BMC Genomics (2014) 0.84
Secretion trap tagging of secreted and membrane-spanning proteins using Arabidopsis gene traps. Plant Physiol (2003) 0.83
Multiple roles for small RNAs during plant reproduction. Curr Opin Plant Biol (2011) 0.82
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Lsd1 and lsd2 control programmed replication fork pauses and imprinting in fission yeast. Cell Rep (2012) 0.80
Establishing epigenetic variation during genome reprogramming. RNA Biol (2013) 0.79
CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing. Proc Natl Acad Sci U S A (2014) 0.78
Nucleolar dominance and DNA methylation directed by small interfering RNA. Mol Cell (2008) 0.76
SnapShot: small RNA-mediated epigenetic modifications. Cell (2012) 0.76
Silent decision: HP1 protein escorts heterochromatic RNAs to their destiny. EMBO J (2012) 0.75
Imprinting: DNA methyltransferases illuminate reprogramming. Curr Biol (2012) 0.75
Chromatin reprogramming: gender equality during Arabidopsis germline differentiation. Curr Biol (2011) 0.75
Cell signaling and gene regulation. Curr Opin Plant Biol (2012) 0.75