Published in Am J Physiol Heart Circ Physiol on December 12, 2008
Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis. J Biol Chem (2012) 1.07
mTOR signaling regulates the processing of pre-rRNA in human cells. Nucleic Acids Res (2011) 1.05
Eukaryotic initiation factor 2B epsilon induces cap-dependent translation and skeletal muscle hypertrophy. J Physiol (2011) 1.04
BCATm deficiency ameliorates endotoxin-induced decrease in muscle protein synthesis and improves survival in septic mice. Am J Physiol Regul Integr Comp Physiol (2010) 0.94
Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1. PLoS One (2011) 0.84
Rapamycin does not affect post-absorptive protein metabolism in human skeletal muscle. Metabolism (2012) 0.83
Three 4-letter words of hypertension-related cardiac hypertrophy: TRPC, mTOR, and HDAC. J Mol Cell Cardiol (2011) 0.83
Disruption of genes encoding eIF4E binding proteins-1 and -2 does not alter basal or sepsis-induced changes in skeletal muscle protein synthesis in male or female mice. PLoS One (2014) 0.79
Quantitative Non-canonical Amino Acid Tagging (QuaNCAT) Proteomics Identifies Distinct Patterns of Protein Synthesis Rapidly Induced by Hypertrophic Agents in Cardiomyocytes, Revealing New Aspects of Metabolic Remodeling. Mol Cell Proteomics (2016) 0.75
The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J Biol Chem (2005) 4.34
Profiling membrane lipids in plant stress responses. Role of phospholipase D alpha in freezing-induced lipid changes in Arabidopsis. J Biol Chem (2002) 4.04
Regulation of peptide-chain elongation in mammalian cells. Eur J Biochem (2002) 2.86
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochem J (2003) 2.84
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell (2013) 2.74
The mTOR pathway in the control of protein synthesis. Physiology (Bethesda) (2006) 2.71
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. J Biol Chem (2007) 2.50
Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins. Mol Cell Biol (2005) 2.47
Quantitative profiling of polar glycerolipid species from organs of wild-type Arabidopsis and a phospholipase Dalpha1 knockout mutant. Phytochemistry (2006) 2.33
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. J Biol Chem (2004) 2.26
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One (2009) 2.20
Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation? Eur J Biochem (2002) 2.20
Translation matters: protein synthesis defects in inherited disease. Nat Rev Genet (2007) 2.19
Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. Neuron (2003) 2.19
Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. J Biol Chem (2004) 2.16
Phospholipase D alpha 1-derived phosphatidic acid interacts with ABI1 phosphatase 2C and regulates abscisic acid signaling. Proc Natl Acad Sci U S A (2004) 2.15
A bifurcating pathway directs abscisic acid effects on stomatal closure and opening in Arabidopsis. Science (2006) 2.09
Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner. J Biol Chem (2002) 2.09
Nutrient control of TORC1, a cell-cycle regulator. Trends Cell Biol (2009) 1.88
A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin. Mol Cell Biol (2004) 1.88
Phospholipase dalpha1 and phosphatidic acid regulate NADPH oxidase activity and production of reactive oxygen species in ABA-mediated stomatal closure in Arabidopsis. Plant Cell (2009) 1.88
The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1. Immunity (2005) 1.85
Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors. Eur J Biochem (2002) 1.78
The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites. J Biol Chem (2002) 1.77
Phospholipase D- and phosphatidic acid-mediated signaling in plants. Biochim Biophys Acta (2009) 1.77
Simultaneous quantification of major phytohormones and related compounds in crude plant extracts by liquid chromatography-electrospray tandem mass spectrometry. Phytochemistry (2008) 1.75
Quantitative analysis of major plant hormones in crude plant extracts by high-performance liquid chromatography-mass spectrometry. Nat Protoc (2010) 1.75
Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA. J Biol Chem (2001) 1.74
The Arabidopsis phospholipase D family. Characterization of a calcium-independent and phosphatidylcholine-selective PLD zeta 1 with distinct regulatory domains. Plant Physiol (2002) 1.67
Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2. J Neurosci (2006) 1.61
The plasma membrane-bound phospholipase Ddelta enhances freezing tolerance in Arabidopsis thaliana. Nat Biotechnol (2004) 1.61
mTOR's role in ageing: protein synthesis or autophagy? Aging (Albany NY) (2009) 1.59
Double knockouts of phospholipases Dzeta1 and Dzeta2 in Arabidopsis affect root elongation during phosphate-limited growth but do not affect root hair patterning. Plant Physiol (2005) 1.57
Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling. J Biol Chem (2008) 1.57
The oleate-stimulated phospholipase D, PLDdelta, and phosphatidic acid decrease H2O2-induced cell death in Arabidopsis. Plant Cell (2003) 1.53
Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif. Mol Cell Biol (2002) 1.53
The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases). Front Biosci (2008) 1.51
Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS Lett (2005) 1.48
Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men. J Physiol (2005) 1.47
Ras/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytes. Circ Res (2002) 1.47
Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2. J Neurosci (2005) 1.40
Differing substrate specificities of members of the DYRK family of arginine-directed protein kinases. FEBS Lett (2002) 1.40
Arabidopsis phospholipase Dalpha1 interacts with the heterotrimeric G-protein alpha-subunit through a motif analogous to the DRY motif in G-protein-coupled receptors. J Biol Chem (2003) 1.39
cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner. EMBO J (2008) 1.37
The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization. Mol Cell Biol (2003) 1.32
mTORC1 signaling: what we still don't know. J Mol Cell Biol (2010) 1.32
Phospholipase Dalpha3 is involved in the hyperosmotic response in Arabidopsis. Plant Cell (2008) 1.31
Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1. J Biol Chem (2003) 1.29
Protein synthesis and its control in neuronal cells with a focus on vanishing white matter disease. Biochem Soc Trans (2009) 1.29
Plant lipidomics: discerning biological function by profiling plant complex lipids using mass spectrometry. Front Biosci (2007) 1.27
Electrospray ionization tandem mass spectrometry scan modes for plant chloroplast lipids. Anal Biochem (2003) 1.27
AtPLAI is an acyl hydrolase involved in basal jasmonic acid production and Arabidopsis resistance to Botrytis cinerea. J Biol Chem (2007) 1.25
Cytosolic glyceraldehyde-3-phosphate dehydrogenases interact with phospholipase Dδ to transduce hydrogen peroxide signals in the Arabidopsis response to stress. Plant Cell (2012) 1.23
Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress. Sci Signal (2012) 1.23
The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. Mol Cell Biol (2003) 1.22
Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2). Biochem J (2005) 1.21
An abietane diterpenoid is a potent activator of systemic acquired resistance. Plant J (2012) 1.21
Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways. Mol Cell Biol (2004) 1.20
Differential degradation of extraplastidic and plastidic lipids during freezing and post-freezing recovery in Arabidopsis thaliana. J Biol Chem (2007) 1.17
Phospholipase D epsilon and phosphatidic acid enhance Arabidopsis nitrogen signaling and growth. Plant J (2009) 1.17
Patatin-related phospholipase A: nomenclature, subfamilies and functions in plants. Trends Plant Sci (2010) 1.17
Stable isotope-labelling analysis of the impact of inhibition of the mammalian target of rapamycin on protein synthesis. Biochem J (2012) 1.17
Lipid species profiling: a high-throughput approach to identify lipid compositional changes and determine the function of genes involved in lipid metabolism and signaling. Curr Opin Plant Biol (2004) 1.16
The rapid activation of protein synthesis by growth hormone requires signaling through mTOR. Am J Physiol Endocrinol Metab (2007) 1.16
The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha. J Biol Chem (2007) 1.16
Enhancing seed quality and viability by suppressing phospholipase D in Arabidopsis. Plant J (2007) 1.14
Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors. Biochemistry (2006) 1.12
A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B. Mol Cell Biol (2007) 1.11
Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis. Biochem Soc Trans (2012) 1.10
Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization. Mol Cell Biol (2003) 1.08
Kif5b is an essential forward trafficking motor for the Kv1.5 cardiac potassium channel. J Physiol (2009) 1.05
mTOR signaling regulates the processing of pre-rRNA in human cells. Nucleic Acids Res (2011) 1.05
Methods for studying signal-dependent regulation of translation factor activity. Methods Enzymol (2007) 1.05
Phospholipase D in the signaling networks of plant response to abscisic acid and reactive oxygen species. Biochim Biophys Acta (2005) 1.04
Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats. Am J Physiol Endocrinol Metab (2011) 1.04
Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase. Biochem J (2012) 1.03
Phospholipase D and phosphatidic acid signalling in plant response to drought and salinity. Plant Cell Environ (2009) 1.03
Nonspecific phospholipase C NPC4 promotes responses to abscisic acid and tolerance to hyperosmotic stress in Arabidopsis. Plant Cell (2010) 1.03
Profiling of plant hormones by mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 1.02
Regulation of the phosphorylation of elongation factor 2 by MEK-dependent signalling in adult rat cardiomyocytes. FEBS Lett (2002) 1.02
eIF2B-related disorders: antenatal onset and involvement of multiple organs. Am J Hum Genet (2003) 1.02
ANG II activates effectors of mTOR via PI3-K signaling in human coronary smooth muscle cells. Am J Physiol Heart Circ Physiol (2004) 1.01
Using unnatural protein fusions to engineer resveratrol biosynthesis in yeast and Mammalian cells. J Am Chem Soc (2006) 1.01
Patatin-related phospholipase pPLAIIIβ-induced changes in lipid metabolism alter cellulose content and cell elongation in Arabidopsis. Plant Cell (2011) 1.00
mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging. BMC Cell Biol (2013) 1.00
Phosphatidic acid binds and stimulates Arabidopsis sphingosine kinases. J Biol Chem (2011) 1.00
Direct infusion mass spectrometry of oxylipin-containing Arabidopsis membrane lipids reveals varied patterns in different stress responses. Plant Physiol (2011) 1.00
ABC50 promotes translation initiation in mammalian cells. J Biol Chem (2009) 0.99
Consolidation and translation regulation. Learn Mem (2012) 0.99
Quantitative proteomics identifies Gemin5, a scaffolding protein involved in ribonucleoprotein assembly, as a novel partner for eukaryotic initiation factor 4E. J Proteome Res (2006) 0.99
Oxidized LDL-mediated macrophage survival involves elongation factor-2 kinase. Arterioscler Thromb Vasc Biol (2008) 0.99
Features in the N and C termini of the MAPK-interacting kinase Mnk1 mediate its nucleocytoplasmic shuttling. J Biol Chem (2003) 0.98