Published in J Biol Chem on August 01, 2008
Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony. J Biol Chem (2010) 2.90
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One (2009) 2.20
Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells. Biochim Biophys Acta (2009) 1.89
Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein. J Biol Chem (2009) 1.67
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Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells. Lab Invest (2010) 1.52
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Functional amino acids in growth, reproduction, and health. Adv Nutr (2010) 1.38
Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling. J Biol Chem (2010) 1.30
RalA functions as an indispensable signal mediator for the nutrient-sensing system. J Biol Chem (2008) 1.28
Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. Free Radic Biol Med (2010) 1.28
Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. Mol Cell Biol (2009) 1.25
Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb. Mol Cell Biol (2009) 1.25
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Rab-family GTPase regulates TOR complex 2 signaling in fission yeast. Curr Biol (2010) 1.15
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Hepatitis C virus NS5A activates the mammalian target of rapamycin (mTOR) pathway, contributing to cell survival by disrupting the interaction between FK506-binding protein 38 (FKBP38) and mTOR. J Biol Chem (2010) 1.07
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mTOR signaling regulates the processing of pre-rRNA in human cells. Nucleic Acids Res (2011) 1.05
Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling. PLoS Genet (2010) 1.04
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Evolution of the TOR pathway. J Mol Evol (2011) 0.95
Molecular basis of the acceleration of the GDP-GTP exchange of human ras homolog enriched in brain by human translationally controlled tumor protein. J Biol Chem (2009) 0.94
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Structural divergence of plant TCTPs. Front Plant Sci (2014) 0.87
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Insights into the role and regulation of TCTP in skeletal muscle. Oncotarget (2016) 0.75
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A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. Biochem J (2007) 2.69
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Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. J Biol Chem (2003) 2.66
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Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones. Nat Struct Biol (2001) 1.75
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The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity. J Biol Chem (2005) 1.43
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