Published in Risk Anal on December 09, 2008
In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project. Environ Health Perspect (2010) 3.84
The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics. Sci Transl Med (2011) 3.80
Designing Endocrine Disruption Out of the Next Generation of Chemicals. Green Chem (2013) 2.47
QSAR modeling: where have you been? Where are you going to? J Med Chem (2014) 2.08
Chemical genomics profiling of environmental chemical modulation of human nuclear receptors. Environ Health Perspect (2011) 1.57
The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform. Drug Discov Today (2010) 1.43
The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality. Drug Discov Today (2013) 1.21
Perspectives on validation of high-throughput assays supporting 21st century toxicity testing. ALTEX (2013) 1.19
Aggregating data for computational toxicology applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System. Int J Mol Sci (2012) 1.16
Identification of chemical compounds that induce HIF-1alpha activity. Toxicol Sci (2009) 1.14
Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicol Sci (2012) 1.12
Genetic toxicology in the 21st century: reflections and future directions. Environ Mol Mutagen (2011) 1.12
Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential. Environ Health Perspect (2014) 1.12
Paradigm shift in toxicity testing and modeling. AAPS J (2012) 1.07
The EDKB: an established knowledge base for endocrine disrupting chemicals. BMC Bioinformatics (2010) 1.03
Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway. Sci Rep (2014) 1.01
Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicol Appl Pharmacol (2011) 1.00
The Salmonella mutagenicity assay: the stethoscope of genetic toxicology for the 21st century. Environ Health Perspect (2010) 1.00
Integrating zebrafish toxicology and nanoscience for safer product development. Green Chem (2013) 0.98
Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines. Environ Mol Mutagen (2011) 0.98
Computational toxicology: realizing the promise of the toxicity testing in the 21st century. Environ Health Perspect (2010) 0.97
Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug-like Molecules. Mol Inform (2012) 0.93
Assessment of compound hepatotoxicity using human plateable cryopreserved hepatocytes in a 1536-well-plate format. Assay Drug Dev Technol (2011) 0.86
Multidimensional profiling platforms reveal metabolic dysregulation caused by organophosphorus pesticides. ACS Chem Biol (2013) 0.85
On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens. Environ Health Perspect (2016) 0.84
Advancing the next generation of health risk assessment. Environ Health Perspect (2012) 0.84
Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing. Toxicol Sci (2015) 0.84
Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene. Toxicol Sci (2011) 0.83
SWIFT-Review: a text-mining workbench for systematic review. Syst Rev (2016) 0.81
Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure. Environ Health Perspect (2015) 0.80
Identification of thyroid hormone receptor active compounds using a quantitative high-throughput screening platform. Curr Chem Genom Transl Med (2014) 0.80
Comparative iron oxide nanoparticle cellular dosimetry and response in mice by the inhalation and liquid cell culture exposure routes. Part Fibre Toxicol (2014) 0.78
Adverse outcome pathway development from protein alkylation to liver fibrosis. Arch Toxicol (2016) 0.77
Carbamate Insecticides Target Human Melatonin Receptors. Chem Res Toxicol (2016) 0.75
Prediction of hERG Liability - Using SVM Classification, Bootstrapping and Jackknifing. Mol Inform (2016) 0.75
Development of a simple measurement method for GluR2 protein expression as an index of neuronal vulnerability. Toxicol Rep (2015) 0.75
Toxicology. Transforming environmental health protection. Science (2008) 7.50
Toxicity testing in the 21st century: implications for human health risk assessment. Risk Anal (2008) 5.57
Prepublication data sharing. Nature (2009) 12.24
Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc Natl Acad Sci U S A (2006) 9.92
High-throughput screening assays for the identification of chemical probes. Nat Chem Biol (2007) 4.50
The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics. Sci Transl Med (2011) 3.80
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol (2012) 3.40
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. Science (2011) 3.30
Compound cytotoxicity profiling using quantitative high-throughput screening. Environ Health Perspect (2008) 3.11
A high-throughput screen for aggregation-based inhibition in a large compound library. J Med Chem (2007) 2.97
Improving the human hazard characterization of chemicals: a Tox21 update. Environ Health Perspect (2013) 2.95
Identification of oxadiazoles as new drug leads for the control of schistosomiasis. Nat Med (2008) 2.90
Fluorescence spectroscopic profiling of compound libraries. J Med Chem (2008) 2.53
Characterization of chemical libraries for luciferase inhibitory activity. J Med Chem (2008) 2.53
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells. Proc Natl Acad Sci U S A (2014) 2.50
DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Hum Mol Genet (2003) 2.39
Compound Management for Quantitative High-Throughput Screening. JALA Charlottesv Va (2008) 2.11
A robotic platform for quantitative high-throughput screening. Assay Drug Dev Technol (2008) 1.90
Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase. J Med Chem (2008) 1.81
Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. Proc Natl Acad Sci U S A (2007) 1.70
Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem (2010) 1.61
Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A (2009) 1.61
Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade. PLoS Negl Trop Dis (2008) 1.58
Chemical genomics profiling of environmental chemical modulation of human nuclear receptors. Environ Health Perspect (2011) 1.57
Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity. Environ Sci Technol (2010) 1.54
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol (2009) 1.52
Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action. Biochem Pharmacol (2010) 1.52
Fourth International Workgroup on Genotoxicity testing: results of the in vivo Comet assay workgroup. Mutat Res (2006) 1.51
A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Nucleic Acids Res (2009) 1.49
Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J Med Chem (2010) 1.45
The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform. Drug Discov Today (2010) 1.43
A role for the melanocortin 4 receptor in sexual function. Proc Natl Acad Sci U S A (2002) 1.38
Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environ Health Perspect (2015) 1.37
Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg Med Chem Lett (2010) 1.37
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A (2012) 1.35
A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. J Med Chem (2009) 1.34
Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One (2009) 1.32
Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries. Nat Biotechnol (2009) 1.30
Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening. Biochemistry (2009) 1.28
Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition. Cancer Res (2009) 1.27
Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor. J Biomol Screen (2008) 1.25
Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening. Chem Res Toxicol (2008) 1.25
A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker. Toxicol In Vitro (2008) 1.24
δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders. J Biol Chem (2012) 1.23
A dual-fluorescence high-throughput cell line system for probing multidrug resistance. Assay Drug Dev Technol (2009) 1.22
Cloning and characterization of Disc1, the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1). Genomics (2002) 1.22
The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality. Drug Discov Today (2013) 1.21
Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening. Assay Drug Dev Technol (2009) 1.20
Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression. Genomics (2002) 1.20
Molecular characterization of the murine SIGNR1 gene encoding a C-type lectin homologous to human DC-SIGN and DC-SIGNR. Gene (2002) 1.19
Collaborative development of 2-hydroxypropyl-β-cyclodextrin for the treatment of Niemann-Pick type C1 disease. Curr Top Med Chem (2014) 1.19
Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia. Cancer Res (2014) 1.19
Perspectives on validation of high-throughput assays supporting 21st century toxicity testing. ALTEX (2013) 1.19
Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction. Anal Biochem (2007) 1.18
Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnership. Cancer Res (2012) 1.16
Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Diabetes (2004) 1.16
Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proc Natl Acad Sci U S A (2012) 1.16
Localization of PPARdelta in murine central nervous system: expression in oligodendrocytes and neurons. Brain Res (2003) 1.15
Identification of chemical compounds that induce HIF-1alpha activity. Toxicol Sci (2009) 1.14
Identification of clinically used drugs that activate pregnane X receptors. Drug Metab Dispos (2010) 1.14
Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory. Proc Natl Acad Sci U S A (2009) 1.13
Genetic toxicology in the 21st century: reflections and future directions. Environ Mol Mutagen (2011) 1.12
Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes. Environ Health Perspect (2013) 1.12
Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicol Sci (2012) 1.12
Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria. ACS Med Chem Lett (2011) 1.12
Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential. Environ Health Perspect (2014) 1.12
A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel. Anal Biochem (2009) 1.11
Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay. Mol Cancer Ther (2009) 1.11
Paradigm shift in toxicity testing and modeling. AAPS J (2012) 1.07
High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase. PLoS One (2012) 1.07
Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk). Bioorg Med Chem Lett (2009) 1.06
Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. J Med Chem (2009) 1.05
A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression. Anal Biochem (2007) 1.05
High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements. Antimicrob Agents Chemother (2010) 1.05
Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features. Toxicol Sci (2009) 1.05
Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. J Med Chem (2011) 1.05
Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem (2010) 1.04
Mitochondria, energetics, epigenetics, and cellular responses to stress. Environ Health Perspect (2014) 1.03
Application of a homogenous membrane potential assay to assess mitochondrial function. Physiol Genomics (2012) 1.03
Tetracycline-inducible gene expression in conditionally immortalized mouse podocytes. Am J Nephrol (2008) 1.02
A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor. Assay Drug Dev Technol (2007) 1.01
Differentiating Alzheimer disease-associated aggregates with small molecules. Neurobiol Dis (2007) 1.00
Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicol Appl Pharmacol (2011) 1.00
A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Nucleic Acids Res (2009) 1.00
Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res (2007) 0.99
Comparison on functional assays for Gq-coupled GPCRs by measuring inositol monophospate-1 and intracellular calcium in 1536-well plate format. Curr Chem Genomics (2008) 0.99
Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format. Methods Enzymol (2006) 0.99
Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening. Comb Chem High Throughput Screen (2008) 0.99
Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1. Anal Bioanal Chem (2012) 0.99
A class of tricyclic compounds blocking malaria parasite oocyst development and transmission. Antimicrob Agents Chemother (2012) 0.98
Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines. Environ Mol Mutagen (2011) 0.98