Phosphorylation determines the binding of microtubule-associated protein 2 (MAP2) to microtubules in living cells.

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Published in J Cell Biol on August 01, 1991

Authors

B Brugg1, A Matus

Author Affiliations

1: Friedrich Miescher Institute, Basel, Switzerland.

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Surface antigens of brain synapses: identification of minor proteins using polyclonal antisera. J Cell Biol (1984) 0.75

[Study of acid-base equilibrium in severe craniocerebral injuies]. Acta Neurol Latinoam (1971) 0.75

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Changes in the cytoplasmic distribution of microtubule-associated protein 2 during the differentiation of cultured cerebellar granule cells. Neuroscience (1985) 0.75

[Water-salt balance in cerebrocranial trauma]. Neurocirugia (1968) 0.75

[Cushing's syndrome in children and adolescents]. Bol Med Hosp Infant Mex (1975) 0.75

[Effect of iatrogenic pseudopregnancy on various hormone levels in the polycystic ovary syndrome. Differences between patients with or without galactorrhea]. Rev Chil Obstet Ginecol (1979) 0.75

Immunocytochemical localization of identified proteins in brain by monoclonal antibodies. Prog Brain Res (1982) 0.75

The effect of a herbicide--sodium salt of 2,4-dichlorophenoxyacetic acid on guerin carcinoma. Rocz Akad Med Bialymst (1996) 0.75

[Electrolytes in cerebrocranial trauma. II. Administration of water, salts and calories in patients with severe cerebrocranial trauma]. Neurocirugia (1968) 0.75

MIT-23: a mitochondrial marker for terminal neuronal differentiation defined by a monoclonal antibody. Cell (1982) 0.75

18B1: an axon-specific antigen associated with many proteins. J Neurochem (1984) 0.75

[Quantitative analysis of the interrelation between the University of Chile and the Western Metropolitan Health Service]. Rev Med Chil (1983) 0.75

[Gonadal dysgenesis]. Rev Chil Obstet Ginecol (1971) 0.75

[Relation between acid-base equilibrium and water-electrolyte balance in craniocerebral injuries]. Acta Neurol Latinoam (1971) 0.75

L-glutamate receptor heterogeneity: labeling of distinct receptor sub-types using radioligand binding techniques. J Recept Res (1984) 0.75

Single-shot cloning of multiple cDNAs coding for a set of related microtubule-associated proteins. Gene (1988) 0.75

[Electrolytes in cerebrocranial trauma. Clinical and laboratory study. I. Biochemical study of the internal environment]. Neurocirugia (1968) 0.75

Influence of monoclonal antibodies on microtubule assembly. J Neurochem (1987) 0.75