Published in Metabolomics on June 01, 2008
Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research. Metabolomics (2009) 2.21
Effect of antibiotic treatment on the intestinal metabolome. Antimicrob Agents Chemother (2011) 1.64
Metabolite signal identification in accurate mass metabolomics data with MZedDB, an interactive m/z annotation tool utilising predicted ionisation behaviour 'rules'. BMC Bioinformatics (2009) 1.44
Metabolite identification and quantitation in LC-MS/MS-based metabolomics. Trends Analyt Chem (2012) 1.23
Impact of salmonella infection on host hormone metabolism revealed by metabolomics. Infect Immun (2011) 1.12
Metabolic host responses to infection by intracellular bacterial pathogens. Front Cell Infect Microbiol (2013) 1.06
Knowledge-based data analysis comes of age. Brief Bioinform (2009) 0.95
Direct infusion mass spectrometry metabolomics dataset: a benchmark for data processing and quality control. Sci Data (2014) 0.91
Insulin sensitivity is reflected by characteristic metabolic fingerprints--a Fourier transform mass spectrometric non-targeted metabolomics approach. PLoS One (2010) 0.90
The deubiquitinase activity of the Salmonella pathogenicity island 2 effector, SseL, prevents accumulation of cellular lipid droplets. Infect Immun (2011) 0.90
Accurate quantitation of standard peptides used for quantitative proteomics. Proteomics (2009) 0.87
Spectral accuracy and sulfur counting capabilities of the LTQ-FT-ICR and the LTQ-Orbitrap XL for small molecule analysis. J Am Soc Mass Spectrom (2011) 0.84
Bioactive food components and cancer-specific metabonomic profiles. J Biomed Biotechnol (2010) 0.84
Chemical signaling in the gastrointestinal tract. F1000 Biol Rep (2011) 0.79
Excite-coupled trapping ring electrode cell (eTREC): radial trapping field control, linearized excitation, and improved detection. Anal Chem (2010) 0.79
Metabonomics reveals drastic changes in anti-inflammatory/pro-resolving polyunsaturated fatty acids-derived lipid mediators in leprosy disease. PLoS Negl Trop Dis (2013) 0.79
Metabolic signatures of triatomine vectors of Trypanosoma cruzi unveiled by metabolomics. PLoS One (2013) 0.78
Targeting proteomics to investigate metastasis-associated mitochondrial proteins. J Bioenerg Biomembr (2012) 0.75
High-Throughput Metabolic Profiling of Soybean Leaves by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Anal Chem (2015) 0.75
Dithranol as a matrix for matrix assisted laser desorption/ionization imaging on a fourier transform ion cyclotron resonance mass spectrometer. J Vis Exp (2013) 0.75
Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A (1998) 192.97
KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res (1999) 40.62
Java Treeview--extensible visualization of microarray data. Bioinformatics (2004) 24.12
HMDB: the Human Metabolome Database. Nucleic Acids Res (2007) 13.38
'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica (1999) 9.04
LMSD: LIPID MAPS structure database. Nucleic Acids Res (2006) 6.21
Metabolomics by numbers: acquiring and understanding global metabolite data. Trends Biotechnol (2004) 5.01
LIPID MAPS online tools for lipid research. Nucleic Acids Res (2007) 3.97
Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor. Plant J (2005) 3.73
Seven Golden Rules for heuristic filtering of molecular formulas obtained by accurate mass spectrometry. BMC Bioinformatics (2007) 3.70
High-throughput classification of yeast mutants for functional genomics using metabolic footprinting. Nat Biotechnol (2003) 3.48
Untargeted large-scale plant metabolomics using liquid chromatography coupled to mass spectrometry. Nat Protoc (2007) 3.41
Integration of transcriptomics and metabolomics for understanding of global responses to nutritional stresses in Arabidopsis thaliana. Proc Natl Acad Sci U S A (2004) 3.41
Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. J Biol Chem (2006) 3.23
Metabolomic database annotations via query of elemental compositions: mass accuracy is insufficient even at less than 1 ppm. BMC Bioinformatics (2006) 3.02
Measuring the metabolome: current analytical technologies. Analyst (2005) 2.74
Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors. Cancer Res (2006) 2.68
Osmoadaptation in bacteria. Adv Microb Physiol (1995) 2.50
Quantitation of choline and its metabolites in tissues and foods by liquid chromatography/electrospray ionization-isotope dilution mass spectrometry. Anal Chem (2002) 2.35
Nontargeted metabolome analysis by use of Fourier Transform Ion Cyclotron Mass Spectrometry. OMICS (2002) 2.32
Metabolomics identifies perturbations in human disorders of propionate metabolism. Clin Chem (2007) 2.31
Solvent-dependent metabolite distribution, clustering, and protein extraction for serum profiling with mass spectrometry. Anal Chem (2006) 2.04
Quantification of intracellular metabolites in Escherichia coli K12 using liquid chromatographic-electrospray ionization tandem mass spectrometric techniques. Anal Biochem (2001) 1.67
Simultaneous determination of the main metabolites in rice leaves using capillary electrophoresis mass spectrometry and capillary electrophoresis diode array detection. Plant J (2004) 1.63
Ultra-performance liquid chromatography coupled to quadrupole-orthogonal time-of-flight mass spectrometry. Rapid Commun Mass Spectrom (2004) 1.48
Deconvolution gas chromatography/mass spectrometry of urinary organic acids--potential for pattern recognition and automated identification of metabolic disorders. Rapid Commun Mass Spectrom (1999) 1.45
Metabolomics applications of FT-ICR mass spectrometry. Mass Spectrom Rev (2005) 1.42
The promise of metabolomics in cancer molecular therapeutics. Curr Opin Mol Ther (2004) 1.05
Scaling MS plateaus with high-resolution FT-ICRMS. Anal Chem (2002) 1.04
Integrated studies on plant biology using multiparallel techniques. Curr Opin Biotechnol (2001) 1.02
Measurement of choline and choline metabolite concentrations using high-pressure liquid chromatography and gas chromatography-mass spectrometry. Anal Biochem (1989) 0.99
Resolution of 11,000 compositionally distinct components in a single electrospray ionization Fourier transform ion cyclotron resonance mass spectrum of crude oil. Anal Chem (2002) 0.98
A metabolomics based approach to assessing the toxicity of the polyaromatic hydrocarbon pyrene to the earthworm Lumbricus rubellus. Chemosphere (2007) 0.96
The molecular make-up of a tumour: proteomics in cancer research. Clin Sci (Lond) (2005) 0.95
Differential metabolomics unraveling light/dark regulation of metabolic activities in Arabidopsis cell culture. Planta (2007) 0.91
Metabolomic applications of electrochemistry/mass spectrometry. J Am Soc Mass Spectrom (2004) 0.91
Metabolic profiling using Fourier-transform ion-cyclotron-resonance mass spectrometry. Anal Bioanal Chem (2007) 0.90
Metabolomic approach to evaluate the toxicological effects of nonylphenol with rat urine. Anal Chem (2007) 0.85
The combination of liquid chromatography/tandem mass spectrometry and chip-based infusion for improved screening and characterization of drug metabolites. Rapid Commun Mass Spectrom (2005) 0.84
Histone demethylation by a family of JmjC domain-containing proteins. Nature (2005) 10.36
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nat Biotechnol (2009) 9.67
Standardizing global gene expression analysis between laboratories and across platforms. Nat Methods (2005) 6.23
Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast. Genes Dev (2003) 4.93
Multiple reaction monitoring-based, multiplexed, absolute quantitation of 45 proteins in human plasma. Mol Cell Proteomics (2009) 3.65
Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med (2012) 3.03
A human proteome detection and quantitation project. Mol Cell Proteomics (2009) 2.80
The human proteome project: current state and future direction. Mol Cell Proteomics (2011) 2.34
Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation. Proc Natl Acad Sci U S A (2007) 2.34
Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows. Bioinformatics (2007) 2.17
Current trends in quantitative proteomics. J Mass Spectrom (2009) 1.82
Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicol Sci (2006) 1.75
Effect of antibiotic treatment on the intestinal metabolome. Antimicrob Agents Chemother (2011) 1.64
Crosslinking combined with mass spectrometry for structural proteomics. Mass Spectrom Rev (2010) 1.63
Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phase. Mol Cell Biol (2003) 1.61
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Res (2009) 1.60
Heading down the wrong pathway: on the influence of correlation within gene sets. BMC Genomics (2010) 1.59
Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene. Environ Health Perspect (2010) 1.59
Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest (2010) 1.59
A quantitative study of the effects of chaotropic agents, surfactants, and solvents on the digestion efficiency of human plasma proteins by trypsin. J Proteome Res (2010) 1.58
Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency. J Biol Chem (2004) 1.47
A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress-response pathway. Curr Biol (2007) 1.47
HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol (2013) 1.45
Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environ Health Perspect (2015) 1.37
Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma. Cancer Lett (2012) 1.36
MRM-based multiplexed quantitation of 67 putative cardiovascular disease biomarkers in human plasma. Proteomics (2012) 1.35
Hydrogen/deuterium exchange mass spectrometry with top-down electron capture dissociation for characterizing structural transitions of a 17 kDa protein. J Am Chem Soc (2009) 1.35
S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism. Proc Natl Acad Sci U S A (2004) 1.32
Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity. Environ Health Perspect (2010) 1.31
Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis. Carcinogenesis (2004) 1.31
An isotopically coded CID-cleavable biotinylated cross-linker for structural proteomics. Mol Cell Proteomics (2010) 1.31
Isotopically coded cleavable cross-linker for studying protein-protein interaction and protein complexes. Mol Cell Proteomics (2005) 1.29
Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology (2007) 1.29
Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR. J Clin Invest (2007) 1.29
Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver. Hepatology (2005) 1.29
FastMap: fast eQTL mapping in homozygous populations. Bioinformatics (2008) 1.25
Electron capture dissociation of electrosprayed protein ions for spatially resolved hydrogen exchange measurements. J Am Chem Soc (2008) 1.25
Mnd2 and Swm1 are core subunits of the Saccharomyces cerevisiae anaphase-promoting complex. J Biol Chem (2003) 1.24
Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet. J Hepatol (2009) 1.23
Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma. Ann Surg Oncol (2007) 1.20
Combined top-down and bottom-up proteomics identifies a phosphorylation site in stem-loop-binding proteins that contributes to high-affinity RNA binding. Proc Natl Acad Sci U S A (2006) 1.20
Cancer cachexia syndrome in head and neck cancer patients: part I. Diagnosis, impact on quality of life and survival, and treatment. Head Neck (2007) 1.18
Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure-activity relationship models of animal carcinogenicity. Environ Health Perspect (2008) 1.17
BiPS, a photocleavable, isotopically coded, fluorescent cross-linker for structural proteomics. Mol Cell Proteomics (2008) 1.17
Discovery of a small-molecule HIV-1 integrase inhibitor-binding site. Proc Natl Acad Sci U S A (2006) 1.16
Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver. Toxicol Sci (2006) 1.16
Standardizing benchmark dose calculations to improve science-based decisions in human health assessments. Environ Health Perspect (2014) 1.15
ICC-CLASS: isotopically-coded cleavable crosslinking analysis software suite. BMC Bioinformatics (2010) 1.14
Metabolomic profiling of a modified alcohol liquid diet model for liver injury in the mouse uncovers new markers of disease. Toxicol Appl Pharmacol (2008) 1.14
Proteomic signatures in plasma during early acute renal allograft rejection. Mol Cell Proteomics (2010) 1.14
Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage. Diabetes (2010) 1.13
In vitro models for liver toxicity testing. Toxicol Res (Camb) (2012) 1.13
Enhancing the bioavailability of resveratrol by combining it with piperine. Mol Nutr Food Res (2011) 1.12
Impact of salmonella infection on host hormone metabolism revealed by metabolomics. Infect Immun (2011) 1.12
Differential effect of a his tag at the N- and C-termini: functional studies with recombinant human serum transferrin. Biochemistry (2002) 1.12
Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicol Sci (2012) 1.12
Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches. Chem Res Toxicol (2011) 1.11
Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicol Sci (2009) 1.11
Three male germline-specific aldolase A isozymes are generated by alternative splicing and retrotransposition. Dev Biol (2007) 1.11
Phosphorylation of paxillin by p38MAPK is involved in the neurite extension of PC-12 cells. J Cell Biol (2004) 1.11
3' end processing of Drosophila melanogaster histone pre-mRNAs: requirement for phosphorylated Drosophila stem-loop binding protein and coevolution of the histone pre-mRNA processing system. Mol Cell Biol (2002) 1.10
Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor. Biochemistry (2009) 1.10
Ad libitum choline intake in healthy individuals meets or exceeds the proposed adequate intake level. J Nutr (2005) 1.10
ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence. Bioinformatics (2012) 1.09
The first pilot project of the consortium for top-down proteomics: a status report. Proteomics (2014) 1.08
Development of an immuno tandem mass spectrometry (iMALDI) assay for EGFR diagnosis. Proteomics Clin Appl (2007) 1.08
Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity. Toxicol Appl Pharmacol (2013) 1.08
A comparison of MS/MS-based, stable-isotope-labeled, quantitation performance on ESI-quadrupole TOF and MALDI-TOF/TOF mass spectrometers. Proteomics (2009) 1.07
Quantitative measurement of young human eye lens crystallins by direct injection Fourier transform ion cyclotron resonance mass spectrometry. Mol Vis (2006) 1.07
Mass-spectrometry-based clinical proteomics--a review and prospective. Analyst (2010) 1.06
Indoor air pollutants and health in the United Arab Emirates. Environ Health Perspect (2012) 1.06
Comment on "Profiling oil sands mixtures from industrial developments and natural groundwaters for source identification". Environ Sci Technol (2014) 1.06
Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis. Environ Health Perspect (2015) 1.05
Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicol Sci (2007) 1.04
An immunoaffinity tandem mass spectrometry (iMALDI) assay for detection of Francisella tularensis. Anal Chim Acta (2007) 1.03
Towards the development of an immuno MALDI (iMALDI) mass spectrometry assay for the diagnosis of hypertension. J Am Soc Mass Spectrom (2010) 1.03
IARC monographs: 40 years of evaluating carcinogenic hazards to humans. Environ Health Perspect (2015) 1.03
Multi-kinase phosphorylation of the APC/C activator Cdh1 revealed by mass spectrometry. Cell Cycle (2004) 1.03
Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma. Mutat Res (2010) 1.03
MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain. Nucleic Acids Res (2011) 1.03
Inhibition of APCCdh1 activity by Cdh1/Acm1/Bmh1 ternary complex formation. J Biol Chem (2006) 1.02
Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet. Toxicol Appl Pharmacol (2012) 1.02
Identification of two small regulatory RNAs linked to virulence in Brucella abortus 2308. Mol Microbiol (2012) 1.01
Design, implementation and multisite evaluation of a system suitability protocol for the quantitative assessment of instrument performance in liquid chromatography-multiple reaction monitoring-MS (LC-MRM-MS). Mol Cell Proteomics (2013) 1.01
Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma. Mol Cancer (2010) 1.01
Integrative chemical-biological read-across approach for chemical hazard classification. Chem Res Toxicol (2013) 1.01
Identification of components of protein complexes. Methods Mol Biol (2005) 1.01
Impaired Ras membrane association and activation in PPARalpha knockout mice after partial hepatectomy. Am J Physiol Gastrointest Liver Physiol (2002) 1.00
In vitro screening for population variability in chemical toxicity. Toxicol Sci (2010) 1.00
Addressing human variability in next-generation human health risk assessments of environmental chemicals. Environ Health Perspect (2012) 1.00
Photoaffinity labeling combined with mass spectrometric approaches as a tool for structural proteomics. Expert Rev Proteomics (2006) 1.00
Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors. Toxicol Sci (2010) 1.00