Published in F1000 Biol Rep on February 01, 2011
Antivirulence activity of the human gut metabolome. MBio (2014) 0.88
Modulation of post-antibiotic bacterial community reassembly and host response by Candida albicans. Sci Rep (2013) 0.86
Future therapy of portal hypertension in liver cirrhosis - a guess. F1000Prime Rep (2014) 0.75
A core gut microbiome in obese and lean twins. Nature (2008) 52.30
An obesity-associated gut microbiome with increased capacity for energy harvest. Nature (2006) 44.35
Microbial ecology: human gut microbes associated with obesity. Nature (2006) 36.98
Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A (2005) 33.66
Metagenomic analysis of the human distal gut microbiome. Science (2006) 29.76
Bacterial community variation in human body habitats across space and time. Science (2009) 24.84
Prokaryotes: the unseen majority. Proc Natl Acad Sci U S A (1998) 21.41
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A (2007) 20.60
Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators. J Bacteriol (1994) 17.55
Microbial ecology of the gastrointestinal tract. Annu Rev Microbiol (1977) 17.41
Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Gut (2005) 10.95
Cellular control of the synthesis and activity of the bacterial luminescent system. J Bacteriol (1970) 10.35
Microbial influences in inflammatory bowel diseases. Gastroenterology (2008) 9.20
Gut microbiota in health and disease. Physiol Rev (2010) 7.76
Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing. Annu Rev Genet (2001) 7.63
REGULATION OF THE TRANSFORMABILITY OF PHEUMOCOCCAL CULTURES BY MACROMOLECULAR CELL PRODUCTS. Proc Natl Acad Sci U S A (1964) 6.80
Listening in on bacteria: acyl-homoserine lactone signalling. Nat Rev Mol Cell Biol (2002) 6.01
Bacterially speaking. Cell (2006) 6.01
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A (2009) 5.86
A model of host-microbial interactions in an open mammalian ecosystem. Science (1996) 5.85
Honor thy symbionts. Proc Natl Acad Sci U S A (2003) 5.72
Bacteria-host communication: the language of hormones. Proc Natl Acad Sci U S A (2003) 4.38
Aspects of light production by Photobacterium fischeri. J Bacteriol (1968) 4.09
Carcinogenesis of Helicobacter pylori. Gastroenterology (2007) 3.63
A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem. Proc Natl Acad Sci U S A (1999) 3.63
Shotgun metaproteomics of the human distal gut microbiota. ISME J (2008) 3.43
Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics. Proc Natl Acad Sci U S A (2002) 3.25
Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes? Diabetologia (2006) 3.21
Role of microorganisms in the evolution of animals and plants: the hologenome theory of evolution. FEMS Microbiol Rev (2008) 2.86
Control of the competent state in Pneumococcus by a hormone-like cell product: an example for a new type of regulatory mechanism in bacteria. Nature (1965) 2.84
Early exposure to infections and antibiotics and the incidence of allergic disease: a birth cohort study with the West Midlands General Practice Research Database. J Allergy Clin Immunol (2002) 2.45
Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases. Curr Opin Infect Dis (2009) 2.44
Small molecules: the missing link in the central dogma. Nat Chem Biol (2005) 2.40
Metabolomics reveals metabolic biomarkers of Crohn's disease. PLoS One (2009) 2.35
Quorum sensing in bacterial virulence. Microbiology (2010) 2.15
The 'microflora hypothesis' of allergic diseases. Clin Exp Allergy (2005) 2.03
Molecular determinants of a symbiotic chronic infection. Annu Rev Genet (2008) 2.02
Quorum sensing in nitrogen-fixing rhizobia. Microbiol Mol Biol Rev (2003) 1.79
Rhizosphere chemical dialogues: plant-microbe interactions. Curr Opin Biotechnol (2009) 1.61
In a map for human life, count the microbes, too. Science (2001) 1.60
Are antibiotics naturally antibiotics? J Ind Microbiol Biotechnol (2006) 1.59
Parallel metatranscriptome analyses of host and symbiont gene expression in the gut of the termite Reticulitermes flavipes. Biotechnol Biofuels (2009) 1.50
Interspecies chemical communication in bacterial development. Annu Rev Microbiol (2009) 1.50
Stress hormones: physiological stress and regulation of metabolism. Curr Opin Pharmacol (2009) 1.47
Neuroendocrine-bacterial interactions in a neurotoxin-induced model of trauma. J Surg Res (1997) 1.24
Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. J Nat Prod (2010) 1.20
Eicosanoids in asthma, allergic inflammation, and host defense. Curr Mol Med (2008) 1.15
Controlling mammalian gene expression with small molecules. Curr Opin Chem Biol (1997) 1.14
Using small molecules to dissect mechanisms of microbial pathogenesis. ACS Chem Biol (2009) 1.14
Human microbiota-secreted factors inhibit shiga toxin synthesis by enterohemorrhagic Escherichia coli O157:H7. Infect Immun (2008) 1.13
Norepinephrine increases the pathogenic potential of Campylobacter jejuni. Gut (2006) 1.13
Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry. Metabolomics (2008) 1.12
Intercellular communication in bacteria. Crit Rev Microbiol (2009) 1.10
99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: psycho-neuroimmunology and the intestinal microbiota: clinical observations and basic mechanisms. Clin Exp Immunol (2010) 1.10
Sex steroids as inflammatory regulators. J Steroid Biochem Mol Biol (2010) 1.08
Diabetes preventive gluten-free diet decreases the number of caecal bacteria in non-obese diabetic mice. Diabetes Metab Res Rev (2006) 1.03
Inhibition of 5-lipoxygenase product synthesis by natural compounds of plant origin. Planta Med (2007) 0.98
Normal mineral homeostasis. Interplay of parathyroid hormone and vitamin D. Endocr Dev (2003) 0.92
A longitudinal analysis on the association between antibiotic use, intestinal microflora, and wheezing during the first year of life. J Asthma (2008) 0.88
Natural and unnatural ribozymes: back to the primordial RNA world. Res Microbiol (2009) 0.87
Chemical biology and bacteria: not simply a matter of life or death. Curr Opin Chem Biol (2006) 0.87
Production of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine by entrapped ACV-synthetase from Streptomyces clavuligerus. J Ind Microbiol (1995) 0.80
Novel approaches to discovery of antibacterial agents. Anim Health Res Rev (2008) 0.80
Regulation of enzymes by small molecules. Ann N Y Acad Sci (1972) 0.76
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe (2008) 11.08
Gut microbiota in health and disease. Physiol Rev (2010) 7.76
Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host Microbe (2007) 5.56
Dissecting virulence: systematic and functional analyses of a pathogenicity island. Proc Natl Acad Sci U S A (2004) 5.34
The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse. Proc Natl Acad Sci U S A (2006) 4.18
Molecular mechanisms of Escherichia coli pathogenicity. Nat Rev Microbiol (2010) 4.13
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proc Natl Acad Sci U S A (2007) 4.04
Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa. PLoS Pathog (2010) 3.76
Antibiotic-induced perturbations of the intestinal microbiota alter host susceptibility to enteric infection. Infect Immun (2008) 3.68
Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host Microbe (2007) 3.28
Manipulation of host-cell pathways by bacterial pathogens. Nature (2007) 2.89
Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening. EMBO J (2003) 2.87
The caspase-1 inflammasome: a pilot of innate immune responses. Cell Host Microbe (2008) 2.71
Evidence of a large novel gene pool associated with prokaryotic genomic islands. PLoS Genet (2005) 2.71
Type III secretion systems and disease. Clin Microbiol Rev (2007) 2.61
Invasive and adherent bacterial pathogens co-Opt host clathrin for infection. Cell Host Microbe (2007) 2.53
Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7. Mol Microbiol (2004) 2.51
Pathogenicity islands: a molecular toolbox for bacterial virulence. Cell Microbiol (2006) 2.44
Recent advances in understanding enteric pathogenic Escherichia coli. Clin Microbiol Rev (2013) 2.43
Shifting the balance: antibiotic effects on host-microbiota mutualism. Nat Rev Microbiol (2011) 2.43
Microbial pathogenesis and cytoskeletal function. Nature (2003) 2.38
Salmonella enterica serovar Typhimurium pathogenicity island 2 is necessary for complete virulence in a mouse model of infectious enterocolitis. Infect Immun (2005) 2.32
Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies. Infect Immun (2004) 2.32
Citrobacter rodentium translocated intimin receptor (Tir) is an essential virulence factor needed for actin condensation, intestinal colonization and colonic hyperplasia in mice. Mol Microbiol (2003) 2.21
Phagocyte sabotage: disruption of macrophage signalling by bacterial pathogens. Nat Rev Mol Cell Biol (2003) 2.21
Structural characterization of the molecular platform for type III secretion system assembly. Nature (2005) 2.20
Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium. Infect Immun (2003) 2.17
Quorum sensing in bacterial virulence. Microbiology (2010) 2.15
Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis. Gastroenterology (2008) 2.05
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system. Nat Struct Mol Biol (2009) 2.02
Interplay between antibacterial effectors: a macrophage antimicrobial peptide impairs intracellular Salmonella replication. Proc Natl Acad Sci U S A (2004) 2.00
The invasion-associated type III secretion system of Salmonella enterica serovar Typhimurium is necessary for intracellular proliferation and vacuole biogenesis in epithelial cells. Cell Microbiol (2002) 2.00
An anti-infective peptide that selectively modulates the innate immune response. Nat Biotechnol (2007) 1.97
Analysis of the contribution of Salmonella pathogenicity islands 1 and 2 to enteric disease progression using a novel bovine ileal loop model and a murine model of infectious enterocolitis. Infect Immun (2005) 1.88
Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice. Infect Immun (2006) 1.87
Molecular analysis as an aid to assess the public health risk of non-O157 Shiga toxin-producing Escherichia coli strains. Appl Environ Microbiol (2008) 1.84
Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications. Cell Host Microbe (2012) 1.81
Expression and secretion of Salmonella pathogenicity island-2 virulence genes in response to acidification exhibit differential requirements of a functional type III secretion apparatus and SsaL. J Biol Chem (2004) 1.81
The role of the intestinal microbiota in enteric infection. J Physiol (2009) 1.80
A positive regulatory loop controls expression of the locus of enterocyte effacement-encoded regulators Ler and GrlA. J Bacteriol (2005) 1.77
Decreased shedding of Escherichia coli O157:H7 by cattle following vaccination with type III secreted proteins. Vaccine (2004) 1.77
Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella. Nat Cell Biol (2002) 1.75
The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak. EMBO Mol Med (2012) 1.75
The Salmonella effector protein SopB protects epithelial cells from apoptosis by sustained activation of Akt. J Biol Chem (2005) 1.74
Negative regulation of Salmonella pathogenicity island 2 is required for contextual control of virulence during typhoid. Proc Natl Acad Sci U S A (2005) 1.73
Attaching and effacing pathogen-induced tight junction disruption in vivo. Cell Microbiol (2006) 1.73
Mice lacking T and B lymphocytes develop transient colitis and crypt hyperplasia yet suffer impaired bacterial clearance during Citrobacter rodentium infection. Infect Immun (2002) 1.73
Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between Chlamydiaceae, cyanobacteria, and the chloroplast. Genome Res (2002) 1.72
Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: importance of the Kupffer cell network. J Immunol (2004) 1.67
Salmonella type III effectors PipB and PipB2 are targeted to detergent-resistant microdomains on internal host cell membranes. Mol Microbiol (2003) 1.67
Secretin of the enteropathogenic Escherichia coli type III secretion system requires components of the type III apparatus for assembly and localization. Infect Immun (2003) 1.67
Effect of antibiotic treatment on the intestinal metabolome. Antimicrob Agents Chemother (2011) 1.64
SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34. J Cell Biol (2008) 1.64
Bacterial effector binding to ribosomal protein s3 subverts NF-kappaB function. PLoS Pathog (2009) 1.61
Translocated intimin receptor and its chaperone interact with ATPase of the type III secretion apparatus of enteropathogenic Escherichia coli. J Bacteriol (2003) 1.58
SifA, a type III secreted effector of Salmonella typhimurium, directs Salmonella-induced filament (Sif) formation along microtubules. Traffic (2002) 1.57
The intestinal microbiota plays a role in Salmonella-induced colitis independent of pathogen colonization. PLoS One (2011) 1.57
Gap junction hemichannels contribute to the generation of diarrhoea during infectious enteric disease. Gut (2009) 1.56
Disruption of the Salmonella-containing vacuole leads to increased replication of Salmonella enterica serovar typhimurium in the cytosol of epithelial cells. Infect Immun (2002) 1.56
Salmonella impairs RILP recruitment to Rab7 during maturation of invasion vacuoles. Mol Biol Cell (2004) 1.56
Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection. J Infect Dis (2006) 1.52
Regulation of type III secretion hierarchy of translocators and effectors in attaching and effacing bacterial pathogens. Infect Immun (2005) 1.51
Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems. Mol Microbiol (2002) 1.51
Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine. PLoS Pathog (2005) 1.50
Crossing the line: selection and evolution of virulence traits. PLoS Pathog (2006) 1.49
Problems with co-funding in Canada. Science (2005) 1.48
Tight junctions as targets of infectious agents. Biochim Biophys Acta (2008) 1.47
The Salmonella enterica serovar typhimurium divalent cation transport systems MntH and SitABCD are essential for virulence in an Nramp1G169 murine typhoid model. Infect Immun (2004) 1.46
Pathogenesis of enteric Salmonella infections. Curr Opin Gastroenterol (2008) 1.46
Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS. Nature (2008) 1.45
Molecular mechanisms of Salmonella virulence and host resistance. Curr Top Microbiol Immunol (2009) 1.45
Transcriptomic assessment of isozymes in the biphenyl pathway of Rhodococcus sp. strain RHA1. Appl Environ Microbiol (2006) 1.44
The role of the immune system in governing host-microbe interactions in the intestine. Nat Immunol (2013) 1.41
Structural analysis of a prototypical ATPase from the type III secretion system. Nat Struct Mol Biol (2007) 1.40
Salmonella infection of gallbladder epithelial cells drives local inflammation and injury in a model of acute typhoid fever. J Infect Dis (2009) 1.39
Host-pathogen interactions: Host resistance factor Nramp1 up-regulates the expression of Salmonella pathogenicity island-2 virulence genes. Proc Natl Acad Sci U S A (2002) 1.39
Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli. Antimicrob Agents Chemother (2005) 1.38
Visualization of vacuolar acidification-induced transcription of genes of pathogens inside macrophages. Mol Biol Cell (2005) 1.37
Structural characterization of a type III secretion system filament protein in complex with its chaperone. Nat Struct Mol Biol (2004) 1.37
Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: role of mitochondrial associated protein (Map). Cell Microbiol (2006) 1.35
Salmonella enterica serovar Typhimurium effectors SopB, SopE, SopE2 and SipA disrupt tight junction structure and function. Cell Microbiol (2006) 1.34
SopD2 is a novel type III secreted effector of Salmonella typhimurium that targets late endocytic compartments upon delivery into host cells. Traffic (2003) 1.33
Phenylacetate catabolism in Rhodococcus sp. strain RHA1: a central pathway for degradation of aromatic compounds. J Bacteriol (2005) 1.32
Modulation of inducible nitric oxide synthase expression by the attaching and effacing bacterial pathogen citrobacter rodentium in infected mice. Infect Immun (2002) 1.29
The gut microbiota: challenging immunology. Nat Rev Immunol (2011) 1.28
The related effector proteins SopD and SopD2 from Salmonella enterica serovar Typhimurium contribute to virulence during systemic infection of mice. Mol Microbiol (2004) 1.27
The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function. Cell Host Microbe (2007) 1.27
CesT is a multi-effector chaperone and recruitment factor required for the efficient type III secretion of both LEE- and non-LEE-encoded effectors of enteropathogenic Escherichia coli. Mol Microbiol (2005) 1.27
Bacterial pathogenesis: exploiting cellular adherence. Curr Opin Cell Biol (2003) 1.27
Aquaporins contribute to diarrhoea caused by attaching and effacing bacterial pathogens. Cell Microbiol (2006) 1.27
Salmonella enterica serovar Typhimurium effector SigD/SopB is membrane-associated and ubiquitinated inside host cells. Cell Microbiol (2002) 1.25
Virulence is positively selected by transmission success between mammalian hosts. Curr Biol (2007) 1.23
Salmonella: from pathogenesis to therapeutics. J Bacteriol (2006) 1.22
A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection. Cell Host Microbe (2013) 1.21
The phosphoinositide phosphatase SopB manipulates membrane surface charge and trafficking of the Salmonella-containing vacuole. Cell Host Microbe (2010) 1.20
Confronting the challenges of natural product-based antifungal discovery. Chem Biol (2011) 1.19
Mn2+ and bacterial pathogenesis. Front Biosci (2004) 1.19