Published in J Neurochem on January 01, 2009
Doublecortin (Dcx) family proteins regulate filamentous actin structure in developing neurons. J Neurosci (2013) 0.92
Effect of doublecortin on self-renewal and differentiation in brain tumor stem cells. Cancer Sci (2011) 0.84
Reprogramming the fate of human glioma cells to impede brain tumor development. Cell Death Dis (2014) 0.83
Single doublecortin gene therapy significantly reduces glioma tumor volume. J Neurosci Res (2010) 0.80
Deregulated proliferation and differentiation in brain tumors. Cell Tissue Res (2014) 0.80
Increasing doublecortin expression promotes migration of human embryonic stem cell-derived neurons. Stem Cells (2012) 0.79
Adenovirus-mediated coexpression of DCX and SPARC radiosensitizes human malignant glioma cells. Cell Mol Neurobiol (2013) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
Cell migration: integrating signals from front to back. Science (2003) 29.13
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem (1995) 9.56
Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer (2006) 8.50
Targeted anti-mitotic therapies: can we improve on tubulin agents? Nat Rev Cancer (2007) 4.16
Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons. Neuron (1999) 3.69
Mechanisms and molecules of the mitotic spindle. Curr Biol (2004) 3.25
Molecular mechanisms of glioma cell migration and invasion. J Neurooncol (2004) 3.04
Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size. Stroke (1998) 3.03
Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion. Int J Biochem Cell Biol (2004) 2.71
Doublecortin is required in mice for lamination of the hippocampus but not the neocortex. J Neurosci (2002) 1.94
Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe. Cell Death Differ (2002) 1.72
Glioblastoma-induced attraction of endogenous neural precursor cells is associated with improved survival. J Neurosci (2005) 1.65
Spinophilin facilitates dephosphorylation of doublecortin by PP1 to mediate microtubule bundling at the axonal wrist. Cell (2007) 1.56
Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases. J Clin Invest (1997) 1.44
De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells. Proc Natl Acad Sci U S A (1995) 1.43
Akt activation suppresses Chk2-mediated, methylating agent-induced G2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence. Cancer Res (2005) 1.42
An anti-oncogenic role for decorin. Down-regulation of ErbB2 leads to growth suppression and cytodifferentiation of mammary carcinoma cells. J Biol Chem (2000) 1.41
Patient mutations in doublecortin define a repeated tubulin-binding domain. J Biol Chem (2000) 1.40
Oligomeric amyloid decreases basal levels of brain-derived neurotrophic factor (BDNF) mRNA via specific downregulation of BDNF transcripts IV and V in differentiated human neuroblastoma cells. J Neurosci (2007) 1.30
Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology. Mol Cell Biol (2002) 1.29
In vivo magnetic resonance imaging tracks adult neural progenitor cell targeting of brain tumor. Neuroimage (2004) 1.28
Systemic vesicular stomatitis virus selectively destroys multifocal glioma and metastatic carcinoma in brain. J Neurosci (2008) 1.21
Lucky 13-microtubule depolymerisation by kinesin-13 motors. J Cell Sci (2006) 1.21
Microtubule-associated protein 2, a marker of neuronal differentiation, induces mitotic defects, inhibits growth of melanoma cells, and predicts metastatic potential of cutaneous melanoma. Am J Pathol (2005) 1.19
Distinct roles of doublecortin modulating the microtubule cytoskeleton. EMBO J (2006) 1.16
Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials. Ann N Y Acad Sci (1999) 1.12
Abnormal cytokinesis after X-irradiation in tumor cells that override the G2 DNA damage checkpoint. Cancer Res (2008) 1.10
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res (2008) 1.10
KLP38B: a mitotic kinesin-related protein that binds PP1. J Cell Biol (1997) 1.07
Cell cycle disturbances and mitotic catastrophes in HeLa Hep2 cells following 2.5 to 10 Gy of ionizing radiation. Clin Cancer Res (2007) 1.02
Geldanamycin induces mitotic catastrophe and subsequent apoptosis in human glioma cells. J Cell Physiol (2004) 1.00
Quantitative detection of Corynebacterium casei in cheese by real-time PCR. Appl Environ Microbiol (2006) 0.99
Ectopic doublecortin gene expression suppresses the malignant phenotype in glioblastoma cells. Cancer Res (2006) 0.99
Bone marrow stromal cells protect oligodendrocytes from oxygen-glucose deprivation injury. J Neurosci Res (2008) 0.97
E-cadherin negatively regulates CD44-hyaluronan interaction and CD44-mediated tumor invasion and branching morphogenesis. J Biol Chem (2003) 0.95
Endogenous plasminogen activator expression after embolic focal cerebral ischemia in mice. Brain Res (1999) 0.95
Site-specific dephosphorylation of doublecortin (DCX) by protein phosphatase 1 (PP1). Mol Cell Neurosci (2006) 0.91
Characterization of the subventricular zone neurogenic response to rat malignant brain tumors. Neuroscience (2007) 0.90
Ectopic decorin expression up-regulates VEGF expression in mouse cerebral endothelial cells via activation of the transcription factors Sp1, HIF1alpha, and Stat3. J Neurochem (2007) 0.90
Doublecortin is preferentially expressed in invasive human brain tumors. Acta Neuropathol (2005) 0.87
Cell division: timing the machine. Nature (2004) 0.87
Evaluation of sensitivity and specificity of doublecortin immunostatining for the detection of infiltrating glioma cells. Brain Tumor Pathol (2008) 0.86
Ectopic expression of doublecortin protects adult rat progenitor cells and human glioma cells from severe oxygen and glucose deprivation. Neuroscience (2006) 0.86
Altered in vitro spreading and cytoskeletal organization in human glioma cells by downregulation of urokinase receptor. Mol Carcinog (1997) 0.84
Protection of adult mouse progenitor cells and human glioma cells by de novo decorin expression in an oxygen- and glucose-deprived cell culture model system. J Cereb Blood Flow Metab (2006) 0.83
Combination of surgical resection and photodynamic therapy of 9L gliosarcoma in the nude rat. Photochem Photobiol (2007) 0.83
Human glioblastoma U87MG cells transduced with a dominant negative p53 (TP53) adenovirus construct undergo radiation-induced mitotic catastrophe. Radiat Res (2007) 0.82
Calyculin A-induced actin phosphorylation and depolymerization in renal epithelial cells. Cell Motil Cytoskeleton (2003) 0.81
Photodynamic therapy with photofrin reduces invasiveness of malignant human glioma cells. Lasers Med Sci (2002) 0.79
Viral mediated cell fusion: viral fusion--the making, or breaking, of a tumour? Gene Ther (2006) 0.77
Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res (2003) 4.29
Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann Neurol (2003) 3.54
Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke (2004) 3.53
Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurol (2009) 3.27
Animal models of traumatic brain injury. Nat Rev Neurosci (2013) 2.75
Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells. Glia (2005) 2.68
Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice. J Cereb Blood Flow Metab (2005) 2.65
Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat. J Neurosci Res (2003) 2.61
Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse. Circ Res (2002) 2.45
Activated neural stem cells contribute to stroke-induced neurogenesis and neuroblast migration toward the infarct boundary in adult rats. J Cereb Blood Flow Metab (2004) 2.41
Ischemic rat brain extracts induce human marrow stromal cell growth factor production. Neuropathology (2002) 2.38
A test for detecting long-term sensorimotor dysfunction in the mouse after focal cerebral ischemia. J Neurosci Methods (2002) 2.35
Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke (2002) 2.24
Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia. J Cereb Blood Flow Metab (2002) 2.22
Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med (2006) 2.22
Treatment of traumatic brain injury in adult rats with intravenous administration of human bone marrow stromal cells. Neurosurgery (2003) 2.16
Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth. Stem Cells (2012) 2.14
Human bone marrow stromal cell treatment improves neurological functional recovery in EAE mice. Exp Neurol (2005) 2.11
Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke. J Cereb Blood Flow Metab (2006) 2.10
Stromal cell-derived factor 1alpha mediates neural progenitor cell motility after focal cerebral ischemia. J Cereb Blood Flow Metab (2006) 2.06
Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration. J Neurosci (2006) 2.06
Improvement in functional recovery with administration of Cerebrolysin after experimental closed head injury. J Neurosurg (2013) 2.02
Angiopoietin1/Tie2 and VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke. J Cereb Blood Flow Metab (2007) 1.89
Intravenous administration of marrow stromal cells (MSCs) increases the expression of growth factors in rat brain after traumatic brain injury. J Neurotrauma (2004) 1.87
Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J Cereb Blood Flow Metab (2013) 1.85
Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: growth factor production. J Neurosci Res (2002) 1.85
Nitric oxide enhances angiogenesis via the synthesis of vascular endothelial growth factor and cGMP after stroke in the rat. Circ Res (2003) 1.81
ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation. Cancer Biol Ther (2009) 1.79
Adjuvant treatment with a glycoprotein IIb/IIIa receptor inhibitor increases the therapeutic window for low-dose tissue plasminogen activator administration in a rat model of embolic stroke. Circulation (2003) 1.77
Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury. J Neurotrauma (2007) 1.76
Erythropoietin enhances neurogenesis and restores spatial memory in rats after traumatic brain injury. J Neurotrauma (2005) 1.74
Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits. Stroke (2006) 1.72
MRI detects white matter reorganization after neural progenitor cell treatment of stroke. Neuroimage (2006) 1.69
Marrow stromal cell transplantation after traumatic brain injury promotes cellular proliferation within the brain. Neurosurgery (2004) 1.68
Angiogenesis, neurogenesis and brain recovery of function following injury. Curr Opin Investig Drugs (2010) 1.67
The neurovascular unit and combination treatment strategies for stroke. Trends Pharmacol Sci (2012) 1.66
Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke. J Cereb Blood Flow Metab (2007) 1.64
Functional microRNA is transferred between glioma cells. Cancer Res (2010) 1.63
Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury. J Neurotrauma (2008) 1.62
Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation. Lancet Neurol (2012) 1.60
MCP-1, MIP-1, IL-8 and ischemic cerebral tissue enhance human bone marrow stromal cell migration in interface culture. Hematology (2002) 1.59
Marrow stromal cell transplantation in stroke and traumatic brain injury. Neurosci Lett (2009) 1.58
Bone marrow-derived mesenchymal stromal cells accelerate wound healing in the rat. Wound Repair Regen (2006) 1.58
Stem Cell Therapy as an Emerging Paradigm for Stroke (STEPS) II. Stroke (2011) 1.58
Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury. Cell Transplant (2002) 1.57
One-year follow-up after bone marrow stromal cell treatment in middle-aged female rats with stroke. Stroke (2007) 1.57
Stroke transiently increases subventricular zone cell division from asymmetric to symmetric and increases neuronal differentiation in the adult rat. J Neurosci (2004) 1.55
Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice. J Neurosci (2005) 1.54
MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles. Stem Cells (2013) 1.51
Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth. Cancer Lett (2013) 1.51
Contralesional axonal remodeling of the corticospinal system in adult rats after stroke and bone marrow stromal cell treatment. Stroke (2008) 1.49
Atorvastatin reduces neurological deficit and increases synaptogenesis, angiogenesis, and neuronal survival in rats subjected to traumatic brain injury. J Neurotrauma (2004) 1.49
MicroRNA-21 protects neurons from ischemic death. FEBS J (2010) 1.48
Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor. Stroke (2005) 1.46
Effects of administration route on migration and distribution of neural progenitor cells transplanted into rats with focal cerebral ischemia, an MRI study. J Cereb Blood Flow Metab (2009) 1.43
Neuroblast division during migration toward the ischemic striatum: a study of dynamic migratory and proliferative characteristics of neuroblasts from the subventricular zone. J Neurosci (2007) 1.41
Investigation of neural progenitor cell induced angiogenesis after embolic stroke in rat using MRI. Neuroimage (2005) 1.41
Ischemic stroke and neurogenesis in the subventricular zone. Neuropharmacology (2008) 1.39
Stroke induces gene profile changes associated with neurogenesis and angiogenesis in adult subventricular zone progenitor cells. J Cereb Blood Flow Metab (2006) 1.39
Neurogenesis in the adult ischemic brain: generation, migration, survival, and restorative therapy. Neuroscientist (2005) 1.37
MicroRNA profiling in subventricular zone after stroke: MiR-124a regulates proliferation of neural progenitor cells through Notch signaling pathway. PLoS One (2011) 1.37
Neurorestorative treatment of stroke: cell and pharmacological approaches. NeuroRx (2006) 1.37
Erythropoietin treatment improves neurological functional recovery in EAE mice. Brain Res (2005) 1.36
Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness. Cancer Sci (2007) 1.35
MiR-146b-5p suppresses EGFR expression and reduces in vitro migration and invasion of glioma. Cancer Invest (2010) 1.35
Adjuvant treatment with neuroserpin increases the therapeutic window for tissue-type plasminogen activator administration in a rat model of embolic stroke. Circulation (2002) 1.34
Bone marrow stromal cells reduce axonal loss in experimental autoimmune encephalomyelitis mice. J Neurosci Res (2006) 1.34
Combination therapy of stroke in rats with a nitric oxide donor and human bone marrow stromal cells enhances angiogenesis and neurogenesis. Brain Res (2004) 1.33
White matter damage and the effect of matrix metalloproteinases in type 2 diabetic mice after stroke. Stroke (2010) 1.33
Allogeneic bone marrow stromal cells promote glial-axonal remodeling without immunologic sensitization after stroke in rats. Exp Neurol (2006) 1.33
Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia. Trends Cardiovasc Med (2002) 1.30
Increasing tPA activity in astrocytes induced by multipotent mesenchymal stromal cells facilitate neurite outgrowth after stroke in the mouse. PLoS One (2010) 1.28
Expression of insulin-like growth factor 1 and receptor in ischemic rats treated with human marrow stromal cells. Brain Res (2004) 1.28
In vivo magnetic resonance imaging tracks adult neural progenitor cell targeting of brain tumor. Neuroimage (2004) 1.28
Magnetic resonance imaging and neurosphere therapy of stroke in rat. Ann Neurol (2003) 1.28
Human marrow stromal cell treatment provides long-lasting benefit after traumatic brain injury in rats. Neurosurgery (2005) 1.27
Long-term recovery after bone marrow stromal cell treatment of traumatic brain injury in rats. J Neurosurg (2006) 1.27
Niaspan increases angiogenesis and improves functional recovery after stroke. Ann Neurol (2007) 1.27
Functional recovery after embolic stroke in rodents by activated protein C. Ann Neurol (2005) 1.26
Multitargeted effects of statin-enhanced thrombolytic therapy for stroke with recombinant human tissue-type plasminogen activator in the rat. Circulation (2005) 1.26
Neurotrophic and growth factor gene expression profiling of mouse bone marrow stromal cells induced by ischemic brain extracts. Neuropathology (2007) 1.26
Gallic acid suppresses cell viability, proliferation, invasion and angiogenesis in human glioma cells. Eur J Pharmacol (2010) 1.25
Remodeling of the corticospinal innervation and spontaneous behavioral recovery after ischemic stroke in adult mice. Stroke (2009) 1.25
Intracerebral transplantation of marrow stromal cells cultured with neurotrophic factors promotes functional recovery in adult rats subjected to traumatic brain injury. J Neurotrauma (2002) 1.25
Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats. J Cereb Blood Flow Metab (2008) 1.24
Collagen scaffolds populated with human marrow stromal cells reduce lesion volume and improve functional outcome after traumatic brain injury. Neurosurgery (2007) 1.24
Neural progenitor cells treated with EPO induce angiogenesis through the production of VEGF. J Cereb Blood Flow Metab (2008) 1.24
Bone marrow stromal cells enhance inter- and intracortical axonal connections after ischemic stroke in adult rats. J Cereb Blood Flow Metab (2010) 1.24
Improvement in neurological outcome after administration of atorvastatin following experimental intracerebral hemorrhage in rats. J Neurosurg (2004) 1.23
Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury. J Neurosurg (2015) 1.22
Global test statistics for treatment effect of stroke and traumatic brain injury in rats with administration of bone marrow stromal cells. J Neurosci Methods (2003) 1.22