Published in EMBO J on December 01, 1990
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J (2001) 9.40
Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function. EMBO J (1991) 4.59
Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B. J Virol (1995) 3.69
Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis. EMBO J (1991) 2.86
Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts. EMBO J (2009) 2.78
Cell cycle regulation of human WEE1. EMBO J (1995) 2.56
Activation of cyclin A-dependent protein kinases during apoptosis. Proc Natl Acad Sci U S A (1994) 2.29
A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle. J Cell Biol (1995) 2.02
Mitotic mechanisms in Alzheimer's disease? J Cell Biol (1996) 2.00
The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe. EMBO J (1991) 1.94
A Rab1 mutant affecting guanine nucleotide exchange promotes disassembly of the Golgi apparatus. J Cell Biol (1994) 1.91
Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus. Mol Cell Biol (1992) 1.83
A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation. EMBO J (2000) 1.67
Protein phosphatase 1 regulates the cytoplasmic dynein-driven formation of endoplasmic reticulum networks in vitro. J Cell Biol (1995) 1.58
Evidence for the regulation of exocytic transport by protein phosphorylation. J Cell Biol (1992) 1.48
Cell-free fusion of endocytic vesicles is regulated by phosphorylation. J Cell Biol (1992) 1.44
Cytoplasmic dynein undergoes intracellular redistribution concomitant with phosphorylation of the heavy chain in response to serum starvation and okadaic acid. J Cell Biol (1994) 1.37
Cytoskeletal integrity in interphase cells requires protein phosphatase activity. Proc Natl Acad Sci U S A (1992) 1.36
A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain. Proc Natl Acad Sci U S A (1996) 1.36
Activation of protein serine/threonine kinases p42, p63, and p87 in Rous sarcoma virus-transformed cells: signal transduction/transformation-dependent MBP kinases. Mol Biol Cell (1992) 1.24
Role of the cdc25C phosphatase in G2 arrest induced by nitrogen mustard. Proc Natl Acad Sci U S A (1994) 1.16
Chemically induced premature mitosis: differential response in rodent and human cells and the relationship to cyclin B synthesis and p34cdc2/cyclin B complex formation. Proc Natl Acad Sci U S A (1991) 1.14
Okadaic acid treatment leads to a fragmentation of the trans-Golgi network and an increase in expression of TGN38 at the cell surface. Biochem J (1994) 1.13
Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm. Mol Biol Cell (1992) 1.12
The Ph1 locus suppresses Cdk2-type activity during premeiosis and meiosis in wheat. Plant Cell (2012) 1.04
Src activity increases and Yes activity decreases during mitosis of human colon carcinoma cells. Mol Cell Biol (1995) 1.03
2-Aminopurine overrides multiple cell cycle checkpoints in BHK cells. Proc Natl Acad Sci U S A (1992) 1.03
Mitosis-specific MPM-2 phosphorylation of DNA topoisomerase IIalpha is regulated directly by protein phosphatase 2A. Biochem J (2007) 1.02
Elevation of cell cycle control proteins during spontaneous immortalization of human keratinocytes. Mol Biol Cell (1993) 1.01
Protein phosphatases and DNA tumor viruses: transformation through the back door? Cell Regul (1991) 1.00
Oct-1 [corrected] and Oct-2 DNA-binding site specificity is regulated in vitro by different kinases. Biochem J (1996) 0.91
Inducing chromosome pairing through premature condensation: analysis of wheat interspecific hybrids. Funct Integr Genomics (2010) 0.90
Okadaic acid: more than a diarrheic toxin. Mar Drugs (2013) 0.90
A truncated isoform of the protein phosphatase 2A B56gamma regulatory subunit may promote genetic instability and cause tumor progression. Am J Pathol (2003) 0.87
Lasonolide A, a potent and reversible inducer of chromosome condensation. Cell Cycle (2012) 0.87
Anticancer activity and protein phosphatase 1 and 2A inhibition of a new generation of cantharidin analogues. Invest New Drugs (2002) 0.86
Phosphorylation of mixed lineage leukemia 5 by CDC2 affects its cellular distribution and is required for mitotic entry. J Biol Chem (2010) 0.86
The H1 phosphorylation state regulates expression of CDC2 and other genes in response to starvation in Tetrahymena thermophila. Mol Cell Biol (2005) 0.84
Effect of doublecortin on self-renewal and differentiation in brain tumor stem cells. Cancer Sci (2011) 0.84
Doublecortin induces mitotic microtubule catastrophe and inhibits glioma cell invasion. J Neurochem (2009) 0.83
Thioredoxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest. Invest New Drugs (2010) 0.83
Okadaic acid regulation of the retinoblastoma gene product is correlated with the inhibition of growth factor-induced cell proliferation in mouse fibroblasts. Proc Natl Acad Sci U S A (1993) 0.82
Modulation of vinblastine cytotoxicity by dilantin (phenytoin) or the protein phosphatase inhibitor okadaic acid involves the potentiation of anti-mitotic effects and induction of apoptosis in human tumour cells. Br J Cancer (1996) 0.81
Inhibition of the serine/threonine protein phosphatases PP1 and PP2A in lymphocytes: effect on mRNA levels for interleukin-2, IL-2R alpha, krox-24, p53, hsc70 and cyclophilin. Immunology (1992) 0.81
Okadaic acid suppresses calcium regulation of mitosis onset in sea urchin embryos. Cell Regul (1991) 0.80
Caffeine-mediated override of checkpoint controls. A requirement for rhp6 (Schizosaccharomyces pombe). Genetics (1999) 0.77
Histone Modification Is Involved in Okadaic Acid (OA) Induced DNA Damage Response and G2-M Transition Arrest in Maize. PLoS One (2016) 0.75
Inhibition of interleukin-2-mediated DNA synthesis in activated human T-lymphoblasts by okadaic acid is accompanied by hyperphosphorylation of lck. Biochem J (1995) 0.75
Universal control mechanism regulating onset of M-phase. Nature (1990) 19.11
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis. Nature (1989) 11.90
The structure and regulation of protein phosphatases. Annu Rev Biochem (1989) 11.46
Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell (1983) 9.90
Cyclin synthesis drives the early embryonic cell cycle. Nature (1989) 9.73
Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. Nature (1987) 8.87
Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. Cell (1989) 8.19
Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics. Biochem J (1988) 8.02
Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell (1988) 6.88
Monoclonal antibodies to mitotic cells. Proc Natl Acad Sci U S A (1983) 6.74
Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell (1989) 5.35
Cyclin is a component of maturation-promoting factor from Xenopus. Cell (1990) 4.70
Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis. Cell (1989) 4.68
In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase. Cell (1990) 4.57
Translation of cyclin mRNA is necessary for extracts of activated xenopus eggs to enter mitosis. Cell (1989) 4.56
The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell (1989) 4.43
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature (1989) 4.27
Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis. Cell (1990) 4.12
MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B. EMBO J (1989) 4.05
Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs. Nature (1990) 3.77
Protein phosphatases come of age. J Biol Chem (1989) 3.77
Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C. Cell (1990) 3.67
Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinase. Cell (1989) 3.56
Premature of chromosome condensation in a ts DNA- mutant of BHK cells. Cell (1978) 3.55
The bimG gene of Aspergillus nidulans, required for completion of anaphase, encodes a homolog of mammalian phosphoprotein phosphatase 1. Cell (1989) 3.27
Dephosphorylation and activation of Xenopus p34cdc2 protein kinase during the cell cycle. Nature (1989) 3.12
Purification of MPF from starfish: identification as the H1 histone kinase p34cdc2 and a possible mechanism for its periodic activation. Cell (1989) 3.05
Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells. Science (1986) 2.89
Regulated expression and phosphorylation of a possible mammalian cell-cycle control protein. Nature (1988) 2.88
Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid. EMBO J (1990) 2.81
Cyclin is a component of the sea urchin egg M-phase specific histone H1 kinase. EMBO J (1989) 2.75
Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase. Cell (1990) 2.47
Regulation of MPF activity in vitro. Cell (1988) 2.43
Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin. FEBS Lett (1987) 2.17
Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs. Cell (1987) 2.13
Movement and segregation of kinetochores experimentally detached from mammalian chromosomes. Nature (1988) 2.10
Activation of M-phase-specific histone H1 kinase by modification of the phosphorylation of its p34cdc2 and cyclin components. Genes Dev (1990) 1.86
Microinjection of p34cdc2 kinase induces marked changes in cell shape, cytoskeletal organization, and chromatin structure in mammalian fibroblasts. Cell (1990) 1.82
Okadaic acid, a specific protein phosphatase inhibitor, induces maturation and MPF formation in Xenopus laevis oocytes. FEBS Lett (1989) 1.79
Cell cycle control genes in fission yeast and mammalian cells. Trends Genet (1988) 1.77
Control of the higher eukaryote cell cycle by p34cdc2 homologues. Biochim Biophys Acta (1989) 1.74
The synthesis of protein(s) for chromosome condensation may be regulated by a post-transcriptional mechanism. J Cell Physiol (1981) 1.71
Involvement of protein phosphatases 1 and 2A in the control of M phase-promoting factor activity in starfish. J Cell Biol (1989) 1.66
Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity. Science (1990) 1.40
Embryology. Under arrest in the cell cycle. Nature (1989) 1.23
Maturation-promoting factor and the regulation of the cell cycle. J Cell Sci Suppl (1989) 1.11
Hyperphosphorylation of N-60, a protein structurally and immunologically related to nucleolin after tumour-promoter treatment. EMBO J (1988) 0.96
M phase-promoting factor: its identification as the M phase-specific H1 histone kinase and its activation by dephosphorylation. J Cell Sci Suppl (1989) 0.95
In vitro polyoma DNA synthesis: inhibition by 1-beta-d-arabinofuranosyl CTP. J Virol (1975) 57.17
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science (1988) 35.59
The protein kinase complement of the human genome. Science (2002) 35.36
The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature (1997) 33.47
Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc Natl Acad Sci U S A (1980) 22.30
Oncogenic kinase signalling. Nature (2001) 16.30
Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol (1991) 15.04
Protein-tyrosine kinases. Annu Rev Biochem (1985) 14.83
Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J (1995) 14.45
Detection and quantification of phosphotyrosine in proteins. Methods Enzymol (1983) 11.89
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett (1997) 11.19
Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc Natl Acad Sci U S A (1990) 9.98
Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell (1994) 9.25
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell (1994) 8.90
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. Nature (1985) 8.36
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature (1995) 8.25
Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. Cell (1989) 8.19
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci U S A (1999) 7.70
A thousand and one protein kinases. Cell (1987) 7.61
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science (1999) 7.60
Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature (1988) 7.45
Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. Nature (1990) 7.34
Long-term consequences of Kawasaki disease. A 10- to 21-year follow-up study of 594 patients. Circulation (1996) 7.29
Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J Cell Biol (1991) 7.18
An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates. Cell (1979) 7.02
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell (1991) 6.89
Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro. Cell (1989) 6.88
Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus. Cell (1980) 6.76
The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell (1988) 6.75
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science (1992) 6.40
Characterization of Rous sarcoma virus src gene products synthesized in vitro. J Virol (1978) 6.39
A new protein containing an SH2 domain that inhibits JAK kinases. Nature (1997) 6.28
Vinculin: a cytoskeletal target of the transforming protein of Rous sarcoma virus. Cell (1981) 5.74
Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells. Mol Cell Biol (1981) 5.67
Temporal and spatial control of cyclin B1 destruction in metaphase. Nat Cell Biol (1999) 5.62
HDAC4 deacetylase associates with and represses the MEF2 transcription factor. EMBO J (1999) 5.54
Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo. J Virol (1978) 5.30
Receptor protein-tyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol (1994) 5.24
Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells. Cell (1981) 5.08
Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med (2000) 5.02
Tyr527 is phosphorylated in pp60c-src: implications for regulation. Science (1986) 4.99
Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. EMBO J (1999) 4.69
A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature (1996) 4.65
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J (1999) 4.65
A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol Cell Biol (1996) 4.61
The Cdt1 protein is required to license DNA for replication in fission yeast. Nature (2000) 4.46
MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J (1997) 4.39
Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc Natl Acad Sci U S A (1995) 4.28
Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene. Proc Natl Acad Sci U S A (1985) 4.28
Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane. Nature (1984) 4.27
Structural basis for phosphoserine-proline recognition by group IV WW domains. Nat Struct Biol (2000) 4.25
Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. Cell (1997) 4.24
Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. J Biol Chem (1984) 4.20
The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA. J Cell Biol (1989) 4.13
Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD. Nat Neurosci (2000) 4.10
Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell (1991) 3.98
Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo. Lancet (1986) 3.93
C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity. J Biol Chem (1984) 3.88
Characterization of T antigens in polyoma-infected and transformed cells. Cell (1978) 3.76
Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase. Plant Physiol (2000) 3.73
Cyclins and cancer. Cell (1991) 3.65
A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex. Cell (1992) 3.64
Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus. Curr Biol (1995) 3.61
Involvement of PIAS1 in the sumoylation of tumor suppressor p53. Mol Cell (2001) 3.56
Premature of chromosome condensation in a ts DNA- mutant of BHK cells. Cell (1978) 3.55
Substrate specificity of protein kinase C. Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements. Eur J Biochem (1986) 3.37
Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation. Proc Natl Acad Sci U S A (1982) 3.28
A tail of two src's: mutatis mutandis. Cell (1987) 3.28
p34cdc2: the S and M kinase? New Biol (1990) 3.26
Temperature-sensitive transformation by Rous sarcoma virus and temperature-sensitive protein kinase activity. J Virol (1980) 3.25
Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity. Proc Natl Acad Sci U S A (2001) 3.24
Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. Mol Cell Biol (1996) 3.21
A simple and rapid method for generating a deletion by PCR. Nucleic Acids Res (1991) 3.20
Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase. J Cell Biol (2001) 3.18
Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. J Biol Chem (2000) 3.17
cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1. EMBO J (1989) 3.10
Classification criteria for polymyositis and dermatomyositis. J Rheumatol (1995) 3.08
CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood (1997) 3.08
Role of methionine in the initiation of haemoglobin synthesis. Nature (1970) 3.02
Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery. Kidney Int (2006) 3.00
MDM2 interacts with MDMX through their RING finger domains. FEBS Lett (1999) 2.98
cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity. Proc Natl Acad Sci U S A (1987) 2.97
A link between cyclin A expression and adhesion-dependent cell cycle progression. Science (1993) 2.96
Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. EMBO J (1995) 2.96
Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins. Cell (1982) 2.92
Four different classes of retroviruses induce phosphorylation of tyrosines present in similar cellular proteins. Mol Cell Biol (1981) 2.88
Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis. EMBO J (1991) 2.86
Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ (2001) 2.85
Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. Nat Struct Biol (2000) 2.85
Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase. Oncogene (2000) 2.84
The characteristics of inhibition of protein synthesis by double-stranded ribonucleic acid in reticulocyte lysates. J Biol Chem (1975) 2.84
A single-point mutation in HCF causes temperature-sensitive cell-cycle arrest and disrupts VP16 function. Genes Dev (1997) 2.84
Integrin signalling and tyrosine phosphorylation: just the FAKs? Trends Cell Biol (1998) 2.83
Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol Cell Biol (1997) 2.83