New insights into the regulation of T cells by gamma(c) family cytokines.

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Published in Nat Rev Immunol on July 01, 2009

Authors

Yrina Rochman1, Rosanne Spolski, Warren J Leonard

Author Affiliations

1: National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1674, USA.

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Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nat Immunol (2012) 1.41

Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism. J Immunol (2010) 1.39

The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements. EMBO J (2002) 1.36

Thymic stromal lymphopoietin: a new cytokine in asthma. Curr Opin Pharmacol (2008) 1.35

Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1. J Immunol (2008) 1.32

Constitutive expression of IL-7 receptor alpha does not support increased expansion or prevent contraction of antigen-specific CD4 or CD8 T cells following Listeria monocytogenes infection. J Immunol (2008) 1.30

Thymic stromal lymphopoietin is a key mediator of breast cancer progression. J Immunol (2011) 1.30

Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma. J Exp Med (2003) 1.29

Thymic stromal lymphopoietin is produced by dendritic cells. J Immunol (2011) 1.28

Analysis of gamma c-family cytokine target genes. Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling. J Biol Chem (2002) 1.28

Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infection. J Immunol (2011) 1.26

IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin. J Immunol (2011) 1.25

Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins. Blood (2006) 1.25

The transcription factor GABP is a critical regulator of B lymphocyte development. Immunity (2007) 1.24

The role of thymic stromal lymphopoietin in CD8+ T cell homeostasis. J Immunol (2008) 1.23

Defective B cell responses in the absence of SH2D1A. Proc Natl Acad Sci U S A (2005) 1.21

Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells. J Virol (2013) 1.18

Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL. Blood (2011) 1.12

T-cell development and function are modulated by dual specificity phosphatase DUSP5. J Biol Chem (2008) 1.10

Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes. Int Immunol (2005) 1.10

Cutting edge: CD4 T cell-mast cell interactions alter IgE receptor expression and signaling. J Immunol (2008) 1.08

IL-21 promotes the pathologic immune response to pneumovirus infection. J Immunol (2012) 1.06

Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation. J Exp Med (2013) 1.06

The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells. Immunity (2013) 1.06