Published in Mol Cell Biol on December 29, 2008
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Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony. J Biol Chem (2010) 2.90
mTOR complex 2 signaling and functions. Cell Cycle (2011) 2.66
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell (2011) 2.34
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest (2010) 2.04
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Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis. Sci Signal (2012) 1.86
Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer. Oncogene (2010) 1.85
Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis. J Clin Invest (2013) 1.68
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High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1. Cell Cycle (2011) 1.44
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Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. J Cell Biol (2011) 1.31
Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling. J Biol Chem (2010) 1.30
Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling. Proc Natl Acad Sci U S A (2012) 1.30
Updates of mTOR inhibitors. Anticancer Agents Med Chem (2010) 1.27
Regulation of TOR by small GTPases. EMBO Rep (2012) 1.24
Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect. J Biol Chem (2011) 1.22
Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1). J Biol Chem (2011) 1.20
Review series: TOR kinase complexes and cell migration. J Cell Biol (2011) 1.19
Phase II trial of the oral mammalian target of rapamycin inhibitor everolimus in relapsed or refractory Waldenstrom macroglobulinemia. J Clin Oncol (2010) 1.18
Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis. Future Oncol (2009) 1.17
The role of diacylglycerol kinase ζ and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy. J Biol Chem (2013) 1.15
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Mammalian target of rapamycin (mTOR) signaling network in skeletal myogenesis. J Biol Chem (2012) 1.13
Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway. Am J Physiol Cell Physiol (2010) 1.12
Phospholipase signalling networks in cancer. Nat Rev Cancer (2012) 1.10
A novel small molecule antagonist of choline kinase-α that simultaneously suppresses MAPK and PI3K/AKT signaling. Oncogene (2011) 1.09
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Phosphatidic acid and lipid-sensing by mTOR. Trends Endocrinol Metab (2013) 1.07
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Phospholipase D in brain function and Alzheimer's disease. Biochim Biophys Acta (2010) 1.06
Mammalian phospholipase D physiological and pathological roles. Acta Physiol (Oxf) (2011) 1.06
PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation. Mol Cell Biol (2012) 1.05
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Intersection of mTOR and STAT signaling in immunity. Trends Immunol (2014) 0.97
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Constitutive activation with overexpression of the mTORC2-phospholipase D1 pathway in uterine leiomyosarcoma and STUMP: morphoproteomic analysis with therapeutic implications. Int J Clin Exp Pathol (2010) 0.96
Phospholipase D2 mediates survival signaling through direct regulation of Akt in glioblastoma cells. J Biol Chem (2013) 0.95
Morphoproteomic analysis reveals an overexpressed and constitutively activated phospholipase D1-mTORC2 pathway in endometrial carcinoma. Int J Clin Exp Pathol (2010) 0.95
Phospholipase D-mTOR requirement for the Warburg effect in human cancer cells. Cancer Lett (2010) 0.95
Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes. J Biol Chem (2011) 0.93
Lipid biology of breast cancer. Biochim Biophys Acta (2013) 0.92
Lymphangioleiomyomatosis (LAM): molecular insights lead to targeted therapies. Respir Med (2010) 0.92
RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells. Cell Signal (2013) 0.91
Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom. BMC Genomics (2010) 0.91
Regulation of mTORC1 complex assembly and signaling by GRp58/ERp57. Mol Cell Biol (2011) 0.90
Resistance training for diabetes prevention and therapy: experimental findings and molecular mechanisms. Biomed Res Int (2013) 0.90
Inhibition of S6 kinase suppresses the apoptotic effect of eIF4E ablation by inducing TGF-β-dependent G1 cell cycle arrest. Cancer Lett (2013) 0.89
Hepatic gluconeogenesis is enhanced by phosphatidic acid which remains uninhibited by insulin in lipodystrophic Agpat2-/- mice. J Biol Chem (2014) 0.88
Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model. PLoS One (2012) 0.88
Regulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and Function. Front Immunol (2013) 0.87
Morphoproteomic profiling of the mammalian target of rapamycin (mTOR) signaling pathway in desmoplastic small round cell tumor (EWS/WT1), Ewing's sarcoma (EWS/FLI1) and Wilms' tumor(WT1). PLoS One (2013) 0.87
Triennial Growth Symposium: leucine acts as a nutrient signal to stimulate protein synthesis in neonatal pigs. J Anim Sci (2010) 0.87
Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine. Am J Physiol Cell Physiol (2012) 0.87
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Mutant ras elevates dependence on serum lipids and creates a synthetic lethality for rapamycin. Mol Cancer Ther (2014) 0.85
Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling. Cell Commun Signal (2013) 0.85
RalGDS-dependent cardiomyocyte autophagy is required for load-induced ventricular hypertrophy. J Mol Cell Cardiol (2013) 0.84
Rapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures. Epilepsia (2012) 0.84
Structural basis for the association of the redox-sensitive target of rapamycin FATC domain with membrane-mimetic micelles. J Biol Chem (2009) 0.84
Lovastatin inhibits VEGFR and AKT activation: synergistic cytotoxicity in combination with VEGFR inhibitors. PLoS One (2010) 0.84
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Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose. Cell Cycle (2015) 0.83
Reduced mortality and moderate alcohol consumption: the phospholipase D-mTOR connection. Cell Cycle (2010) 0.83
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The role of phospholipase D in modulating the MTOR signaling pathway in polycystic kidney disease. PLoS One (2013) 0.82
Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans. Aging Cell (2014) 0.82
mTOR signaling in lymphangioleiomyomatosis. Lymphat Res Biol (2010) 0.81
Inhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol. J Biol Chem (2014) 0.81
The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling. Carcinogenesis (2015) 0.81
Mammalian Target of Rapamycin Inhibitors Resistance Mechanisms in Clear Cell Renal Cell Carcinoma. Curr Signal Transduct Ther (2014) 0.81
Reciprocal regulation of AMP-activated protein kinase and phospholipase D. J Biol Chem (2015) 0.80
Tumor progression and the different faces of the PERK kinase. Oncogene (2015) 0.80
Mechanisms mediating the effects of alcohol and HIV anti-retroviral agents on mTORC1, mTORC2 and protein synthesis in myocytes. World J Biol Chem (2012) 0.80
Rapamycin inhibits VEGF-induced microvascular hyperpermeability in vivo. Microcirculation (2010) 0.79
Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. PLoS Biol (2016) 0.79
Synergistic Effects between mTOR Complex 1/2 and Glycolysis Inhibitors in Non-Small-Cell Lung Carcinoma Cells. PLoS One (2015) 0.79
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Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes. Biochem J (2013) 0.79
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RNA sequencing identifies upregulated kyphoscoliosis peptidase and phosphatidic acid signaling pathways in muscle hypertrophy generated by transgenic expression of myostatin propeptide. Int J Mol Sci (2015) 0.78
Activation of AMPK/TSC2/PLD by alcohol regulates mTORC1 and mTORC2 assembly in C2C12 myocytes. Alcohol Clin Exp Res (2013) 0.78
Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis. Oncogene (2016) 0.78
Exercise and dietary change ameliorate high fat diet induced obesity and insulin resistance via mTOR signaling pathway. J Exerc Nutrition Biochem (2016) 0.78
Multifaceted role of insulin-like growth factors and mammalian target of rapamycin in skeletal muscle. Endocrinol Metab Clin North Am (2012) 0.78
Simultaneous activation and inhibition of autophagy sensitizes cancer cells to chemotherapy. Oncotarget (2016) 0.77
A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast. PLoS Genet (2014) 0.77
Phorbol ester stimulates ethanolamine release from the metastatic basal prostate cancer cell line PC3 but not from prostate epithelial cell lines LNCaP and P4E6. Br J Cancer (2014) 0.77
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Defining the role of mTOR in cancer. Cancer Cell (2007) 21.63
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res (2006) 18.44
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell (2006) 18.36
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell (2002) 18.22
mTOR and cancer: insights into a complex relationship. Nat Rev Cancer (2006) 11.86
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell (2007) 9.68
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol (2007) 8.07
Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene (2006) 6.54
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mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J Biol Chem (2005) 5.62
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Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood (2006) 3.13
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. J Biol Chem (2007) 3.09
Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity. EMBO J (1997) 2.49
Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2. J Biol Chem (2008) 2.38
Phospholipase D in cell proliferation and cancer. Mol Cancer Res (2003) 2.13
Phospholipase D confers rapamycin resistance in human breast cancer cells. Oncogene (2003) 2.13
Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin. J Biol Chem (2003) 2.12
Regulation of mTOR by phosphatidic acid? Cancer Res (2007) 2.05
Phospholipase D1 is an effector of Rheb in the mTOR pathway. Proc Natl Acad Sci U S A (2008) 1.97
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Phospholipase D couples survival and migration signals in stress response of human cancer cells. J Biol Chem (2006) 1.78
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Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Clin Cancer Res (2008) 1.43
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Defective TGF-beta signaling sensitizes human cancer cells to rapamycin. Oncogene (2007) 1.27
HIF alpha expression in VHL-deficient renal cancer cells is dependent on phospholipase D. Oncogene (2007) 1.23
PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals. Cell Signal (2006) 1.11
Targeting mTOR-mediated survival signals in anticancer therapeutic strategies. Expert Rev Anticancer Ther (2004) 1.10
Suppression of TGF-beta signaling by phospholipase D. Cell Cycle (2007) 0.98
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Phospholipase D confers rapamycin resistance in human breast cancer cells. Oncogene (2003) 2.13
Use of an innovative, affordable, and open-source short message service-based tool to monitor malaria in remote areas of Uganda. Am J Trop Med Hyg (2011) 2.10
Examining the production costs of antiretroviral drugs. AIDS (2006) 1.97
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Phospholipase D couples survival and migration signals in stress response of human cancer cells. J Biol Chem (2006) 1.78
The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2. Nat Cell Biol (2007) 1.72
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A simple and efficient method for purification of intact white spot syndrome virus (WSSV) viral particles. Virus Res (2005) 1.22
Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1). J Biol Chem (2011) 1.20
Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells. Biochem Biophys Res Commun (2003) 1.20
Suppression of hypoxia-inducible factor 2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells. Cancer Res (2009) 1.18
Efficient synthesis and photodynamic activity of porphyrin-saccharide conjugates: targeting and incapacitating cancer cells. Biochemistry (2004) 1.16
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Association of a clinical knowledge support system with improved patient safety, reduced complications and shorter length of stay among Medicare beneficiaries in acute care hospitals in the United States. Int J Med Inform (2008) 1.15
Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proc Natl Acad Sci U S A (2006) 1.14
Survival signals generated by estrogen and phospholipase D in MCF-7 breast cancer cells are dependent on Myc. Mol Cell Biol (2005) 1.12
Proteomic analysis of the major envelope and nucleocapsid proteins of white spot syndrome virus. J Virol (2006) 1.10
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mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells. J Biol Chem (2005) 1.03
Localization of mRNAs coding for peroxisomal proteins in the yeast, Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2009) 1.02
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Suppression of TGF-beta signaling by phospholipase D. Cell Cycle (2007) 0.98
Myc stabilization in response to estrogen and phospholipase D in MCF-7 breast cancer cells. FEBS Lett (2006) 0.98
Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53. Mol Cell Biol (2004) 0.97
Trypanosoma brucei gambiense trypanosomiasis in Terego county, northern Uganda, 1996: a lot quality assurance sampling survey. Am J Trop Med Hyg (2004) 0.96
Suppression of AKT phosphorylation restores rapamycin-based synthetic lethality in SMAD4-defective pancreatic cancer cells. Mol Cancer Res (2013) 0.95
Phospholipase D-mTOR requirement for the Warburg effect in human cancer cells. Cancer Lett (2010) 0.95
VP26 of white spot syndrome virus functions as a linker protein between the envelope and nucleocapsid of virions by binding with VP51. J Virol (2008) 0.94
Phospholipase D2 stimulates cell protrusion in v-Src-transformed cells. Biochem Biophys Res Commun (2002) 0.94
Downregulating PKC delta provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression. Oncogene (2002) 0.94
Suppression of cell migration by protein kinase Cdelta. Oncogene (2005) 0.94
Phospholipase D overcomes cell cycle arrest induced by high-intensity Raf signaling. Oncogene (2002) 0.94
Four major envelope proteins of white spot syndrome virus bind to form a complex. J Virol (2009) 0.93
Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis. Breast Cancer Res (2012) 0.91
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A report with consensus statements of the International Society of Nephrology 2004 Consensus Workshop on Prevention of Progression of Renal Disease, Hong Kong, June 29, 2004. Kidney Int Suppl (2005) 0.87
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Mutant ras elevates dependence on serum lipids and creates a synthetic lethality for rapamycin. Mol Cancer Ther (2014) 0.85
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Identification of three immediate-early genes of white spot syndrome virus. Arch Virol (2011) 0.83
Quantifying acute changes in volume and nutritional status during haemodialysis using bioimpedance analysis. Nephrology (Carlton) (2012) 0.82
Analysis of white spot syndrome virus envelope protein complexome by two-dimensional blue native/SDS PAGE combined with mass spectrometry. Arch Virol (2011) 0.82
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Elevated phospholipase D activity induces apoptosis in normal rat fibroblasts. Biochem Biophys Res Commun (2002) 0.81
Increased utilization of peritoneal dialysis to cope with mounting demand for renal replacement therapy--perspectives from Asian countries. Perit Dial Int (2007) 0.81
Line probe and automated real-time PCR TB assays warrant adherence to strict quality assurance measures. Int J Tuberc Lung Dis (2012) 0.80
Low concentrations of a non-hydrolysable tetra-S-glycosylated porphyrin and low light induces apoptosis in human breast cancer cells via stress of the endoplasmic reticulum. Photochem Photobiol Sci (2008) 0.80
A genomic integration method for the simultaneous visualization of endogenous mRNAs and their translation products in living yeast. RNA (2011) 0.80
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The RGD motif in VP31 of white spot syndrome virus is involved in cell adhesion. Arch Virol (2011) 0.77
Source identification of bacterial and viral pathogens and their survival/fading in the process of wastewater treatment, reclamation, and environmental reuse. World J Microbiol Biotechnol (2014) 0.77
Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway. Biochem Biophys Res Commun (2010) 0.76
Estimation of contamination sources of human enteroviruses in a wastewater treatment and reclamation system by PCR-DGGE. Food Environ Virol (2014) 0.76
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Garcinia benzophenones inhibit the growth of human colon cancer cells and synergize with sulindac sulfide and turmeric. Anticancer Agents Med Chem (2013) 0.75
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Vibration characteristics of a circular cylindrical ceramic tube piezoelectric transducer with helical electrodes. IEEE Trans Ultrason Ferroelectr Freq Control (2009) 0.75
A facile preparative method for Au-core, block copolymer-shell nanoparticles by UV irradiation of polystyrene-block-poly (2-vinyl pyridine)/HAuCl4 solutions. J Nanosci Nanotechnol (2010) 0.75
Expression and characterization of recombinant thermostable alkaline phosphatase from a novel thermophilic bacterium Thermus thermophilus XM. Acta Biochim Biophys Sin (Shanghai) (2007) 0.75
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Low-abundance envelope protein VP12 of white spot syndrome virus interacts with envelope protein VP150 and capsid protein VP51. Virus Res (2013) 0.75
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