Published in Arthritis Rheum on January 01, 2009
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet (2012) 5.11
Genetics and epigenetics of rheumatoid arthritis. Nat Rev Rheumatol (2013) 2.20
Pre-rheumatoid arthritis: predisposition and transition to clinical synovitis. Nat Rev Rheumatol (2012) 1.78
Selective IgA deficiency in autoimmune diseases. Mol Med (2011) 1.31
The rheumatoid arthritis HLA-DRB1 shared epitope. Curr Opin Rheumatol (2010) 1.21
Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations. Hum Mol Genet (2014) 1.21
Autoantibodies in rheumatoid arthritis: rheumatoid factors and anticitrullinated protein antibodies. QJM (2009) 1.13
Conserved 33-kb haplotype in the MHC class III region regulates chronic arthritis. Proc Natl Acad Sci U S A (2016) 0.98
Interactions between amino acid-defined major histocompatibility complex class II variants and smoking in seropositive rheumatoid arthritis. Arthritis Rheumatol (2015) 0.95
Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe. Hum Mutat (2012) 0.83
Conditional analysis of the major histocompatibility complex in rheumatoid arthritis. BMC Proc (2009) 0.81
Genetic association of htSNPs across the major histocompatibility complex with rheumatoid arthritis in an African-American population. Genes Immun (2009) 0.80
Genetic markers as therapeutic target in rheumatoid arthritis: A game changer in clinical therapy? Rheumatol Int (2016) 0.80
NF-κB and Rheumatoid Arthritis: Will Understanding Genetic Risk Lead to a Therapeutic Reward? For Immunopathol Dis Therap (2013) 0.79
Bagging optimal ROC curve method for predictive genetic tests, with an application for rheumatoid arthritis. J Biopharm Stat (2010) 0.77
Rheumatoid arthritis: identifying and characterising polymorphisms using rat models. Dis Model Mech (2016) 0.77
Challenges in mapping non-HLA-DRB1 major histocompatibility genes in rheumatoid arthritis: comment on the article by Vignal et al. Arthritis Rheum (2009) 0.75
Association study of HLA-B alleles with idiopathic male infertility in Han population of China. J Assist Reprod Genet (2011) 0.75
Reply to Liu et al.: Translation of rat congenic data to humans on a conserved MHC-III haplotype associated with rheumatoid arthritis. Proc Natl Acad Sci U S A (2016) 0.75
Identification of novel genetic loci for osteoporosis and/or rheumatoid arthritis using cFDR approach. PLoS One (2017) 0.75
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
Approximate Bayesian computation in population genetics. Genetics (2002) 13.06
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90
Epigenome-wide association studies for common human diseases. Nat Rev Genet (2011) 7.96
Rheumatoid arthritis association at 6q23. Nat Genet (2007) 6.71
Simultaneous analysis of all SNPs in genome-wide and re-sequencing association studies. PLoS Genet (2008) 6.66
Identifying adaptive genetic divergence among populations from genome scans. Mol Ecol (2004) 5.31
Assessment of cumulative evidence on genetic associations: interim guidelines. Int J Epidemiol (2007) 4.96
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Bayesian statistical methods for genetic association studies. Nat Rev Genet (2009) 4.37
Sequence-level population simulations over large genomic regions. Genetics (2007) 4.04
Inferring population history with DIY ABC: a user-friendly approach to approximate Bayesian computation. Bioinformatics (2008) 4.02
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat Genet (2009) 3.52
Improved heritability estimation from genome-wide SNPs. Am J Hum Genet (2012) 3.48
Genome-wide significance for dense SNP and resequencing data. Genet Epidemiol (2008) 3.26
Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nat Genet (2008) 3.18
AIP mutation in pituitary adenomas in the 18th century and today. N Engl J Med (2011) 3.14
Logistic regression protects against population structure in genetic association studies. Genome Res (2005) 2.94
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. J Allergy Clin Immunol (2011) 2.24
Fregene: simulation of realistic sequence-level data in populations and ascertained samples. BMC Bioinformatics (2008) 2.23
Population structure and inbreeding from pedigree analysis of purebred dogs. Genetics (2008) 2.14
Impact of psychological factors on subjective disease activity assessments in patients with severe rheumatoid arthritis. Arthritis Care Res (Hoboken) (2014) 2.11
Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy. Arthritis Rheum (2010) 2.08
Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Hum Mol Genet (2008) 2.08
Genome-wide association mapping to candidate polymorphism resolution in the unsequenced barley genome. Proc Natl Acad Sci U S A (2010) 1.96
Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population. Arthritis Rheum (2009) 1.95
Alcohol consumption is inversely associated with risk and severity of rheumatoid arthritis. Rheumatology (Oxford) (2010) 1.91
Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease. Arthritis Res Ther (2010) 1.85
Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis. Arthritis Rheum (2008) 1.73
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. Ann Rheum Dis (2012) 1.66
Ethiopian genetic diversity reveals linguistic stratification and complex influences on the Ethiopian gene pool. Am J Hum Genet (2012) 1.60
Age-related loss of CpG methylation in the tumour necrosis factor promoter. Cytokine (2011) 1.58
Informed conditioning on clinical covariates increases power in case-control association studies. PLoS Genet (2012) 1.57
Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes. Hum Mol Genet (2009) 1.55
Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study. Lancet Neurol (2006) 1.54
Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis. PLoS Genet (2013) 1.54
The tumor necrosis factor polymorphism TNF (-308) is associated with susceptibility to meningococcal sepsis, but not with lethality. Crit Care Med (2009) 1.50
Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations. Pharmacogenomics (2004) 1.47
Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci. Arthritis Rheum (2011) 1.44
Functional constraint and small insertions and deletions in the ENCODE regions of the human genome. Genome Biol (2007) 1.43
Confounding between recombination and selection, and the Ped/Pop method for detecting selection. Genome Res (2008) 1.42
A genome-wide association study of the metabolic syndrome in Indian Asian men. PLoS One (2010) 1.42
cnvHap: an integrative population and haplotype-based multiplatform model of SNPs and CNVs. Nat Methods (2010) 1.41
Independent associations of anti-cyclic citrullinated peptide antibodies and rheumatoid factor with radiographic severity of rheumatoid arthritis. Arthritis Res Ther (2006) 1.40
Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Hum Mol Genet (2009) 1.37
Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment. Ann Rheum Dis (2013) 1.37
Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis (2010) 1.36
Inferring combined CNV/SNP haplotypes from genotype data. Bioinformatics (2010) 1.35
Multipoint linkage-disequilibrium mapping narrows location interval and identifies mutation heterogeneity. Proc Natl Acad Sci U S A (2003) 1.33
On optimal selection of summary statistics for approximate Bayesian computation. Stat Appl Genet Mol Biol (2010) 1.28
Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor. Arthritis Rheum (2008) 1.25
Genetic screening for Niemann-Pick disease type C in adults with neurological and psychiatric symptoms: findings from the ZOOM study. Hum Mol Genet (2013) 1.24
Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways. J Biol Chem (2007) 1.17
Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort. Arthritis Rheum (2012) 1.17
Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis. Hum Mol Genet (2008) 1.16
Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. Hum Mol Genet (2011) 1.12
Role of tumour necrosis factor gene polymorphisms (-308 and -238) in breast cancer susceptibility and severity. Breast Cancer Res (2004) 1.10
Disease association tests by inferring ancestral haplotypes using a hidden markov model. Bioinformatics (2008) 1.09
Variation in estimated recombination rates across human populations. Hum Genet (2007) 1.09
A genome-wide association study of neuroticism in a population-based sample. PLoS One (2010) 1.09
Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study. Ann Rheum Dis (2009) 1.07
PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population. Ann Rheum Dis (2009) 1.06
Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways. Ann Rheum Dis (2010) 1.06
Treatment of rheumatoid arthritis with tumour necrosis factor inhibitors. Br J Pharmacol (2011) 1.04
Inference of haplotypic phase and missing genotypes in polyploid organisms and variable copy number genomic regions. BMC Bioinformatics (2008) 1.01
Worldwide F(ST) estimates relative to five continental-scale populations. Ann Hum Genet (2014) 1.00
The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis. Arthritis Res Ther (2007) 0.99
Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis. Arthritis Res Ther (2010) 0.98
Daytime alertness in Parkinson's disease: potentially dose-dependent, divergent effects by drug class. Mov Disord (2012) 0.98
Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance. Pharmacogenet Genomics (2006) 0.97
Response to Lee et al.: SNP-based heritability analysis with dense data. Am J Hum Genet (2013) 0.97
Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking. PLoS Genet (2013) 0.96
Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients. Ann Rheum Dis (2010) 0.96
Using penalised logistic regression to fine map HLA variants for rheumatoid arthritis. Ann Hum Genet (2011) 0.96
Storytelling and story testing in domestication. Proc Natl Acad Sci U S A (2014) 0.96
Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration. Hum Genomics (2011) 0.95
Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis. Arthritis Res Ther (2004) 0.94
Confirmation of association of FCGR3B but not FCGR3A copy number with susceptibility to autoantibody positive rheumatoid arthritis. Hum Mutat (2012) 0.94
Genetic variability of VEGF pathway genes in six randomized phase III trials assessing the addition of bevacizumab to standard therapy. Angiogenesis (2014) 0.94
Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis. Arthritis Res Ther (2008) 0.94
Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment. Ann Rheum Dis (2010) 0.93
5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-epsilon kinase. Bioorg Med Chem Lett (2006) 0.93
Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. Pharmacogenet Genomics (2009) 0.91
Immunoscreening of phage-displayed cDNA-encoded polypeptides identifies B cell targets in autoimmune disease. Biochem Biophys Res Commun (2002) 0.88
Additional genetic susceptibility for rheumatoid arthritis telomeric of the DRB1 locus. Arthritis Rheum (2004) 0.88
Expression of the autoimmunity associated TNFAIP3 is increased in rheumatoid arthritis but does not differ according to genotype at 6q23. Rheumatology (Oxford) (2012) 0.87
Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach. Pharmacogenet Genomics (2007) 0.87
Dissection of the FCGR3A association with RA: increased association in men and with autoantibody positive disease. Ann Rheum Dis (2009) 0.87
Allele-dose association of the C5orf30 rs26232 variant with joint damage in rheumatoid arthritis. Arthritis Rheum (2013) 0.87
Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort. Arthritis Res Ther (2012) 0.86