Published in Arthritis Rheum on September 01, 2008
Epigenetic mechanisms in Alzheimer's disease. Neurobiol Aging (2011) 3.83
Obesity related methylation changes in DNA of peripheral blood leukocytes. BMC Med (2010) 2.24
Genetics and epigenetics of rheumatoid arthritis. Nat Rev Rheumatol (2013) 2.20
IL6-mediated suppression of miR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis. Mol Cell (2012) 1.59
Genetic polymorphism directs IL-6 expression in fibroblasts but not selected other cell types. Proc Natl Acad Sci U S A (2015) 1.48
The epigenetics of autoimmunity. Cell Mol Immunol (2011) 1.47
Epigenetic control in rheumatoid arthritis synovial fibroblasts. Nat Rev Rheumatol (2009) 1.32
Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases. Trends Mol Med (2011) 1.25
Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation. Rheumatol Int (2008) 1.15
White blood cell global methylation and IL-6 promoter methylation in association with diet and lifestyle risk factors in a cancer-free population. Epigenetics (2012) 1.07
The effect of preconception paternal alcohol exposure on epigenetic remodeling of the h19 and rasgrf1 imprinting control regions in mouse offspring. Front Genet (2012) 1.03
Promoter hypomethylation results in increased expression of protein phosphatase 2A in T cells from patients with systemic lupus erythematosus. J Immunol (2011) 1.02
Epigenetics and autoimmune diseases. Autoimmune Dis (2012) 0.97
Nasal cell DNA methylation, inflammation, lung function and wheezing in children with asthma. Epigenomics (2012) 0.96
Epigenetic control of cytokine gene expression: regulation of the TNF/LT locus and T helper cell differentiation. Adv Immunol (2013) 0.94
Epigenetic contributions in the development of rheumatoid arthritis. Arthritis Res Ther (2012) 0.93
DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology. J Autoimmun (2013) 0.93
Epigenetics in the pathogenesis of RA. Semin Immunopathol (2017) 0.93
Cardiovascular risk in systemic autoimmune diseases: epigenetic mechanisms of immune regulatory functions. Clin Dev Immunol (2011) 0.92
Association between blood pressure and DNA methylation of retrotransposons and pro-inflammatory genes. Int J Epidemiol (2013) 0.92
Genome-scale case-control analysis of CD4+ T-cell DNA methylation in juvenile idiopathic arthritis reveals potential targets involved in disease. Clin Epigenetics (2012) 0.89
Differential DNA methylation regions in cytokine and transcription factor genomic loci associate with childhood physical aggression. PLoS One (2013) 0.89
Assessment of global DNA methylation in peripheral blood cell subpopulations of early rheumatoid arthritis before and after methotrexate. Arthritis Res Ther (2015) 0.87
Hypermethylation of EBF3 and IRX1 genes in synovial fibroblasts of patients with rheumatoid arthritis. Mol Cells (2013) 0.86
Hypomethylation of proximal CpG motif of interleukin-10 promoter regulates its expression in human rheumatoid arthritis. Acta Pharmacol Sin (2011) 0.85
Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations. Epigenetics (2014) 0.84
Epigenetic alterations and microRNA misexpression in cancer and autoimmune diseases: a critical review. Clin Rev Allergy Immunol (2014) 0.84
Environmental Epigenetics: Crossroad between Public Health, Lifestyle, and Cancer Prevention. Biomed Res Int (2015) 0.84
Targeted DNA methylation using an artificially bisected M.HhaI fused to zinc fingers. PLoS One (2012) 0.83
The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter. Mol Nutr Food Res (2015) 0.81
Analysis of MEFV exon methylation and expression patterns in familial Mediterranean fever. BMC Med Genet (2011) 0.81
CrossHub: a tool for multi-way analysis of The Cancer Genome Atlas (TCGA) in the context of gene expression regulation mechanisms. Nucleic Acids Res (2016) 0.80
Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation. Mol Nutr Food Res (2015) 0.79
Potential of epigenetic therapies in non-cancerous conditions. Front Genet (2014) 0.79
The potential role of DNA methylation in abdominal aortic aneurysms. Int J Mol Sci (2015) 0.78
Longitudinal Study of DNA Methylation of Inflammatory Genes and Cancer Risk. Cancer Epidemiol Biomarkers Prev (2015) 0.78
Hypomethylation of Interleukin-6 Promoter is Associated with the Risk of Coronary Heart Disease. Arq Bras Cardiol (2016) 0.78
CMV promoter mutants with a reduced propensity to productivity loss in CHO cells. Sci Rep (2015) 0.77
Methylation changes in the TFAP2E promoter region are associated with BRAF mutation and poorer overall & disease free survival in colorectal cancer. Oncoscience (2015) 0.77
Mitochondrial epigenetics in bone remodeling during hyperhomocysteinemia. Mol Cell Biochem (2014) 0.77
Increased methylation of interleukin 6 gene is associated with obesity in Korean women. Mol Cells (2015) 0.76
Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases? Arthritis Res Ther (2013) 0.76
The epigenetic paradigm in periodontitis pathogenesis. J Indian Soc Periodontol (2015) 0.76
Interleukin 6 SNP rs1800797 associates with the risk of adult-onset asthma. Genes Immun (2016) 0.76
Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications. Ther Adv Musculoskelet Dis (2015) 0.76
Rheumatoid Arthritis, Immunosenescence and the Hallmarks of Aging. Curr Aging Sci (2015) 0.76
Methylome-wide association study of whole blood DNA in the Norfolk Island isolate identifies robust loci associated with age. Aging (Albany NY) (2017) 0.75
NFKB1 Promoter DNA from nt+402 to nt+99 Is Hypomethylated in Different Human Immune Cells. PLoS One (2016) 0.75
Differentially Methylated DNA Regions in Monozygotic Twin Pairs Discordant for Rheumatoid Arthritis: An Epigenome-Wide Study. Front Immunol (2016) 0.75
Quantitative survey of multiple CpGs from 5 genes identifies CpG methylation panel discriminating between high- and low-grade cervical intraepithelial neoplasia. Clin Epigenetics (2015) 0.75
Effects of chronic variable stress on cognition and Bace1 expression among wild-type mice. Transl Psychiatry (2016) 0.75
Rheumatoid arthritis naïve T cells share hypermethylation sites with synoviocytes. Arthritis Rheumatol (2016) 0.75
Exercise-conditioned plasma attenuates nuclear concentrations of DNA methyltransferase 3B in human peripheral blood mononuclear cells. Physiol Rep (2015) 0.75
Preliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed women. Transl Psychiatry (2016) 0.75
Decreased Methylation Level of H3K27me3 Increases Seizure Susceptibility. Mol Neurobiol (2016) 0.75
[Epigentics in rheumatic diseases]. Z Rheumatol (2011) 0.75
MTHFR gene variants and non-MALT lymphoma development in primary Sjogren's syndrome. Sci Rep (2017) 0.75
Genomics and epigenomics in rheumatic diseases: what do they provide in terms of diagnosis and disease management? Clin Rheumatol (2017) 0.75
Interleukin-6 promoter haplotypes are associated with etanercept response in patients with rheumatoid arthritis. Clin Rheumatol (2015) 0.75
Detecting rare asymmetrically methylated cytosines and decoding methylation patterns in the honeybee genome. R Soc Open Sci (2017) 0.75
Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood. Proc Natl Acad Sci U S A (2017) 0.75
Inflammatory genes TNFα and IL6 display no signs of increased H3K4me3 in circulating monocytes from untreated rheumatoid arthritis patients. Genes Immun (2017) 0.75
Hypomethylation of interleukin-6 (IL-6) gene increases the risk of essential hypertension: a matched case-control study. J Hum Hypertens (2017) 0.75
Epigenetics in SLE. Curr Rheumatol Rep (2017) 0.75
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90
Rheumatoid arthritis association at 6q23. Nat Genet (2007) 6.71
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat Genet (2009) 3.52
Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nat Genet (2008) 3.18
Immunogenicity and safety of a two-dose schedule of whole-virion and AS03A-adjuvanted 2009 influenza A (H1N1) vaccines: a randomised, multicentre, age-stratified, head-to-head trial. Lancet Infect Dis (2010) 2.67
Impact of psychological factors on subjective disease activity assessments in patients with severe rheumatoid arthritis. Arthritis Care Res (Hoboken) (2014) 2.11
Moxifloxacin monotherapy is effective in hospitalized patients with community-acquired pneumonia: the MOTIV study--a randomized clinical trial. Clin Infect Dis (2008) 2.09
Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy. Arthritis Rheum (2010) 2.08
Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Hum Mol Genet (2008) 2.08
New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions. J Allergy Clin Immunol (2006) 2.06
Cytokine gene polymorphisms in heavy drinkers with and without decompensated liver disease: a case-control study. Am J Gastroenterol (2008) 2.00
Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage. J Infect Dis (2006) 1.99
Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population. Arthritis Rheum (2009) 1.95
Severity of meningococcal disease associated with genomic bacterial load. Clin Infect Dis (2009) 1.92
Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci. Arthritis Rheum (2009) 1.92
Alcohol consumption is inversely associated with risk and severity of rheumatoid arthritis. Rheumatology (Oxford) (2010) 1.91
Clinical and laboratory features distinguishing pandemic H1N1 influenza-related pneumonia from interpandemic community-acquired pneumonia in adults. Thorax (2011) 1.91
Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease. Arthritis Res Ther (2010) 1.85
Numerical scoring for the BILAG-2004 index. Rheumatology (Oxford) (2010) 1.83
Pneumococcal disease in HIV-infected Malawian adults: acute mortality and long-term survival. AIDS (2002) 1.79
Community-acquired pneumonia mortality: a potential link to antibiotic prescribing trends in general practice. Respir Med (2004) 1.76
Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context. Hum Mol Genet (2006) 1.74
British Isles Lupus Assessment Group 2004 index is valid for assessment of disease activity in systemic lupus erythematosus. Arthritis Rheum (2007) 1.74
A sequence-based map of the nine genes of the human interleukin-1 cluster. Genomics (2002) 1.58
Age-related loss of CpG methylation in the tumour necrosis factor promoter. Cytokine (2011) 1.58
Informed conditioning on clinical covariates increases power in case-control association studies. PLoS Genet (2012) 1.57
Toll-like receptors in health and disease: complex questions remain. J Immunol (2003) 1.57
Revised British Isles Lupus Assessment Group 2004 index: a reliable tool for assessment of systemic lupus erythematosus activity. Arthritis Rheum (2006) 1.56
Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes. Hum Mol Genet (2009) 1.55
Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis. PLoS Genet (2013) 1.54
Flavohemoglobin Hmp protects Salmonella enterica serovar typhimurium from nitric oxide-related killing by human macrophages. Infect Immun (2002) 1.53
The BILAG-2004 index is sensitive to change for assessment of SLE disease activity. Rheumatology (Oxford) (2009) 1.52
Genetic polymorphism of the binding domain of surfactant protein-A2 increases susceptibility to meningococcal disease. Clin Infect Dis (2006) 1.51
The tumor necrosis factor polymorphism TNF (-308) is associated with susceptibility to meningococcal sepsis, but not with lethality. Crit Care Med (2009) 1.50
Nitric oxide metabolism in Neisseria meningitidis. J Bacteriol (2002) 1.49
Low-dose aspirin vs low-dose aspirin plus low-intensity warfarin in thromboprophylaxis: a prospective, multicentre, randomized, open, controlled trial in patients positive for antiphospholipid antibodies (ALIWAPAS). Rheumatology (Oxford) (2013) 1.46
Differences between asthmatics and nonasthmatics hospitalised with influenza A infection. Eur Respir J (2012) 1.44
Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci. Arthritis Rheum (2011) 1.44
Management of meningitis. Clin Med (2005) 1.43
Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance. J Clin Invest (2005) 1.42
Nitric oxide in chemostat-cultured Escherichia coli is sensed by Fnr and other global regulators: unaltered methionine biosynthesis indicates lack of S nitrosation. J Bacteriol (2006) 1.42
Independent associations of anti-cyclic citrullinated peptide antibodies and rheumatoid factor with radiographic severity of rheumatoid arthritis. Arthritis Res Ther (2006) 1.40
Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009-2010 in the UK. Thorax (2012) 1.40
Nitric oxide detoxification systems enhance survival of Neisseria meningitidis in human macrophages and in nasopharyngeal mucosa. Infect Immun (2005) 1.37
Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Hum Mol Genet (2009) 1.37
Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment. Ann Rheum Dis (2013) 1.37
Strategies to increase influenza vaccination rates: outcomes of a nationwide cross-sectional survey of UK general practice. BMJ Open (2012) 1.37
Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis (2010) 1.36
Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection. FASEB J (2004) 1.33
Interaction of the Salmonella typhimurium transcription and virulence factor SlyA with target DNA and identification of members of the SlyA regulon. J Biol Chem (2002) 1.32
Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fcgamma receptors correlates with intracellular bacterial load. J Infect Dis (2003) 1.28
Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor. Arthritis Rheum (2008) 1.25
The use of Systemic Lupus Erythematosus Disease Activity Index-2000 to define active disease and minimal clinically meaningful change based on data from a large cohort of systemic lupus erythematosus patients. Rheumatology (Oxford) (2011) 1.25
The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis. Am J Hum Genet (2004) 1.24
Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways. J Biol Chem (2007) 1.17
Invasion by Neisseria meningitidis varies widely between clones and among nasopharyngeal mucosae derived from adult human hosts. Microbiology (2002) 1.17
C-reactive protein levels are influenced by common IL-1 gene variations. Cytokine (2002) 1.17
Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort. Arthritis Rheum (2012) 1.17
Interleukin-1 gene polymorphisms and chronic periodontitis in adult whites: a systematic review and meta-analysis. J Periodontol (2012) 1.17
Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis. Hum Mol Genet (2008) 1.16
Regulation of denitrification genes in Neisseria meningitidis by nitric oxide and the repressor NsrR. J Bacteriol (2006) 1.14
Numerical scoring for the Classic BILAG index. Rheumatology (Oxford) (2009) 1.13
Neisseria meningitidis lactate permease is required for nasopharyngeal colonization. Infect Immun (2005) 1.11
Role of tumour necrosis factor gene polymorphisms (-308 and -238) in breast cancer susceptibility and severity. Breast Cancer Res (2004) 1.10
The pathogen Neisseria meningitidis requires oxygen, but supplements growth by denitrification. Nitrite, nitric oxide and oxygen control respiratory flux at genetic and metabolic levels. Mol Microbiol (2005) 1.10
Activation of toll-like receptor 2 (TLR2) and TLR4/MD2 by Neisseria is independent of capsule and lipooligosaccharide (LOS) sialylation but varies widely among LOS from different strains. Infect Immun (2003) 1.09
NsrR: a key regulator circumventing Salmonella enterica serovar Typhimurium oxidative and nitrosative stress in vitro and in IFN-gamma-stimulated J774.2 macrophages. Microbiology (2007) 1.08
Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study. Ann Rheum Dis (2009) 1.07
PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population. Ann Rheum Dis (2009) 1.06
Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways. Ann Rheum Dis (2010) 1.06
Oseltamivir, zanamivir and amantadine in the prevention of influenza: a systematic review. J Infect (2010) 1.06
IL1B gene promoter haplotype pairs predict clinical levels of interleukin-1beta and C-reactive protein. Hum Genet (2008) 1.06
Interleukin-1: a key inflammatory mediator in psoriasis? Cytokine (2006) 1.06
A functional microsatellite of the macrophage migration inhibitory factor gene associated with meningococcal disease. FASEB J (2011) 1.05
Variation in the TNF gene promoter and risk of osteolysis after total hip arthroplasty. J Bone Miner Res (2003) 1.05
Treatment of rheumatoid arthritis with tumour necrosis factor inhibitors. Br J Pharmacol (2011) 1.04
Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms. Infect Immun (2006) 1.04
Nasopharyngeal colonization by Neisseria lactamica and induction of protective immunity against Neisseria meningitidis. Clin Infect Dis (2011) 1.04
Host genetics and outcome in meningococcal disease: a systematic review and meta-analysis. Lancet Infect Dis (2010) 1.03
Mannose-binding lectin enhances phagocytosis and killing of Neisseria meningitidis by human macrophages. J Leukoc Biol (2004) 1.03
A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci. PLoS Pathog (2011) 1.02
Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults. J Infect Dis (2003) 1.02
Characterisation of receptor binding by the chemotaxis inhibitory protein of Staphylococcus aureus and the effects of the host immune response. Mol Immunol (2007) 1.01
Primary macrophages from HIV-infected adults show dysregulated cytokine responses to Salmonella, but normal internalization and killing. AIDS (2007) 1.01
Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease. J Immunol (2010) 1.01
Metabolism of nitric oxide by Neisseria meningitidis modifies release of NO-regulated cytokines and chemokines by human macrophages. Microbes Infect (2007) 0.99
Peroxynitrite toxicity in Escherichia coli K12 elicits expression of oxidative stress responses and protein nitration and nitrosylation. J Biol Chem (2010) 0.99
The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis. Arthritis Res Ther (2007) 0.99
Nosocomial pandemic (H1N1) 2009, United Kingdom, 2009-2010. Emerg Infect Dis (2011) 0.98
Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis. Arthritis Res Ther (2010) 0.98
Daytime alertness in Parkinson's disease: potentially dose-dependent, divergent effects by drug class. Mov Disord (2012) 0.98
Superantigen recognition by HLA class II on monocytes up-regulates toll-like receptor 4 and enhances proinflammatory responses to endotoxin. Blood (2005) 0.97
Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking. PLoS Genet (2013) 0.96