Published in Exp Cell Res on January 15, 2009
Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo. PLoS One (2014) 1.05
Evading anti-angiogenic therapy: resistance to anti-angiogenic therapy in solid tumors. Am J Transl Res (2015) 0.87
Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. J Exp Med (2014) 0.81
Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice. PLoS One (2015) 0.78
Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Mol Cell Proteomics (2013) 0.77
Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype. PLoS One (2017) 0.75
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature (1996) 18.47
Mechanisms of angiogenesis. Nature (1997) 18.04
Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science (1994) 12.83
Rho GTPases and signaling networks. Genes Dev (1997) 11.70
Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med (2001) 9.53
RHO-GTPases and cancer. Nat Rev Cancer (2002) 8.03
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci U S A (1999) 7.88
Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature (1989) 7.30
Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood (2004) 7.21
Regulation of cell motility by mitogen-activated protein kinase. J Cell Biol (1997) 7.14
Definition of two angiogenic pathways by distinct alpha v integrins. Science (1995) 6.00
Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein. J Cell Biol (1984) 5.96
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nat Med (2006) 5.22
Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med (2002) 4.87
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature (1995) 4.84
Signaling vascular morphogenesis and maintenance. Science (1997) 4.55
Novel purification of vitronectin from human plasma by heparin affinity chromatography. Cell Struct Funct (1988) 4.54
Mouse model of angiogenesis. Am J Pathol (1998) 4.28
Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer (2008) 4.27
Universal GFP reporter for the study of vascular development. Genesis (2000) 3.97
Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity (1999) 3.84
Age-dependent impairment of angiogenesis. Circulation (1999) 3.47
Syk is required for integrin signaling in neutrophils. Immunity (2002) 3.39
Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev (1999) 3.35
Growth of microvessels in serum-free matrix culture of rat aorta. A quantitative assay of angiogenesis in vitro. Lab Invest (1990) 3.28
rac, a novel ras-related family of proteins that are botulinum toxin substrates. J Biol Chem (1989) 3.21
Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system. Blood (1996) 2.76
Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells. Blood (2004) 2.76
Vascular wall resident progenitor cells: a source for postnatal vasculogenesis. Development (2006) 2.20
Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components. J Biol Chem (1993) 2.13
Role of vascular endothelial-cadherin in vascular morphogenesis. Development (1999) 2.06
Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis. Cancer Cell (2005) 2.01
Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. Proc Natl Acad Sci U S A (2000) 1.97
Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product. Immunity (1996) 1.95
Integrin signaling is critical for pathological angiogenesis. J Exp Med (2006) 1.91
Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes. Mol Biol Cell (2000) 1.79
The Id proteins and angiogenesis. Oncogene (2001) 1.70
Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development. Dev Cell (2006) 1.50
What tangled webs they weave: Rho-GTPase control of angiogenesis. Cell Mol Life Sci (2007) 1.42
Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways. J Immunol (2001) 1.41
The mechanism involved in the regulation of phospholipase Cgamma1 activity in cell migration. Oncogene (2002) 1.33
Identification of shc as the primary protein binding to the tyrosine-phosphorylated beta 3 subunit of alpha IIbbeta 3 during outside-in integrin platelet signaling. J Biol Chem (2000) 1.25
Syk is required for monocyte/macrophage chemotaxis to CX3CL1 (Fractalkine). J Immunol (2005) 1.25
Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase. J Mol Biol (2005) 1.23
Integrin-mediated death: an explanation of the integrin-knockout phenotype? Nat Med (2002) 1.20
Syk expression and novel function in a wide variety of tissues. Biochem Biophys Res Commun (2001) 1.18
Integrins alpha(v)beta3 and alpha(v)beta5 are expressed by endothelium of high-risk neuroblastoma and their inhibition is associated with increased endogenous ceramide. Cancer Res (2000) 1.13
Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes. Immunity (1998) 1.13
The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity. Mol Cell Biol (2006) 1.13
Primary endothelial cells isolated from the yolk sac and para-aortic splanchnopleura support the expansion of adult marrow stem cells in vitro. Blood (2003) 1.07
Expression of Von Willebrand factor, an endothelial cell marker, is up-regulated by angiogenesis factors: a potential method for objective assessment of tumor angiogenesis. Int J Cancer (2000) 1.06
Rac2 specificity in macrophage integrin signaling: potential role for Syk kinase. J Biol Chem (2003) 1.01
Potential of baboon endothelial progenitor cells for tissue engineered vascular grafts. J Biomed Mater Res A (2008) 0.97
Syk expression in endothelial cells and their morphologic defects in embryonic Syk-deficient mice. Blood (2001) 0.95
Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells. Blood (2002) 0.95
Regulation of hematopoietic cell development and activation by adapter proteins. Immunol Res (2003) 0.79
Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation (2003) 7.29
Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood (2004) 7.21
Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation (2004) 6.90
A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks. Circ Res (2007) 4.34
Assessing identity, phenotype, and fate of endothelial progenitor cells. Arterioscler Thromb Vasc Biol (2008) 4.07
Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials. Circulation (2005) 3.61
Human CD34+AC133+VEGFR-2+ cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors. Exp Hematol (2007) 3.42
Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. Biochim Biophys Acta (2006) 3.10
The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell Stem Cell (2008) 3.09
CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development (2003) 3.09
Biomechanical forces promote embryonic haematopoiesis. Nature (2009) 2.99
Robust functional vascular network formation in vivo by cooperation of adipose progenitor and endothelial cells. Circ Res (2009) 2.80
Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution. Nat Genet (2013) 2.76
Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells. Blood (2004) 2.76
Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells. Blood (2005) 2.72
BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development (2004) 2.50
'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis. J Neuropathol Exp Neurol (2006) 2.37
Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Blood (2004) 2.35
All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac. Blood (2007) 2.31
A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity. Cancer Res (2008) 2.30
Lung microvascular endothelium is enriched with progenitor cells that exhibit vasculogenic capacity. Am J Physiol Lung Cell Mol Physiol (2007) 2.21
Injury of the renal microvascular endothelium alters barrier function after ischemia. Am J Physiol Renal Physiol (2003) 2.19
Obesity is associated with increased levels of circulating hepatocyte growth factor. J Am Coll Cardiol (2003) 2.14
Flow cytometric identification and functional characterization of immature and mature circulating endothelial cells. Arterioscler Thromb Vasc Biol (2012) 2.07
A low fT3 level as a prognostic marker in patients with acute myocardial infarctions. Intern Med (2012) 2.02
Trend and disease burden of bacillary dysentery in China (1991-2000). Bull World Health Organ (2006) 1.93
Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension. Am J Pathol (2008) 1.90
High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo. Tissue Eng Part A (2011) 1.87
Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. J Lipid Res (2007) 1.82
Ontogeny of CD24 in the human kidney. Kidney Int (2010) 1.81
White adipose tissue cells are recruited by experimental tumors and promote cancer progression in mouse models. Cancer Res (2009) 1.78
Selective regulation of arterial branching morphogenesis by synectin. Dev Cell (2006) 1.77
Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence. Blood (2012) 1.72
PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy. J Biol Chem (2001) 1.66
Adult murine bone marrow-derived very small embryonic-like stem cells differentiate into the hematopoietic lineage after coculture over OP9 stromal cells. Exp Hematol (2010) 1.63
The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration. Cancer Res (2008) 1.63
Regulation of XIAP translation and induction by MDM2 following irradiation. Cancer Cell (2009) 1.60
IFATS collection: The conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats. Stem Cells (2009) 1.57
Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. J Immunol (2007) 1.56
Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential. Proc Natl Acad Sci U S A (2011) 1.55
Sonic hedgehog and retinoic acid synergistically promote sensory fate specification from bone marrow-derived pluripotent stem cells. Proc Natl Acad Sci U S A (2005) 1.50
Exercise acutely increases circulating endothelial progenitor cells and monocyte-/macrophage-derived angiogenic cells. J Am Coll Cardiol (2004) 1.50
Extracellular matrix scaffolds are repopulated by bone marrow-derived cells in a mouse model of achilles tendon reconstruction. J Orthop Res (2006) 1.49
Roles of spleen and liver in development of the murine hematopoietic system. Exp Hematol (2002) 1.49
Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability. Blood (2007) 1.48
PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny and identifies a population of erythroid progenitors. Blood (2004) 1.47
IFATS collection: Human adipose tissue-derived stem cells induce angiogenesis and nerve sprouting following myocardial infarction, in conjunction with potent preservation of cardiac function. Stem Cells (2009) 1.45
Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization. Stem Cells (2007) 1.45
Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-alpha via the p38 mitogen-activated protein kinase pathway. FASEB J (2009) 1.45
Renal ontogeny in the rhesus monkey (Macaca mulatta) and directed differentiation of human embryonic stem cells towards kidney precursors. Differentiation (2009) 1.45
Alpha5beta1 integrin as a cellular coreceptor for human parvovirus B19: requirement of functional activation of beta1 integrin for viral entry. Blood (2003) 1.45
Blood island formation: longstanding observations and modern interpretations. Exp Hematol (2005) 1.44
Mechanisms of disease: the PI3K-Akt-PTEN signaling node--an intercept point for the control of angiogenesis in brain tumors. Nat Clin Pract Neurol (2007) 1.44
Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking. Am J Respir Crit Care Med (2010) 1.42
Endothelial progenitor cells: quo vadis? J Mol Cell Cardiol (2010) 1.41
Rac2 concentrations in umbilical cord neutrophils. Biol Neonate (2006) 1.39
Isolation and characterization of endothelial progenitor cells from human blood. Curr Protoc Stem Cell Biol (2008) 1.36
A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis. Blood (2003) 1.36
SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse. Blood (2010) 1.36
Therapeutic potential of adipose-derived stem cells in vascular growth and tissue repair. Curr Opin Organ Transplant (2010) 1.36
Endothelial cells in the early murine yolk sac give rise to CD41-expressing hematopoietic cells. Stem Cells Dev (2005) 1.35
Definitive hematopoietic commitment within the embryonic vascular endothelial-cadherin(+) population. Exp Hematol (2002) 1.35
Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection. J Clin Invest (2011) 1.35
Clonogenic endothelial progenitor cells are sensitive to oxidative stress. Stem Cells (2006) 1.34
IFATS collection: Adipose stromal cell differentiation is reduced by endothelial cell contact and paracrine communication: role of canonical Wnt signaling. Stem Cells (2008) 1.32
The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation. Endocrinology (2009) 1.32
Cord blood stem and progenitor cells. Methods Enzymol (2006) 1.29
Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase. J Biol Chem (2006) 1.29
Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis. Blood (2009) 1.29
PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma. Cancer Res (2005) 1.28
PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment. Cancer Res (2003) 1.27
Endothelial colony-forming cell role in neoangiogenesis and tissue repair. Curr Opin Organ Transplant (2010) 1.27
Adipose tissue progenitor cells directly interact with endothelial cells to induce vascular network formation. Tissue Eng Part A (2010) 1.24
Impaired nuclear transport and uncoating limit recombinant adeno-associated virus 2 vector-mediated transduction of primary murine hematopoietic cells. Hum Gene Ther (2004) 1.23
Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain. Blood (2006) 1.22
Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity. Cancer Res (2009) 1.22
Critical roles of lysosomal acid lipase in myelopoiesis. Am J Pathol (2010) 1.22
A synthesized pheromone induces upstream movement in female sea lamprey and summons them into traps. Proc Natl Acad Sci U S A (2009) 1.20
Biomimetic apatite-coated alginate/chitosan microparticles as osteogenic protein carriers. Biomaterials (2009) 1.20
Extremely low penetrance of deafness associated with the mitochondrial 12S rRNA mutation in 16 Chinese families: implication for early detection and prevention of deafness. Biochem Biophys Res Commun (2006) 1.19
Delayed arteriogenesis in hypercholesterolemic mice. Circulation (2005) 1.19
Epigenetic regulation of NANOG by miR-302 cluster-MBD2 completes induced pluripotent stem cell reprogramming. Stem Cells (2013) 1.19
Ectopical expression of human MUC18 increases metastasis of human prostate cancer cells. Gene (2004) 1.16
IFATS collection: Combinatorial peptides identify alpha5beta1 integrin as a receptor for the matricellular protein SPARC on adipose stromal cells. Stem Cells (2008) 1.16
Hematopoietic stem cell repopulating ability can be maintained in vitro by some primary endothelial cells. Exp Hematol (2004) 1.16