Published in Diabetes on August 01, 2006
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol (2011) 6.83
Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci U S A (2007) 4.24
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem (2008) 4.16
Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell (2009) 4.01
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab (2011) 3.98
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes (2009) 3.39
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat Rev Drug Discov (2011) 3.08
Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol (2009) 2.65
Diabetic neuropathy: mechanisms to management. Pharmacol Ther (2008) 2.57
AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest (2013) 2.44
AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab (2010) 2.40
AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes. Circ Res (2010) 2.35
Resveratrol alleviates alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol (2008) 2.33
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab (2009) 2.25
AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem (2010) 2.21
AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives. Acta Physiol (Oxf) (2009) 2.13
AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol (2010) 2.11
AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J (2009) 2.09
Validation of anti-aging drugs by treating age-related diseases. Aging (Albany NY) (2009) 2.01
AMP-activated protein kinase and its downstream transcriptional pathways. Cell Mol Life Sci (2010) 1.95
NOX enzymes as novel targets for drug development. Semin Immunopathol (2008) 1.90
Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors. Br J Pharmacol (2007) 1.90
Caloric restriction, SIRT1 and longevity. Trends Endocrinol Metab (2009) 1.89
Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion. J Biol Chem (2009) 1.86
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol Rev (2011) 1.85
Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. Am J Physiol Heart Circ Physiol (2009) 1.85
The coordination of nuclear and mitochondrial communication during aging and calorie restriction. Ageing Res Rev (2009) 1.79
Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci (2010) 1.78
TAp63 is a master transcriptional regulator of lipid and glucose metabolism. Cell Metab (2012) 1.77
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J (2011) 1.65
Lipotoxicity in the heart. Biochim Biophys Acta (2009) 1.60
The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance. Endocr Rev (2009) 1.57
Targeting the AMPK pathway for the treatment of Type 2 diabetes. Front Biosci (Landmark Ed) (2009) 1.51
SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells. J Pharmacol Exp Ther (2010) 1.47
Mitochondria as a therapeutic target in heart failure. J Am Coll Cardiol (2012) 1.46
Mitochondria and cardiovascular aging. Circ Res (2012) 1.46
Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5'-AMP-activated protein kinase. J Biol Chem (2007) 1.43
Effects of resveratrol and SIRT1 on PGC-1α activity and mitochondrial biogenesis: a reevaluation. PLoS Biol (2013) 1.40
Resveratrol, sirtuins, and the promise of a DR mimetic. Mech Ageing Dev (2010) 1.39
Dietary polyphenols as potential nutraceuticals in management of diabetes: a review. J Diabetes Metab Disord (2013) 1.32
The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice. Circulation (2012) 1.32
Recent advances in understanding the anti-diabetic actions of dietary flavonoids. J Nutr Biochem (2013) 1.27
Mitochondria and endothelial function. Circ Res (2013) 1.27
Resveratrol as a calorie restriction mimetic: therapeutic implications. Trends Cell Biol (2012) 1.26
Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo. J Biol Chem (2008) 1.26
AMPK activation: a therapeutic target for type 2 diabetes? Diabetes Metab Syndr Obes (2014) 1.25
Dietary polyphenols and obesity. Nutrients (2010) 1.23
Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement. Antioxid Redox Signal (2014) 1.23
Calorie restriction: is AMPK a key sensor and effector? Physiology (Bethesda) (2011) 1.23
Roles of SIRT1 in the acute and restorative phases following induction of inflammation. J Biol Chem (2010) 1.18
Resveratrol in prevention and treatment of common clinical conditions of aging. Clin Interv Aging (2008) 1.17
Biochemical effects of SIRT1 activators. Biochim Biophys Acta (2009) 1.16
Polyphenols: benefits to the cardiovascular system in health and in aging. Nutrients (2013) 1.14
Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes (2012) 1.14
Targeting AMPK for cancer prevention and treatment. Oncotarget (2015) 1.13
Vascular oxidative stress: the common link in hypertensive and diabetic vascular disease. J Cardiovasc Pharmacol (2010) 1.13
Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics. Am J Physiol Heart Circ Physiol (2013) 1.12
Resveratrol inhibits foam cell formation via NADPH oxidase 1- mediated reactive oxygen species and monocyte chemotactic protein-1. Exp Mol Med (2009) 1.12
Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. Gastroenterology (2013) 1.11
Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain. Mol Pain (2012) 1.10
Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2. PLoS One (2011) 1.10
Acute exercise activates AMPK and eNOS in the mouse aorta. Am J Physiol Heart Circ Physiol (2011) 1.08
NOX1, 2, 4, 5: counting out oxidative stress. Br J Pharmacol (2011) 1.08
TOR signaling never gets old: aging, longevity and TORC1 activity. Ageing Res Rev (2010) 1.07
Up-regulation of adiponectin by resveratrol: the essential roles of the Akt/FOXO1 and AMP-activated protein kinase signaling pathways and DsbA-L. J Biol Chem (2010) 1.06
Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Acta Pharmacol Sin (2009) 1.04
SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol. Diabetes (2010) 1.04
Tea and cardiovascular disease. Pharmacol Res (2011) 1.03
Redox regulation of the AMP-activated protein kinase. PLoS One (2010) 1.03
Resveratrol retards progression of diabetic nephropathy through modulations of oxidative stress, proinflammatory cytokines, and AMP-activated protein kinase. J Biomed Sci (2011) 1.03
Resveratrol and diabetic cardiac function: focus on recent in vitro and in vivo studies. J Bioenerg Biomembr (2012) 1.02
Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway. PLoS One (2012) 1.01
Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis. Aging (Albany NY) (2011) 0.99
Retinoic acid receptor β stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice. J Biol Chem (2013) 0.99
AMP-activated protein kinase and metabolic control. Handb Exp Pharmacol (2011) 0.99
Continued postnatal administration of resveratrol prevents diet-induced metabolic syndrome in rat offspring born growth restricted. Diabetes (2011) 0.98
Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats. Diabetes (2011) 0.98
Mitochondrial protection by resveratrol. Exerc Sport Sci Rev (2011) 0.98
Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs. PLoS One (2013) 0.97
Perspectives of Targeting mTORC1-S6K1 in Cardiovascular Aging. Front Physiol (2012) 0.97
A2b adenosine receptor regulates hyperlipidemia and atherosclerosis. Circulation (2011) 0.97
AMPK: a cellular metabolic and redox sensor. A minireview. Front Biosci (Landmark Ed) (2014) 0.97
Green and black tea extracts inhibit HMG-CoA reductase and activate AMP kinase to decrease cholesterol synthesis in hepatoma cells. J Nutr Biochem (2008) 0.96
Dietary resveratrol prevents Alzheimer's markers and increases life span in SAMP8. Age (Dordr) (2012) 0.96
The quest for selective nox inhibitors and therapeutics: challenges, triumphs and pitfalls. Antioxid Redox Signal (2013) 0.96
Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights. J Nutr Biochem (2011) 0.95
C-peptide activates AMPKα and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes. Diabetes (2013) 0.94
Resveratrol ameliorates high glucose-induced protein synthesis in glomerular epithelial cells. Cell Signal (2009) 0.94
Resveratrol inhibits neuronal apoptosis and elevated Ca2+/calmodulin-dependent protein kinase II activity in diabetic mouse retina. Diabetes (2010) 0.94
Anti-obesity effects of Lysimachia foenum-graecum characterized by decreased adipogenesis and regulated lipid metabolism. Exp Mol Med (2011) 0.92
Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways. Radiat Oncol (2011) 0.92
Protective effects of AMP-activated protein kinase in the cardiovascular system. J Cell Mol Med (2010) 0.91
AMPK: An emerging target for modification of injury-induced pain plasticity. Neurosci Lett (2013) 0.91
Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B. FASEB J (2008) 0.91
Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension. Am J Clin Nutr (2010) 0.90
Late chronic catechin antioxidant treatment is deleterious to the endothelial function in aging mice with established atherosclerosis. Am J Physiol Heart Circ Physiol (2010) 0.90
Catalysis and mechanistic insights into sirtuin activation. Chembiochem (2010) 0.89
Long-term tea intake is associated with reduced prevalence of (type 2) diabetes mellitus among elderly people from Mediterranean islands: MEDIS epidemiological study. Yonsei Med J (2009) 0.89
Turn up the power - pharmacological activation of mitochondrial biogenesis in mouse models. Br J Pharmacol (2014) 0.88
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem (2008) 4.16
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab (2011) 3.98
S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide. Nat Med (2004) 3.15
Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J Clin Invest (2002) 2.89
AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J Biol Chem (2004) 2.83
Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathway. Proc Natl Acad Sci U S A (2010) 2.41
Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging. Am J Physiol Heart Circ Physiol (2006) 2.19
S-glutathiolation of Ras mediates redox-sensitive signaling by angiotensin II in vascular smooth muscle cells. J Biol Chem (2004) 2.09
Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells. J Biol Chem (2006) 1.98
Strain-stimulated hypertrophy in cardiac myocytes is mediated by reactive oxygen species-dependent Ras S-glutathiolation. J Mol Cell Cardiol (2006) 1.96
Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells. Role of peroxynitrite. J Biol Chem (2003) 1.81
Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase. J Biol Chem (2002) 1.74
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J (2011) 1.65
Arterial stiffening precedes systolic hypertension in diet-induced obesity. Hypertension (2013) 1.65
Thiol oxidation in signaling and response to stress: detection and quantification of physiological and pathophysiological thiol modifications. Free Radic Biol Med (2007) 1.63
Isotope-coded affinity tag (ICAT) approach to redox proteomics: identification and quantitation of oxidant-sensitive cysteine thiols in complex protein mixtures. J Proteome Res (2004) 1.58
S-glutathiolation by peroxynitrite of p21ras at cysteine-118 mediates its direct activation and downstream signaling in endothelial cells. FASEB J (2006) 1.47
Carbon monoxide induces relaxation of human internal thoracic and radial arterial grafts. Interact Cardiovasc Thorac Surg (2008) 1.45
Temporal control of NF-kappaB activation by ERK differentially regulates interleukin-1beta-induced gene expression. J Biol Chem (2003) 1.41
Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras. Circulation (2005) 1.37
Isotope-coded affinity tag approach to identify and quantify oxidant-sensitive protein thiols. Mol Cell Proteomics (2004) 1.33
The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice. Circulation (2012) 1.32
High glucose oxidizes SERCA cysteine-674 and prevents inhibition by nitric oxide of smooth muscle cell migration. J Mol Cell Cardiol (2007) 1.24
Cysteine-674 of the sarco/endoplasmic reticulum calcium ATPase is required for the inhibition of cell migration by nitric oxide. Arterioscler Thromb Vasc Biol (2007) 1.23
S-glutathiolation of p21ras by peroxynitrite mediates endothelial insulin resistance caused by oxidized low-density lipoprotein. Arterioscler Thromb Vasc Biol (2006) 1.22
Nitroxyl activates SERCA in cardiac myocytes via glutathiolation of cysteine 674. Circ Res (2009) 1.22
Quantitative assessment of tyrosine nitration of manganese superoxide dismutase in angiotensin II-infused rat kidney. Am J Physiol Heart Circ Physiol (2003) 1.19
Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease. Ann Med (2012) 1.18
Upregulation of Nox4 by TGF{beta}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat. Circ Res (2010) 1.17
Redox-mediated reciprocal regulation of SERCA and Na+-Ca2+ exchanger contributes to sarcoplasmic reticulum Ca2+ depletion in cardiac myocytes. Free Radic Biol Med (2010) 1.17
Cysteine-674 oxidation and degradation of sarcoplasmic reticulum Ca(2+) ATPase in diabetic pig aorta. Free Radic Biol Med (2008) 1.14
Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans. Br J Pharmacol (2013) 1.14
Redox regulation of sirtuin-1 by S-glutathiolation. Antioxid Redox Signal (2010) 1.13
The thromboxane A2 receptor antagonist S18886 prevents enhanced atherogenesis caused by diabetes mellitus. Circulation (2005) 1.13
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone. Circulation (2007) 1.13
Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress. J Mol Cell Cardiol (2011) 1.11
Antioxidant improves smooth muscle sarco/endoplasmic reticulum Ca(2+)-ATPase function and lowers tyrosine nitration in hypercholesterolemia and improves nitric oxide-induced relaxation. Circ Res (2002) 1.10
Oxidative posttranslational modifications mediate decreased SERCA activity and myocyte dysfunction in Galphaq-overexpressing mice. Circ Res (2010) 1.10
Role of iPLA2 and store-operated channels in agonist-induced Ca2+ influx and constriction in cerebral, mesenteric, and carotid arteries. Am J Physiol Heart Circ Physiol (2007) 1.09
Role of superoxide anion in regulating pressor and vascular hypertrophic response to angiotensin II. Am J Physiol Heart Circ Physiol (2002) 1.08
Quantification of oxidative posttranslational modifications of cysteine thiols of p21ras associated with redox modulation of activity using isotope-coded affinity tags and mass spectrometry. Free Radic Biol Med (2006) 1.08
Endothelium-dependent contractions in SHR: a tale of prostanoid TP and IP receptors. Br J Pharmacol (2009) 1.07
Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II. Circulation (2005) 1.06
Multilayer polypeptide nanoscale coatings incorporating IL-12 for the prevention of biomedical device-associated infections. Biomaterials (2009) 1.05
The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice. Diabetes (2006) 1.05
Altered thrombus formation in von Willebrand factor-deficient mice expressing von Willebrand factor variants with defective binding to collagen or GPIIbIIIa. Blood (2008) 1.05
Hydrogen peroxide-mediated SERCA cysteine 674 oxidation contributes to impaired cardiac myocyte relaxation in senescent mouse heart. J Am Heart Assoc (2013) 1.04
Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosis. Proc Natl Acad Sci U S A (2004) 1.03
Targeting the redox regulation of SERCA in vascular physiology and disease. Curr Opin Pharmacol (2010) 1.01
(Pro)renin promotes fibrosis gene expression in HEK cells through a Nox4-dependent mechanism. Am J Physiol Renal Physiol (2011) 1.01
Glucose-6-phosphate dehydrogenase deficiency decreases vascular superoxide and atherosclerotic lesions in apolipoprotein E(-/-) mice. Arterioscler Thromb Vasc Biol (2006) 1.00
Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis. FASEB J (2011) 0.97
Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs. PLoS One (2013) 0.97
A(3) adenosine receptor deficiency does not influence atherogenesis. J Cell Biochem (2004) 0.95
Detailed map of oxidative post-translational modifications of human p21ras using Fourier transform mass spectrometry. Anal Chem (2006) 0.95
Redox regulation of SERCA2 is required for vascular endothelial growth factor-induced signaling and endothelial cell migration. Antioxid Redox Signal (2012) 0.95
Activation of thromboxane receptor upregulates interleukin (IL)-1beta-induced VCAM-1 expression through JNK signaling. Arterioscler Thromb Vasc Biol (2007) 0.95