Structure-function studies of the RNA polymerase II elongation complex.

Evolution of multisubunit RNA polymerases in the three domains of life. Nat Rev Microbiol (2011) 2.24

Biogenic mechanisms and utilization of small RNAs derived from human protein-coding genes. Nat Struct Mol Biol (2011) 1.51

Macromolecular micromovements: how RNA polymerase translocates. Curr Opin Struct Biol (2009) 1.07

Basic mechanism of transcription by RNA polymerase II. Biochim Biophys Acta (2012) 0.98

Molecular mechanisms of RNA polymerase--the F/E (RPB4/7) complex is required for high processivity in vitro. Nucleic Acids Res (2009) 0.92

RNA polymerase stalls in a post-translocated register and can hyper-translocate. Transcription (2012) 0.90

Molecular basis of transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis. DNA Repair (Amst) (2014) 0.85

Computational simulation strategies for analysis of multisubunit RNA polymerases. Chem Rev (2013) 0.82

RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications. Crit Rev Biochem Mol Biol (2015) 0.80

Deletion of switch 3 results in an archaeal RNA polymerase that is defective in transcript elongation. J Biol Chem (2010) 0.80

T7 RNA polymerases backed up by covalently trapped proteins catalyze highly error prone transcription. J Biol Chem (2012) 0.79

Soaking of DNA into crystals of archaeal RNA polymerase achieved by desalting in droplets. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.75

Translocation and fidelity of Escherichia coli RNA polymerase. Transcription (2013) 0.75

Version 1.2 of the Crystallography and NMR system. Nat Protoc (2007) 13.01

Zero-dose extrapolation as part of macromolecular synchrotron data reduction. Acta Crystallogr D Biol Crystallogr (2003) 12.96

Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov (2005) 9.47

Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. Science (2001) 8.92

Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution. Science (2001) 8.24

Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution. Nature (2002) 6.74

DNA excision repair. Annu Rev Biochem (1996) 6.71

Architecture of RNA polymerase II and implications for the transcription mechanism. Science (2000) 5.12

Structural basis for transcription elongation by bacterial RNA polymerase. Nature (2007) 5.09

Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis. Cell (2006) 4.49

Structural basis for substrate loading in bacterial RNA polymerase. Nature (2007) 4.40

Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS. Mol Cell (2004) 4.20

The PILATUS 1M detector. J Synchrotron Radiat (2006) 4.16

A mechanism for all polymerases. Nature (1998) 3.79

Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center. Cell (2004) 3.34

Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage. Cell (2003) 3.30

Mechanisms of transcription-coupled DNA repair. Nat Rev Mol Cell Biol (2002) 3.12

Structural basis of transcription: separation of RNA from DNA by RNA polymerase II. Science (2004) 3.08

Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription. Proc Natl Acad Sci U S A (2003) 2.92

The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin. Mol Cell (2008) 2.62

Nucleotide excision repair in yeast. Mutat Res (2000) 2.54

Structures of complete RNA polymerase II and its subcomplex, Rpb4/7. J Biol Chem (2004) 2.52

Structural basis of transcription inhibition by alpha-amanitin and implications for RNA polymerase II translocation. Nat Struct Mol Biol (2008) 2.47

Architecture of initiation-competent 12-subunit RNA polymerase II. Proc Natl Acad Sci U S A (2003) 2.39

The 8-nucleotide-long RNA:DNA hybrid is a primary stability determinant of the RNA polymerase II elongation complex. J Biol Chem (2000) 2.35

Structure of eukaryotic RNA polymerases. Annu Rev Biophys (2008) 2.28

Unified two-metal mechanism of RNA synthesis and degradation by RNA polymerase. EMBO J (2003) 2.10

Replication of a cis-syn thymine dimer at atomic resolution. Nature (2003) 2.07

Yeast RNA polymerase II at 5 A resolution. Cell (1999) 1.90

RNA polymerase II stalled at a thymine dimer: footprint and effect on excision repair. Nucleic Acids Res (1997) 1.87

CPD damage recognition by transcribing RNA polymerase II. Science (2007) 1.80

Recognition of cisplatin adducts by cellular proteins. Mutat Res (2001) 1.78

Molecular basis of RNA-dependent RNA polymerase II activity. Nature (2007) 1.71

RNA polymerase encounters with DNA damage: transcription-coupled repair or transcriptional mutagenesis? Chem Rev (2006) 1.67

RNA polymerase II bypass of oxidative DNA damage is regulated by transcription elongation factors. EMBO J (2006) 1.50

Electron crystal structure of an RNA polymerase II transcription elongation complex. Cell (1999) 1.44

Nucleotide insertion opposite a cis-syn thymine dimer by a replicative DNA polymerase from bacteriophage T7. Nat Struct Mol Biol (2004) 1.40

Behavior of T7 RNA polymerase and mammalian RNA polymerase II at site-specific cisplatin adducts in the template DNA. J Biol Chem (2003) 1.34

Mechanism of transcriptional stalling at cisplatin-damaged DNA. Nat Struct Mol Biol (2007) 1.32

Transcription by eucaryotic and procaryotic RNA polymerases of DNA modified at a d(GG) or a d(AG) site by the antitumor drug cis-diamminedichloroplatinum(II). Biochemistry (1991) 1.29

Divide and conquer: nucleotide excision repair battles cancer and ageing. Curr Opin Cell Biol (2003) 1.20

New structural and mechanistic insight into the A-rule and the instructional and non-instructional behavior of DNA photoproducts and other lesions. Mutat Res (2002) 1.19

RNA polymerase II blockage by cisplatin-damaged DNA. Stability and polyubiquitylation of stalled polymerase. J Biol Chem (2005) 1.19

Model for XPC-independent transcription-coupled repair of pyrimidine dimers in humans. J Biol Chem (1997) 1.13

Fate of RNA polymerase II stalled at a cisplatin lesion. J Biol Chem (2003) 1.06

Spectrum of DNA--platinum adduct recognition by prokaryotic and eukaryotic DNA-dependent RNA polymerases. Biochemistry (1993) 1.03

Blockage of RNA polymerase II at a cyclobutane pyrimidine dimer and 6-4 photoproduct. Biochem Biophys Res Commun (2004) 0.99

Nucleotide sequence context effect of a cyclobutane pyrimidine dimer upon RNA polymerase II transcription. J Biol Chem (1997) 0.92

Jamming the ratchet of transcription. Nat Struct Mol Biol (2008) 0.86

DNA photodamage recognition by RNA polymerase II. FEBS Lett (2007) 0.85

Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS. Mol Cell (2004) 4.20

Architecture of the RNA polymerase II-TFIIF complex revealed by cross-linking and mass spectrometry. EMBO J (2010) 3.40

Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage. Cell (2003) 3.30

Uniform transitions of the general RNA polymerase II transcription complex. Nat Struct Mol Biol (2010) 3.25

RNA polymerase II-TFIIB structure and mechanism of transcription initiation. Nature (2009) 2.98

Recognition of RNA polymerase II carboxy-terminal domain by 3'-RNA-processing factors. Nature (2004) 2.86

Functional architecture of RNA polymerase I. Cell (2007) 2.86

A structural perspective of CTD function. Genes Dev (2005) 2.85

Structures of complete RNA polymerase II and its subcomplex, Rpb4/7. J Biol Chem (2004) 2.52

Structural basis of transcription inhibition by alpha-amanitin and implications for RNA polymerase II translocation. Nat Struct Mol Biol (2008) 2.47

Architecture of initiation-competent 12-subunit RNA polymerase II. Proc Natl Acad Sci U S A (2003) 2.39

Dynamic transcriptome analysis measures rates of mRNA synthesis and decay in yeast. Mol Syst Biol (2011) 2.37

Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution. Proc Natl Acad Sci U S A (2002) 2.37

Architecture of the RNA polymerase-Spt4/5 complex and basis of universal transcription processivity. EMBO J (2011) 2.22

Structural basis of RNA polymerase II backtracking, arrest and reactivation. Nature (2011) 2.19

CTD tyrosine phosphorylation impairs termination factor recruitment to RNA polymerase II. Science (2012) 2.05

Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA. Mol Cell (2009) 2.00

Mechanism of translesion transcription by RNA polymerase II and its role in cellular resistance to DNA damage. Mol Cell (2012) 1.96

Iwr1 directs RNA polymerase II nuclear import. Mol Cell (2011) 1.88

Conservation between the RNA polymerase I, II, and III transcription initiation machineries. Mol Cell (2012) 1.86

Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies. Proc Natl Acad Sci U S A (2011) 1.85

A nano-positioning system for macromolecular structural analysis. Nat Methods (2008) 1.84

Structure of human mitochondrial RNA polymerase. Nature (2011) 1.82

CPD damage recognition by transcribing RNA polymerase II. Science (2007) 1.80

A cytoplasmic complex mediates specific mRNA recognition and localization in yeast. PLoS Biol (2011) 1.78

Comparative dynamic transcriptome analysis (cDTA) reveals mutual feedback between mRNA synthesis and degradation. Genome Res (2012) 1.77

RNA polymerase fidelity and transcriptional proofreading. Curr Opin Struct Biol (2009) 1.77

Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast. Curr Biol (2005) 1.76

Molecular basis of RNA-dependent RNA polymerase II activity. Nature (2007) 1.71

Structure of an archaeal RNA polymerase. J Mol Biol (2007) 1.65

Single-molecule tracking of mRNA exiting from RNA polymerase II. Proc Natl Acad Sci U S A (2007) 1.59

Molecular basis of RNA polymerase III transcription repression by Maf1. Cell (2010) 1.57

DNA sequence- and conformation-directed positioning of nucleosomes by chromatin-remodeling complexes. Proc Natl Acad Sci U S A (2007) 1.53

Structure of a bifunctional DNA primase-polymerase. Nat Struct Mol Biol (2004) 1.52

Structure and function of the initially transcribing RNA polymerase II-TFIIB complex. Nature (2012) 1.48

Structure and mechanism of RNA polymerase II CTD phosphatases. Mol Cell (2004) 1.46

Surface area and the seabed area, volume, depth, slope, and topographic variation for the world's seas, oceans, and countries. Environ Sci Technol (2010) 1.44

Transcriptome surveillance by selective termination of noncoding RNA synthesis. Cell (2013) 1.43

Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20. Nat Struct Mol Biol (2006) 1.43

RNA polymerase I structure and transcription regulation. Nature (2013) 1.42

RNA polymerase I contains a TFIIF-related DNA-binding subcomplex. Mol Cell (2010) 1.40

Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model. Mol Cell (2006) 1.39

Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif. Nucleic Acids Res (2010) 1.38

Global analysis of eukaryotic mRNA degradation reveals Xrn1-dependent buffering of transcript levels. Mol Cell (2013) 1.35

Mechanism of transcriptional stalling at cisplatin-damaged DNA. Nat Struct Mol Biol (2007) 1.32

Nano positioning system reveals the course of upstream and nontemplate DNA within the RNA polymerase II elongation complex. Nucleic Acids Res (2009) 1.32

Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies. MAbs (2012) 1.29

Structural basis of initial RNA polymerase II transcription. EMBO J (2011) 1.29

Structural biology of RNA polymerase III: mass spectrometry elucidates subcomplex architecture. Structure (2007) 1.19

A conserved mediator hinge revealed in the structure of the MED7.MED21 (Med7.Srb7) heterodimer. J Biol Chem (2005) 1.17

Structure of the Mediator head module. Nature (2012) 1.17

Structure-function analysis of the RNA polymerase cleft loops elucidates initial transcription, DNA unwinding and RNA displacement. Nucleic Acids Res (2007) 1.17

Crosslinking-MS analysis reveals RNA polymerase I domain architecture and basis of rRNA cleavage. Nucleic Acids Res (2012) 1.17

A movie of RNA polymerase II transcription. Cell (2012) 1.17

A movie of the RNA polymerase nucleotide addition cycle. Curr Opin Struct Biol (2009) 1.17

Structure and in vivo requirement of the yeast Spt6 SH2 domain. J Mol Biol (2009) 1.16

Identification, structure, and functional requirement of the Mediator submodule Med7N/31. EMBO J (2008) 1.14

Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs. Nat Struct Mol Biol (2005) 1.14

A simple strategy for preparation of sensor arrays: molecularly structured monolayers as recognition elements. Chem Commun (Camb) (2003) 1.14

Structure and carboxyl-terminal domain (CTD) binding of the Set2 SRI domain that couples histone H3 Lys36 methylation to transcription. J Biol Chem (2005) 1.14

Template misalignment in multisubunit RNA polymerases and transcription fidelity. Mol Cell (2006) 1.13

An extended winged helix domain in general transcription factor E/IIE alpha. J Biol Chem (2003) 1.13

A structural perspective on Mediator function. Curr Opin Cell Biol (2012) 1.13

The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity. BMC Cell Biol (2004) 1.10

Periodic mRNA synthesis and degradation co-operate during cell cycle gene expression. Mol Syst Biol (2014) 1.10

Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth. Genes Dev (2011) 1.09

Structural basis of transcription elongation. Biochim Biophys Acta (2012) 1.09

Genome-associated RNA polymerase II includes the dissociable Rpb4/7 subcomplex. J Biol Chem (2008) 1.08

Structure and VP16 binding of the Mediator Med25 activator interaction domain. Nat Struct Mol Biol (2011) 1.08

Fluorescence detection of nucleic acids and proteins in multi-component crystals. Acta Crystallogr D Biol Crystallogr (2006) 1.07

Structure of human mitochondrial RNA polymerase elongation complex. Nat Struct Mol Biol (2013) 1.06

Torpedo nuclease Rat1 is insufficient to terminate RNA polymerase II in vitro. J Biol Chem (2009) 1.05

Molecular basis of transcriptional mutagenesis at 8-oxoguanine. J Biol Chem (2009) 1.04

The mRNA transcription/processing factor Ssu72 is a potential tyrosine phosphatase. J Biol Chem (2003) 1.03

Structure-system correlation identifies a gene regulatory Mediator submodule. Genes Dev (2008) 1.03

Dynamic architecture of a minimal RNA polymerase II open promoter complex. Mol Cell (2012) 1.01

A tandem SH2 domain in transcription elongation factor Spt6 binds the phosphorylated RNA polymerase II C-terminal repeat domain (CTD). J Biol Chem (2010) 1.00

The spt5 C-terminal region recruits yeast 3' RNA cleavage factor I. Mol Cell Biol (2012) 0.99

Multisubunit RNA polymerases melt only a single DNA base pair downstream of the active site. J Biol Chem (2007) 0.99

A novel intermediate in transcription initiation by human mitochondrial RNA polymerase. Nucleic Acids Res (2014) 0.98

Model of the Mediator middle module based on protein cross-linking. Nucleic Acids Res (2013) 0.98

Archaeal transcription: function of an alternative transcription factor B from Pyrococcus furiosus. J Bacteriol (2007) 0.97

Structure of the mediator subunit cyclin C and its implications for CDK8 function. J Mol Biol (2005) 0.97

Evolution of two modes of intrinsic RNA polymerase transcript cleavage. J Biol Chem (2011) 0.97

Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization. Nucleic Acids Res (2011) 0.96

Impact of molecular processing in the hinge region of therapeutic IgG4 antibodies on disposition profiles in cynomolgus monkeys. Drug Metab Dispos (2010) 0.96

A conformational switch underlies ClpP protease function. Angew Chem Int Ed Engl (2011) 0.96

RNA polymerase III subunit architecture and implications for open promoter complex formation. Proc Natl Acad Sci U S A (2012) 0.96

Preparation and topology of the Mediator middle module. Nucleic Acids Res (2010) 0.95

Different frameshift mutation spectra in non-repetitive DNA of MutSalpha- and MutLalpha-deficient fission yeast cells. DNA Repair (Amst) (2003) 0.94

Site specific phosphorylation of yeast RNA polymerase I. Nucleic Acids Res (2007) 0.94

Biogenesis of multisubunit RNA polymerases. Trends Biochem Sci (2012) 0.94