PubRank

Nigel Mackman

Author PubWeight™ 173.66‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 2003 9.12
2 The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 2002 4.28
3 Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med 2012 3.63
4 Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. J Exp Med 2007 3.35
5 Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall. Blood 2004 3.31
6 Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis. Blood 2004 2.41
7 Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation. J Clin Invest 2008 2.39
8 Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets. J Exp Med 2006 2.39
9 TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and -independent pathways. J Immunol 2007 2.32
10 Microparticles in hemostasis and thrombosis. Circ Res 2011 2.26
11 Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia. Blood 2003 2.20
12 Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation. Blood 2004 2.16
13 Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice. Blood 2010 2.10
14 The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Nat Med 2003 1.98
15 Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy. Circulation 2007 1.97
16 Role of tissue factor in cancer. J Clin Oncol 2009 1.91
17 Regulation of tissue factor--mediated initiation of the coagulation cascade by cell surface grp78. Arterioscler Thromb Vasc Biol 2005 1.82
18 Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages. J Immunol 2008 1.74
19 PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice. Arterioscler Thromb Vasc Biol 2004 1.65
20 Chlamydia pneumoniae induces tissue factor expression in mouse macrophages via activation of Egr-1 and the MEK-ERK1/2 pathway. Circ Res 2003 1.59
21 Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1. Circ Res 2008 1.55
22 Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease. Blood 2014 1.53
23 Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. J Clin Invest 2012 1.51
24 Protease-activated receptor-2 regulates the innate immune response to viral infection in a coxsackievirus B3-induced myocarditis. J Am Coll Cardiol 2013 1.50
25 Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood 2007 1.49
26 Monocytic microparticles activate endothelial cells in an IL-1β-dependent manner. Blood 2011 1.48
27 PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of FcγRI. Blood 2012 1.48
28 Critical review of mouse models of venous thrombosis. Arterioscler Thromb Vasc Biol 2012 1.46
29 Increased microparticle tissue factor activity in cancer patients with Venous Thromboembolism. Thromb Res 2009 1.43
30 Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C. J Immunol 2005 1.36
31 Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation. Blood 2012 1.34
32 Vascular smooth muscle-derived tissue factor is critical for arterial thrombosis after ferric chloride-induced injury. Blood 2008 1.32
33 Role of tissue factor in haemostasis, thrombosis, angiogenesis and inflammation: lessons from low tissue factor mice. Thromb Haemost 2004 1.28
34 A balance between tissue factor and tissue factor pathway inhibitor is required for embryonic development and hemostasis in adult mice. Blood 2004 1.26
35 Platelet ITAM signaling is critical for vascular integrity in inflammation. J Clin Invest 2013 1.24
36 Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome. J Clin Invest 2008 1.23
37 Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice. Hepatology 2007 1.23
38 Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity. Cancer Res 2009 1.22
39 Tissue factor in hemostasis and thrombosis. Semin Thromb Hemost 2006 1.21
40 Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer. Blood 2012 1.20
41 Tissue factor regulation by epidermal growth factor receptor and epithelial-to-mesenchymal transitions: effect on tumor initiation and angiogenesis. Cancer Res 2008 1.19
42 Tumor-derived tissue factor-positive microparticles and venous thrombosis in cancer patients. Blood 2013 1.19
43 Factor XIII activity mediates red blood cell retention in venous thrombi. J Clin Invest 2014 1.18
44 Tissue factor deficiency and PAR-1 deficiency are protective against renal ischemia reperfusion injury. Blood 2006 1.18
45 Tissue factor and its measurement in whole blood, plasma, and microparticles. Semin Thromb Hemost 2010 1.17
46 Oncogenes, trousseau syndrome, and cancer-related changes in the coagulome of mice and humans. Cancer Res 2006 1.16
47 COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. J Exp Med 2007 1.16
48 Tissue factor and thrombosis: The clot starts here. Thromb Haemost 2010 1.16
49 Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms. Cancer Res 2006 1.13
50 Tissue factor, coagulation proteases, and protease-activated receptors in endotoxemia and sepsis. Crit Care Med 2004 1.12
51 Regulation of tissue factor and inflammatory mediators by Egr-1 in a mouse endotoxemia model. Blood 2003 1.11
52 Induction of tissue factor expression in human endothelial cells by CD40 ligand is mediated via activator protein 1, nuclear factor kappa B, and Egr-1. J Biol Chem 2002 1.11
53 PAR-1 contributes to the innate immune response during viral infection. J Clin Invest 2013 1.09
54 Role of tissue factor in venous thrombosis. Annu Rev Physiol 2011 1.09
55 Cellular sources of tissue factor in endotoxemia and sepsis. Thromb Res 2010 1.09
56 Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway. J Biol Chem 2008 1.08
57 Contribution of host-derived tissue factor to tumor neovascularization. Arterioscler Thromb Vasc Biol 2008 1.08
58 Insulin activation of the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway reduces lipopolysaccharide-induced inflammation in mice. J Pharmacol Exp Ther 2008 1.07
59 Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice. Am J Physiol Gastrointest Liver Physiol 2009 1.07
60 Tissue Factor and Atherothrombosis. J Atheroscler Thromb 2015 1.05
61 Tissue factor-activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy. Cancer Res 2011 1.04
62 Detection of endogenous tissue factor levels in plasma using the calibrated automated thrombogram assay. Thromb Res 2009 1.04
63 Coagulation activation and microparticle-associated coagulant activity in cancer patients. An exploratory prospective study. Thromb Haemost 2012 1.04
64 Tissue factor activity is increased in a combined platelet and microparticle sample from cancer patients. Thromb Res 2008 1.04
65 TLR4/CD14-mediated PI3K activation is an essential component of interferon-dependent VSV resistance in macrophages. Mol Immunol 2008 1.02
66 Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies. Blood 2009 1.01
67 Protease-activated receptor 2 deficiency reduces cardiac ischemia/reperfusion injury. Arterioscler Thromb Vasc Biol 2010 1.00
68 Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica. J Immunol 2011 1.00
69 RASA3 is a critical inhibitor of RAP1-dependent platelet activation. J Clin Invest 2015 0.99
70 Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress. Thorax 2012 0.99
71 Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-alpha expression in macrophages by reducing IL-10 expression. Mol Immunol 2009 0.99
72 Alternatively spliced tissue factor - one cut too many? Thromb Haemost 2007 0.98
73 Protease-activated receptors and myocardial infarction. IUBMB Life 2011 0.98
74 β-adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells. Circulation 2012 0.97
75 Circulating microparticle tissue factor, thromboembolism and survival in pancreaticobiliary cancers. Thromb Res 2013 0.97
76 Potent inhibition of thrombin with a monoclonal antibody against tissue factor (Sunol-cH36): results of the PROXIMATE-TIMI 27 trial. Eur Heart J 2005 0.97
77 Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet. Am J Pathol 2011 0.96
78 Lipopolysaccharide inhibition of glucose production through the Toll-like receptor-4, myeloid differentiation factor 88, and nuclear factor kappa b pathway. Hepatology 2009 0.96
79 NF-kappaB transcription factor p50 critically regulates tissue factor in deep vein thrombosis. J Biol Chem 2008 0.95
80 The role of tumor-and host-related tissue factor pools in oncogene-driven tumor progression. Thromb Res 2007 0.95
81 Protease-activated receptors mediate crosstalk between coagulation and fibrinolysis. Blood 2010 0.95
82 Tissue factor and thrombin mediate myocardial ischemia-reperfusion injury. Ann Thorac Surg 2003 0.94
83 Multiple roles of the coagulation protease cascade during virus infection. Blood 2014 0.94
84 On the trail of microparticles. Circ Res 2009 0.93
85 Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease. Blood 2012 0.93
86 Eculizumab therapy results in rapid and sustained decreases in markers of thrombin generation and inflammation in patients with PNH independent of its effects on hemolysis and microparticle formation. Thromb Res 2012 0.93
87 Anthracycline treatment of the human monocytic leukemia cell line THP-1 increases phosphatidylserine exposure and tissue factor activity. Thromb Res 2011 0.91
88 Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations. Proc Natl Acad Sci U S A 2014 0.91
89 Coagulation, protease-activated receptors, and viral myocarditis. J Cardiovasc Transl Res 2013 0.91
90 Hepatocyte tissue factor activates the coagulation cascade in mice. Blood 2013 0.90
91 Microparticles and cancer. Pathophysiol Haemost Thromb 2009 0.89
92 Microvesicles as risk markers for venous thrombosis. Expert Rev Hematol 2013 0.89
93 Sources of tissue factor that contribute to thrombosis after rupture of an atherosclerotic plaque. Thromb Res 2012 0.88
94 Role of coagulation factors in cerebral venous sinus and cerebral microvascular thrombosis. Neurosurgery 2010 0.88
95 Tissue factor in health and disease. Front Biosci (Elite Ed) 2012 0.87
96 Atherosclerosis in mice is not affected by a reduction in tissue factor expression. Arterioscler Thromb Vasc Biol 2005 0.87
97 Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver injury. Toxicol Sci 2010 0.87
98 Venous thromboembolism: a need for more public awareness and research into mechanisms. Arterioscler Thromb Vasc Biol 2008 0.87
99 Role of tissue factor in atherothrombosis. Curr Atheroscler Rep 2012 0.86
100 Microparticle-associated tissue factor activity in patients with pancreatic cancer: correlation with clinicopathological features. Eur J Clin Invest 2013 0.86
101 A novel class of antioxidants inhibit LPS induction of tissue factor by selective inhibition of the activation of ASK1 and MAP kinases. Arterioscler Thromb Vasc Biol 2007 0.86
102 Venous thromboembolism in multiple myeloma: current perspectives in pathogenesis. Eur J Cancer 2010 0.84
103 Effect of PAR-2 Deficiency in Mice on KC Expression after Intratracheal LPS Administration. J Signal Transduct 2011 0.84
104 The development of cardiac fibrosis in low tissue factor mice is gender-dependent and is associated with differential regulation of urokinase plasminogen activator. J Mol Cell Cardiol 2007 0.84
105 Interleukin-10 suppresses tissue factor expression in lipopolysaccharide-stimulated macrophages via inhibition of Egr-1 and a serum response element/MEK-ERK1/2 pathway. Circ Res 2005 0.84
106 Impact of chemotherapy on thrombin generation and on the protein C pathway in breast cancer patients. Pathophysiol Haemost Thromb 2011 0.83
107 Fibrin facilitates both innate and T cell-mediated defense against Yersinia pestis. J Immunol 2013 0.83
108 Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice. Toxicol Appl Pharmacol 2010 0.83
109 Genetic susceptibility to thrombosis. Curr Atheroscler Rep 2006 0.83
110 Mouse models in haemostasis and thrombosis. Thromb Haemost 2004 0.82
111 Dexamethasone enhances LPS induction of tissue factor expression in human monocytic cells by increasing tissue factor mRNA stability. J Leukoc Biol 2004 0.82
112 Factor VIIa and tissue factor--from cell biology to animal models. Thromb Res 2010 0.82
113 Mice deficient in tissue factor demonstrate attenuated intimal hyperplasia in response to vascular injury and decreased smooth muscle cell migration. Thromb Haemost 2004 0.82
114 Platelet tissue factor: to be or not to be. Thromb Res 2013 0.82
115 Wound healing in hemophilia B mice and low tissue factor mice. Thromb Res 2010 0.81
116 Prothrombotic mechanisms and anticoagulant therapy in dogs with immune-mediated hemolytic anemia. J Vet Emerg Crit Care (San Antonio) 2013 0.81
117 Use of mouse models to study the role of tissue factor in tumor biology. Semin Thromb Hemost 2008 0.81
118 Dysregulated coagulation associated with hypofibrinogenaemia and plasma hypercoagulability: implications for identifying coagulopathic mechanisms in humans. Thromb Haemost 2012 0.81
119 Blood coagulation and blood vessel development: is tissue factor the missing link? Arterioscler Thromb Vasc Biol 2011 0.81
120 Protease activated receptor-2 contributes to heart failure. PLoS One 2013 0.81
121 MPs or ICs? Blood 2011 0.80
122 MP's and VTE's: Fact or fiction. Thromb Res 2011 0.79
123 Tissue factor and tissue factor pathway inhibitor as key regulators of global hemostasis: measurement of their levels in coagulation assays. Semin Thromb Hemost 2010 0.79
124 Circulating microparticle tissue factor activity is increased in patients with cirrhosis. Hepatology 2014 0.79
125 The antithrombotic effects of statins. Annu Rev Med 2014 0.79
126 A non-anticoagulant synthetic pentasaccharide reduces inflammation in a murine model of kidney ischemia-reperfusion injury. Thromb Haemost 2006 0.78
127 Uremic serum and ubiquitylation of tissue factor. Circulation 2012 0.78
128 Regulation of thrombin-induced plasminogen activator inhibitor-1 in 4T1 murine breast cancer cells. Blood Coagul Fibrinolysis 2011 0.78
129 Validation of a novel tissue factor assay in experimental human endotoxemia. Thromb Res 2003 0.78
130 The contribution of tumor and host tissue factor expression to oncogene-driven gliomagenesis. Biochem Biophys Res Commun 2014 0.78
131 Postprandial elevation of tissue factor antigen in the blood of healthy adults. Thromb Haemost 2005 0.78
132 2011 Nobel Prize in Physiology or Medicine: Toll-like receptors, dendritic cells, and their roles in atherosclerosis. Arterioscler Thromb Vasc Biol 2011 0.78
133 PML/RARalpha plays a role for basal activity and retinoid-induced repression of the tissue factor promoter in acute promyelocytic leukemia cells. Thromb Haemost 2003 0.78
134 Del-etion of microvesicles from the circulation. Circulation 2012 0.77
135 Protease-Activated Receptor 1 Enhances Poly I:C Induction of the Antiviral Response in Macrophages and Mice. J Innate Immun 2016 0.77
136 Myeloid cell tissue factor does not contribute to venous thrombogenesis in an electrolytic injury model. Thromb Res 2011 0.77
137 Protease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation. Cardiology 2016 0.76
138 Tissue factor and factor VIIa: understanding the molecular mechanism. Thromb Res 2008 0.76
139 Does tissue factor expression by vascular smooth muscle cells provide a link between C-reactive protein and cardiovascular disease? Arterioscler Thromb Vasc Biol 2008 0.76
140 How do oxidized phospholipids inhibit LPS signaling? Arterioscler Thromb Vasc Biol 2003 0.76
141 Comment on "tissue factor-dependent chemokine production aggravates experimental colitis". Mol Med 2011 0.75
142 Microvesicle Tissue Factor Activity and Interleukin-8 Levels are Associated with Mortality in Patients with Influenza A/H1N1 Infection. Crit Care Med 2016 0.75
143 Venous thromboembolism: risk factors, biomarkers, and treatment. Arterioscler Thromb Vasc Biol 2009 0.75
144 Effects of enalapril on disseminated intravascular thrombin formation during systemic inflammation. Cardiovasc Res 2003 0.75
145 Safety and efficacy of thrombin-JMI: a multidisciplinary expert group consensus. Clin Appl Thromb Hemost 2010 0.75