Published in Proc Natl Acad Sci U S A on January 30, 2009
A Family of non-GPCR Chemosensors Defines an Alternative Logic for Mammalian Olfaction. Cell (2016) 1.49
An olfactory subsystem that detects carbon disulfide and mediates food-related social learning. Curr Biol (2010) 1.44
Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans. Proc Natl Acad Sci U S A (2010) 1.42
Guanylyl cyclase structure, function and regulation. Cell Signal (2011) 1.40
Temperature, oxygen, and salt-sensing neurons in C. elegans are carbon dioxide sensors that control avoidance behavior. Neuron (2011) 1.30
Central functions of bicarbonate in S-type anion channel activation and OST1 protein kinase in CO2 signal transduction in guard cell. EMBO J (2011) 1.25
Physiological carbon dioxide, bicarbonate, and pH sensing. Pflugers Arch (2010) 1.18
Mammalian pheromones. Annu Rev Physiol (2013) 1.16
Carbon dioxide-sensing in organisms and its implications for human disease. Cell Mol Life Sci (2013) 1.10
Stimulation of guanylyl cyclase-D by bicarbonate. Biochemistry (2009) 1.09
Olfactory receptors: G protein-coupled receptors and beyond. J Neurochem (2009) 1.08
Sensing, physiological effects and molecular response to elevated CO2 levels in eukaryotes. J Cell Mol Med (2009) 1.06
Receptor guanylyl cyclases in mammalian olfactory function. Mol Cell Biochem (2009) 1.04
Olfactory mechanisms of stereotyped behavior: on the scent of specialized circuits. Curr Opin Neurobiol (2010) 1.03
Elevated carbon dioxide blunts mammalian cAMP signaling dependent on inositol 1,4,5-triphosphate receptor-mediated Ca2+ release. J Biol Chem (2012) 1.02
A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity. PLoS One (2012) 1.00
Mammalian olfactory receptors. Front Cell Neurosci (2009) 0.99
Out of thin air: sensory detection of oxygen and carbon dioxide. Neuron (2011) 0.98
Grueneberg ganglion olfactory subsystem employs a cGMP signaling pathway. J Comp Neurol (2009) 0.96
Distinct ONE-GC transduction modes and motifs of the odorants: Uroguanylin and CO(2). Biochem Biophys Res Commun (2009) 0.91
A chemoreceptor that detects molecular carbon dioxide. J Biol Chem (2013) 0.91
Physiological sensing of carbon dioxide/bicarbonate/pH via cyclic nucleotide signaling. Sensors (Basel) (2011) 0.87
Allosteric modification, the primary ATP activation mechanism of atrial natriuretic factor receptor guanylate cyclase. Biochemistry (2011) 0.86
Functional and evolutionary aspects of chemoreceptors. Front Cell Neurosci (2012) 0.84
Ca(2+)-sensors and ROS-GC: interlocked sensory transduction elements: a review. Front Mol Neurosci (2012) 0.84
A bicarbonate cofactor modulates 1,4-dihydroxy-2-naphthoyl-coenzyme a synthase in menaquinone biosynthesis of Escherichia coli. J Biol Chem (2010) 0.83
Ca(2+) sensor GCAP1: A constitutive element of the ONE-GC-modulated odorant signal transduction pathway. Biochemistry (2010) 0.83
A novel role for the zinc-finger transcription factor EGL-46 in the differentiation of gas-sensing neurons in Caenorhabditis elegans. Genetics (2014) 0.83
The neurobiology of sensing respiratory gases for the control of animal behavior. Front Biol (Beijing) (2012) 0.82
Environmental CO2 inhibits Caenorhabditis elegans egg-laying by modulating olfactory neurons and evokes widespread changes in neural activity. Proc Natl Acad Sci U S A (2015) 0.81
A new Rac/PAK/GC/cGMP signaling pathway. Mol Cell Biochem (2009) 0.81
Role of Receptor Protein Tyrosine Phosphatase γ in Sensing Extracellular CO2 and HCO3. J Am Soc Nephrol (2016) 0.81
Effect of acute acid-base disturbances on ErbB1/2 tyrosine phosphorylation in rabbit renal proximal tubules. Am J Physiol Renal Physiol (2013) 0.80
Molecular and neuronal homology between the olfactory systems of zebrafish and mouse. Sci Rep (2015) 0.79
High density and ligand affinity confer ultrasensitive signal detection by a guanylyl cyclase chemoreceptor. J Cell Biol (2014) 0.79
The response to high CO2 levels requires the neuropeptide secretion component HID-1 to promote pumping inhibition. PLoS Genet (2014) 0.79
Bicarbonate Modulates Photoreceptor Guanylate Cyclase (ROS-GC) Catalytic Activity. J Biol Chem (2015) 0.79
Ca(2+) modulation of ANF-RGC: new signaling paradigm interlocked with blood pressure regulation. Biochemistry (2012) 0.78
Defying the stereotype: non-canonical roles of the Peptide hormones guanylin and uroguanylin. Front Endocrinol (Lausanne) (2011) 0.76
The human olfactory transcriptome. BMC Genomics (2016) 0.76
Integrative Signaling Networks of Membrane Guanylate Cyclases: Biochemistry and Physiology. Front Mol Neurosci (2016) 0.76
The ANF-RGC gene motif (669)WTAPELL(675) is vital for blood pressure regulation: biochemical mechanism. Biochemistry (2013) 0.76
Chronic immobilization stress occludes in vivo cortical activation in an animal model of panic induced by carbon dioxide inhalation. Front Behav Neurosci (2014) 0.76
Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase from the crotonase fold superfamily. PLoS One (2013) 0.76
Olfactory carbon dioxide detection by insects and other animals. Mol Cells (2013) 0.75
Insect olfactory receptors are heteromeric ligand-gated ion channels. Nature (2008) 6.13
Two chemosensory receptors together mediate carbon dioxide detection in Drosophila. Nature (2006) 5.74
Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels. Nature (2008) 5.38
Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science (2000) 5.36
A single population of olfactory sensory neurons mediates an innate avoidance behaviour in Drosophila. Nature (2004) 4.52
A genome-wide survey of human pseudogenes. Genome Res (2003) 4.34
Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions. Endocr Rev (2005) 3.80
The molecular basis of CO2 reception in Drosophila. Proc Natl Acad Sci U S A (2007) 3.73
Guanylyl cyclase is a heat-stable enterotoxin receptor. Cell (1990) 3.31
Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. Proc Natl Acad Sci U S A (1999) 3.26
A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor. Nature (1989) 3.21
Guanylin: an endogenous activator of intestinal guanylate cyclase. Proc Natl Acad Sci U S A (1992) 2.92
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment. Nat Struct Mol Biol (2004) 2.52
Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol Pharmacol (1996) 2.27
Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse. Science (2007) 2.18
Acute carbon dioxide avoidance in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2008) 1.97
Fluorescent sensors for rapid monitoring of intracellular cGMP. Nat Methods (2006) 1.96
A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway. Proc Natl Acad Sci U S A (1997) 1.95
Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium. Proc Natl Acad Sci U S A (2007) 1.88
A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons. Proc Natl Acad Sci U S A (1995) 1.77
Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase. Proc Natl Acad Sci U S A (1993) 1.70
Two membrane forms of guanylyl cyclase found in the eye. Proc Natl Acad Sci U S A (1995) 1.57
Molecular cloning of a retina-specific membrane guanylyl cyclase. Neuron (1992) 1.56
The protein kinase domain of the ANP receptor is required for signaling. Science (1989) 1.54
A cGMP-signaling pathway in a subset of olfactory sensory neurons. Proc Natl Acad Sci U S A (2000) 1.48
Electrophysiological characterization of rat and mouse olfactory receptor neurons from an intact epithelial preparation. J Neurosci Methods (1999) 1.42
Encoding olfactory signals via multiple chemosensory systems. Crit Rev Biochem Mol Biol (2007) 1.22
Cloning and expression of guanylin. Its existence in various mammalian tissues. J Biol Chem (1992) 1.21
ONE-GC membrane guanylate cyclase, a trimodal odorant signal transducer. Biochem Biophys Res Commun (2008) 1.20
Conservation of the kinaselike regulatory domain is essential for activation of the natriuretic peptide receptor guanylyl cyclases. Mol Cell Biol (1992) 1.09
From odor and pheromone transduction to the organization of the sense of smell. Trends Neurosci (2001) 1.06
Axonal wiring of guanylate cyclase-D-expressing olfactory neurons is dependent on neuropilin 2 and semaphorin 3F. Development (2007) 1.00
Degeneration of the olfactory guanylyl cyclase D gene during primate evolution. PLoS One (2007) 0.96
Real-time monitoring of nasal mucosal pH during carbon dioxide stimulation: implications for stimulus dynamics. Chem Senses (2003) 0.95
Calcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neurons. J Neurosci (1998) 0.95
The second messenger cascade in olfactory receptor neurons. Curr Opin Neurobiol (1991) 0.91
Olfactory CO(2) chemoreceptors. Respir Physiol (2001) 0.87
Determination of carbon dioxide detection thresholds in trained rats. Physiol Behav (1991) 0.84
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell (2012) 6.56
RTP family members induce functional expression of mammalian odorant receptors. Cell (2004) 4.09
Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nat Methods (2011) 4.02
Genetic variation in a human odorant receptor alters odour perception. Nature (2007) 3.30
Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A (2006) 3.24
Odor coding by a Mammalian receptor repertoire. Sci Signal (2009) 2.84
Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse. Science (2007) 2.18
Habenula "cholinergic" neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes. Neuron (2011) 2.14
Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5. Mol Cell (2006) 2.02
Precise circuitry links bilaterally symmetric olfactory maps. Neuron (2008) 1.84
Synergism of accessory factors in functional expression of mammalian odorant receptors. J Biol Chem (2007) 1.80
Dual functions of mammalian olfactory sensory neurons as odor detectors and mechanical sensors. Nat Neurosci (2007) 1.71
The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse. Chem Senses (2007) 1.63
Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol. Chem Senses (2012) 1.63
Evaluating cell-surface expression and measuring activation of mammalian odorant receptors in heterologous cells. Nat Protoc (2008) 1.54
Odor information processing by the olfactory bulb analyzed in gene-targeted mice. Neuron (2010) 1.51
Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively. J Neurosci (2013) 1.48
G protein G(alpha)o is essential for vomeronasal function and aggressive behavior in mice. Proc Natl Acad Sci U S A (2011) 1.41
Optogenetic activation of basal forebrain cholinergic neurons modulates neuronal excitability and sensory responses in the main olfactory bulb. J Neurosci (2012) 1.32
Functional analysis of a mammalian odorant receptor subfamily. J Neurochem (2006) 1.30
Sour taste responses in mice lacking PKD channels. PLoS One (2011) 1.29
SR1, a mouse odorant receptor with an unusually broad response profile. J Neurosci (2009) 1.28
High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis. FASEB J (2009) 1.25
Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations. Mamm Genome (2006) 1.23
Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior. Science (2011) 1.19
Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1. EMBO Rep (2008) 1.19
Activation state of the M3 muscarinic acetylcholine receptor modulates mammalian odorant receptor signaling. Sci Signal (2011) 1.18
Receptors for bitter and sweet taste. Curr Opin Neurobiol (2002) 1.15
Functional evolution of mammalian odorant receptors. PLoS Genet (2012) 1.05
Neural detection of gases--carbon dioxide, oxygen--in vertebrates and invertebrates. Curr Opin Neurobiol (2009) 1.04
Calreticulin chaperones regulate functional expression of vomeronasal type 2 pheromone receptors. Proc Natl Acad Sci U S A (2011) 1.03
Diverse patterns of odor representation by neurons in the anterior piriform cortex of awake mice. J Neurosci (2010) 1.02
Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria. FASEB J (2009) 0.98
Promoted interaction of nuclear factor-κB with demethylated cystathionine-β-synthetase gene contributes to gastric hypersensitivity in diabetic rats. J Neurosci (2013) 0.97
Crucial role of copper in detection of metal-coordinating odorants. Proc Natl Acad Sci U S A (2012) 0.96
Postsynaptic potentiation of corticospinal projecting neurons in the anterior cingulate cortex after nerve injury. Mol Pain (2014) 0.94
Cortical-like functional organization of the pheromone-processing circuits in the medial amygdala. J Neurophysiol (2007) 0.93
General olfactory sensitivity database (GOSdb): candidate genes and their genomic variations. Hum Mutat (2012) 0.93
RNA-binding proteins SOP-2 and SOR-1 form a novel PcG-like complex in C. elegans. Development (2006) 0.92
Structural basis for the catalytic mechanism of phosphothreonine lyase. Nat Struct Mol Biol (2007) 0.92
Increasing glucose 6-phosphate dehydrogenase activity restores redox balance in vascular endothelial cells exposed to high glucose. PLoS One (2012) 0.91
Receptors, circuits, and behaviors: new directions in chemical senses. J Neurosci (2008) 0.89
Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates. Proc Natl Acad Sci U S A (2009) 0.89
Structural Insights into KChIP4a Modulation of Kv4.3 Inactivation. J Biol Chem (2008) 0.89
Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone. PLoS One (2012) 0.88
Electrophysiological analysis of a songbird basal ganglia circuit essential for vocal plasticity. Brain Res Bull (2002) 0.86
Synergistic toxic effect of nano-TiO and As(V) on Ceriodaphnia dubia. Sci Total Environ (2011) 0.84
Pharmacogenetic activation of midbrain dopaminergic neurons induces hyperactivity. Neurosci Bull (2013) 0.84
Metabolic effects of fluoxetine in adults with type 2 diabetes mellitus: a meta-analysis of randomized placebo-controlled trials. PLoS One (2011) 0.84
RAMP like proteins : RTP and REEP family of proteins. Adv Exp Med Biol (2012) 0.83
Common promoter elements in odorant and vomeronasal receptor genes. PLoS One (2011) 0.83
Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity. Proc Natl Acad Sci U S A (2012) 0.82
Receptor-transporting protein 1 short (RTP1S) mediates translocation and activation of odorant receptors by acting through multiple steps. J Biol Chem (2012) 0.82
Assaying surface expression of chemosensory receptors in heterologous cells. J Vis Exp (2011) 0.80
Electroacupuncture suppresses mechanical allodynia and nuclear factor κ B signaling in streptozotocin-induced diabetic rats. CNS Neurosci Ther (2012) 0.80
An imaging-based approach to identify ligands for olfactory receptors. Neuropharmacology (2004) 0.80
The Effects of Allopurinol on the Carotid Intima-media Thickness in Patients with Type 2 Diabetes and Asymptomatic Hyperuricemia: A Three-year Randomized Parallel-controlled Study. Intern Med (2015) 0.79
Synergistic toxic effect of nano-Al2O3 and As(V) on Ceriodaphnia dubia. Environ Pollut (2011) 0.79
The value of an acute octreotide suppression test in predicting short-term efficacy of somatostatin analogues in acromegaly. Endocr J (2016) 0.78
Studies on the sorption of tetracycline onto clays and marine sediment from seawater. J Colloid Interface Sci (2010) 0.77
De novo mutation of PHEX in a type 1 diabetes patient. J Pediatr Endocrinol Metab (2016) 0.77
Relationship between platelet volume indices with macrovascular and peripheral neuropathy complications in type 2 diabetic patients. J Diabetes (2013) 0.77
Taste perception: how sweet it is (to be transcribed by you). Curr Biol (2009) 0.77
Unfolding the mystery of olfactory receptor gene expression. Dev Cell (2013) 0.76
N-acetyl-L-cysteine inhibits wear particle-induced prosthesis loosening. J Surg Res (2011) 0.76
Aldehyde recognition and discrimination by mammalian odorant receptors via functional group-specific hydration chemistry. ACS Chem Biol (2014) 0.75
Chemoreception scientists gather under the Florida sun: The 31st Annual Association for Chemoreception Sciences meeting. Ann N Y Acad Sci (2009) 0.75
Purinergic P2X receptors and diabetic neuropathic pain. Sheng Li Xue Bao (2012) 0.75
Sagittal component alignment is less reliable than coronal component alignment in a Chinese population undergoing navigated TKA. J Orthop Surg Res (2014) 0.75
A protocol for heterologous expression and functional assay for mouse pheromone receptors. Methods Mol Biol (2013) 0.75
Correction: Increased autophagy in fibroblast-like synoviocytes leads to immune enhancement potential in rheumatoid arthritis. Oncotarget (2017) 0.75
A novel mutation in the glutamate dehydrogenase (GLUD1) of a patient with congenital hyperinsulinism-hyperammonemia (HI/HA). J Pediatr Endocrinol Metab (2016) 0.75
Selectively metallized polymeric substrates by microcontact printing an aluminum(III) porphyrin complex. J Am Chem Soc (2010) 0.75
Numerical assessment of the reduction of specific absorption rate by adding high dielectric materials for fetus MRI at 3 T. Biomed Tech (Berl) (2016) 0.75
2-D graphical representation for characteristic sequences of DNA and its application. J Biochem Mol Biol (2006) 0.75
The role of metals in mammalian olfaction of low molecular weight organosulfur compounds. Nat Prod Rep (2017) 0.75
External fixator followed by a plate for distraction, reduction, and fixation in neglected femoral diaphyseal fractures. Injury (2013) 0.75
Next-generation sequencing of the human olfactory receptors. Methods Mol Biol (2013) 0.75
[Investigation of urinary cadmium characteristics of the general population in three non-cadmium-polluted rural areas in China]. Wei Sheng Yan Jiu (2014) 0.75