Published in Clin Microbiol Rev on July 01, 2010
Treating Clostridium difficile infection with fecal microbiota transplantation. Clin Gastroenterol Hepatol (2011) 3.81
Clostridium difficile infection: epidemiology, risk factors and management. Nat Rev Gastroenterol Hepatol (2010) 2.61
Microevolutionary analysis of Clostridium difficile genomes to investigate transmission. Genome Biol (2012) 2.04
Diagnosis of Clostridium difficile infection: an ongoing conundrum for clinicians and for clinical laboratories. Clin Microbiol Rev (2013) 1.85
High-throughput DNA sequence analysis reveals stable engraftment of gut microbiota following transplantation of previously frozen fecal bacteria. Gut Microbes (2013) 1.85
Role of the intestinal microbiota in resistance to colonization by Clostridium difficile. Gastroenterology (2014) 1.77
Evaluation of a loop-mediated isothermal amplification assay for diagnosis of Clostridium difficile infections. J Clin Microbiol (2011) 1.62
A modified R-type bacteriocin specifically targeting Clostridium difficile prevents colonization of mice without affecting gut microbiota diversity. MBio (2015) 1.59
Predictors of first recurrence of Clostridium difficile infection: implications for initial management. Clin Infect Dis (2012) 1.51
Clostridium difficile has two parallel and essential Sec secretion systems. J Biol Chem (2011) 1.50
Multiple factors modulate biofilm formation by the anaerobic pathogen Clostridium difficile. J Bacteriol (2012) 1.47
Clostridium difficile carriage in elderly subjects and associated changes in the intestinal microbiota. J Clin Microbiol (2011) 1.34
Comparative susceptibilities to fidaxomicin (OPT-80) of isolates collected at baseline, recurrence, and failure from patients in two phase III trials of fidaxomicin against Clostridium difficile infection. Antimicrob Agents Chemother (2011) 1.33
Genetic organisation, mobility and predicted functions of genes on integrated, mobile genetic elements in sequenced strains of Clostridium difficile. PLoS One (2011) 1.29
Global analysis of the sporulation pathway of Clostridium difficile. PLoS Genet (2013) 1.24
Appraising contemporary strategies to combat multidrug resistant gram-negative bacterial infections--proceedings and data from the Gram-Negative Resistance Summit. Clin Infect Dis (2011) 1.22
Anti-infective activities of lactobacillus strains in the human intestinal microbiota: from probiotics to gastrointestinal anti-infectious biotherapeutic agents. Clin Microbiol Rev (2014) 1.17
Breakthroughs in the treatment and prevention of Clostridium difficile infection. Nat Rev Gastroenterol Hepatol (2016) 1.13
Evaluation of three enzyme immunoassays and a loop-mediated isothermal amplification test for the laboratory diagnosis of Clostridium difficile infection. Eur J Clin Microbiol Infect Dis (2012) 1.12
The Clostridium difficile cell wall protein CwpV is antigenically variable between strains, but exhibits conserved aggregation-promoting function. PLoS Pathog (2011) 1.11
Epidemiology of Clostridium difficile infection. J Pharm Pract (2013) 1.10
Impact of change to molecular testing for Clostridium difficile infection on healthcare facility-associated incidence rates. Infect Control Hosp Epidemiol (2013) 1.10
Using a dog's superior olfactory sensitivity to identify Clostridium difficile in stools and patients: proof of principle study. BMJ (2012) 1.08
Asymptomatic Clostridium difficile colonisation and onward transmission. PLoS One (2013) 1.07
Adverse drug reactions in special populations - the elderly. Br J Clin Pharmacol (2015) 1.07
Clostridium difficile infection: epidemiology, diagnosis and understanding transmission. Nat Rev Gastroenterol Hepatol (2016) 1.03
Resistant starch diet induces change in the swine microbiome and a predominance of beneficial bacterial populations. Microbiome (2015) 1.01
Community-associated Clostridium difficile infections, Monroe County, New York, USA. Emerg Infect Dis (2012) 1.01
Clostridium difficile prevalence rates in a large healthcare system stratified according to patient population, age, gender, and specimen consistency. Eur J Clin Microbiol Infect Dis (2011) 1.01
An enhanced DNA fingerprinting service to investigate potential Clostridium difficile infection case clusters sharing the same PCR ribotype. J Clin Microbiol (2011) 1.00
Evidence of in vivo prophage induction during Clostridium difficile infection. Appl Environ Microbiol (2012) 1.00
Spo0A differentially regulates toxin production in evolutionarily diverse strains of Clostridium difficile. PLoS One (2013) 0.99
Clostridium difficile infection. Nat Rev Dis Prim (2016) 0.99
C. difficile 630Δerm Spo0A regulates sporulation, but does not contribute to toxin production, by direct high-affinity binding to target DNA. PLoS One (2012) 0.98
Roles of cysteine proteases Cwp84 and Cwp13 in biogenesis of the cell wall of Clostridium difficile. J Bacteriol (2011) 0.98
Clostridium difficile is an autotrophic bacterial pathogen. PLoS One (2013) 0.97
Multiplex PCR method for detection of Clostridium difficile tcdA, tcdB, cdtA, and cdtB and internal in-frame deletion of tcdC. J Clin Microbiol (2011) 0.96
High prevalence of Clostridium difficile colonization among nursing home residents in Hesse, Germany. PLoS One (2012) 0.96
The membrane as a target for controlling hypervirulent Clostridium difficile infections. J Antimicrob Chemother (2012) 0.96
Fecal microbiota transplantation broadening its application beyond intestinal disorders. World J Gastroenterol (2015) 0.96
Clostridium difficile exposure as an insidious source of infection in healthcare settings: an epidemiological model. BMC Infect Dis (2013) 0.96
Rapid diagnosis of Clostridium difficile infection by multiplex real-time PCR. Eur J Clin Microbiol Infect Dis (2011) 0.96
Mechanisms of hypervirulent Clostridium difficile ribotype 027 displacement of endemic strains: an epidemiological model. Sci Rep (2015) 0.96
Immune responses to Clostridium difficile infection. Trends Mol Med (2012) 0.95
Recent advances in the understanding of antibiotic resistance in Clostridium difficile infection. Ther Adv Infect Dis (2016) 0.95
Diversity and Evolution in the Genome of Clostridium difficile. Clin Microbiol Rev (2015) 0.94
Proteomic analysis of a NAP1 Clostridium difficile clinical isolate resistant to metronidazole. PLoS One (2014) 0.92
Epidemiology of Clostridium difficile infection and risk factors for unfavorable clinical outcomes: results of a hospital-based study in Barcelona, Spain. J Clin Microbiol (2013) 0.92
Identification of a Novel Lipoprotein Regulator of Clostridium difficile Spore Germination. PLoS Pathog (2015) 0.91
Clostridium difficile PCR Ribotype 018, a Successful Epidemic Genotype. J Clin Microbiol (2015) 0.91
A case of toxic megacolon caused by clostridium difficile infection and treated with fecal microbiota transplantation. Gut Liver (2015) 0.91
Prevalence and duration of asymptomatic Clostridium difficile carriage among healthy subjects in Pittsburgh, Pennsylvania. J Clin Microbiol (2014) 0.91
Clostridium difficile Infection: Epidemiology, Pathogenesis, Risk Factors, and Therapeutic Options. Scientifica (Cairo) (2014) 0.91
ICU-Onset Clostridium difficile infection in a university hospital in China: a prospective cohort study. PLoS One (2014) 0.91
Bacteriotherapy for the treatment of intestinal dysbiosis caused by Clostridium difficile infection. Curr Opin Microbiol (2013) 0.90
Extended multilocus variable-number tandem-repeat analysis of Clostridium difficile correlates exactly with ribotyping and enables identification of hospital transmission. J Clin Microbiol (2011) 0.90
Prospects for flavonoid and related phytochemicals as nature-inspired treatments for Clostridium difficile infection. J Appl Microbiol (2014) 0.90
Sequence variation in tcdA and tcdB of Clostridium difficile: ST37 with truncated tcdA is a potential epidemic strain in China. J Clin Microbiol (2014) 0.90
Development and evaluation of a novel, semiautomated Clostridium difficile typing platform. J Clin Microbiol (2012) 0.90
Modified multiple-locus variable-number tandem-repeat analysis for rapid identification and typing of Clostridium difficile during institutional outbreaks. J Clin Microbiol (2011) 0.90
Real-time cellular analysis coupled with a specimen enrichment accurately detects and quantifies Clostridium difficile toxins in stool. J Clin Microbiol (2014) 0.89
Characterization of temperate phages infecting Clostridium difficile isolates of human and animal origins. Appl Environ Microbiol (2014) 0.89
Refractory Clostridium difficile Infection Successfully Treated with Tigecycline, Rifaximin, and Vancomycin. Case Rep Med (2012) 0.88
A randomised phase 1 study to investigate safety, pharmacokinetics and impact on gut microbiota following single and multiple oral doses in healthy male subjects of SMT19969, a novel agent for Clostridium difficile infections. BMC Infect Dis (2015) 0.87
Clostridium difficile in a HIV-infected cohort: incidence, risk factors, and clinical outcomes. AIDS (2013) 0.87
Clostridium difficile drug pipeline: challenges in discovery and development of new agents. J Med Chem (2015) 0.86
Clostridium difficile virulence factors: Insights into an anaerobic spore-forming pathogen. Gut Microbes (2014) 0.86
Prospective observational study comparing three different treatment regimes in patients with Clostridium difficile infection. Antimicrob Agents Chemother (2012) 0.86
Clostridium difficile--a moving target. F1000 Med Rep (2011) 0.85
Phenotypic and genotypic analysis of Clostridium difficile isolates: a single-center study. J Clin Microbiol (2014) 0.85
Comparative transcriptional analysis of clinically relevant heat stress response in Clostridium difficile strain 630. PLoS One (2012) 0.85
Development and validation of an internationally-standardized, high-resolution capillary gel-based electrophoresis PCR-ribotyping protocol for Clostridium difficile. PLoS One (2015) 0.85
Epidemiology, risk factors, and outcomes of Clostridium difficile infection in kidney transplant recipients. Transpl Infect Dis (2012) 0.84
Short-term genome stability of serial Clostridium difficile ribotype 027 isolates in an experimental gut model and recurrent human disease. PLoS One (2013) 0.84
Fecal transplant in refractory Clostridium difficile colitis. Dtsch Arztebl Int (2013) 0.83
Mode of action and bactericidal properties of surotomycin against growing and nongrowing Clostridium difficile. Antimicrob Agents Chemother (2015) 0.83
New role for human α-defensin 5 in the fight against hypervirulent Clostridium difficile strains. Infect Immun (2014) 0.83
Toxigenic Clostridium difficile PCR ribotypes from wastewater treatment plants in southern Switzerland. Appl Environ Microbiol (2012) 0.83
Hype or hypervirulence: a reflection on problematic C. difficile strains. Virulence (2013) 0.83
Bacteriophage Combinations Significantly Reduce Clostridium difficile Growth In Vitro and Proliferation In Vivo. Antimicrob Agents Chemother (2015) 0.83
Biofilm formation of Clostridium difficile and susceptibility to Manuka honey. BMC Complement Altern Med (2014) 0.82
Clostridium difficile infection in Chilean patients submitted to hematopoietic stem cell transplantation. Rev Bras Hematol Hemoter (2015) 0.82
Regulation of Clostridium difficile spore germination by the CspA pseudoprotease domain. Biochimie (2015) 0.82
Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control. BMC Syst Biol (2012) 0.82
Fecal Microbiota Transplantation Using Upper Gastrointestinal Tract for the Treatment of Refractory or Severe Complicated Clostridium difficile Infection in Elderly Patients in Poor Medical Condition: The First Study in an Asian Country. Gastroenterol Res Pract (2016) 0.81
Clostridium difficile infection seasonality: patterns across hemispheres and continents - a systematic review. PLoS One (2015) 0.81
Microbiome manipulation with faecal microbiome transplantation as a therapeutic strategy in Clostridium difficile infection. QJM (2014) 0.81
Glutamine and alanyl-glutamine increase RhoA expression and reduce Clostridium difficile toxin-a-induced intestinal epithelial cell damage. Biomed Res Int (2012) 0.80
A prediction model for Clostridium difficile recurrence. J Community Hosp Intern Med Perspect (2015) 0.80
Neutralization of Clostridium difficile Toxin B Mediated by Engineered Lactobacilli That Produce Single-Domain Antibodies. Infect Immun (2015) 0.80
Recurrent Clostridium difficile infection and the microbiome. J Gastroenterol (2015) 0.80
Multi-institution case-control and cohort study of risk factors for the development and mortality of Clostridium difficile infections in Japan. BMJ Open (2014) 0.80
Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole. Antimicrob Agents Chemother (2014) 0.80
Clostridium difficile infection diagnosis in a paediatric population: comparison of methodologies. Eur J Clin Microbiol Infect Dis (2014) 0.79
Comparative nutritional and chemical phenome of Clostridium difficile isolates determined using phenotype microarrays. Int J Infect Dis (2014) 0.79
The role of the humoral immune response to Clostridium difficile toxins A and B in susceptibility to C. difficile infection: a case-control study. Anaerobe (2014) 0.79
Asymptomatic carriers of toxigenic C. difficile in long-term care facilities: a meta-analysis of prevalence and risk factors. PLoS One (2015) 0.79
Clostridium difficile infection among hospitalized HIV-infected individuals: epidemiology and risk factors: results from a case-control study (2002-2013). BMC Infect Dis (2015) 0.79
Identification and characterization of glycoproteins on the spore surface of Clostridium difficile. J Bacteriol (2014) 0.79
An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med (2005) 18.10
A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med (2005) 16.59
Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe. Lancet (2005) 12.54
Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. CMAJ (2004) 9.93
Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003. Emerg Infect Dis (2006) 7.64
Emergence of fluoroquinolones as the predominant risk factor for Clostridium difficile-associated diarrhea: a cohort study during an epidemic in Quebec. Clin Infect Dis (2005) 7.16
Emergence of Clostridium difficile-associated disease in North America and Europe. Clin Microbiol Infect (2006) 6.90
Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease. JAMA (2005) 6.87
Outbreak of Clostridium difficile infection in a long-term care facility: association with gatifloxacin use. Clin Infect Dis (2004) 5.67
Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec. CMAJ (2005) 5.59
Toxin B is essential for virulence of Clostridium difficile. Nature (2009) 5.49
Recommendations for surveillance of Clostridium difficile-associated disease. Infect Control Hosp Epidemiol (2007) 5.37
A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use. Infect Control Hosp Epidemiol (2005) 5.26
Fulminant Clostridium difficile: an underappreciated and increasing cause of death and complications. Ann Surg (2002) 4.91
Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, Canada. Clin Infect Dis (2005) 4.89
Asymptomatic carriers are a potential source for transmission of epidemic and nonepidemic Clostridium difficile strains among long-term care facility residents. Clin Infect Dis (2007) 4.77
Narrative review: the new epidemic of Clostridium difficile-associated enteric disease. Ann Intern Med (2006) 4.64
Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole. Clin Infect Dis (2005) 4.42
The ClosTron: a universal gene knock-out system for the genus Clostridium. J Microbiol Methods (2007) 4.20
Diagnosis of Clostridium difficile infection by toxin detection kits: a systematic review. Lancet Infect Dis (2008) 4.07
Prospective, controlled, cross-over trial of alcohol-based hand gel in critical care units . Infect Control Hosp Epidemiol (2008) 4.03
Increase in adult Clostridium difficile-related hospitalizations and case-fatality rate, United States, 2000-2005. Emerg Infect Dis (2008) 3.88
Health care-associated Clostridium difficile infection in adults admitted to acute care hospitals in Canada: a Canadian Nosocomial Infection Surveillance Program Study. Clin Infect Dis (2009) 3.86
Risk factors for Clostridium difficile infection. J Hosp Infect (1998) 3.81
Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium. Genome Biol (2009) 3.66
Severe Clostridium difficile-associated disease in populations previously at low risk--four states, 2005. MMWR Morb Mortal Wkly Rep (2005) 3.60
Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078. Clin Infect Dis (2008) 3.49
Diarrhea etiology in a Children's Hospital Emergency Department: a prospective cohort study. Clin Infect Dis (2006) 3.43
The World Health Organization Guidelines on Hand Hygiene in Health Care and their consensus recommendations. Infect Control Hosp Epidemiol (2009) 3.40
Clostridium difficile infection caused by the epidemic BI/NAP1/027 strain. Gastroenterology (2009) 3.29
Prospective study of Clostridium difficile infections in Europe with phenotypic and genotypic characterisation of the isolates. Clin Microbiol Infect (2007) 3.27
Clostridium difficile--associated disease in a setting of endemicity: identification of novel risk factors. Clin Infect Dis (2007) 3.21
Comparison of nine commercially available Clostridium difficile toxin detection assays, a real-time PCR assay for C. difficile tcdB, and a glutamate dehydrogenase detection assay to cytotoxin testing and cytotoxigenic culture methods. J Clin Microbiol (2009) 3.18
Clostridium difficile-associated diarrhea and colitis in adults. A prospective case-controlled epidemiologic study. Arch Intern Med (1986) 3.06
A case-control study of community-associated Clostridium difficile infection. J Antimicrob Chemother (2008) 3.01
Control of an outbreak of infection with the hypervirulent Clostridium difficile BI strain in a university hospital using a comprehensive "bundle" approach. Clin Infect Dis (2007) 2.90
Epidemics of diarrhea caused by a clindamycin-resistant strain of Clostridium difficile in four hospitals. N Engl J Med (1999) 2.87
A portrait of the geographic dissemination of the Clostridium difficile North American pulsed-field type 1 strain and the epidemiology of C. difficile-associated disease in Québec. Clin Infect Dis (2006) 2.85
Prevalence of PCR ribotypes among Clostridium difficile isolates from pigs, calves, and other species. J Clin Microbiol (2007) 2.76
European Society of Clinical Microbiology and Infectious Diseases (ESCMID): data review and recommendations for diagnosing Clostridium difficile-infection (CDI). Clin Microbiol Infect (2009) 2.69
CodY, a global regulator of stationary phase and virulence in Gram-positive bacteria. Curr Opin Microbiol (2005) 2.56
Increasing prevalence and severity of Clostridium difficile colitis in hospitalized patients in the United States. Arch Surg (2007) 2.55
Decrease in nosocomial Clostridium difficile-associated diarrhea by restricting clindamycin use. Ann Intern Med (1994) 2.44
Update of Clostridium difficile infection due to PCR ribotype 027 in Europe, 2008. Euro Surveill (2008) 2.43
Comparison of clinical and microbiological response to treatment of Clostridium difficile-associated disease with metronidazole and vancomycin. Clin Infect Dis (2008) 2.37
Frequency of antibiotic-associated diarrhoea in 2462 antibiotic-treated hospitalized patients: a prospective study. J Antimicrob Chemother (2001) 2.35
Epidemiological features of Clostridium difficile-associated disease among inpatients at children's hospitals in the United States, 2001-2006. Pediatrics (2008) 2.31
Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria. PLoS Pathog (2009) 2.29
Pseudomembranous colitis associated with ciprofloxacin. Lancet (1990) 2.29
Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev (2005) 2.25
Clostridium difficile in retail meat products, USA, 2007. Emerg Infect Dis (2009) 2.24
Epidemiology of Clostridium difficile in infants. J Infect Dis (1982) 2.20
Molecular analysis of Clostridium difficile PCR ribotype 027 isolates from Eastern and Western Canada. J Clin Microbiol (2006) 2.18
Risk factors for Clostridium difficile carriage and C. difficile-associated diarrhea in a cohort of hospitalized patients. J Infect Dis (1990) 2.17
Hospital disinfectants and spore formation by Clostridium difficile. Lancet (2000) 2.13
Clostridium difficile PCR ribotypes in calves, Canada. Emerg Infect Dis (2006) 2.12
Efficacy of hospital cleaning agents and germicides against epidemic Clostridium difficile strains. Infect Control Hosp Epidemiol (2007) 2.06
Measures to control and prevent Clostridium difficile infection. Clin Infect Dis (2008) 2.04
Infection control measures to limit the spread of Clostridium difficile. Clin Microbiol Infect (2008) 2.01
Systematic review of the risk of enteric infection in patients taking acid suppression. Am J Gastroenterol (2007) 2.00
Clostridium difficile infection in Ohio hospitals and nursing homes during 2006. Infect Control Hosp Epidemiol (2009) 2.00
Reassessment of Clostridium difficile susceptibility to metronidazole and vancomycin. Antimicrob Agents Chemother (2002) 2.00
Binary toxin-producing, large clostridial toxin-negative Clostridium difficile strains are enterotoxic but do not cause disease in hamsters. J Infect Dis (2006) 1.99
Toxinotype V Clostridium difficile in humans and food animals. Emerg Infect Dis (2008) 1.98
Clindamycin, cephalosporins, fluoroquinolones, and Clostridium difficile-associated diarrhea: this is an antimicrobial resistance problem. Clin Infect Dis (2004) 1.98
Surveillance for community-associated Clostridium difficile--Connecticut, 2006. MMWR Morb Mortal Wkly Rep (2008) 1.98
Spread and epidemiology of Clostridium difficile polymerase chain reaction ribotype 027/toxinotype III in The Netherlands. Clin Infect Dis (2007) 1.97
Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years. Infect Control Hosp Epidemiol (2003) 1.97
Proteomic and genomic characterization of highly infectious Clostridium difficile 630 spores. J Bacteriol (2009) 1.96
Clinical risk factors for severe Clostridium difficile-associated disease. Emerg Infect Dis (2009) 1.95
Quinolone use as a risk factor for nosocomial Clostridium difficile-associated diarrhea. Infect Control Hosp Epidemiol (2001) 1.95
A European survey of diagnostic methods and testing protocols for Clostridium difficile. Clin Microbiol Infect (2003) 1.94
Emergence of reduced susceptibility to metronidazole in Clostridium difficile. J Antimicrob Chemother (2008) 1.91
Patterns of antibiotic use and risk of hospital admission because of Clostridium difficile infection. CMAJ (2008) 1.91
Clinical severity of Clostridium difficile PCR ribotype 027: a case-case study. PLoS One (2008) 1.88
Impact of a reduction in the use of high-risk antibiotics on the course of an epidemic of Clostridium difficile-associated disease caused by the hypervirulent NAP1/027 strain. Clin Infect Dis (2007) 1.87
Typing and subtyping of Clostridium difficile isolates by using multiple-locus variable-number tandem-repeat analysis. J Clin Microbiol (2006) 1.87
A prospective nationwide study of Clostridium difficile-associated diarrhea in Sweden. The Swedish C. difficile Study Group. Clin Infect Dis (1998) 1.84
Strategies to prevent clostridium difficile infections in acute care hospitals. Infect Control Hosp Epidemiol (2008) 1.84
Fluoroquinolone use and Clostridium difficile-associated diarrhea. Emerg Infect Dis (2003) 1.76
Changing epidemiology of Clostridium difficile-associated disease in children. Infect Control Hosp Epidemiol (2007) 1.73
Characterization of toxin A-negative, toxin B-positive Clostridium difficile isolates from outbreaks in different countries by amplified fragment length polymorphism and PCR ribotyping. J Clin Microbiol (2004) 1.73
PCR ribotyping of Clostridium difficile isolates originating from human and animal sources. J Med Microbiol (2005) 1.72
Clostridium difficile infections in a Canadian tertiary care hospital before and during a regional epidemic associated with the BI/NAP1/027 strain. Antimicrob Agents Chemother (2008) 1.71
Hand hygiene with soap and water is superior to alcohol rub and antiseptic wipes for removal of Clostridium difficile. Infect Control Hosp Epidemiol (2009) 1.70
Characteristics and incidence of Clostridium difficile-associated disease in The Netherlands, 2005. Clin Microbiol Infect (2007) 1.66
Clostridium difficile PCR ribotype 078 toxinotype V found in diarrhoeal pigs identical to isolates from affected humans. Environ Microbiol (2009) 1.65
The distribution of Clostridium difficile in the environment of South Wales. J Med Microbiol (1996) 1.64
Antibiotics and hospital-acquired Clostridium difficile-associated diarrhoea: a systematic review. J Antimicrob Chemother (2003) 1.64
Molecular epidemiology of hospital-associated and community-acquired Clostridium difficile infection in a Swedish county. J Clin Microbiol (2004) 1.62
Faecal metronidazole concentrations during oral and intravenous therapy for antibiotic associated colitis due to Clostridium difficile. Gut (1986) 1.61
Temporal effects of antibiotic use and hand rub consumption on the incidence of MRSA and Clostridium difficile. J Antimicrob Chemother (2008) 1.60
Is Clostridium difficile-associated infection a potentially zoonotic and foodborne disease? Clin Microbiol Infect (2007) 1.56
Possible seasonality of Clostridium difficile in retail meat, Canada. Emerg Infect Dis (2009) 1.55
Update of Clostridium difficile-associated disease due to PCR ribotype 027 in Europe. Euro Surveill (2007) 1.55
Clostridium difficile ribotype 027, toxinotype III, the Netherlands. Emerg Infect Dis (2006) 1.52
Evaluation of Clostridium difficile-associated disease pressure as a risk factor for C difficile-associated disease. Arch Intern Med (2007) 1.50
Two time-series analyses of the impact of antibiotic consumption and alcohol-based hand disinfection on the incidences of nosocomial methicillin-resistant Staphylococcus aureus infection and Clostridium difficile infection. Infect Control Hosp Epidemiol (2009) 1.48
Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med (2009) 8.30
Once versus thrice daily gentamicin in patients with serious infections. Lancet (1993) 4.92
European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection. Clin Microbiol Infect (2014) 3.33
A case-control study of community-associated Clostridium difficile infection. J Antimicrob Chemother (2008) 3.01
epic2: National evidence-based guidelines for preventing healthcare-associated infections in NHS hospitals in England. J Hosp Infect (2007) 2.77
European Society of Clinical Microbiology and Infectious Diseases (ESCMID): data review and recommendations for diagnosing Clostridium difficile-infection (CDI). Clin Microbiol Infect (2009) 2.69
Comparison of the effect of detergent versus hypochlorite cleaning on environmental contamination and incidence of Clostridium difficile infection. J Hosp Infect (2003) 2.68
[New developments in antifungal therapy: fluconazole, itraconazole, voriconazole, caspofungin]. Ned Tijdschr Geneeskd (2004) 2.55
European Society of Clinical Microbiology and Infectious Diseases (ESCMID): treatment guidance document for Clostridium difficile infection (CDI). Clin Microbiol Infect (2009) 2.44
Use of perioperative mupirocin to prevent methicillin-resistant Staphylococcus aureus (MRSA) orthopaedic surgical site infections. J Hosp Infect (2003) 2.40
Complement deficiencies in patients over ten years old with meningococcal disease due to uncommon serogroups. Lancet (1989) 2.39
Application of whole-cell DNA restriction endonuclease profiles to the epidemiology of Clostridium difficile-induced diarrhea. J Clin Microbiol (1987) 2.34
Clinical and economic burden of Clostridium difficile infection in Europe: a systematic review of healthcare-facility-acquired infection. J Hosp Infect (2012) 2.31
Characterization of Clostridium difficile isolates using capillary gel electrophoresis-based PCR ribotyping. J Med Microbiol (2008) 2.17
Hospital disinfectants and spore formation by Clostridium difficile. Lancet (2000) 2.13
Characteristics of successive epidemics of respiratory syncytial virus infection. Lancet (1991) 2.02
Infection control measures to limit the spread of Clostridium difficile. Clin Microbiol Infect (2008) 2.01
Recurrence of symptoms in Clostridium difficile infection--relapse or reinfection? J Hosp Infect (1998) 2.00
Membrane fusion of Semliki Forest virus requires sphingolipids in the target membrane. EMBO J (1994) 1.99
Spread and epidemiology of Clostridium difficile polymerase chain reaction ribotype 027/toxinotype III in The Netherlands. Clin Infect Dis (2007) 1.97
Rapid diagnosis of central-venous-catheter-related bloodstream infection without catheter removal. Lancet (1999) 1.96
Changing epidemiology of Clostridium difficile infection following the introduction of a national ribotyping-based surveillance scheme in England. Clin Infect Dis (2012) 1.86
Fusobacterium nucleatum septicemia and portal vein thrombosis. Clin Infect Dis (1999) 1.83
Clostridium difficile: a European perspective. J Infect (2012) 1.81
Prevalence of Campylobacter-associated diarrhea among patients infected with human immunodeficiency virus. Clin Infect Dis (1997) 1.80
Characteristics and incidence of Clostridium difficile-associated disease in The Netherlands, 2005. Clin Microbiol Infect (2007) 1.66
Value of lysozyme agar incorporation and alkaline thioglycollate exposure for the environmental recovery of Clostridium difficile. J Hosp Infect (2000) 1.65
The slime of coagulase-negative staphylococci: biochemistry and relation to adherence. FEMS Microbiol Rev (1993) 1.62
Prospective evaluation of hospital isolation room capacity. J Hosp Infect (2006) 1.59
Evaluation of chromogenic meticillin-resistant Staphylococcus aureus media: sensitivity versus turnaround time. J Hosp Infect (2012) 1.58
Real-time PCR assay using fine-needle aspirates and tissue biopsy specimens for rapid diagnosis of mycobacterial lymphadenitis in children. J Clin Microbiol (2004) 1.57
Methicillin-resistant Staphylococcus aureus in trauma and orthopaedic practice. J Bone Joint Surg Br (2005) 1.54
Inherited complement deficiency in children surviving fulminant meningococcal septic shock. Eur J Pediatr (1995) 1.53
Clostridium difficile infection in the community: a zoonotic disease? Clin Microbiol Infect (2012) 1.52
Comparison of two matrix-assisted laser desorption ionisation-time of flight mass spectrometry methods for the identification of clinically relevant anaerobic bacteria. Clin Microbiol Infect (2011) 1.51
Aeromonas infections and their treatment. J Antimicrob Chemother (1995) 1.49
Clinical relevance of antibiotic-induced endotoxin release. Antimicrob Agents Chemother (1994) 1.48
Potential for aerosolization of Clostridium difficile after flushing toilets: the role of toilet lids in reducing environmental contamination risk. J Hosp Infect (2011) 1.47
The effects of storage conditions on viability of Clostridium difficile vegetative cells and spores and toxin activity in human faeces. J Clin Pathol (2003) 1.46
Lignocaine spray applicators are a potential source of cross-infection in the anaesthetic room. Anaesthesia (1993) 1.44
Ciprofloxacin and CAPD peritonitis. J Antimicrob Chemother (1990) 1.40
Effectiveness of topical chlorhexidine powder as an alternative to hexachlorophane for the control of Staphylococcus aureus in neonates. J Hosp Infect (2004) 1.40
[Diarrhea due to Clostridium difficile toxin in hemato-oncological patients]. Ned Tijdschr Geneeskd (2001) 1.39
Does hospital cleanliness correlate with methicillin-resistant Staphylococcus aureus bacteraemia rates? J Hosp Infect (2006) 1.39
Slime production and adherence by coagulase-negative staphylococci. J Hosp Infect (1991) 1.39
Role of environmental cleaning in controlling an outbreak of Acinetobacter baumannii on a neurosurgical intensive care unit. J Hosp Infect (2004) 1.37
Mutagenesis of the RGD motif in the yellow fever virus 17D envelope protein. Virology (1999) 1.35
Role of neutrophil Fc gamma RIIa (CD32) and Fc gamma RIIIb (CD16) polymorphic forms in phagocytosis of human IgG1- and IgG3-opsonized bacteria and erythrocytes. Immunology (1994) 1.35
Rapid diagnosis of toxinogenic Clostridium difficile in faecal samples with internally controlled real-time PCR. Clin Microbiol Infect (2006) 1.34
Application of multiple-locus variable-number tandem-repeat analysis to determine clonal spread of toxin A-negative Clostridium difficile in a general hospital in Buenos Aires, Argentina. Clin Microbiol Infect (2009) 1.34
Reduced susceptibility of Clostridium difficile to metronidazole. J Antimicrob Chemother (2001) 1.32
Comparative analysis of prevalence, risk factors, and molecular epidemiology of antibiotic-associated diarrhea due to Clostridium difficile, Clostridium perfringens, and Staphylococcus aureus. J Clin Microbiol (2006) 1.31
Assessment of complement deficiency in patients with meningococcal disease in The Netherlands. Clin Infect Dis (1999) 1.30
Release of tumor necrosis factor alpha and interleukin 6 during antibiotic killing of Escherichia coli in whole blood: influence of antibiotic class, antibiotic concentration, and presence of septic serum. Infect Immun (1995) 1.30
Use of highly discriminatory fingerprinting to analyze clusters of Clostridium difficile infection cases due to epidemic ribotype 027 strains. J Clin Microbiol (2008) 1.30
The susceptibility of Mycobacterium tuberculosis to isoniazid and the Arg-->Leu mutation at codon 463 of katG are not associated. J Clin Microbiol (2001) 1.27
Clinical and microbiological characteristics of community-onset Clostridium difficile infection in The Netherlands. Clin Microbiol Infect (2009) 1.27
Fusion of Semliki Forest virus with cholesterol-containing liposomes at low pH: a specific requirement for sphingolipids. Mol Membr Biol (1995) 1.26
Evaluation of a novel endoluminal brush method for in situ diagnosis of catheter related sepsis. J Clin Pathol (1997) 1.26
Characterization of cell envelope proteins of Staphylococcus epidermidis cultured in human peritoneal dialysate. Infect Immun (1991) 1.25
Complement deficiency predisposes for meningitis due to nongroupable meningococci and Neisseria-related bacteria. Clin Infect Dis (1994) 1.24
Prospective study of the risk of Clostridium difficile diarrhoea in elderly patients following treatment with cefotaxime or piperacillin-tazobactam. Aliment Pharmacol Ther (1998) 1.24
Relatedness of human and animal Clostridium difficile PCR ribotype 078 isolates determined on the basis of multilocus variable-number tandem-repeat analysis and tetracycline resistance. J Clin Microbiol (2010) 1.23
First isolation of Clostridium difficile 027 in Japan. Euro Surveill (2007) 1.23
Ecological replacement of Enterococcus faecalis by multiresistant clonal complex 17 Enterococcus faecium. Clin Microbiol Infect (2007) 1.23
Molecular epidemiology of endemic Clostridium difficile infection. Epidemiol Infect (2001) 1.21
Struggling with recurrent Clostridium difficile infections: is donor faeces the solution? Euro Surveill (2009) 1.20
Evidence to support the existence of subgroups within the UK epidemic Clostridium difficile strain (PCR ribotype 1). J Hosp Infect (2003) 1.19
Decrease of hypervirulent Clostridium difficile PCR ribotype 027 in the Netherlands. Euro Surveill (2009) 1.18
[Treatment of recurrent Clostridium difficile-associated diarrhoea with a suspension of donor faeces]. Ned Tijdschr Geneeskd (2008) 1.18
Antibiotic-induced endotoxin release in patients with gram-negative urosepsis: a double-blind study comparing imipenem and ceftazidime. J Infect Dis (1995) 1.16
Rapid diagnosis of Legionnaires' disease using an immunochromatographic assay for Legionella pneumophila serogroup 1 antigen in urine during an outbreak in the Netherlands. J Clin Microbiol (2000) 1.16
Importance of medium and atmosphere type to both slime production and adherence by coagulase-negative staphylococci. J Hosp Infect (1992) 1.15
Laboratory diagnosis of Clostridium perfringens antibiotic-associated diarrhoea. J Med Microbiol (2002) 1.15
[Epidemiology of Clostridium difficile PCR ribotype 027 in the Netherlands 2005-present and the emergence of other subtypes]. Ned Tijdschr Geneeskd (2008) 1.14
Evaluation of three enzyme immunoassays and a loop-mediated isothermal amplification test for the laboratory diagnosis of Clostridium difficile infection. Eur J Clin Microbiol Infect Dis (2012) 1.12
Successful combat of an outbreak due to Clostridium difficile PCR ribotype 027 and recognition of specific risk factors. Clin Microbiol Infect (2009) 1.12
Fatal mucormycosis presenting as an appendiceal mass with metastatic spread to the liver during chemotherapy-induced granulocytopenia. Scand J Infect Dis (1990) 1.10
Antibiotics and Clostridium difficile. Microbes Infect (1999) 1.10
Inaccuracy of routine susceptibility tests for detection of erythromycin resistance of Campylobacter jejuni and Campylobacter coli. Clin Microbiol Infect (2010) 1.09
Multiple organ dysfunction syndrome induced by whole-body hyperthermia and polychemotherapy in a patient with disseminated leiomyosarcoma of the uterus. Intensive Care Med (1999) 1.09
Binding of mannan-binding protein to various bacterial pathogens of meningitis. Clin Exp Immunol (1994) 1.09
Epidemiology of Clostridium difficile infections in a tertiary-care hospital in Korea. Clin Microbiol Infect (2012) 1.09
Lymphadenitis in children is caused by Mycobacterium avium hominissuis and not related to 'bird tuberculosis'. Eur J Clin Microbiol Infect Dis (2008) 1.08
Relapse of Legionella longbeachae infection in an immunocompromised patient. Neth J Med (1996) 1.08
Clostridium difficile in Dutch animals: their presence, characteristics and similarities with human isolates. Clin Microbiol Infect (2011) 1.08
Community-onset Clostridium difficile-associated diarrhoea not associated with antibiotic usage--two case reports with review of the changing epidemiology of Clostridium difficile-associated diarrhoea. Neth J Med (2008) 1.08
Vancomycin-resistant enterococci. Lancet (1993) 1.07
Dysfunctional properdin in a Dutch family with meningococcal disease. N Engl J Med (1988) 1.06