Published in Evol Bioinform Online on June 13, 2008
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The Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activation. Proc Natl Acad Sci U S A (2005) 1.94
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Kinetic scaffolding mediated by a phospholipase C-beta and Gq signaling complex. Science (2010) 1.78
Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton. J Biol Chem (2003) 1.72
Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation. Oncogene (2004) 1.66
General and versatile autoinhibition of PLC isozymes. Mol Cell (2008) 1.62
Crystal structure of Rac1 bound to its effector phospholipase C-beta2. Nat Struct Mol Biol (2006) 1.60
Crystal structure of the multifunctional Gbeta5-RGS9 complex. Nat Struct Mol Biol (2008) 1.52
A microtubule interactome: complexes with roles in cell cycle and mitosis. PLoS Biol (2008) 1.50
Regulation of phospholipase C isozymes by ras superfamily GTPases. Annu Rev Pharmacol Toxicol (2006) 1.47
A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs. Curr Biol (2005) 1.41
Structural and functional properties of the human notch-1 ligand binding region. Structure (2004) 1.40
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PH domain of ELMO functions in trans to regulate Rac activation via Dock180. Nat Struct Mol Biol (2004) 1.36
Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain. J Biol Chem (2007) 1.35
The pleckstrin homology domain of phospholipase C-beta2 as an effector site for Rac. J Biol Chem (2003) 1.31
Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins. J Biol Chem (2004) 1.29
Type III effector activation via nucleotide binding, phosphorylation, and host target interaction. PLoS Pathog (2007) 1.29
Solution structure and dynamics of a prototypical chordin-like cysteine-rich repeat (von Willebrand Factor type C module) from collagen IIA. J Biol Chem (2004) 1.27
A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q. Nat Struct Biol (2002) 1.23
The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation. J Mol Biol (2007) 1.22
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression. Nat Struct Mol Biol (2007) 1.22
Crystal structures of the type III effector protein AvrPphF and its chaperone reveal residues required for plant pathogenesis. Structure (2004) 1.22
Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes. J Biol Chem (2010) 1.18
Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain. J Biol Chem (2002) 1.18
Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation. J Biol Chem (2003) 1.16
Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation. J Biol Chem (2004) 1.16
Quantification of isozyme-specific activation of phospholipase C-beta2 by Rac GTPases and phospholipase C-epsilon by Rho GTPases in an intact cell assay system. Methods Enzymol (2006) 1.13
SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC. J Biol Chem (2011) 1.13
Established and emerging fluorescence-based assays for G-protein function: Ras-superfamily GTPases. Comb Chem High Throughput Screen (2003) 1.11
A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis. Dev Cell (2011) 1.10
Auto-inhibition of the Dbl family protein Tim by an N-terminal helical motif. J Biol Chem (2007) 1.06
RhoA activates purified phospholipase C-epsilon by a guanine nucleotide-dependent mechanism. J Biol Chem (2004) 1.05
Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting. J Biol Chem (2003) 1.05
Activation of human phospholipase C-eta2 by Gbetagamma. Biochemistry (2008) 1.04
Solution structure and dynamics of a calcium binding epidermal growth factor-like domain pair from the neonatal region of human fibrillin-1. J Biol Chem (2003) 1.03
Larger than Dbl: new structural insights into RhoA activation. Trends Biochem Sci (2005) 1.02
Molecular cloning and characterization of PLC-eta2. Biochem J (2005) 0.99
Dual activation of phospholipase C-epsilon by Rho and Ras GTPases. J Biol Chem (2008) 0.99
Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta. J Mol Biol (2003) 0.99
High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay. J Biomol Screen (2009) 0.98
The phospholipase C isozymes and their regulation. Subcell Biochem (2012) 0.97
Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. Mol Cell Biol (2004) 0.96
Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteins. Biochemistry (2008) 0.96
The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity. Biochem J (2006) 0.95
An assessment of the uses of homologous interactions. Bioinformatics (2007) 0.93
Phospholipase C isozymes as effectors of Ras superfamily GTPases. J Lipid Res (2008) 0.92
Crystal structure of the DH/PH fragment of Dbs without bound GTPase. Structure (2004) 0.92
Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodes. Chem Rev (2011) 0.87
Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling. Biochim Biophys Acta (2003) 0.87
Structural insights into fibronectin type III domain-mediated signaling. J Mol Biol (2006) 0.87
RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity. Mol Cell Biol (2002) 0.86
A fluorogenic, small molecule reporter for mammalian phospholipase C isozymes. ACS Chem Biol (2011) 0.86
Direct activation of human phospholipase C by its well known inhibitor u73122. J Biol Chem (2011) 0.85
Identification and removal of O-linked and non-covalently linked sugars from recombinant protein produced using Pichia pastoris. Protein Expr Purif (2004) 0.83
Affinity tag for protein purification and detection based on the disulfide-linked complex of InaD and NorpA. Biotechniques (2002) 0.83
Functional analysis of cdc42 residues required for Guanine nucleotide exchange. J Biol Chem (2002) 0.82
Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes. Biochemistry (2013) 0.82
Effects of the N2144S mutation on backbone dynamics of a TB-cbEGF domain pair from human fibrillin-1. J Mol Biol (2002) 0.82
Prediction of protein-protein interfaces on G-protein beta subunits reveals a novel phospholipase C beta2 binding domain. J Mol Biol (2009) 0.82
Small molecule inhibitors of phospholipase C from a novel high-throughput screen. J Biol Chem (2013) 0.81
AvrRpm1 missense mutations weakly activate RPS2-mediated immune response in Arabidopsis thaliana. PLoS One (2012) 0.80
A calcium dependent de-adhesion mechanism regulates the direction and rate of cell migration: a mathematical model. In Silico Biol (2006) 0.80
A Cdc42 mutant specifically activated by intersectin. Biochemistry (2005) 0.80
1H, 13C, and 15N resonance assignments of human Notch-1 calcium binding EGF domains 11-13. J Biomol NMR (2004) 0.79
Overview of affinity tags for protein purification. Curr Protoc Protein Sci (2004) 0.79
High-throughput fluorescence polarization assay for the enzymatic activity of GTPase-activating protein of ADP-ribosylation factor (ARFGAP). J Biomol Screen (2011) 0.79
The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae. Mol Biol Cell (2012) 0.78
Fluorescent phosphatidylinositol 4,5-bisphosphate derivatives with modified 6-hydroxy group as novel substrates for phospholipase C. Biochemistry (2012) 0.77
Direct activation of purified phospholipase C epsilon by RhoA studied in reconstituted phospholipid vesicles. Methods Enzymol (2006) 0.77
Assays of complex formation between RGS protein G gamma subunit-like domains and G beta subunits. Methods Enzymol (2002) 0.77
Shape and dynamics of a calcium-binding protein investigated by nitrogen-15 NMR relaxation. Methods Mol Biol (2002) 0.77
The use of dipolar couplings for the structure refinement of a pair of calcium-binding EGF domains. Methods Mol Biol (2002) 0.75
Regulation of PLCbeta isoforms by Rac. Methods Enzymol (2006) 0.75
N-Terminal domain linkage modulates the folding properties of protein S epidermal growth factor-like modules. Biochemistry (2004) 0.75