Diadenosine pentaphosphate is a potent activator of cardiac ryanodine receptors revealing a novel high-affinity binding site for adenine nucleotides.

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Published in Br J Pharmacol on February 13, 2009

Authors

L Song1, S M Carter, Y Chen, R Sitsapesan

Author Affiliations

1: Department of Physiology & Pharmacology, University of Bristol, School of Medical Sciences, University Walk, Bristol, UK.

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Data transformations for improved display and fitting of single-channel dwell time histograms. Biophys J (1987) 9.64

Ryanodine receptor/Ca2+ release channels and their regulation by endogenous effectors. Annu Rev Physiol (1994) 5.79

Quantitative description of three modes of activity of fast chloride channels from rat skeletal muscle. J Physiol (1986) 5.52

AppppA, heat-shock stress, and cell oxidation. Proc Natl Acad Sci U S A (1983) 3.68

AppppA and related adenylylated nucleotides are synthesized as a consequence of oxidation stress. Cell (1984) 3.25

The gating of the sheep skeletal sarcoplasmic reticulum Ca(2+)-release channel is regulated by luminal Ca2+. J Membr Biol (1995) 1.74

Sheep cardiac sarcoplasmic reticulum calcium-release channels: modification of conductance and gating by temperature. J Physiol (1991) 1.58

Diadenosine 5', 5"'-P1, P4-tetraphosphate: a pleiotropically acting alarmone? Cell (1983) 1.35

Diadenosine polyphosphates: their biological and pharmacological significance. J Pharmacol Toxicol Methods (1995) 1.27

The interactions of ATP, ADP, and inorganic phosphate with the sheep cardiac ryanodine receptor. Biophys J (1998) 1.14

Regulation of the calcium release channel from rabbit skeletal muscle by the nucleotides ATP, AMP, IMP and adenosine. J Physiol (2001) 1.06

A comparison of the effects of ATP and tetracaine on spontaneous Ca(2+) release from rat permeabilised cardiac myocytes. J Physiol (2001) 1.06

The effects of diadenosine polyphosphates on the cardiovascular system. Cardiovasc Res (1999) 1.02

Regulation of ryanodine receptor calcium release channels by diadenosine polyphosphates. J Neurochem (1996) 0.89

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Endogenous diadenosine tetraphosphate, diadenosine pentaphosphate, and diadenosine hexaphosphate in human myocardial tissue. Hypertension (2004) 0.85

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Adenosine(5')hexaphospho(5')adenosine stimulation of a Ca(2+)-induced Ca(2+)-release channel from skeletal muscle sarcoplasmic reticulum. Eur J Biochem (1992) 0.83

Activation and labelling of the purified skeletal muscle ryanodine receptor by an oxidized ATP analogue. Biochem J (1995) 0.80

Altered inhibition of the rat skeletal ryanodine receptor/calcium release channel by magnesium in the presence of ATP. Pflugers Arch (2001) 0.80

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Ensembl 2007. Nucleic Acids Res (2006) 20.10

Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nat Genet (1996) 15.73

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Ensembl 2005. Nucleic Acids Res (2005) 15.13

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Ensembl 2004. Nucleic Acids Res (2004) 11.88

Ensembl 2006. Nucleic Acids Res (2006) 11.66

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Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem (1999) 10.14

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell (2000) 8.95

Data management and analysis for gene expression arrays. Nat Genet (1998) 8.60

Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns. Cancer Res (2001) 8.34

Ratio-based decisions and the quantitative analysis of cDNA microarray images. J Biomed Opt (1997) 8.32

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science (2001) 7.66

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Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science (1997) 6.23

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CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature (1997) 5.45

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J (1998) 5.34

Tumor induction of VEGF promoter activity in stromal cells. Cell (1998) 5.20

A candidate prostate cancer susceptibility gene at chromosome 17p. Nat Genet (2001) 5.06

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc Natl Acad Sci U S A (1996) 5.04

Cross-bridge model of muscle contraction. Quantitative analysis. Biophys J (1980) 4.91

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood (1997) 4.78

Prevention of fat-induced insulin resistance by salicylate. J Clin Invest (2001) 4.74

Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays. Cancer Res (1998) 4.68

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Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol (1994) 2.70

Cooperative effects in models of steady-state transport across membranes. I. Proc Natl Acad Sci U S A (1970) 2.68

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Interactions between endogenous gamma interferon and tumor necrosis factor in host resistance against primary and secondary Listeria monocytogenes infections. Infect Immun (1989) 2.28

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ERG oncoprotein expression in prostate cancer: clonal progression of ERG-positive tumor cells and potential for ERG-based stratification. Prostate Cancer Prostatic Dis (2010) 2.24

Use of Monte Carlo calculations in the study of microtubule subunit kinetics. Proc Natl Acad Sci U S A (1983) 2.23

Near full-length clones and reference sequences for subtype C isolates of HIV type 1 from three different continents. AIDS Res Hum Retroviruses (2001) 2.23

Genetic diversity of Bacillus cereus/B. thuringiensis isolates from natural sources. Curr Microbiol (1998) 2.21

Two-dimensional imaging through diffusing media using 150-fs gated electronic holography techniques. Opt Lett (1991) 2.21

Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer. Proc Natl Acad Sci U S A (2001) 2.16

Analysis of gene-specific DNA damage and repair using quantitative polymerase chain reaction. Methods (2000) 2.16

CD47, a ligand for the macrophage fusion receptor, participates in macrophage multinucleation. J Biol Chem (2000) 2.15