Published in Cell Cycle on March 02, 2009
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To differentiate or not--routes towards metastasis. Nat Rev Cancer (2012) 3.59
TransmiR: a transcription factor-microRNA regulation database. Nucleic Acids Res (2009) 2.80
Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol Ther (2011) 2.75
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging (Albany NY) (2011) 2.72
microRNA-34c is a novel target to treat dementias. EMBO J (2011) 2.44
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99
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miR-29 and miR-30 regulate B-Myb expression during cellular senescence. Proc Natl Acad Sci U S A (2010) 1.81
Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice. Mol Cancer Ther (2011) 1.76
The role of miRNAs in regulating gene expression networks. J Mol Biol (2013) 1.74
MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1. Am J Physiol Endocrinol Metab (2010) 1.73
Aberrant regulation and function of microRNAs in cancer. Curr Biol (2014) 1.72
A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition. J Biol Chem (2010) 1.61
MicroRNAs and their roles in aging. J Cell Sci (2012) 1.60
miR-34: from bench to bedside. Oncotarget (2014) 1.59
Synthetic miR-34a mimics as a novel therapeutic agent for multiple myeloma: in vitro and in vivo evidence. Clin Cancer Res (2012) 1.50
Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells. PLoS One (2011) 1.48
MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo. PLoS One (2012) 1.45
Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice. EMBO Mol Med (2011) 1.38
Xenoestrogen-induced epigenetic repression of microRNA-9-3 in breast epithelial cells. Cancer Res (2009) 1.37
Circulatory miR34a as an RNAbased, noninvasive biomarker for brain aging. Aging (Albany NY) (2011) 1.35
MicroRNA-34a: a potential therapeutic target in human cancer. Cell Death Dis (2014) 1.32
HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs. J Biol Chem (2011) 1.28
Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF. J Hematol Oncol (2012) 1.23
MicroRNA Regulation of SIRT1. Front Physiol (2012) 1.21
A miR-34a-SIRT6 axis in the squamous cell differentiation network. EMBO J (2013) 1.18
Systematic proteome analysis identifies transcription factor YY1 as a direct target of miR-34a. J Proteome Res (2010) 1.17
Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders. J Biol Chem (2011) 1.17
Anti-oncogenic microRNA-203 induces senescence by targeting E2F3 protein in human melanoma cells. J Biol Chem (2012) 1.17
The Impact of MicroRNAs on Brain Aging and Neurodegeneration. Curr Gerontol Geriatr Res (2012) 1.14
Controlling SIRT1 expression by microRNAs in health and metabolic disease. Aging (Albany NY) (2010) 1.12
MiR-34b is associated with clinical outcome in triple-negative breast cancer patients. Diagn Pathol (2012) 1.11
Myc overexpression brings out unexpected antiapoptotic effects of miR-34a. Oncogene (2011) 1.11
miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma. Neuro Oncol (2010) 1.10
Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells. PLoS One (2012) 1.10
The ways and means that fine tune Sirt1 activity. Trends Biochem Sci (2013) 1.07
MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame. PLoS One (2012) 1.06
c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver. Mol Cell Biol (2014) 1.06
Renal protective effect of sirtuin 1. J Diabetes Res (2014) 1.05
Converging miRNA functions in diverse brain disorders: a case for miR-124 and miR-126. Exp Neurol (2011) 1.04
MicroRNA-34c enhances murine male germ cell apoptosis through targeting ATF1. PLoS One (2012) 1.03
miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II/III colorectal cancer. Oncogene (2014) 1.02
MicroRNAs and senescence. Aging (Albany NY) (2011) 1.01
MicroRNAs in skeletal muscle and their regulation with exercise, ageing, and disease. Front Physiol (2013) 1.00
p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells. Cell Cycle (2013) 1.00
MicroRNA dysregulation in the spinal cord following traumatic injury. PLoS One (2012) 0.98
Gene expression analysis of skin grafts and cultured keratinocytes using synthetic RNA normalization reveals insights into differentiation and growth control. BMC Genomics (2015) 0.97
The Tumor Cytosol miRNAs, Fluid miRNAs, and Exosome miRNAs in Lung Cancer. Front Oncol (2015) 0.96
The role of microRNAs in Helicobacter pylori pathogenesis and gastric carcinogenesis. Front Cell Infect Microbiol (2012) 0.94
Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53 on Drosha complex activity. J Exp Clin Cancer Res (2016) 0.94
MicroRNAs in human embryonic and cancer stem cells. Yonsei Med J (2010) 0.93
Diet, microRNAs and prostate cancer. Pharm Res (2010) 0.93
miR-20a and miR-290, multi-faceted players with a role in tumourigenesis and senescence. J Cell Mol Med (2010) 0.93
Transcriptional control of cancer metastasis. Trends Cell Biol (2013) 0.92
Sirt7 promotes gastric cancer growth and inhibits apoptosis by epigenetically inhibiting miR-34a. Sci Rep (2015) 0.92
MicroRNAs and triple negative breast cancer. Int J Mol Sci (2013) 0.91
Reactivation of p53 by novel MDM2 inhibitors: implications for pancreatic cancer therapy. Curr Cancer Drug Targets (2010) 0.91
MicroRNAs in cancer diagnosis and therapy: from bench to bedside. Surg Today (2012) 0.90
Cancer Stem Cells in Colorectal Cancer: Genetic and Epigenetic Changes. J Stem Cell Res Ther (2012) 0.90
Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells. Oncotarget (2011) 0.89
SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress. Genes Cancer (2013) 0.89
Regulatory networks between neurotrophins and miRNAs in brain diseases and cancers. Acta Pharmacol Sin (2014) 0.87
New insights into p53 functions through its target microRNAs. J Mol Cell Biol (2014) 0.87
MicroRNAs as putative mediators of treatment response in prostate cancer. Nat Rev Urol (2012) 0.86
Quantitative proteomic analysis of gene regulation by miR-34a and miR-34c. PLoS One (2014) 0.85
MiR-34a inhibits migration and invasion by regulating the SIRT1/p53 pathway in human SW480 cells. Mol Med Rep (2015) 0.85
Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness. Oncotarget (2015) 0.85
Environmental alterations of epigenetics prior to the birth. Int Rev Neurobiol (2014) 0.85
Immortalization of MEF is characterized by the deregulation of specific miRNAs with potential tumor suppressor activity. Aging (Albany NY) (2011) 0.84
Rapid regulation of microRNA following induction of long-term potentiation in vivo. Front Mol Neurosci (2014) 0.84
Stress Inducibility of SIRT1 and Its Role in Cytoprotection and Cancer. Genes Cancer (2013) 0.83
A computational approach to identifying gene-microRNA modules in cancer. PLoS Comput Biol (2015) 0.83
Widespread microRNA dysregulation in multiple system atrophy - disease-related alteration in miR-96. Eur J Neurosci (2013) 0.82
Teratogen-induced alterations in microRNA-34, microRNA-125b and microRNA-155 expression: correlation with embryonic p53 genotype and limb phenotype. BMC Dev Biol (2010) 0.82
MicroRNAs Regulate Key Effector Pathways of Senescence. J Aging Res (2011) 0.82
SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism. Genome Integr (2013) 0.82
ENU mutagenesis reveals that Notchless homolog 1 (Drosophila) affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation development. BMC Genet (2012) 0.82
Expression of senescence-associated microRNAs and target genes in cellular aging and modulation by tocotrienol-rich fraction. Oxid Med Cell Longev (2014) 0.81
miRNA-34a underexpressed in Merkel cell polyomavirus-negative Merkel cell carcinoma. Virchows Arch (2014) 0.81
Low miR-34a and miR-192 are associated with unfavorable prognosis in patients suffering from osteosarcoma. Am J Transl Res (2015) 0.81
MiR-34a-5p promotes the multi-drug resistance of osteosarcoma by targeting the CD117 gene. Oncotarget (2016) 0.81
The Role of microRNAs in Mitochondria: Small Players Acting Wide. Genes (Basel) (2014) 0.80
miRNAs and Other Epigenetic Changes as Biomarkers in Triple Negative Breast Cancer. Int J Mol Sci (2015) 0.80
Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells. Cell Death Differ (2014) 0.80
Rapamycin induces pluripotent genes associated with avoidance of replicative senescence. Cell Cycle (2013) 0.80
Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia. Oncotarget (2016) 0.80
The role of microRNAs in cellular senescence and age-related conditions of cartilage and bone. Acta Orthop (2014) 0.79
Prenatal exposure to chromium induces early reproductive senescence by increasing germ cell apoptosis and advancing germ cell cyst breakdown in the F1 offspring. Dev Biol (2014) 0.79
Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets. Diabetologia (2016) 0.79
Differential mRNA expression levels of human histone-modifying enzymes in normal karyotype B cell pediatric acute lymphoblastic leukemia. Int J Mol Sci (2013) 0.79
Robust Distal Tip Cell Pathfinding in the Face of Temperature Stress Is Ensured by Two Conserved microRNAS in Caenorhabditis elegans. Genetics (2015) 0.79
Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs. PLoS One (2016) 0.78
Transcriptional Response of Polycomb Group Genes to Status Epilepticus in Mice is Modified by Prior Exposure to Epileptic Preconditioning. Front Neurol (2015) 0.78
Modulation of microRNAs by phytochemicals in cancer: underlying mechanisms and translational significance. Biomed Res Int (2015) 0.78
MicroRNAs in inner ear biology and pathogenesis. Hear Res (2012) 0.78
MicroRNAs in Lymphoma: Regulatory Role and Biomarker Potential. Curr Genomics (2015) 0.78
Caloric restriction-mediated induction of lipid metabolism gene expression in liver is enhanced by Keap1-knockdown. Pharm Res (2013) 0.78
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell (2007) 14.58
miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A (2008) 6.24
MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci U S A (2008) 5.15
Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. Cell (2003) 4.55
P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. Proc Natl Acad Sci U S A (2010) 2.49
Outbreak management and implications of a nosocomial norovirus outbreak. Clin Infect Dis (2007) 1.87
A novel class of fusion polypeptides inhibits exocytosis. Mol Pharmacol (2004) 1.78
Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling. J Exp Med (2008) 1.56
Regulation of platelet granule exocytosis by S-nitrosylation. Proc Natl Acad Sci U S A (2005) 1.52
Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arterioscler Thromb Vasc Biol (2014) 1.45
Antibody to human leukocyte antigen triggers endothelial exocytosis. Proc Natl Acad Sci U S A (2007) 1.39
Gene therapy with inducible nitric oxide synthase protects against myocardial infarction via a cyclooxygenase-2-dependent mechanism. Circ Res (2003) 1.23
Stat3 mediates interleukin-6 [correction of interelukin-6] inhibition of human endothelial nitric-oxide synthase expression. J Biol Chem (2006) 1.18
Ets-1 and Ets-2 regulate the expression of microRNA-126 in endothelial cells. Arterioscler Thromb Vasc Biol (2010) 1.17
HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size. Circ Res (2005) 1.14
A novel inhibitor of N-ethylmaleimide-sensitive factor decreases leukocyte trafficking and peritonitis. J Pharmacol Exp Ther (2005) 1.14
Increased endothelial exocytosis and generation of endothelin-1 contributes to constriction of aged arteries. Circ Res (2010) 1.13
Inhibition of N-ethylmaleimide-sensitive factor protects against myocardial ischemia/reperfusion injury. Circ Res (2007) 1.08
Viral protease cleavage of inhibitor of kappaBalpha triggers host cell apoptosis. Proc Natl Acad Sci U S A (2006) 1.07
Glutamate mediates platelet activation through the AMPA receptor. J Exp Med (2008) 1.04
MicroRNA-22 regulates hypoxia signaling in colon cancer cells. PLoS One (2011) 1.01
Nitric oxide regulates vascular calcification by interfering with TGF- signalling. Cardiovasc Res (2007) 1.01
Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis. Blood (2004) 1.01
Nerve growth factor-regulated emergence of functional delta-opioid receptors. J Neurosci (2010) 0.96
TIMAP, a novel CAAX box protein regulated by TGF-beta1 and expressed in endothelial cells. Am J Physiol Cell Physiol (2002) 0.95
Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor. J Cell Biol (2005) 0.95
Histone deacetylase isoforms regulate innate immune responses by deacetylating mitogen-activated protein kinase phosphatase-1. J Leukoc Biol (2013) 0.94
Pathogen recognition by Toll-like receptor 2 activates Weibel-Palade body exocytosis in human aortic endothelial cells. J Biol Chem (2007) 0.94
Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion. J Clin Invest (2014) 0.93
Sphingosine 1-phosphate activates Weibel-Palade body exocytosis. Proc Natl Acad Sci U S A (2004) 0.92
Smad2 mediates transforming growth factor-beta induction of endothelial nitric oxide synthase expression. Circ Res (2002) 0.92
Thioredoxin increases exocytosis by denitrosylating N-ethylmaleimide-sensitive factor. J Biol Chem (2011) 0.91
VAMP-1, VAMP-2, and syntaxin-4 regulate ANP release from cardiac myocytes. J Mol Cell Cardiol (2010) 0.91
Inducible nitric oxide synthase expression inhibition by adenovirus E1A. Proc Natl Acad Sci U S A (2003) 0.89
Exocytosis of endothelial cells is regulated by N-ethylmaleimide-sensitive factor. Methods Mol Biol (2008) 0.89
Epigallocatechin gallate inhibits endothelial exocytosis. Biol Chem (2008) 0.86
Glutamate excitotoxicity mediates neuronal apoptosis after hypothermic circulatory arrest. Ann Thorac Surg (2010) 0.85
Aldosterone activates endothelial exocytosis. Proc Natl Acad Sci U S A (2009) 0.84
Ceramide triggers Weibel-Palade body exocytosis. Circ Res (2004) 0.83
Nitric oxide signaling comes of age: 20 years and thriving. Cardiovasc Res (2007) 0.83
Rac1 regulates the release of Weibel-Palade Bodies in human aortic endothelial cells. Chin Med J (Engl) (2004) 0.82
Nitric oxide inhibits exocytosis of cytolytic granules from lymphokine-activated killer cells. Proc Natl Acad Sci U S A (2006) 0.82
Nitric oxide inhibits the adenovirus proteinase in vitro and viral infectivity in vivo. FASEB J (2003) 0.80
Peroxynitrite inhibition of Coxsackievirus infection by prevention of viral RNA entry. Proc Natl Acad Sci U S A (2004) 0.79
Integrin-linked kinase plays a key role in coxsackievirus replication. Circ Res (2006) 0.79
Myocardial reperfusion injury. N Engl J Med (2007) 0.79
Exogenous thioredoxin reduces inflammation in autoimmune myocarditis. Circulation (2004) 0.79
Mature hepatocyte growth factor/scatter factor on the surface of human granulocytes is released by a mechanism involving activated factor Xa. J Immunol (2006) 0.78
L-arginine ameliorates the abnormal sympathetic response of the dysfunctional human coronary microvasculature. Angiology (2004) 0.77
Inhibitor of NF kappa B alpha is a host sensor of coxsackievirus infection. Cell Cycle (2007) 0.77
Beneficial effects of neuronal nitric oxide synthase in atherosclerosis. Arterioscler Thromb Vasc Biol (2006) 0.76
Correction: SNAP23 Regulates Endothelial Exocytosis of von Willebrand Factor. PLoS One (2016) 0.75
Prior hospital admission predicts thirty-day hospital readmission for heart failure patients. Cardiol J (2016) 0.75
Novel pathogenetic mechanisms in myocarditis: nitric oxide signaling. Heart Fail Clin (2005) 0.75