Published in Annu Rev Pathol on January 01, 2010
Autophagy and the integrated stress response. Mol Cell (2010) 11.21
Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell (2010) 7.20
Epigenetic protein families: a new frontier for drug discovery. Nat Rev Drug Discov (2012) 6.70
Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol (2012) 4.86
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell (2013) 4.85
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature (2011) 4.48
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (2011) 4.16
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell (2011) 3.64
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell (2013) 3.50
Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (2013) 3.40
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab (2011) 3.38
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat Struct Mol Biol (2010) 3.27
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature (2012) 2.96
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell (2011) 2.73
Influence of metabolism on epigenetics and disease. Cell (2013) 2.64
Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell (2010) 2.50
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype. Cell Metab (2015) 2.48
Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci (2010) 2.37
A two-way street: reciprocal regulation of metabolism and signalling. Nat Rev Mol Cell Biol (2012) 2.35
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Mol Cell (2011) 2.29
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY) (2010) 2.27
Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov (2012) 2.22
The aging stress response. Mol Cell (2010) 2.19
Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation (2010) 2.19
The critical role of metabolic pathways in aging. Diabetes (2012) 2.12
SIRT1: recent lessons from mouse models. Nat Rev Cancer (2010) 2.07
NAD+ and sirtuins in aging and disease. Trends Cell Biol (2014) 2.07
The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nat Commun (2011) 2.00
Retracted SIRT1 protects against α-synuclein aggregation by activating molecular chaperones. J Neurosci (2012) 2.00
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99
miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells. J Biol Chem (2011) 1.98
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat Med (2011) 1.97
The metabolic footprint of aging in mice. Sci Rep (2011) 1.93
Muscle wasting in disease: molecular mechanisms and promising therapies. Nat Rev Drug Discov (2015) 1.90
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. Proc Natl Acad Sci U S A (2011) 1.90
Histone acetylation: molecular mnemonics on the chromatin. Nat Rev Neurosci (2013) 1.77
SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator. J Biol Chem (2010) 1.75
Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression. Aging (Albany NY) (2011) 1.74
Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. J Clin Invest (2011) 1.74
Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. Cell Metab (2013) 1.74
HDAC inhibitor-based therapies: can we interpret the code? Mol Oncol (2012) 1.67
The intersection between aging and cardiovascular disease. Circ Res (2012) 1.61
From sirtuin biology to human diseases: an update. J Biol Chem (2012) 1.60
The SirT3 divining rod points to oxidative stress. Mol Cell (2011) 1.58
The dynamic regulation of NAD metabolism in mitochondria. Trends Endocrinol Metab (2012) 1.55
Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics (2012) 1.54
Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival. Mol Cell Biol (2011) 1.53
Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization. Exp Neurol (2013) 1.52
Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1α-FXR signaling and alters systemic bile acid homeostasis. Gastroenterology (2013) 1.50
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci U S A (2010) 1.49
Protein lysine acylation and cysteine succination by intermediates of energy metabolism. ACS Chem Biol (2012) 1.49
Quercetin and cancer chemoprevention. Evid Based Complement Alternat Med (2011) 1.49
Metabolism and the circadian clock converge. Physiol Rev (2013) 1.47
SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells. J Biol Chem (2010) 1.46
Epigenetic mechanisms in diabetic vascular complications. Cardiovasc Res (2011) 1.43
Janus-faced role of SIRT1 in tumorigenesis. Ann N Y Acad Sci (2012) 1.43
Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1. Diabetes Care (2011) 1.41
p63-microRNA feedback in keratinocyte senescence. Proc Natl Acad Sci U S A (2012) 1.41
Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes. PLoS One (2015) 1.40
Mitochondrial protein acetylation regulates metabolism. Essays Biochem (2012) 1.40
Acetylation-dependent regulation of Skp2 function. Cell (2012) 1.40
NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab (2015) 1.38
SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. Cell Metab (2011) 1.37
Sirtuins: guardians of mammalian healthspan. Trends Genet (2014) 1.36
SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse. Blood (2010) 1.36
Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. J Biol Chem (2011) 1.35
Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Arch Biochem Biophys (2010) 1.34
Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine. ACS Chem Biol (2011) 1.33
Regulation of metabolism: the circadian clock dictates the time. Trends Endocrinol Metab (2011) 1.32
Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc Natl Acad Sci U S A (2010) 1.30
SIRT1 and SIRT2: emerging targets in neurodegeneration. EMBO Mol Med (2013) 1.30
Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A (2011) 1.29
Anti-inflammatory therapies for cardiovascular disease. Eur Heart J (2014) 1.28
Chromatin regulation and genome maintenance by mammalian SIRT6. Trends Biochem Sci (2010) 1.28
AMPK at the nexus of energetics and aging. Cell Metab (2014) 1.28
FoxO1 mediates an autofeedback loop regulating SIRT1 expression. J Biol Chem (2010) 1.27
Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1α. Neurobiol Dis (2012) 1.26
Fueling the flame: bioenergy couples metabolism and inflammation. J Leukoc Biol (2012) 1.26
SIRT1 and energy metabolism. Acta Biochim Biophys Sin (Shanghai) (2013) 1.25
Identification of a SIRT1 mutation in a family with type 1 diabetes. Cell Metab (2013) 1.25
Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells. Int J Biol Sci (2010) 1.24
SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity. PLoS One (2012) 1.23
Regulation of SIRT1 activity by genotoxic stress. Genes Dev (2012) 1.22
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase. J Biol Chem (2012) 1.19
Structure-based development of novel sirtuin inhibitors. Aging (Albany NY) (2011) 1.19
Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. Aging Cell (2013) 1.19
SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress. Stem Cells (2014) 1.19
Roles of SIRT1 in the acute and restorative phases following induction of inflammation. J Biol Chem (2010) 1.18
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Proc Natl Acad Sci U S A (2013) 1.18
Mammalian sirtuins and energy metabolism. Int J Biol Sci (2011) 1.17
Dietary restriction: standing up for sirtuins. Science (2010) 1.17
Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis. FEBS Lett (2011) 1.17
Signaling in control of cell growth and metabolism. Cold Spring Harb Perspect Biol (2012) 1.16
Herbal therapies for type 2 diabetes mellitus: chemistry, biology, and potential application of selected plants and compounds. Evid Based Complement Alternat Med (2013) 1.16
SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60. Mol Cell Biol (2012) 1.15
Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modifications. Biochim Biophys Acta (2010) 1.15
The nucleolus—guardian of cellular homeostasis and genome integrity. Chromosoma (2013) 1.14
Aging and reprogramming: a two-way street. Curr Opin Cell Biol (2012) 1.14
Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes (2012) 1.14
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature (1992) 25.54
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell (2006) 19.16
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell (1998) 18.32
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature (2003) 17.52
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet (2005) 16.79
Tumor spectrum analysis in p53-mutant mice. Curr Biol (1994) 16.60
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97
Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature (2001) 14.44
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 14.43
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science (2000) 12.98
Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov (2006) 11.77
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J (2004) 11.00
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science (1997) 10.90
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature (2009) 10.59
Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature (2004) 10.36
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature (2004) 10.32
Mitochondrial dysfunction and type 2 diabetes. Science (2005) 10.25
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature (2007) 10.21
Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A (2004) 9.25
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun (2000) 9.09
p53 regulates mitochondrial respiration. Science (2006) 9.06
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell (2007) 8.94
Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89
Extrachromosomal rDNA circles--a cause of aging in yeast. Cell (1997) 8.68
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. Genes Dev (2006) 8.48
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature (2002) 8.45
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell (2003) 8.34
Genetic pathways that regulate ageing in model organisms. Nature (2000) 8.19
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation (2004) 7.77
Sirtuins in mammals: insights into their biological function. Biochem J (2007) 7.60
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J (2007) 7.30
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science (2004) 7.29
Retracted Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science (2004) 7.21
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci U S A (2006) 7.00
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science (2005) 6.69
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A (2008) 6.53
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell (2008) 6.44
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature (2003) 6.25
miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A (2008) 6.24
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J Biol Chem (2002) 6.15
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell (2009) 6.09
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02
An unusual form of transcriptional silencing in yeast ribosomal DNA. Genes Dev (1997) 6.00
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A (2006) 5.96
Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature (2007) 5.94
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem Biophys Res Commun (1999) 5.83
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol (2005) 5.54
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science (2007) 5.49
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab (2008) 5.44
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab (2005) 5.39
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol (2002) 5.37
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J Biol Chem (2004) 5.37
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science (2009) 5.35
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science (2009) 5.30
SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30
Substrate-specific activation of sirtuins by resveratrol. J Biol Chem (2005) 5.28
Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci U S A (2008) 5.21
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell (2008) 5.11
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science (2001) 5.03
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab (2009) 5.02
SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell (2007) 5.01
Increase in activity during calorie restriction requires Sirt1. Science (2005) 4.90
SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89
CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature (2009) 4.83
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem (2005) 4.80
Toward a unified theory of caloric restriction and longevity regulation. Mech Ageing Dev (2005) 4.77
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab (2007) 4.75
Asymmetric inheritance of oxidatively damaged proteins during cytokinesis. Science (2003) 4.71
Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell (1999) 4.71
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J (2007) 4.66
DBC1 is a negative regulator of SIRT1. Nature (2008) 4.66
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science (2004) 4.61
Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev (2004) 4.51
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature (2008) 4.43
The biochemistry of sirtuins. Annu Rev Biochem (2006) 4.32
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One (2008) 4.32
Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast. Genes Dev (1997) 4.31
Axonal self-destruction and neurodegeneration. Science (2002) 4.30
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci U S A (2002) 4.27
Sir2 blocks extreme life-span extension. Cell (2005) 4.25
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev Cell (2005) 4.16
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature (2003) 17.52
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov (2006) 11.77
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature (2007) 10.21
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature (2003) 6.25
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J Biol Chem (2002) 6.15
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J (2007) 4.66
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One (2008) 4.32
HST2 mediates SIR2-independent life-span extension by calorie restriction. Science (2005) 4.12
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell (2004) 3.73
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69
Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (2013) 3.40
MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol (2007) 3.19
Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. J Biol Chem (2002) 2.91
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol Appl Pharmacol (2007) 2.37
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY) (2010) 2.27
The role of nuclear architecture in genomic instability and ageing. Nat Rev Mol Cell Biol (2007) 2.17
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99
Design and synthesis of compounds that extend yeast replicative lifespan. Aging Cell (2006) 1.93
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiol Mol Biol Rev (2003) 1.78
SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci (2010) 1.71
Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy. Aging (Albany NY) (2009) 1.62
The intersection between aging and cardiovascular disease. Circ Res (2012) 1.61
Small molecules that regulate lifespan: evidence for xenohormesis. Mol Microbiol (2004) 1.59
Xenohormesis: sensing the chemical cues of other species. Cell (2008) 1.50
Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity? Exp Gerontol (2006) 1.49
Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. Protein Sci (2009) 1.46
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem (2005) 1.40
SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. Cell Metab (2011) 1.37
Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. J Biol Chem (2011) 1.35
Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A (2011) 1.29
Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2012) 1.29
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat Chem Biol (2013) 1.23
Sirtuins: a conserved key unlocking AceCS activity. Trends Biochem Sci (2006) 1.19
SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity. Diabetes (2010) 1.18
Dietary restriction: standing up for sirtuins. Science (2010) 1.17
Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes (2012) 1.14
Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. Biochim Biophys Acta (2011) 1.05
Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin. Mol Cell Biol (2012) 1.01
Aging: past, present and future. Aging (Albany NY) (2009) 1.01
Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice. Invest Ophthalmol Vis Sci (2011) 0.99
The role of protein arginine methylation in the formation of silent chromatin. Genes Dev (2006) 0.99
Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway. Circulation (2013) 0.99
Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice. Haematologica (2013) 0.99
Germline energetics, aging, and female infertility. Cell Metab (2013) 0.97
A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Mol Cell Biol (2013) 0.96
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell (2014) 0.94
The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction. Aging (Albany NY) (2012) 0.94
Characterization of murine SIRT3 transcript variants and corresponding protein products. J Cell Biochem (2010) 0.93
Life-span extension in yeast. Science (2006) 0.92
Caloric restriction and life span determination of yeast cells. Methods Mol Biol (2007) 0.90
NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell (2009) 0.90
Impact papers on aging in 2009. Aging (Albany NY) (2010) 0.89
The "metabolic winter" hypothesis: a cause of the current epidemics of obesity and cardiometabolic disease. Metab Syndr Relat Disord (2014) 0.89
Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase. EMBO Rep (2011) 0.86
Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism. Aging Cell (2014) 0.86
Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy. Angiogenesis (2013) 0.83
GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A (2014) 0.83
Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism. Cell Cycle (2013) 0.83
An unSIRTain role in longevity. Nat Med (2011) 0.82
Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay. Methods Mol Biol (2013) 0.82
TPE or not TPE? It's no longer a question. Trends Pharmacol Sci (2002) 0.80
Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene. Cell Cycle (2012) 0.78
A blueprint for developing therapeutic approaches that increase healthspan and delay death. J Gerontol A Biol Sci Med Sci (2010) 0.77
Correction: nicotinamide impairs entry into and exit from meiosis I in mouse oocytes. PLoS One (2015) 0.75
Measuring PGC-1α and its acetylation status in mouse primary myotubes. Methods Mol Biol (2015) 0.75
David A. Sinclair, Ph.D is interviewed by Vicki Glaser. Rejuvenation Res (2008) 0.75