Published in Genome Integr on December 20, 2013
Nuclear DNA damage signalling to mitochondria in ageing. Nat Rev Mol Cell Biol (2016) 0.99
SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin. Front Aging Neurosci (2014) 0.88
SIRTain regulators of premature senescence and accelerated aging. Protein Cell (2015) 0.82
Poly(ADP-ribose) polymerase 1-sirtuin 1 functional interplay regulates LPS-mediated high mobility group box 1 secretion. Mol Med (2015) 0.81
Modelling and analysis of the feeding regimen induced entrainment of hepatocyte circadian oscillators using petri nets. PLoS One (2015) 0.79
Predicted Role of NAD Utilization in the Control of Circadian Rhythms during DNA Damage Response. PLoS Comput Biol (2015) 0.78
A fully integrated new paradigm for lithium's mode of action - lithium utilizes latent cellular fail-safe mechanisms. Neuropsychiatr Dis Treat (2017) 0.75
Circadian molecular clock in lung pathophysiology. Am J Physiol Lung Cell Mol Physiol (2015) 0.75
DNA Damage Response and Autophagy: A Meaningful Partnership. Front Genet (2016) 0.75
Mitochondrial determinants of cancer health disparities. Semin Cancer Biol (2017) 0.75
Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability. Nucleic Acids Res (2017) 0.75
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97
Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05
The DNA damage response: ten years after. Mol Cell (2007) 11.80
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell (2003) 8.34
The first 30 years of p53: growing ever more complex. Nat Rev Cancer (2009) 8.00
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science (2004) 7.29
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell (2005) 6.79
PARP inhibition: PARP1 and beyond. Nat Rev Cancer (2010) 6.70
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell (2008) 6.44
The PARP superfamily. Bioessays (2004) 6.14
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68
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Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science (2009) 5.30
Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell (2007) 5.29
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci U S A (1997) 5.24
Circadian regulator CLOCK is a histone acetyltransferase. Cell (2006) 5.24
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol Cell (2010) 5.06
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem (2005) 4.80
DBC1 is a negative regulator of SIRT1. Nature (2008) 4.66
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science (2004) 4.61
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell (1999) 4.07
Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene (2007) 3.85
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. Mol Cell (2007) 3.67
Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes. Science (2008) 3.45
Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol (2006) 3.37
Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going? Microbiol Mol Biol Rev (2006) 3.31
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J Biol Chem (2005) 3.31
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat Struct Mol Biol (2013) 3.18
How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17
SIRT6 promotes DNA repair under stress by activating PARP1. Science (2011) 2.99
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab (2011) 2.94
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85
On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1. Genes Dev (2012) 2.82
Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity. J Biol Chem (2005) 2.73
MiR-34, SIRT1 and p53: the feedback loop. Cell Cycle (2009) 2.71
SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell Stem Cell (2008) 2.67
CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature (2007) 2.65
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell (2010) 2.52
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ Res (2008) 2.51
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat Cell Biol (2007) 2.47
SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell (2007) 2.42
Phosphorylation regulates SIRT1 function. PLoS One (2008) 2.30
GAPDH mediates nitrosylation of nuclear proteins. Nat Cell Biol (2010) 2.22
Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage. Cell Cycle (2006) 2.17
JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS One (2009) 2.07
MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair. Mol Cell Biol (2010) 2.03
Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J Biol Chem (2005) 1.93
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. Proc Natl Acad Sci U S A (2011) 1.90
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats. PLoS One (2011) 1.81
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol Cell Biol (2009) 1.79
A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. J Cell Biol (2009) 1.73
Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation. Nat Cell Biol (2007) 1.73
Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos). Sci Signal (2011) 1.73
SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell (2013) 1.71
Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters. J Biol Chem (2009) 1.70
Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. Proc Natl Acad Sci U S A (2006) 1.68
Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase. J Biol Chem (1998) 1.67
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J Biol Chem (2010) 1.65
PARP1 ADP-ribosylates lysine residues of the core histone tails. Nucleic Acids Res (2010) 1.64
Mediation of cell death by poly(ADP-ribose) polymerase-1. Pharmacol Res (2005) 1.57
PARP-2 regulates SIRT1 expression and whole-body energy expenditure. Cell Metab (2011) 1.55
Poly(ADP-ribose) polymerase is a catalytic dimer and the automodification reaction is intermolecular. J Biol Chem (1993) 1.53
AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells. Cancer Res (2012) 1.52
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. PLoS One (2009) 1.43
Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair. J Mol Cell Biol (2013) 1.37
H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion. Cell Physiol Biochem (2007) 1.36
Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1. Biochem J (2007) 1.36
Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells. Genes Cells (2005) 1.32
SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60. J Biol Chem (2010) 1.30
SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism. Mol Cancer Res (2008) 1.30
PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase. Oncogene (2003) 1.30
Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool. J Biol Chem (2010) 1.27
Peptide switch is essential for Sirt1 deacetylase activity. Mol Cell (2011) 1.26
A formal MIM specification and tools for the common exchange of MIM diagrams: an XML-Based format, an API, and a validation method. BMC Bioinformatics (2011) 1.25
Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1. Proc Natl Acad Sci U S A (2007) 1.23
Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks. DNA Repair (Amst) (2008) 1.23
Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition. BMC Mol Biol (2007) 1.23
Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2. Biochem Biophys Res Commun (2009) 1.23
Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One (2012) 1.23
Regulation of SIRT1 activity by genotoxic stress. Genes Dev (2012) 1.22
Differences among cell types in NAD(+) compartmentalization: a comparison of neurons, astrocytes, and cardiac myocytes. J Neurosci Res (2007) 1.22
MicroRNA Regulation of SIRT1. Front Physiol (2012) 1.21
Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture. PLoS One (2011) 1.18
Are poly(ADP-ribosyl)ation by PARP-1 and deacetylation by Sir2 linked? Bioessays (2003) 1.17
Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci U S A (2011) 1.17
Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function. FASEB J (2009) 1.15
SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60. Mol Cell Biol (2012) 1.15
DNA-damage-responsive acetylation of pRb regulates binding to E2F-1. EMBO Rep (2006) 1.14
A functional link between SIRT1 deacetylase and NBS1 in DNA damage response. Cell Cycle (2007) 1.10
AsSIRTing the DNA damage response. Trends Cell Biol (2008) 1.05
The Systems Biology Graphical Notation. Nat Biotechnol (2009) 8.53
Apoptotic susceptibility of cancer cells selected for camptothecin resistance: gene expression profiling, functional analysis, and molecular interaction mapping. Cancer Res (2003) 3.52
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J Biol Chem (2003) 3.45
Molecular interaction maps of bioregulatory networks: a general rubric for systems biology. Mol Biol Cell (2005) 2.82
CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set. Cancer Res (2012) 2.57
Repair of and checkpoint response to topoisomerase I-mediated DNA damage. Mutat Res (2003) 2.50
The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses. Mol Cell Biol (2007) 2.41
Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks. Oncogene (2004) 2.36
The human beta-globin locus control region can silence as well as activate gene expression. Mol Cell Biol (2005) 2.19
mRNA and microRNA expression profiles of the NCI-60 integrated with drug activities. Mol Cancer Ther (2010) 2.00
Preventing gene silencing with human replicators. Nat Biotechnol (2006) 1.84
Software support for SBGN maps: SBGN-ML and LibSBGN. Bioinformatics (2012) 1.69
Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks. EMBO Rep (2009) 1.69
Inhibition of histone deacetylase in cancer cells slows down replication forks, activates dormant origins, and induces DNA damage. Cancer Res (2010) 1.53
Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses. Cancer Res (2007) 1.51
Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress. J Mol Biol (2007) 1.50
Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes. DNA Repair (Amst) (2006) 1.45
Genome-wide depletion of replication initiation events in highly transcribed regions. Genome Res (2011) 1.44
Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways. Mol Cell Biol (2008) 1.39
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex. Mol Cancer Ther (2006) 1.36
Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes. J Cell Biol (2011) 1.36
Transcriptional regulation of mitotic genes by camptothecin-induced DNA damage: microarray analysis of dose- and time-dependent effects. Cancer Res (2002) 1.34
UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1. Cancer Res (2002) 1.32
Apoptosis induced by topoisomerase inhibitors. Curr Med Chem Anticancer Agents (2003) 1.31
The cyclin-dependent kinase inhibitor Dacapo promotes replication licensing during Drosophila endocycles. EMBO J (2007) 1.30
Chk2 molecular interaction map and rationale for Chk2 inhibitors. Clin Cancer Res (2006) 1.28
The human beta-globin replication initiation region consists of two modular independent replicators. Mol Cell Biol (2004) 1.28
Molecular interaction maps--a diagrammatic graphical language for bioregulatory networks. Sci STKE (2004) 1.27
Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma. Cancer Res (2006) 1.26
A formal MIM specification and tools for the common exchange of MIM diagrams: an XML-Based format, an API, and a validation method. BMC Bioinformatics (2011) 1.25
Dynamic alterations of replication timing in mammalian cells. Curr Biol (2003) 1.21
Candidate DNA replication initiation regions at human trinucleotide repeat disease loci. Hum Mol Genet (2003) 1.17
Depicting combinatorial complexity with the molecular interaction map notation. Mol Syst Biol (2006) 1.17
DNA methylation supports intrinsic epigenetic memory in mammalian cells. PLoS Genet (2006) 1.17
DNA-PK is involved in repairing a transient surge of DNA breaks induced by deceleration of DNA replication. J Mol Biol (2007) 1.17
Targeting chk2 kinase: molecular interaction maps and therapeutic rationale. Curr Pharm Des (2005) 1.17
ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin. J Cell Biol (2012) 1.07
Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle. PLoS Genet (2013) 1.07
Impact of p53 knockout and topotecan treatment on gene expression profiles in human colon carcinoma cells: a pharmacogenomic study. Cancer Res (2003) 1.07
Werner syndrome protein directly binds to the AAA ATPase p97/VCP in an ATP-dependent fashion. J Struct Biol (2004) 1.07
Circuit diagrams for biological networks. Mol Syst Biol (2006) 1.06
Genome-wide analysis of novel splice variants induced by topoisomerase I poisoning shows preferential occurrence in genes encoding splicing factors. Cancer Res (2010) 1.05
Transcription poisoning by Topoisomerase I is controlled by gene length, splice sites, and miR-142-3p. Cancer Res (2013) 1.05
Chromatin challenges during DNA replication: a systems representation. Mol Biol Cell (2007) 1.04
Preferential localization of human origins of DNA replication at the 5'-ends of expressed genes and at evolutionarily conserved DNA sequences. PLoS One (2011) 1.04
A chromatin structure-based model accurately predicts DNA replication timing in human cells. Mol Syst Biol (2014) 1.04
PathVisio-MIM: PathVisio plugin for creating and editing Molecular Interaction Maps (MIMs). Bioinformatics (2011) 1.01
Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response. Proc Natl Acad Sci U S A (2012) 1.01
Functional categories associated with clusters of genes that are co-expressed across the NCI-60 cancer cell lines. PLoS One (2012) 0.94
Chromosome fragility and the abnormal replication of the FMR1 locus in fragile X syndrome. Hum Mol Genet (2014) 0.92
Concordance of gene expression and functional correlation patterns across the NCI-60 cell lines and the Cancer Genome Atlas glioblastoma samples. PLoS One (2012) 0.89
Cooperative sequence modules determine replication initiation sites at the human beta-globin locus. Hum Mol Genet (2006) 0.89
PathVisio-Validator: a rule-based validation plugin for graphical pathway notations. Bioinformatics (2011) 0.89
Using drug response data to identify molecular effectors, and molecular "omic" data to identify candidate drugs in cancer. Hum Genet (2014) 0.89
Prevention of transcriptional silencing by a replicator-binding complex consisting of SWI/SNF, MeCP1, and hnRNP C1/C2. Mol Cell Biol (2011) 0.88
Importance of the fourth alpha-helix within the CAP homology domain of type II topoisomerase for DNA cleavage site recognition and quinolone action. Antimicrob Agents Chemother (2002) 0.86
Initiation of DNA replication at the human beta-globin 3' enhancer. Nucleic Acids Res (2005) 0.84
[Cell cycle and checkpoints in oncology: new therapeutic targets]. Med Sci (Paris) (2003) 0.84
HAUSP-regulated switch from auto- to p53 ubiquitination by Mdm2 (in silico discovery). Math Biosci (2007) 0.83
Predicted functions of MdmX in fine-tuning the response of p53 to DNA damage. PLoS Comput Biol (2010) 0.83
Network architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis. Cell Cycle (2009) 0.82
PathVisio-Faceted Search: an exploration tool for multi-dimensional navigation of large pathways. Bioinformatics (2013) 0.82
4-nitroquinoline-1-oxide induces the formation of cellular topoisomerase I-DNA cleavage complexes. Cancer Res (2006) 0.82
The chromatin backdrop of DNA replication: lessons from genetics and genome-scale analyses. Biochim Biophys Acta (2012) 0.82
Targeted deletion of the chicken beta-globin regulatory elements reveals a cooperative gene silencing activity. J Biol Chem (2005) 0.79
Mapping replication origin sequences in eukaryotic chromosomes. Curr Protoc Cell Biol (2014) 0.77
Best practices for mapping replication origins in eukaryotic chromosomes. Curr Protoc Cell Biol (2014) 0.76
Interactions of MCP1 with components of the replication machinery in mammalian cells. Int J Biol Sci (2011) 0.75