Published in Proc Natl Acad Sci U S A on February 17, 2009
A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival. Genes Dev (2013) 1.55
Molecular pathways: targeting mechanisms of asbestos and erionite carcinogenesis in mesothelioma. Clin Cancer Res (2011) 1.47
FAS-associated factor 1 (FAF1): diverse functions and implications for oncogenesis. Cell Cycle (2009) 1.15
Germline mutation of Bap1 accelerates development of asbestos-induced malignant mesothelioma. Cancer Res (2014) 1.11
ERK2 is essential for the growth of human epithelioid malignant mesotheliomas. Int J Cancer (2011) 1.00
Fas-associated factor 1 antagonizes Wnt signaling by promoting β-catenin degradation. Mol Biol Cell (2011) 1.00
Genome-wide gene-environment interaction analysis for asbestos exposure in lung cancer susceptibility. Carcinogenesis (2012) 0.99
Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis. PLoS One (2011) 0.99
Structure and interaction of ubiquitin-associated domain of human Fas-associated factor 1. Protein Sci (2009) 0.99
Role of mutagenicity in asbestos fiber-induced carcinogenicity and other diseases. J Toxicol Environ Health B Crit Rev (2011) 0.98
p97-containing complexes in proliferation control and cancer: emerging culprits or guilt by association? Genes Cancer (2010) 0.96
Consensus Report of the 2015 Weinman International Conference on Mesothelioma. J Thorac Oncol (2016) 0.95
Role of p97/VCP (Cdc48) in genome stability. Front Genet (2013) 0.94
A Phosphotyrosine Proteomic Screen Identifies Multiple Tyrosine Kinase Signaling Pathways Aberrantly Activated in Malignant Mesothelioma. Genes Cancer (2010) 0.93
Distinct patterns of 1p and 19q alterations identify subtypes of human gliomas that have different prognoses. Neuro Oncol (2010) 0.86
Zoledronic acid produces combinatory anti-tumor effects with cisplatin on mesothelioma by increasing p53 expression levels. PLoS One (2013) 0.85
Factors that impact susceptibility to fiber-induced health effects. J Toxicol Environ Health B Crit Rev (2011) 0.84
A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-κB signaling in chordoma biology. PLoS One (2013) 0.83
Genetic variants in fas signaling pathway genes and risk of gastric cancer. Int J Cancer (2013) 0.83
Fas-associated factor 1 is a scaffold protein that promotes β-transducin repeat-containing protein (β-TrCP)-mediated β-catenin ubiquitination and degradation. J Biol Chem (2012) 0.83
UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids. J Lipid Res (2013) 0.81
Syntenic relationships between genomic profiles of fiber-induced murine and human malignant mesothelioma. Am J Pathol (2011) 0.81
Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure. Bioanalysis (2015) 0.81
Reduced FAF1 Expression and Helicobacter Infection: Correlations with Clinicopathological Features in Gastric Cancer. Gastroenterol Res Pract (2012) 0.80
Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice. Carcinogenesis (2015) 0.79
Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations. Cancer Res (2016) 0.79
Evaluation of polymorphisms in predicted target sites for micro RNAs differentially expressed in endometriosis. Mol Hum Reprod (2010) 0.79
Inflammation-Related IL1β/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma. Cancer Prev Res (Phila) (2016) 0.77
Update in environmental and occupational medicine 2009. Am J Respir Crit Care Med (2010) 0.76
Fas-associated factor (Faf1) is a novel CD40 interactor that regulates CD40-induced NF-κB activation via a negative feedback loop. Cell Death Dis (2014) 0.75
Crystallization and preliminary X-ray crystallographic analysis of human FAF1 UBX domain. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.75
UBXD Proteins: A Family of Proteins with Diverse Functions in Cancer. Int J Mol Sci (2016) 0.75
HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma. Oncotarget (2017) 0.75
Fas-associated factor 1 inhibits tumor growth by suppressing Helicobacter pylori-induced activation of NF-κB signaling in human gastric carcinoma. Oncotarget (2016) 0.75
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell (1997) 12.41
Divorcing ARF and p53: an unsettled case. Nat Rev Cancer (2006) 5.17
Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science (2005) 5.14
The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim Biophys Acta (1998) 4.45
A high-resolution map of segmental DNA copy number variation in the mouse genome. PLoS Genet (2006) 3.24
Tumor spectrum in ARF-deficient mice. Cancer Res (1999) 3.11
The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis. Oncogene (2004) 2.14
TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis. Proc Natl Acad Sci U S A (2006) 2.14
p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma. Cancer Res (1994) 1.95
Significant gene content variation characterizes the genomes of inbred mouse strains. Genome Res (2007) 1.88
A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc Natl Acad Sci U S A (1995) 1.82
Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB. J Biol Chem (2003) 1.44
Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth. Oncogene (2005) 1.41
A mouse model recapitulating molecular features of human mesothelioma. Cancer Res (2005) 1.39
Asbestos, chromosomal deletions, and tumor suppressor gene alterations in human malignant mesothelioma. J Cell Physiol (1999) 1.38
Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters. Proc Natl Acad Sci U S A (2006) 1.37
Cytotoxicity of long and short crocidolite asbestos fibers in vitro and in vivo. Cancer Res (1990) 1.37
Microarray comparative genomic hybridization detection of chromosomal imbalances in uterine cervix carcinoma. BMC Cancer (2005) 1.27
Codeletion of p15 and p16 in primary malignant mesothelioma. Oncogene (1995) 1.24
Fas-associated factor 1, FAF1, is a member of Fas death-inducing signaling complex. J Biol Chem (2003) 1.20
Bortezomib inhibits nuclear factor-kappaB dependent survival and has potent in vivo activity in mesothelioma. Clin Cancer Res (2007) 1.19
FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly. J Biol Chem (2007) 1.17
Inhibitor of apoptosis proteins are regulated by tumour necrosis factor-alpha in malignant pleural mesothelioma. J Pathol (2007) 1.15
Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells. J Natl Cancer Inst (2000) 1.04
Immunohistochemical analysis of the p16INK4 cyclin-dependent kinase inhibitor in malignant mesothelioma. J Natl Cancer Inst (1995) 1.04
Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression. Oncogene (1998) 1.02
Hemizygosity of Nf2 is associated with increased susceptibility to asbestos-induced peritoneal tumours. Oncogene (2003) 0.98
Accelerated progression of asbestos-induced mesotheliomas in heterozygous p53+/- mice. Toxicol Sci (2002) 0.95
Modeling INK4/ARF tumor suppression in the mouse. Curr Mol Med (2007) 0.92
Similar tumor suppressor gene alteration profiles in asbestos-induced murine and human mesothelioma. Cell Cycle (2005) 0.89
Susceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers. Environ Health Perspect (1997) 0.88
Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation. Int J Cancer (2005) 0.87
Perturbations of the AKT signaling pathway in human cancer. Oncogene (2005) 6.64
Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem (2004) 4.27
Germline BAP1 mutations predispose to malignant mesothelioma. Nat Genet (2011) 4.26
Human hepatic stem cells from fetal and postnatal donors. J Exp Med (2007) 4.15
Asbestos exposure, pleural mesothelioma, and serum osteopontin levels. N Engl J Med (2005) 4.11
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell (2010) 3.79
Fibulin-3 as a blood and effusion biomarker for pleural mesothelioma. N Engl J Med (2012) 3.52
Extrapleural pneumonectomy versus pleurectomy/decortication in the surgical management of malignant pleural mesothelioma: results in 663 patients. J Thorac Cardiovasc Surg (2008) 2.93
AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene (2004) 2.67
Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism. Am J Respir Crit Care Med (2002) 2.56
Biological interactions of graphene-family nanomaterials: an interdisciplinary review. Chem Res Toxicol (2011) 2.24
BAP1 and cancer. Nat Rev Cancer (2013) 2.23
Mesothelioma epidemiology, carcinogenesis, and pathogenesis. Curr Treat Options Oncol (2008) 2.20
TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis. Proc Natl Acad Sci U S A (2006) 2.14
p21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem (2001) 2.05
Chromosomal imbalances in human lung cancer. Oncogene (2002) 2.00
Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors. Proc Natl Acad Sci U S A (2008) 1.97
High Incidence of Somatic BAP1 alterations in sporadic malignant mesothelioma. J Thorac Oncol (2015) 1.93
Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions. Carcinogenesis (2004) 1.92
T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell (2010) 1.85
A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor. Cancer J (2004) 1.85
A transmembrane motif governs the surface trafficking of nicotinic acetylcholine receptors. Nat Neurosci (2002) 1.85
GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signaling. Mol Cell Biol (2006) 1.85
GATA6 regulates differentiation of distal lung epithelium. Development (2002) 1.82
The pathogenesis of mesothelioma. Semin Oncol (2002) 1.80
LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex. Mol Cell Biol (2007) 1.79
APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction. Mol Cell Biol (2006) 1.78
Acute inhibition of Rho-kinase improves cardiac contractile function in streptozotocin-diabetic rats. Cardiovasc Res (2007) 1.77
RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer. Cancer Res (2007) 1.76
Structural basis for regulation of protein phosphatase 1 by inhibitor-2. J Biol Chem (2007) 1.74
Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation. Proc Natl Acad Sci U S A (2010) 1.72
RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model. Clin Cancer Res (2007) 1.72
Cancer and inflammation: promise for biologic therapy. J Immunother (2010) 1.72
Frequent activation of AKT2 kinase in human pancreatic carcinomas. J Cell Biochem (2002) 1.70
Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos? Wiley Interdiscip Rev Nanomed Nanobiotechnol (2010) 1.64
Microglia/macrophage polarization dynamics in white matter after traumatic brain injury. J Cereb Blood Flow Metab (2013) 1.62
Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesothelioma. Cancer Res (2012) 1.61
Continuous exposure to chrysotile asbestos can cause transformation of human mesothelial cells via HMGB1 and TNF-α signaling. Am J Pathol (2013) 1.61
The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. Mol Cell Biol (2005) 1.60
The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. J Biol Chem (2002) 1.59
Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations. Cancer Biol Ther (2004) 1.58
ZnO/TiO2 nanocable structured photoelectrodes for CdS/CdSe quantum dot co-sensitized solar cells. Nanoscale (2012) 1.57
Cellular and molecular parameters of mesothelioma. J Cell Biochem (2006) 1.57
Hsp27 protects against ischemic brain injury via attenuation of a novel stress-response cascade upstream of mitochondrial cell death signaling. J Neurosci (2008) 1.56
High-resolution mapping of amplifications and deletions in pediatric osteosarcoma by use of CGH analysis of cDNA microarrays. Genes Chromosomes Cancer (2003) 1.52
Gene expression profiles predict survival and progression of pleural mesothelioma. Clin Cancer Res (2004) 1.51
Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. Oncogene (2005) 1.48
Phase II study of erlotinib in patients with malignant pleural mesothelioma: a Southwest Oncology Group Study. J Clin Oncol (2007) 1.46
Age-dependent mobilization of circulating endothelial progenitor cells in infants and young children undergoing cardiac surgery with cardiopulmonary bypass. Cytokine (2009) 1.45
AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival. Oncogene (2002) 1.44
Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth. Oncogene (2005) 1.41
On the origin of Tibetans and their genetic basis in adapting high-altitude environments. PLoS One (2011) 1.40
A mouse model recapitulating molecular features of human mesothelioma. Cancer Res (2005) 1.39
mTOR is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary. Clin Cancer Res (2009) 1.39
Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters. Proc Natl Acad Sci U S A (2006) 1.37
Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse. J Pharmacol Exp Ther (2006) 1.36
Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation. Nat Nanotechnol (2011) 1.35
Genetic predisposition to fiber carcinogenesis causes a mesothelioma epidemic in Turkey. Cancer Res (2006) 1.35
Diverse mechanisms of AKT pathway activation in human malignancy. Curr Cancer Drug Targets (2013) 1.33
Asbestos is not just asbestos: an unrecognised health hazard. Lancet Oncol (2013) 1.33
Regulation of acetylcholine receptor clustering by the tumor suppressor APC. Nat Neurosci (2003) 1.31
Adsorption of essential micronutrients by carbon nanotubes and the implications for nanotoxicity testing. Small (2008) 1.29
SV40 and human tumours: myth, association or causality? Nat Rev Cancer (2002) 1.29
Some oral poliovirus vaccines were contaminated with infectious SV40 after 1961. Cancer Res (2005) 1.29
Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B. Blood (2012) 1.29
Graphene microsheets enter cells through spontaneous membrane penetration at edge asperities and corner sites. Proc Natl Acad Sci U S A (2013) 1.28
Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. J Exp Med (2011) 1.27
Soluble mesothelin-related peptide level elevation in mesothelioma serum and pleural effusions. Ann Thorac Surg (2008) 1.26
Retracted Aberrant methylation profile of human malignant mesotheliomas and its relationship to SV40 infection. Oncogene (2005) 1.25
The SV40 large T antigen-p53 complexes bind and activate the insulin-like growth factor-I promoter stimulating cell growth. Cancer Res (2008) 1.25
Notch-1 induction, a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells. Oncogene (2003) 1.25
Early detection of malignant pleural mesothelioma in asbestos-exposed individuals with a noninvasive proteomics-based surveillance tool. PLoS One (2012) 1.24
The Presence of Asbestos in the Natural Environment is Likely Related to Mesothelioma in Young Individuals and Women from Southern Nevada. J Thorac Oncol (2015) 1.24
hsa-miR-29c* is linked to the prognosis of malignant pleural mesothelioma. Cancer Res (2010) 1.22
Chemical transformations of nanosilver in biological environments. ACS Nano (2012) 1.21
Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling. Biol Reprod (2004) 1.21
A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment. ACS Nano (2013) 1.20
Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance. Cancer Res (2004) 1.20
Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. Mol Cell Biol (2004) 1.19
A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice. Cancer Res (2008) 1.19
Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcome. Genes Chromosomes Cancer (2011) 1.18
Protein kinase C phosphorylation disrupts Na+/H+ exchanger regulatory factor 1 autoinhibition and promotes cystic fibrosis transmembrane conductance regulator macromolecular assembly. J Biol Chem (2007) 1.18
Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways. J Allergy Clin Immunol (2011) 1.17
Biodurability of Single-Walled Carbon Nanotubes Depends on Surface Functionalization. Carbon N Y (2010) 1.15
FAS-associated factor 1 (FAF1): diverse functions and implications for oncogenesis. Cell Cycle (2009) 1.15
Many LINE1 elements contribute to the transcriptome of human somatic cells. Genome Biol (2009) 1.15
Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesothelioma. Mol Cancer Ther (2008) 1.14
Current status of screening for malignant pleural mesothelioma. Semin Thorac Cardiovasc Surg (2009) 1.14
Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade. J Neurosci (2011) 1.13
Discrete subcellular partitioning of human retrotransposon RNAs despite a common mechanism of genome insertion. Hum Mol Genet (2010) 1.13
Frequency of use and predictors of cancer-directed surgery in the management of malignant pleural mesothelioma in a community-based (Surveillance, Epidemiology, and End Results [SEER]) population. J Thorac Oncol (2010) 1.12