Published in Genes Cancer on September 02, 2010
Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system. Nat Cell Biol (2012) 3.90
Inhibitors of the AAA+ chaperone p97. Molecules (2015) 1.61
The structural and functional basis of the p97/valosin-containing protein (VCP)-interacting motif (VIM): mutually exclusive binding of cofactors to the N-terminal domain of p97. J Biol Chem (2011) 0.98
Signal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97. Mol Cell (2012) 0.96
Cdc48: a swiss army knife of cell biology. J Amino Acids (2013) 0.94
Role of p97/VCP (Cdc48) in genome stability. Front Genet (2013) 0.94
SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy. PLoS One (2011) 0.87
Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97. ACS Med Chem Lett (2015) 0.84
ATP binding to p97/VCP D1 domain regulates selective recruitment of adaptors to its proximal N-domain. PLoS One (2012) 0.83
Perturbations to the ubiquitin conjugate proteome in yeast δubx mutants identify Ubx2 as a regulator of membrane lipid composition. Mol Cell Proteomics (2013) 0.81
From neurodevelopment to neurodegeneration: the interaction of neurofibromin and valosin-containing protein/p97 in regulation of dendritic spine formation. J Biomed Sci (2012) 0.80
Point-of-care test for cervical cancer in LMICs. Oncotarget (2016) 0.80
Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. Nat Commun (2016) 0.76
Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells. BMC Cancer (2015) 0.75
UBXD Proteins: A Family of Proteins with Diverse Functions in Cancer. Int J Mol Sci (2016) 0.75
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Central pore residues mediate the p97/VCP activity required for ERAD. Mol Cell (2006) 4.56
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J (2010) 3.90
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UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Cell (2008) 3.41
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Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways. Mol Cell Biol (2001) 3.09
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. Autophagy (2010) 2.99
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The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25. Oncogene (2001) 2.97
Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains. Nat Struct Biol (2003) 2.93
Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin. Nature (2007) 2.84
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The ubiquitylation machinery of the endoplasmic reticulum. Nature (2009) 2.66
Diverse functions with a common regulator: ubiquitin takes command of an AAA ATPase. J Struct Biol (2006) 2.66
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A small molecule inhibitor of inducible heat shock protein 70. Mol Cell (2009) 2.63
UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97. Cell Mol Life Sci (2008) 2.59
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev (2007) 2.56
HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO J (2006) 2.52
Dissecting the ER-associated degradation of a misfolded polytopic membrane protein. Cell (2008) 2.41
Nucleotide dependent motion and mechanism of action of p97/VCP. J Mol Biol (2005) 2.31
RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis. J Cell Sci (2003) 2.21
Ubx2 links the Cdc48 complex to ER-associated protein degradation. Nat Cell Biol (2005) 2.12
p62/SQSTM1: a missing link between protein aggregates and the autophagy machinery. Autophagy (2006) 2.09
Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3. J Cell Biol (2006) 2.00
The crystal structure of murine p97/VCP at 3.6A. J Struct Biol (2003) 1.98
Tumor microenvironment and neurofibromatosis type I: connecting the GAPs. Oncogene (2007) 1.97
p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis. Dev Cell (2006) 1.95
Ubiquitin in trafficking: the network at work. Exp Cell Res (2008) 1.94
Ubiquitin receptors and ERAD: a network of pathways to the proteasome. Semin Cell Dev Biol (2007) 1.88
Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. Nature (2003) 1.88
The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis. Cell (2003) 1.84
The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Mol Cell (2009) 1.82
Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease. J Biol Chem (2008) 1.82
Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity. Genes Dev (2008) 1.81
Increased expression of valosin-containing protein (p97) is associated with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma. Ann Surg Oncol (2004) 1.78
Targeting the hypoxia-inducible factor (HIF) pathway in cancer. Expert Rev Mol Med (2009) 1.74
Insights into adaptor binding to the AAA protein p97. Biochem Soc Trans (2008) 1.66
Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone. Hum Mol Genet (2010) 1.64
Going through the motions: the ATPase cycle of p97. J Struct Biol (2006) 1.61
Imbalances in p97 co-factor interactions in human proteinopathy. EMBO Rep (2010) 1.55
VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments. J Cell Biol (2004) 1.55
A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. J Mol Biol (2009) 1.54
The UBX domain: a widespread ubiquitin-like module. J Mol Biol (2001) 1.49
Conformational changes in the AAA ATPase p97-p47 adaptor complex. EMBO J (2006) 1.48
The Png1-Rad23 complex regulates glycoprotein turnover. J Cell Biol (2006) 1.43
The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism. J Biol Chem (2004) 1.41
Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation. EMBO Rep (2004) 1.40
Doa1 is a Cdc48 adapter that possesses a novel ubiquitin binding domain. Mol Cell Biol (2006) 1.39
Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice. Proc Natl Acad Sci U S A (2009) 1.38
Hexamerization of p97-VCP is promoted by ATP binding to the D1 domain and required for ATPase and biological activities. Biochem Biophys Res Commun (2003) 1.38
Cdc48p(Npl4p/Ufd1p) binds and segregates membrane-anchored/tethered complexes via a polyubiquitin signal present on the anchors. Mol Cell (2007) 1.37
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Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase. J Biol Chem (2008) 1.36
Xp11.2 translocation renal cell carcinoma. Arch Pathol Lab Med (2010) 1.36
Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway. Mol Cell Biol (2005) 1.33
Parkin-mediated ubiquitin signalling in aggresome formation and autophagy. Biochem Soc Trans (2010) 1.31
A ubiquitin-selective AAA-ATPase mediates transcriptional switching by remodelling a repressor-promoter DNA complex. Nat Cell Biol (2009) 1.31
Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation. J Cell Sci (2006) 1.30
The localization and phosphorylation of p47 are important for Golgi disassembly-assembly during the cell cycle. J Cell Biol (2003) 1.29
Targeted deletion of p97 (VCP/CDC48) in mouse results in early embryonic lethality. Biochem Biophys Res Commun (2007) 1.27
Microarray comparative genomic hybridization detection of chromosomal imbalances in uterine cervix carcinoma. BMC Cancer (2005) 1.27
AAA ATPase p97/VCP: cellular functions, disease and therapeutic potential. J Cell Mol Med (2008) 1.23
Structural insights into the p97-Ufd1-Npl4 complex. Proc Natl Acad Sci U S A (2007) 1.22
D1 ring is stable and nucleotide-independent, whereas D2 ring undergoes major conformational changes during the ATPase cycle of p97-VCP. J Biol Chem (2003) 1.22
Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation. Proc Natl Acad Sci U S A (2007) 1.21
p97/p47-Mediated biogenesis of Golgi and ER. J Biochem (2005) 1.21
FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly. J Biol Chem (2007) 1.17
Elevated expression of valosin-containing protein (p97) in hepatocellular carcinoma is correlated with increased incidence of tumor recurrence. J Clin Oncol (2003) 1.16
Cdc48p is required for the cell cycle commitment point at Start via degradation of the G1-CDK inhibitor Far1p. J Cell Biol (2003) 1.15
Expression of valosin-containing protein in colorectal carcinomas as a predictor for disease recurrence and prognosis. Clin Cancer Res (2004) 1.13
Expression level of valosin-containing protein (p97) is correlated with progression and prognosis of non-small-cell lung carcinoma. Ann Surg Oncol (2004) 1.13
Tyrosine phosphorylation of p97 regulates transitional endoplasmic reticulum assembly in vitro. Proc Natl Acad Sci U S A (2000) 1.13
The pro-apoptotic FAS-associated factor 1 is specifically reduced in human gastric carcinomas. Int J Oncol (2003) 1.10
The valosin-containing protein (VCP) is a target of Akt signaling required for cell survival. J Biol Chem (2006) 1.09
The PUB domain functions as a p97 binding module in human peptide N-glycanase. J Biol Chem (2006) 1.08
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Expression level of valosin-containing protein (p97) is associated with prognosis of esophageal carcinoma. Clin Cancer Res (2004) 1.07
Expression level of valosin-containing protein is strongly associated with progression and prognosis of gastric carcinoma. J Clin Oncol (2003) 1.04
The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans. Mol Cell Biol (2010) 1.03
Ubxd1 is a novel co-factor of the human p97 ATPase. Int J Biochem Cell Biol (2008) 1.03
Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins. J Biol Chem (2005) 1.01
UBXD1 binds p97 through two independent binding sites. Biochem Biophys Res Commun (2009) 0.99
Detailed structural insights into the p97-Npl4-Ufd1 interface. J Biol Chem (2007) 0.99
Increased expression of valosin-containing protein (p97) is correlated with disease recurrence in follicular thyroid cancer. Ann Surg Oncol (2005) 0.97
2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97). Bioorg Med Chem Lett (2010) 0.97
Valosin-containing protein (p97) and Ki-67 expression is a useful marker in detecting malignant behavior of pancreatic endocrine neoplasms. Oncology (2004) 0.95