Published in EMBO Rep on February 20, 2009
A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4. Proc Natl Acad Sci U S A (2009) 2.06
Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining. Proc Natl Acad Sci U S A (2010) 1.94
53BP1: pro choice in DNA repair. Trends Cell Biol (2013) 1.75
gammaH2A binds Brc1 to maintain genome integrity during S-phase. EMBO J (2010) 1.28
Role of PTIP in class switch recombination and long-range chromatin interactions at the immunoglobulin heavy chain locus. Mol Cell Biol (2011) 1.13
Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast. PLoS Genet (2010) 1.11
The AID-induced DNA damage response in chromatin. Mol Cell (2013) 1.04
AID targeting is dependent on RNA polymerase II pausing. Semin Immunol (2012) 1.01
High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5. BMC Genet (2010) 0.95
Three-dimensional architecture of the IgH locus facilitates class switch recombination. Ann N Y Acad Sci (2012) 0.94
Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombination. Biochim Biophys Acta (2012) 0.90
PAXIP1 Potentiates the Combination of WEE1 Inhibitor AZD1775 and Platinum Agents in Lung Cancer. Mol Cancer Ther (2016) 0.79
Arrested spermatogenesis and evidence for DNA damage in PTIP mutant testes. Dev Biol (2012) 0.75
Chromatin modifications and their function. Cell (2007) 55.98
A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J (1997) 15.10
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem (2004) 14.93
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell (2007) 9.73
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature (2006) 9.30
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell (2007) 9.25
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 8.71
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell (2005) 8.39
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell (2006) 8.12
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (2007) 7.61
The BRCT domain is a phospho-protein binding domain. Science (2003) 7.42
ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev (2000) 7.28
BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science (2003) 6.88
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature (2004) 6.72
Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Mol Cell Biol (2006) 5.74
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell (2004) 5.29
The logic of TGFbeta signaling. FEBS Lett (2006) 5.26
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem (2007) 4.79
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci U S A (2007) 4.75
The ATM-mediated DNA-damage response: taking shape. Trends Biochem Sci (2006) 4.67
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat Cell Biol (2002) 4.45
Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair (Amst) (2006) 3.61
A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A (2002) 3.46
Pax-2 controls multiple steps of urogenital development. Development (1995) 3.42
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr Biol (2000) 3.34
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell (2006) 3.10
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol Biol Cell (2005) 3.08
Mutation of the PAX2 gene in a family with optic nerve colobomas, renal anomalies and vesicoureteral reflux. Nat Genet (1995) 3.03
The histone methyltransferase SET8 is required for S-phase progression. J Cell Biol (2007) 2.74
PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase. J Cell Biol (2007) 2.39
The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Dev Cell (2007) 2.20
Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stability. J Biol Chem (2008) 1.99
Pax genes and organogenesis. Bioessays (1997) 1.98
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. Proc Natl Acad Sci U S A (2008) 1.84
Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage. EMBO J (2004) 1.66
Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4. Mol Biol Cell (2005) 1.66
Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination. Proc Natl Acad Sci U S A (2008) 1.66
BRCT domain-containing protein PTIP is essential for progression through mitosis. Mol Cell Biol (2003) 1.63
Disruption of the developmentally regulated Rev3l gene causes embryonic lethality. Curr Biol (2000) 1.63
Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast. Proc Natl Acad Sci U S A (2002) 1.61
Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. J Mol Biol (2008) 1.57
Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. J Biol Chem (2004) 1.55
PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin. Nucleic Acids Res (2000) 1.52
The RAD6 pathway: control of DNA damage bypass and mutagenesis by ubiquitin and SUMO. Chembiochem (2005) 1.49
Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage. Nucleic Acids Res (2007) 1.48
Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. J Biol Chem (2009) 1.39
Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor beta signaling. Mol Cell Biol (2001) 1.19
Esc4/Rtt107 and the control of recombination during replication. DNA Repair (Amst) (2006) 1.19
The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter. J Biol Chem (2002) 1.19
ATM signaling and 53BP1. Radiother Oncol (2005) 1.15
A role for Chd1 and Set2 in negatively regulating DNA replication in Saccharomyces cerevisiae. Genetics (2008) 1.09
Pax transactivation-domain interacting protein is required for urine concentration and osmotolerance in collecting duct epithelia. J Am Soc Nephrol (2007) 1.01
Rtt107/Esc4 binds silent chromatin and DNA repair proteins using different BRCT motifs. BMC Mol Biol (2006) 0.99
PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage. DNA Repair (Amst) (2008) 0.95
Missense mutation and hexanucleotide duplication in the PAX2 gene in two unrelated families with renal-coloboma syndrome (MIM 120330). Hum Genet (1998) 0.90
SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. Nat Genet (2011) 3.74
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell (2010) 3.43
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol Cell (2009) 3.38
Phosphorylation of Slx4 by Mec1 and Tel1 regulates the single-strand annealing mode of DNA repair in budding yeast. Mol Cell Biol (2007) 1.61
Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases. Mol Cell (2013) 1.57
Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. J Biol Chem (2004) 1.55
Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage. Nucleic Acids Res (2007) 1.48
Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage. DNA Repair (Amst) (2008) 1.39
DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage. Nat Struct Mol Biol (2012) 1.38
Slx4 becomes phosphorylated after DNA damage in a Mec1/Tel1-dependent manner and is required for repair of DNA alkylation damage. Biochem J (2005) 1.32
Identification of the MMS22L-TONSL complex that promotes homologous recombination. Mol Cell (2010) 1.21
Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR. DNA Repair (Amst) (2007) 1.10
Localization-dependent and -independent roles of SLX4 in regulating telomeres. Cell Rep (2013) 1.05
Mec1/Tel1-dependent phosphorylation of Slx4 stimulates Rad1-Rad10-dependent cleavage of non-homologous DNA tails. DNA Repair (Amst) (2010) 1.03
Identification and characterization of FUS/TLS as a new target of ATM. Biochem J (2008) 1.01
Biochemical characterisation of the SWI/SNF family member HLTF. Biochem Biophys Res Commun (2009) 0.96
PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage. DNA Repair (Amst) (2008) 0.95
Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex. J Biol Chem (2012) 0.94
Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage. FEBS J (2008) 0.91
Simulation methods for multipole imaging systems and aberration correctors. Ultramicroscopy (2002) 0.75