Published in Mol Biol Cell on March 02, 2005
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
Human CtIP promotes DNA end resection. Nature (2007) 10.63
A dynamic model for replication protein A (RPA) function in DNA processing pathways. Nucleic Acids Res (2006) 4.49
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev (2007) 3.58
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev (2008) 2.86
Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses. J Cell Physiol (2006) 2.83
Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem (2006) 2.76
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol Cell (2006) 2.73
DNA mismatch repair: molecular mechanism, cancer, and ageing. Mech Ageing Dev (2008) 2.40
ATR signalling: more than meeting at the fork. Biochem J (2011) 2.37
The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling. Mol Cell Biol (2008) 2.17
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. Mol Cell Biol (2006) 2.09
Function of a conserved checkpoint recruitment domain in ATRIP proteins. Mol Cell Biol (2007) 2.02
Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans. EMBO J (2005) 1.94
Emerging common themes in regulation of PIKKs and PI3Ks. EMBO J (2009) 1.88
Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks. Mol Cell Biol (2006) 1.82
Common mechanisms of PIKK regulation. DNA Repair (Amst) (2009) 1.73
DNA damage sensing by the ATM and ATR kinases. Cold Spring Harb Perspect Biol (2013) 1.72
Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling. Genes Dev (2005) 1.71
ATR autophosphorylation as a molecular switch for checkpoint activation. Mol Cell (2011) 1.70
Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling. EMBO J (2006) 1.65
Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. J Cell Biol (2015) 1.65
Telomere protection by TPP1/POT1 requires tethering to TIN2. Mol Cell (2011) 1.62
ATRIP associates with replication protein A-coated ssDNA through multiple interactions. Proc Natl Acad Sci U S A (2006) 1.55
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev (2010) 1.55
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling. Proc Natl Acad Sci U S A (2010) 1.53
Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences. Mol Cell Biol (2006) 1.51
ATRIP oligomerization is required for ATR-dependent checkpoint signaling. J Biol Chem (2005) 1.51
Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress. J Mol Biol (2007) 1.50
TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks. J Cell Biol (2009) 1.43
Herpes simplex virus type I disrupts the ATR-dependent DNA-damage response during lytic infection. J Cell Sci (2006) 1.43
The essential kinase ATR: ensuring faithful duplication of a challenging genome. Nat Rev Mol Cell Biol (2017) 1.38
Functional genomic screens identify CINP as a genome maintenance protein. Proc Natl Acad Sci U S A (2009) 1.38
Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. J Biol Chem (2010) 1.37
Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1. Mol Biol Cell (2010) 1.34
Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians. Crit Rev Biochem Mol Biol (2010) 1.30
How ATR turns on: TopBP1 goes on ATRIP with ATR. Genes Dev (2008) 1.30
Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment. EMBO J (2011) 1.28
Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage. Cancer Res (2007) 1.27
Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response. Mol Cell (2008) 1.21
The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted. J Cell Biol (2007) 1.17
Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase. J Biol Chem (2011) 1.16
Expanded roles for Chk1 in genome maintenance. J Biol Chem (2008) 1.15
Activation of ATR and related PIKKs. Cell Cycle (2008) 1.12
Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forks. Mol Biol Cell (2005) 1.10
ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled. J Virol (2010) 1.07
Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome. PLoS Genet (2012) 1.06
Structural dynamics and single-stranded DNA binding activity of the three N-terminal domains of the large subunit of replication protein A from small angle X-ray scattering. Biochemistry (2010) 1.04
A high-throughput fluorescence polarization anisotropy assay for the 70N domain of replication protein A. Anal Biochem (2011) 1.03
Control of histone methylation and genome stability by PTIP. EMBO Rep (2009) 1.01
Parvovirus B19 infection of human primary erythroid progenitor cells triggers ATR-Chk1 signaling, which promotes B19 virus replication. J Virol (2011) 1.00
Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis. Nucleic Acids Res (2009) 1.00
The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways. J Biol Chem (2009) 0.99
Discovery of a potent stapled helix peptide that binds to the 70N domain of replication protein A. J Med Chem (2014) 0.97
The replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplication. Genes (Basel) (2013) 0.97
Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A. ACS Med Chem Lett (2013) 0.95
Replication checkpoint: tuning and coordination of replication forks in s phase. Genes (Basel) (2013) 0.95
ETAA1 acts at stalled replication forks to maintain genome integrity. Nat Cell Biol (2016) 0.95
Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2. Nucleus (2012) 0.94
The PSO4 protein complex associates with replication protein A (RPA) and modulates the activation of ataxia telangiectasia-mutated and Rad3-related (ATR). J Biol Chem (2014) 0.93
Identification and characterization of SMARCAL1 protein complexes. PLoS One (2013) 0.93
Extracellular signal-regulated kinases modulate DNA damage response - a contributing factor to using MEK inhibitors in cancer therapy. Curr Med Chem (2011) 0.92
Function of the ATR N-terminal domain revealed by an ATM/ATR chimera. Exp Cell Res (2007) 0.92
A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair. Nucleic Acids Res (2013) 0.92
BID binds to replication protein A and stimulates ATR function following replicative stress. Mol Cell Biol (2011) 0.91
Human single-stranded DNA binding proteins are essential for maintaining genomic stability. BMC Mol Biol (2013) 0.91
DNA structure-specific priming of ATR activation by DNA-PKcs. J Cell Biol (2013) 0.91
RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response. J Biol Chem (2011) 0.90
Efficient herpes simplex virus 1 replication requires cellular ATR pathway proteins. J Virol (2012) 0.89
An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence. PLoS Genet (2013) 0.88
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA. Cell Rep (2016) 0.88
SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway. Genes Dev (2014) 0.88
Role of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts. Nucleic Acids Res (2011) 0.87
The fork and the kinase: a DNA replication tale from a CHK1 perspective. Mutat Res Rev Mutat Res (2014) 0.87
ATR checkpoint kinase and CRL1βTRCP collaborate to degrade ASF1a and thus repress genes overlapping with clusters of stalled replication forks. Genes Dev (2014) 0.87
ATR signaling at a glance. J Cell Sci (2009) 0.87
In vitro analysis of the role of replication protein A (RPA) and RPA phosphorylation in ATR-mediated checkpoint signaling. J Biol Chem (2012) 0.87
E3 ligase RFWD3 participates in replication checkpoint control. J Biol Chem (2011) 0.85
Surface reengineering of RPA70N enables cocrystallization with an inhibitor of the replication protein A interaction motif of ATR interacting protein. Biochemistry (2013) 0.84
Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts. Cell Biochem Biophys (2007) 0.84
ATRIP from TopBP1 to ATR--in vitro activation of a DNA damage checkpoint. Proc Natl Acad Sci U S A (2010) 0.83
A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast. PLoS Genet (2010) 0.83
Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism. PLoS Genet (2014) 0.83
Herpes simplex virus type 1 single strand DNA binding protein and helicase/primase complex disable cellular ATR signaling. PLoS Pathog (2013) 0.82
Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo. Mol Biol Cell (2012) 0.82
Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substrates. PLoS One (2011) 0.82
Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection. J Virol (2011) 0.81
Molecular mechanisms of DNA replication checkpoint activation. Genes (Basel) (2014) 0.80
Theoretical prediction of the binding free energy for mutants of replication protein A. J Mol Model (2011) 0.80
RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response. Curr Biol (2016) 0.78
Enhancer of Rudimentary Homolog Affects the Replication Stress Response through Regulation of RNA Processing. Mol Cell Biol (2015) 0.78
RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling. Nucleic Acids Res (2015) 0.78
The N-terminus of RPA large subunit and its spatial position are important for the 5'->3' resection of DNA double-strand breaks. Nucleic Acids Res (2015) 0.77
Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage. J Biol Chem (2016) 0.77
The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function. G3 (Bethesda) (2013) 0.77
The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair. Nucleic Acids Res (2016) 0.76
Mutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinase. PLoS One (2014) 0.76
The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization. J Biol Chem (2016) 0.76
Characterization of the interaction between Rfa1 and Rad24 in Saccharomyces cerevisiae. PLoS One (2015) 0.76
DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP. Nucleic Acids Res (2016) 0.75
Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics (1996) 24.62
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science (2003) 18.29
Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev (2001) 12.46
Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell (2004) 9.74
ATR and ATRIP: partners in checkpoint signaling. Science (2001) 7.58
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev (2000) 7.29
ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev (2000) 7.28
ATR and ATM regulate the timing of DNA replication origin firing. Nat Cell Biol (2004) 4.39
Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev (2001) 4.28
A central role for DNA replication forks in checkpoint activation and response. Mol Cell (2003) 4.15
ATM and ATR: networking cellular responses to DNA damage. Curr Opin Genet Dev (2001) 4.05
Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci U S A (2003) 3.88
Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Proc Natl Acad Sci U S A (2004) 3.12
A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins. Nat Cell Biol (1999) 3.05
An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol Cell (2003) 2.96
Activation of the DNA replication checkpoint through RNA synthesis by primase. Science (2000) 2.83
The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes Dev (2000) 2.82
Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol Cell (2002) 2.22
LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae. EMBO J (2000) 2.22
Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. Curr Biol (2001) 2.20
A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. Genes Dev (2002) 2.09
Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae. Mol Cell Biol (2001) 2.09
Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. Mol Cell (2003) 2.08
The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint. J Biol Chem (2002) 1.92
Preferential binding of ATR protein to UV-damaged DNA. Proc Natl Acad Sci U S A (2002) 1.87
Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. EMBO J (2004) 1.75
Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1. J Biol Chem (2004) 1.70
Physical interaction between replication protein A and Rad51 promotes exchange on single-stranded DNA. J Biol Chem (2004) 1.65
ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation. Curr Biol (2003) 1.55
Cut5 is required for the binding of Atr and DNA polymerase alpha to genotoxin-damaged chromatin. J Biol Chem (2003) 1.53
Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase. J Biol Chem (2004) 1.51
DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells. J Biol Chem (2004) 1.47
Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities. Mol Cell Biol (2004) 1.45
A novel protein activity mediates DNA binding of an ATR-ATRIP complex. J Biol Chem (2004) 1.23
A novel mutant allele of Schizosaccharomyces pombe rad26 defective in monitoring S-phase progression to prevent premature mitosis. Mol Cell Biol (1997) 1.21
Single-strand DNA gaps trigger an ATR- and Cdc7-dependent checkpoint. Cell Cycle (2003) 1.09
Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage. FEBS Lett (2004) 0.94
Fission yeast Rad26 responds to DNA damage independently of Rad3. BMC Genet (2003) 0.91
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
DNA repair mediated by endonuclease-independent LINE-1 retrotransposition. Nat Genet (2002) 4.58
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev (2002) 4.58
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev (2008) 2.86
Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem (2006) 2.76
Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell (2008) 2.71
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks. Genes Dev (2009) 2.50
Analysis of protein dynamics at active, stalled, and collapsed replication forks. Genes Dev (2011) 2.47
ATR signalling: more than meeting at the fork. Biochem J (2011) 2.37
The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling. Mol Cell Biol (2008) 2.17
Function of a conserved checkpoint recruitment domain in ATRIP proteins. Mol Cell Biol (2007) 2.02
SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication. Genes Dev (2012) 1.85
DDB1 maintains genome integrity through regulation of Cdt1. Mol Cell Biol (2006) 1.84
Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates. Chem Biol (2013) 1.82
Alu elements and hominid phylogenetics. Proc Natl Acad Sci U S A (2003) 1.81
Common mechanisms of PIKK regulation. DNA Repair (Amst) (2009) 1.73
ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Genes Dev (2013) 1.70
Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A (2008) 1.58
ATRIP oligomerization is required for ATR-dependent checkpoint signaling. J Biol Chem (2005) 1.51
DNA damage response: three levels of DNA repair regulation. Cold Spring Harb Perspect Biol (2013) 1.48
Monitoring the spatiotemporal dynamics of proteins at replication forks and in assembled chromatin using isolation of proteins on nascent DNA. Nat Protoc (2012) 1.45
Identification of proteins at active, stalled, and collapsed replication forks using isolation of proteins on nascent DNA (iPOND) coupled with mass spectrometry. J Biol Chem (2013) 1.43
Substrate-selective repair and restart of replication forks by DNA translocases. Cell Rep (2013) 1.39
Functional genomic screens identify CINP as a genome maintenance protein. Proc Natl Acad Sci U S A (2009) 1.38
Cyclin-dependent kinase 9-cyclin K functions in the replication stress response. EMBO Rep (2010) 1.36
Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage. Cancer Res (2007) 1.27
Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair. J Biol Chem (2010) 1.26
LINE-1 preTa elements in the human genome. J Mol Biol (2003) 1.16
Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase. J Biol Chem (2011) 1.16
Activation of ATR and related PIKKs. Cell Cycle (2008) 1.12
Following the LINEs: an analysis of primate genomic variation at human-specific LINE-1 insertion sites. Mol Biol Evol (2003) 1.08
ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled. J Virol (2010) 1.07
Label-free quantitation of protein modifications by pseudo selected reaction monitoring with internal reference peptides. J Proteome Res (2012) 1.05
Shwachman-Bodian Diamond syndrome is a multi-functional protein implicated in cellular stress responses. Hum Mol Genet (2009) 1.02
HDAC3 is essential for DNA replication in hematopoietic progenitor cells. J Clin Invest (2013) 1.02
SMARCAL1 and replication stress: an explanation for SIOD? Nucleus (2010) 1.01
Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4. PLoS Genet (2013) 0.99
A role for CDK9-cyclin K in maintaining genome integrity. Cell Cycle (2011) 0.98
Discovery of a potent stapled helix peptide that binds to the 70N domain of replication protein A. J Med Chem (2014) 0.97
Schimke Immunoosseous Dysplasia associated with undifferentiated carcinoma and a novel SMARCAL1 mutation in a child. Pediatr Blood Cancer (2013) 0.96
Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS One (2013) 0.93
Identification and characterization of SMARCAL1 protein complexes. PLoS One (2013) 0.93
Function of the ATR N-terminal domain revealed by an ATM/ATR chimera. Exp Cell Res (2007) 0.92
Straightening out the LINEs: LINE-1 orthologous loci. Genomics (2005) 0.88
Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase. J Biol Chem (2011) 0.82
Purification of proteins on newly synthesized DNA using iPOND. Methods Mol Biol (2015) 0.81
Phosphorylation of a C-terminal auto-inhibitory domain increases SMARCAL1 activity. Nucleic Acids Res (2013) 0.79
SOSS1/2: Sensors of single-stranded DNA at a break. Mol Cell (2009) 0.78
Defining genome maintenance pathways using functional genomic approaches. Crit Rev Biochem Mol Biol (2011) 0.77
Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature (2016) 0.75
Advancing Health Equity Through Student Empowerment and Professional Success: A Statewide Approach. J Nurs Educ (2016) 0.75
Publisher correction: The essential kinase ATR: ensuring faithful duplication of a challenging genome. Nat Rev Mol Cell Biol (2017) 0.75