PubRank

Vincent W Yang

Author PubWeight™ 114.09‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development 2002 5.09
2 Mammalian Krüppel-like factors in health and diseases. Physiol Rev 2010 4.09
3 Primary chemoprevention of familial adenomatous polyposis with sulindac. N Engl J Med 2002 3.16
4 Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer. Oncogene 2004 2.96
5 Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. Cell Res 2005 2.73
6 The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology. Bioessays 2007 2.40
7 Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells. Gastroenterology 2008 2.31
8 Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage. J Biol Chem 2002 2.19
9 Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. J Mol Biol 2003 2.11
10 Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity. Oncogene 2003 2.11
11 Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression. Mol Cell Biol 2006 1.96
12 Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage. J Biol Chem 2003 1.76
13 Krüppel-like factor 6 regulates mitochondrial function in the kidney. J Clin Invest 2015 1.72
14 Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res 2007 1.71
15 Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras. Oncogene 2004 1.70
16 Secondary chemoprevention of Barrett's esophagus with celecoxib: results of a randomized trial. J Natl Cancer Inst 2007 1.65
17 Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene. Nucleic Acids Res 2002 1.64
18 Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol. Hepatology 2012 1.64
19 Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis. Gastroenterology 2007 1.58
20 The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer. Gastroenterology 2009 1.56
21 Human cancer cells commonly acquire DNA damage during mitotic arrest. Cancer Res 2007 1.47
22 Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium. Mol Cancer Res 2008 1.46
23 Near IR heptamethine cyanine dye-mediated cancer imaging. Clin Cancer Res 2010 1.44
24 Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage. Oncogene 2005 1.40
25 Implementing screening for Lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting. Genet Med 2011 1.37
26 All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Kruppel-like factor 5. FEBS Lett 2004 1.35
27 KLF4 suppresses transformation of pre-B cells by ABL oncogenes. Blood 2006 1.33
28 Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation. FEBS Lett 2005 1.31
29 Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells. Mol Cancer Res 2008 1.30
30 Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine. Cancer Res 2009 1.29
31 Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor. Am J Physiol Gastrointest Liver Physiol 2003 1.29
32 Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5. J Biol Chem 2007 1.29
33 Kruppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells. Nucleic Acids Res 2006 1.28
34 Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells. J Biol Chem 2004 1.22
35 p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells. Cancer Res 2007 1.20
36 SUMOylation regulates nuclear localization of Krüppel-like factor 5. J Biol Chem 2008 1.18
37 The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells. Histol Histopathol 2009 1.15
38 Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene. Dev Biol 2010 1.14
39 Krüppel-like factor 5 mediates transmissible murine colonic hyperplasia caused by Citrobacter rodentium infection. Gastroenterology 2008 1.11
40 Krüppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestine. Gastroenterology 2011 1.10
41 KLF4 is a FOXO target gene that suppresses B cell proliferation. Int Immunol 2008 1.08
42 Expression of the tumor suppressor Krüppel-like factor 4 as a prognostic predictor for colon cancer. Cancer Epidemiol Biomarkers Prev 2010 1.06
43 The Role of Inflammation in the Pathogenesis of Colorectal Cancer. Curr Colorectal Cancer Rep 2009 1.04
44 Krüppel-like factor 5 protects against dextran sulfate sodium-induced colonic injury in mice by promoting epithelial repair. Gastroenterology 2010 1.03
45 Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations. Mol Cancer 2010 1.03
46 The Pathobiology of Krüppel-like Factors in Colorectal Cancer. Curr Colorectal Cancer Rep 2008 1.02
47 Kruppel-like factors regulate the Lama1 gene encoding the laminin alpha1 chain. J Biol Chem 2003 1.02
48 Protein inhibitor of activated STAT1 interacts with and up-regulates activities of the pro-proliferative transcription factor Krüppel-like factor 5. J Biol Chem 2006 1.02
49 Prostanoids, ornithine decarboxylase, and polyamines in primary chemoprevention of familial adenomatous polyposis. Gastroenterology 2004 1.01
50 Transcriptional profiling of the cell cycle checkpoint gene krüppel-like factor 4 reveals a global inhibitory function in macromolecular biosynthesis. Gene Expr 2006 0.98
51 Reversal effects of pantoprazole on multidrug resistance in human gastric adenocarcinoma cells by down-regulating the V-ATPases/mTOR/HIF-1α/P-gp and MRP1 signaling pathway in vitro and in vivo. J Cell Biochem 2012 0.98
52 Lysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylation of Bad. Biochim Biophys Acta 2007 0.97
53 The challenges facing GI investigators today and what (more) the GI societies can do to help. Gastroenterology 2007 0.97
54 Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and Krüppel-like factor 5. J Biol Chem 2013 0.97
55 Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts. Mol Cancer 2013 0.96
56 Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening. Mol Cancer Ther 2011 0.94
57 Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening. Mol Cancer Ther 2009 0.93
58 Modeling using baseline characteristics in a small multicenter clinical trial for Barrett's esophagus. Contemp Clin Trials 2008 0.92
59 A small ubiquitin-related modifier-interacting motif functions as the transcriptional activation domain of Krüppel-like factor 4. J Biol Chem 2010 0.92
60 The E3 ubiquitin ligase SMAD ubiquitination regulatory factor 2 negatively regulates Krüppel-like factor 5 protein. J Biol Chem 2011 0.91
61 Genetic polymorphisms of human flavin-containing monooxygenase 3: implications for drug metabolism and clinical perspectives. Pharmacogenomics 2007 0.90
62 Helicobacter pylori promotes the expression of Krüppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo. PLoS One 2013 0.90
63 Notch1 regulates the effects of matrix metalloproteinase-9 on colitis-associated cancer in mice. Gastroenterology 2011 0.90
64 Genetics of colorectal cancer. MedGenMed 2004 0.87
65 Genetic polymorphisms of flavin monooxygenase 3 in sulindac-induced regression of colorectal adenomas in familial adenomatous polyposis. Cancer Epidemiol Biomarkers Prev 2005 0.87
66 Molecular Genetics of Colorectal Cancer: An Overview. Curr Colorectal Cancer Rep 2006 0.87
67 Genetic deletion of Klf4 in the mouse intestinal epithelium ameliorates dextran sodium sulfate-induced colitis by modulating the NF-κB pathway inflammatory response. Inflamm Bowel Dis 2014 0.86
68 Genetic and Chemical Models of Colorectal Cancer in Mice. Curr Colorectal Cancer Rep 2010 0.85
69 Genetic polymorphisms of human flavin monooxygenase 3 in sulindac-mediated primary chemoprevention of familial adenomatous polyposis. Clin Cancer Res 2004 0.85
70 Mitotic Origins of Chromosomal Instability in Colorectal Cancer. Curr Colorectal Cancer Rep 2007 0.84
71 A colon cancer-derived mutant of Krüppel-like factor 5 (KLF5) is resistant to degradation by glycogen synthase kinase 3β (GSK3β) and the E3 ubiquitin ligase F-box and WD repeat domain-containing 7α (FBW7α). J Biol Chem 2014 0.84
72 Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells. J Biol Chem 2013 0.83
73 Convergence of the thyroid hormone and gut-enriched Krüppel-like factor pathways in the context of enterocyte differentiation. J Gastrointest Surg 2003 0.83
74 Quantitative endoscopy in the chemoprevention of Barrett's Esophagus Trial. Dis Esophagus 2008 0.82
75 Diabetic nephropathy in a nonobese mouse model of type 2 diabetes mellitus. Am J Physiol Renal Physiol 2014 0.82
76 Role of prolonged mitotic checkpoint activation in the formation and treatment of cancer. Future Oncol 2009 0.82
77 An Update on the Biology of RAS/RAF Mutations in Colorectal Cancer. Curr Colorectal Cancer Rep 2011 0.82
78 Colon cancer: an update and future directions. Gastroenterology 2010 0.82
79 Expression profiling and pathway analysis of Krüppel-like factor 4 in mouse embryonic fibroblasts. Am J Cancer Res 2011 0.82
80 CDK1 regulates mediator of DNA damage checkpoint 1 during mitotic DNA damage. Cancer Res 2012 0.82
81 Inhibition of cell transformation by sulindac sulfide is confined to specific oncogenic pathways. Cancer Lett 2002 0.81
82 APC as a checkpoint gene: the beginning or the end? Gastroenterology 2002 0.81
83 Pharmacogenetics and diseases of the colon. Curr Opin Gastroenterol 2007 0.81
84 Activation of the human pregnancy-specific glycoprotein PSG-5 promoter by KLF4 and Sp1. Biochem Biophys Res Commun 2006 0.81
85 Oral contraceptives and polyp regression in familial adenomatous polyposis. Gastroenterology 2005 0.81
86 Chemoprevention of familial adenomatous polyposis by bromo-noscapine (EM011) in the Apc(Min/+) mouse model. Int J Cancer 2012 0.79
87 High-throughput screening strategies for targeted identification of therapeutic compounds in colorectal cancer. Future Oncol 2012 0.78
88 Prostaglandin E2 and Krüppel-like transcription factors synergistically induce the expression of decay-accelerating factor in intestinal epithelial cells. Immunology 2008 0.77
89 The future of physician-scientists-demise or opportunity? Gastroenterology 2006 0.75
90 Reinvesting in US biomedical research--the time is now. Gastroenterology 2009 0.75
91 Recent changes in relationships between medical school physicians and industry. Gastroenterology 2010 0.75
92 Our new president-Anil K. Rustgi, MD. Gastroenterology 2013 0.75