Implementing screening for Lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting.

PubWeight™: 1.37‹?› | Rank: Top 10%

🔗 View Article (PMC 3762677)

Published in Genet Med on October 27, 2011

Authors

Cecelia A Bellcross1, Sara R Bedrosian, Elvan Daniels, Debra Duquette, Heather Hampel, Kory Jasperson, Djenaba A Joseph, Celia Kaye, Ira Lubin, Laurence J Meyer, Michele Reyes, Maren T Scheuner, Sheri D Schully, Leigha Senter, Sherri L Stewart, Jeanette St Pierre, Judith Westman, Paul Wise, Vincent W Yang, Muin J Khoury

Author Affiliations

1: Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. cbellcr@emory.edu

Articles citing this

Multilevel research and the challenges of implementing genomic medicine. J Natl Cancer Inst Monogr (2012) 1.21

Public health action in genomics is now needed beyond newborn screening. Public Health Genomics (2012) 1.17

Comparing universal Lynch syndrome tumor-screening programs to evaluate associations between implementation strategies and patient follow-through. Genet Med (2014) 1.00

Underutilization of Lynch syndrome screening in a multisite study of patients with colorectal cancer. Genet Med (2013) 0.95

Genetic predisposition to colorectal cancer: where we stand and future perspectives. World J Gastroenterol (2014) 0.90

Impact of age cutoffs on a lynch syndrome screening program. J Oncol Pract (2012) 0.90

Relationship between PTEN, DNA mismatch repair, and tumor histotype in endometrial carcinoma: retained positive expression of PTEN preferentially identifies sporadic non-endometrioid carcinomas. Mod Pathol (2013) 0.86

Implementation of routine screening for Lynch syndrome in university and safety-net health system settings: successes and challenges. Genet Med (2013) 0.86

Deficient mismatch repair: Read all about it (Review). Int J Oncol (2015) 0.84

The genetic basis of Lynch syndrome and its implications for clinical practice and risk management. Appl Clin Genet (2014) 0.84

Creation of a network to promote universal screening for Lynch syndrome: the LynchSyndrome Screening Network. J Genet Couns (2014) 0.83

Reflex testing for Lynch syndrome: if we build it, will they come? Lessons learned from the uptake of clinical genetics services by individuals with newly diagnosed colorectal cancer (CRC). Fam Cancer (2014) 0.82

Stakeholder perspectives on implementing a universal Lynch syndrome screening program: a qualitative study of early barriers and facilitators. Genet Med (2015) 0.82

Direct-to-patient disclosure of results of mismatch repair screening for Lynch syndrome via electronic personal health record: a feasibility study. Genet Med (2014) 0.82

When is Genomic Testing Cost-Effective? Testing for Lynch Syndrome in Patients with Newly-Diagnosed Colorectal Cancer and Their Relatives. Healthcare (Basel) (2015) 0.81

Preferences for genetic testing for colorectal cancer within a population-based screening program: a discrete choice experiment. Eur J Hum Genet (2015) 0.80

Universal Screening of Colorectal Cancers for Lynch Syndrome: Challenges and Opportunities. Dig Dis Sci (2015) 0.77

Management strategies in Lynch syndrome and familial adenomatous polyposis: a national healthcare survey in Japan. Cancer Sci (2016) 0.75

Hereditary Cancer: Example of a Public Health Approach to Ensure Population Health Benefits of Genetic Medicine. Healthcare (Basel) (2016) 0.75

Qualitative Comparative Analysis: A Hybrid Method for Identifying Factors Associated with Program Effectiveness. J Mix Methods Res (2015) 0.75

Colorectal cancer: Cascade genetic testing in Lynch syndrome: room for improvement. Nat Rev Gastroenterol Hepatol (2013) 0.75

Recent advances in understanding Lynch syndrome. F1000Res (2016) 0.75

ReCAP: Oncologists' Selection of Genetic and Molecular Testing in the Evolving Landscape of Stage II Colorectal Cancer. J Oncol Pract (2016) 0.75

Role of the clinical pathology laboratory in the evaluation of endometrial carcinomas for Lynch syndrome. Semin Diagn Pathol (2014) 0.75

Applying public health screening criteria: how does universal newborn screening compare to universal tumor screening for Lynch syndrome in adults with colorectal cancer? J Genet Couns (2014) 0.75

Expert and Advocacy Group Consensus Findings on the Horizon of Public Health Genetic Testing. Healthcare (Basel) (2016) 0.75

Choosing not to undergo predictive genetic testing for hereditary colorectal cancer syndromes: expanding our understanding of decliners and declining. J Behav Med (2017) 0.75

Articles cited by this

Cancer statistics, 2009. CA Cancer J Clin (2009) 83.57

Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst (2004) 14.97

Colorectal cancer screening and surveillance: clinical guidelines and rationale-Update based on new evidence. Gastroenterology (2003) 14.67

New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology (1999) 11.94

Hereditary colorectal cancer. N Engl J Med (2003) 11.86

Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). N Engl J Med (2005) 9.39

Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med (1998) 8.47

Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer. Gastroenterology (2000) 8.41

Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol (2005) 8.15

Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Cancer (1999) 6.73

Prophylactic surgery to reduce the risk of gynecologic cancers in the Lynch syndrome. N Engl J Med (2006) 5.70

The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Initiative: methods of the EGAPP Working Group. Genet Med (2009) 5.69

Feasibility of screening for Lynch syndrome among patients with colorectal cancer. J Clin Oncol (2008) 5.47

Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: a systematic review. JAMA (2006) 4.87

Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome. JAMA (2011) 4.84

Recommendations from the EGAPP Working Group: genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives. Genet Med (2009) 4.79

Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer). J Med Genet (2007) 4.62

Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients. Cancer Res (2006) 4.26

Population-based molecular detection of hereditary nonpolyposis colorectal cancer. J Clin Oncol (2000) 3.98

EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome. Genet Med (2009) 3.57

Cancer risk associated with germline DNA mismatch repair gene mutations. Hum Mol Genet (1997) 3.41

The clinical phenotype of Lynch syndrome due to germ-line PMS2 mutations. Gastroenterology (2008) 3.35

The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome. Int J Cancer (2008) 2.95

The cost-effectiveness of genetic testing strategies for Lynch syndrome among newly diagnosed patients with colorectal cancer. Genet Med (2010) 2.81

Cancer risk in hereditary nonpolyposis colorectal cancer syndrome: later age of onset. Gastroenterology (2005) 2.80

Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome. Gastroenterology (2009) 2.75

AGA technical review on hereditary colorectal cancer and genetic testing. Gastroenterology (2001) 2.63

Risks of Lynch syndrome cancers for MSH6 mutation carriers. J Natl Cancer Inst (2009) 2.56

Decrease in mortality in Lynch syndrome families because of surveillance. Gastroenterology (2006) 2.34

Metachronous colorectal cancer risk for mismatch repair gene mutation carriers: the advantage of more extensive colon surgery. Gut (2010) 2.30

NCCN clinical practice guidelines in oncology. Colorectal cancer screening. J Natl Compr Canc Netw (2010) 2.13

Cumulative lifetime incidence of extracolonic cancers in Lynch syndrome: a report of 121 families with proven mutations. Clin Genet (2009) 2.05

Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members. J Clin Oncol (2009) 1.92

Surveillance for hereditary nonpolyposis colorectal cancer: a long-term study on 114 families. Dis Colon Rectum (2002) 1.91

One to 2-year surveillance intervals reduce risk of colorectal cancer in families with Lynch syndrome. Gastroenterology (2010) 1.91

Guidelines for colonoscopy surveillance after cancer resection: a consensus update by the American Cancer Society and the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology (2006) 1.89

Immunohistochemistry staining for the mismatch repair proteins in the clinical care of patients with colorectal cancer. Genet Med (2009) 1.76

Surveillance colonoscopy improves survival in a cohort of subjects with a single mismatch repair gene mutation. Colorectal Dis (2009) 1.75

Does microsatellite instability predict the efficacy of adjuvant chemotherapy in colorectal cancer? A systematic review with meta-analysis. Eur J Cancer (2009) 1.74

Management of extracolonic tumours in patients with Lynch syndrome. Lancet Oncol (2009) 1.53

Use of microsatellite instability and immunohistochemistry testing for the identification of individuals at risk for Lynch syndrome. Fam Cancer (2005) 1.47

Germline hypermethylation of MLH1 and EPCAM deletions are a frequent cause of Lynch syndrome. Genes Chromosomes Cancer (2009) 1.43

Hereditary nonpolyposis colorectal cancer: diagnostic strategies and their implications. Evid Rep Technol Assess (Full Rep) (2007) 1.42

Comment on: Screening for Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) among Endometrial Cancer Patients. Cancer Res (2007) 1.38

Current priorities for public health practice in addressing the role of human genomics in improving population health. Am J Prev Med (2011) 1.36

Informed consent to microsatellite instability and immunohistochemistry screening for Lynch syndrome. Genet Med (2011) 1.31

Outcomes of interest in evidence-based evaluations of genetic tests. Genet Med (2010) 1.30

American Gastroenterological Association medical position statement: hereditary colorectal cancer and genetic testing. Gastroenterology (2001) 1.24

Colorectal cancer in HNPCC: cumulative lifetime incidence, survival and tumour distribution. A report of 121 families with proven mutations. Clin Genet (2008) 1.20

Interfaces across the cancer continuum offer opportunities to improve the process of care. J Natl Cancer Inst Monogr (2010) 1.18

Interpretation of immunohistochemistry for mismatch repair proteins is only reliable in a specialized setting. Am J Surg Pathol (2008) 1.17

Point: justification for Lynch syndrome screening among all patients with newly diagnosed colorectal cancer. J Natl Compr Canc Netw (2010) 1.16

Constitutional (germline) MLH1 epimutation as an aetiological mechanism for hereditary non-polyposis colorectal cancer. J Med Genet (2009) 1.11

Assessment of MLH1 promoter methylation in relation to gene expression requires specific analysis. Oncogene (2007) 1.04

Counterpoint: implementing population genetic screening for Lynch Syndrome among newly diagnosed colorectal cancer patients--will the ends justify the means? J Natl Compr Canc Netw (2010) 1.01

To screen or not to screen for Lynch syndrome. J Natl Cancer Inst (2010) 0.91

Methylation pattern of different regions of the MLH1 promoter and silencing of gene expression in hereditary and sporadic colorectal cancer. Genes Chromosomes Cancer (2001) 0.86

Identifying Lynch syndrome. Int J Cancer (2009) 0.83

Articles by these authors

Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). N Engl J Med (2005) 9.39

Letting the genome out of the bottle--will we get our wish? N Engl J Med (2008) 9.10

Deploying whole genome sequencing in clinical practice and public health: meeting the challenge one bin at a time. Genet Med (2011) 8.48

Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases. Am J Epidemiol (2006) 7.66

Ethical and practical guidelines for reporting genetic research results to study participants: updated guidelines from a National Heart, Lung, and Blood Institute working group. Circ Cardiovasc Genet (2010) 6.74

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet (2008) 6.71

The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development (2002) 5.09

A navigator for human genome epidemiology. Nat Genet (2008) 5.07

Assessment of cumulative evidence on genetic associations: interim guidelines. Int J Epidemiol (2007) 4.96

Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology. Int J Epidemiol (2008) 4.53

How many genes underlie the occurrence of common complex diseases in the population? Int J Epidemiol (2005) 4.46

Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet (2012) 4.27

Sodium and potassium intake and mortality among US adults: prospective data from the Third National Health and Nutrition Examination Survey. Arch Intern Med (2011) 4.22

Mammalian Krüppel-like factors in health and diseases. Physiol Rev (2010) 4.09

Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. JAMA (2012) 3.85

Can family history be used as a tool for public health and preventive medicine? Genet Med (2002) 3.76

National Institutes of Health approaches to dissemination and implementation science: current and future directions. Am J Public Health (2012) 3.72

The clinical phenotype of Lynch syndrome due to germ-line PMS2 mutations. Gastroenterology (2008) 3.35

A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions. Am J Hum Genet (2008) 3.25

Recommendations for returning genomic incidental findings? We need to talk! Genet Med (2013) 3.23

A road map for efficient and reliable human genome epidemiology. Nat Genet (2006) 3.21

Primary chemoprevention of familial adenomatous polyposis with sulindac. N Engl J Med (2002) 3.16

Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal cancer. Science (2008) 3.16

What is the clinical utility of genetic testing? Genet Med (2006) 3.01

Research priorities for evaluating family history in the prevention of common chronic diseases. Am J Prev Med (2003) 2.99

Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer. Oncogene (2004) 2.96

The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop. Genet Med (2009) 2.91

The cost-effectiveness of genetic testing strategies for Lynch syndrome among newly diagnosed patients with colorectal cancer. Genet Med (2010) 2.81

Identification of Lynch syndrome among patients with colorectal cancer. JAMA (2012) 2.77

Improving validation practices in "omics" research. Science (2011) 2.73

Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. Cell Res (2005) 2.73

Surveillance of demographic characteristics and health behaviors among adult cancer survivors--Behavioral Risk Factor Surveillance System, United States, 2009. MMWR Surveill Summ (2012) 2.57

Transforming epidemiology for 21st century medicine and public health. Cancer Epidemiol Biomarkers Prev (2013) 2.56

Risks of Lynch syndrome cancers for MSH6 mutation carriers. J Natl Cancer Inst (2009) 2.56

Strengthening the reporting of genetic association studies (STREGA): an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement. J Clin Epidemiol (2009) 2.45

Genetic/familial high-risk assessment: breast and ovarian. J Natl Compr Canc Netw (2010) 2.45

Family history in public health practice: a genomic tool for disease prevention and health promotion. Annu Rev Public Health (2010) 2.43

The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology. Bioessays (2007) 2.40

Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLoS Genet (2013) 2.39

Long-range PCR facilitates the identification of PMS2-specific mutations. Hum Mutat (2006) 2.39

STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. PLoS Med (2009) 2.39

The genomic applications in practice and prevention network. Genet Med (2009) 2.39

The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases. Genet Med (2007) 2.34

Tracking the epidemiology of human genes in the literature: the HuGE Published Literature database. Am J Epidemiol (2006) 2.34

Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells. Gastroenterology (2008) 2.31

Most published research findings are false-but a little replication goes a long way. PLoS Med (2007) 2.26

Family history and prevalence of diabetes in the U.S. population: the 6-year results from the National Health and Nutrition Examination Survey (1999-2004). Diabetes Care (2007) 2.22

Developing Family Healthware, a family history screening tool to prevent common chronic diseases. Prev Chronic Dis (2008) 2.20

Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage. J Biol Chem (2002) 2.19

Health care provider and consumer awareness, perceptions, and use of direct-to-consumer personal genomic tests, United States, 2008. Genet Med (2009) 2.17

DNA banking for epidemiologic studies: a review of current practices. Epidemiology (2002) 2.16

The path from genome-based research to population health: development of an international public health genomics network. Genet Med (2006) 2.15

Invited commentary: genes, environment, and hybrid vigor. Am J Epidemiol (2009) 2.15

NCCN clinical practice guidelines in oncology. Colorectal cancer screening. J Natl Compr Canc Netw (2010) 2.13

Practical barriers to timely primary care access: impact on adult use of emergency department services. Arch Intern Med (2008) 2.12

Genomic profiling to promote a healthy lifestyle: not ready for prime time. Nat Genet (2003) 2.11

Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. J Mol Biol (2003) 2.11

Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity. Oncogene (2003) 2.11

Cardiovascular risk factors among Asian Americans: results from a National Health Survey. Ann Epidemiol (2009) 2.10

Evolution of the "drivers" of translational cancer epidemiology: analysis of funded grants and the literature. Am J Epidemiol (2015) 2.04

The possible effect of altitude on regional variation in suicide rates. Med Hypotheses (2009) 1.99

Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Cancer Epidemiol Biomarkers Prev (2011) 1.99

Future health applications of genomics: priorities for communication, behavioral, and social sciences research. Am J Prev Med (2010) 1.98

Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression. Mol Cell Biol (2006) 1.96

Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway. Am J Hum Genet (2003) 1.94

Improving the prediction of complex diseases by testing for multiple disease-susceptibility genes. Am J Hum Genet (2003) 1.85

Trends in esophageal cancer incidence by histology, United States, 1998-2003. Int J Cancer (2008) 1.85

Genomics and the prevention and control of common chronic diseases: emerging priorities for public health action. Prev Chronic Dis (2005) 1.84

Required sample size and nonreplicability thresholds for heterogeneous genetic associations. Proc Natl Acad Sci U S A (2008) 1.84

Effective treatment of biliary cystadenoma. Ann Surg (2005) 1.83

STrengthening the REporting of Genetic Association studies (STREGA)--an extension of the STROBE statement. Eur J Clin Invest (2009) 1.82

On the use of population attributable fraction to determine sample size for case-control studies of gene-environment interaction. Epidemiology (2003) 1.82

Awareness and utilization of BRCA1/2 testing among U.S. primary care physicians. Am J Prev Med (2011) 1.80

A population-based study of the clinical course of chronic fatigue syndrome. Health Qual Life Outcomes (2003) 1.80

The accuracy of cancer mortality statistics based on death certificates in the United States. Cancer Epidemiol (2010) 1.79

Oophorectomy after menopause and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev (2012) 1.78

From public health emergency to public health service: the implications of evolving criteria for newborn screening panels. Pediatrics (2006) 1.77

Population-based study of the prevalence of family history of cancer: implications for cancer screening and prevention. Genet Med (2006) 1.77

Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage. J Biol Chem (2003) 1.76

Immunohistochemistry staining for the mismatch repair proteins in the clinical care of patients with colorectal cancer. Genet Med (2009) 1.76

GAPscreener: an automatic tool for screening human genetic association literature in PubMed using the support vector machine technique. BMC Bioinformatics (2008) 1.75

The next generation of large-scale epidemiologic research: implications for training cancer epidemiologists. Am J Epidemiol (2014) 1.73

Krüppel-like factor 6 regulates mitochondrial function in the kidney. J Clin Invest (2015) 1.72

"Drivers" of translational cancer epidemiology in the 21st century: needs and opportunities. Cancer Epidemiol Biomarkers Prev (2013) 1.72

Breast cancer screening among adult women--Behavioral Risk Factor Surveillance System, United States, 2010. MMWR Morb Mortal Wkly Rep (2012) 1.72

Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res (2007) 1.71

Functional significance and clinical phenotype of nontruncating mismatch repair variants of MLH1. Gastroenterology (2005) 1.70

Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras. Oncogene (2004) 1.70

Cancer GAMAdb: database of cancer genetic associations from meta-analyses and genome-wide association studies. Eur J Hum Genet (2011) 1.69

Family history of type 2 diabetes: a population-based screening tool for prevention? Genet Med (2006) 1.67

Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations. Am J Epidemiol (2006) 1.67