Published in Crit Care Med on April 01, 2009
Both high level pressure support ventilation and controlled mechanical ventilation induce diaphragm dysfunction and atrophy. Crit Care Med (2012) 1.87
Clinical review: ventilator-induced diaphragmatic dysfunction--human studies confirm animal model findings! Crit Care (2011) 1.55
Mechanical ventilation reduces rat diaphragm blood flow and impairs oxygen delivery and uptake. Crit Care Med (2012) 1.53
Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy. J Appl Physiol (1985) (2011) 1.46
Effect of training on inspiratory load compensation in weaned and unweaned mechanically ventilated ICU patients. Respir Care (2013) 1.43
Prolonged mechanical ventilation alters diaphragmatic structure and function. Crit Care Med (2009) 1.41
Mitochondrial signaling contributes to disuse muscle atrophy. Am J Physiol Endocrinol Metab (2012) 1.16
Intrinsic apoptosis in mechanically ventilated human diaphragm: linkage to a novel Fos/FoxO1/Stat3-Bim axis. FASEB J (2011) 1.15
Oxidation enhances myofibrillar protein degradation via calpain and caspase-3. Free Radic Biol Med (2010) 1.15
Oxidative stress and disuse muscle atrophy: cause or consequence? Curr Opin Clin Nutr Metab Care (2012) 1.12
Mechanistic links between oxidative stress and disuse muscle atrophy. Antioxid Redox Signal (2011) 1.11
Time course analysis of mechanical ventilation-induced diaphragm contractile muscle dysfunction in the rat. J Physiol (2014) 1.06
Endurance exercise attenuates ventilator-induced diaphragm dysfunction. J Appl Physiol (1985) (2011) 0.97
Skeletal muscle mitochondrial H2 O2 emission increases with immobilization and decreases after aerobic training in young and older men. J Physiol (2015) 0.93
Mechanical ventilation-induced oxidative stress in the diaphragm: role of heme oxygenase-1. Chest (2010) 0.87
Titin-based mechanosensing and signaling: role in diaphragm atrophy during unloading? Am J Physiol Lung Cell Mol Physiol (2010) 0.82
Bench-to-bedside review: Diaphragm muscle function in disuse and acute high-dose corticosteroid treatment. Crit Care (2009) 0.81
Can antioxidants protect against disuse muscle atrophy? Sports Med (2014) 0.81
Lumican expression in diaphragm induced by mechanical ventilation. PLoS One (2011) 0.78
The stress protein/chaperone Grp94 counteracts muscle disuse atrophy by stabilizing subsarcolemmal neuronal nitric oxide synthase. Antioxid Redox Signal (2013) 0.78
Dysfunction of respiratory muscles in critically ill patients on the intensive care unit. J Cachexia Sarcopenia Muscle (2016) 0.77
Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation. Proc Natl Acad Sci U S A (2016) 0.77
Partial Support Ventilation and Mitochondrial-Targeted Antioxidants Protect against Ventilator-Induced Decreases in Diaphragm Muscle Protein Synthesis. PLoS One (2015) 0.77
Regulation of NADPH oxidases in skeletal muscle. Free Radic Biol Med (2016) 0.77
AT1 receptor blocker losartan protects against mechanical ventilation-induced diaphragmatic dysfunction. J Appl Physiol (1985) (2015) 0.76
Diminished force production and mitochondrial respiratory deficits are strain-dependent myopathies of subacute limb ischemia. J Vasc Surg (2016) 0.76
The serine protease, dipeptidyl peptidase IV as a myokine: dietary protein and exercise mimetics as a stimulus for transcription and release. Physiol Rep (2016) 0.75
Redox control of skeletal muscle atrophy. Free Radic Biol Med (2016) 0.75
Awake extracorporeal membrane oxygenation in patients with severe postoperative acute respiratory distress syndrome. J Thorac Dis (2016) 0.75
Chronic critical illness: are we saving patients or creating victims? Rev Bras Ter Intensiva (2017) 0.75
The calpain system. Physiol Rev (2003) 9.95
Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension (2007) 5.80
Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am J Respir Cell Mol Biol (1994) 3.23
Mechanical ventilation-induced diaphragmatic atrophy is associated with oxidative injury and increased proteolytic activity. Am J Respir Crit Care Med (2002) 2.99
Oxidative stress and disuse muscle atrophy. J Appl Physiol (1985) (2007) 2.53
Mechanisms of disuse muscle atrophy: role of oxidative stress. Am J Physiol Regul Integr Comp Physiol (2005) 2.38
NADPH oxidases: not just for leukocytes anymore! Trends Biochem Sci (2003) 2.27
Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress. Am J Physiol Heart Circ Physiol (2003) 2.09
Mechanical ventilation results in progressive contractile dysfunction in the diaphragm. J Appl Physiol (1985) (2002) 1.89
Trolox attenuates mechanical ventilation-induced diaphragmatic dysfunction and proteolysis. Am J Respir Crit Care Med (2004) 1.85
Hindlimb unloading increases oxidative stress and disrupts antioxidant capacity in skeletal muscle. Free Radic Biol Med (2003) 1.78
Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling. J Physiol (2007) 1.71
Caspase-3 regulation of diaphragm myonuclear domain during mechanical ventilation-induced atrophy. Am J Respir Crit Care Med (2006) 1.70
Expression of a calpastatin transgene slows muscle wasting and obviates changes in myosin isoform expression during murine muscle disuse. J Physiol (2002) 1.58
Macrophages, not neutrophils, infiltrate skeletal muscle in mice deficient in P/E selectins after mechanical reloading. Am J Physiol Regul Integr Comp Physiol (2003) 1.55
Expression of myosin heavy chain isoforms in stimulated fast and slow rat muscles. J Neurosci (1990) 1.55
Prevention of unloading-induced atrophy by vitamin E supplementation: links between oxidative stress and soleus muscle proteolysis? Free Radic Biol Med (2006) 1.40
Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase. Arch Biochem Biophys (2007) 1.40
Macrophage invasion does not contribute to muscle membrane injury during inflammation. J Leukoc Biol (1999) 1.38
Effect of the NADPH oxidase inhibitor apocynin on ischemia-reperfusion lung injury. Am J Physiol Heart Circ Physiol (2000) 1.22
Redox regulation of diaphragm proteolysis during mechanical ventilation. Am J Physiol Regul Integr Comp Physiol (2008) 1.19
Mechanism of 6-hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration of dopaminergic neurons. J Neurochem (2007) 1.18
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Complement activation promotes muscle inflammation during modified muscle use. Am J Pathol (2000) 1.07
Effects of apocynin, a drug isolated from the roots of Picrorhiza kurroa, on arachidonic acid metabolism. FEBS Lett (1992) 1.00
Apocynin increases glutathione synthesis and activates AP-1 in alveolar epithelial cells. FEBS Lett (1999) 1.00
Changes in a rat facial muscle after facial nerve injury and repair. Muscle Nerve (2001) 0.98
Muscle impairment occurs rapidly and precedes inflammatory cell accumulation after mechanical loading. Am J Physiol Regul Integr Comp Physiol (2002) 0.97
Reloading the diaphragm following mechanical ventilation does not promote injury. Chest (2005) 0.96
The inhibition of xanthine and succinic oxidases by carbonyl reagents. J Biol Chem (1959) 0.95
The bovine calpastatin gene promoter and a new N-terminal region of the protein are targets for cAMP-dependent protein kinase activity. J Biol Chem (1998) 0.93
Evidence against the involvement of multiple radical generating sites in the expression of the vascular cell adhesion molecule-1. Free Radic Res (1998) 0.93
Ovarian hormone status and skeletal muscle inflammation during recovery from disuse in rats. Exp Physiol (2006) 0.91
Apocynin improves diaphragmatic function after endotoxin administration. J Appl Physiol (1985) (1999) 0.86
Expression of calpastatin isoforms in muscle and functionality of multiple calpastatin promoters. Arch Biochem Biophys (2004) 0.84
Dantrolene downregulates the gene expression and activity of the ubiquitin-proteasome proteolytic pathway in septic skeletal muscle. J Surg Res (2002) 0.83
Lycopene supplementation attenuated xanthine oxidase and myeloperoxidase activities in skeletal muscle tissues of rats after exhaustive exercise. Br J Nutr (2005) 0.83
cAMP responsiveness of the bovine calpastatin gene promoter. Biochim Biophys Acta (1998) 0.81
Effect of anabolic agents on calpastatin promoters in porcine skeletal muscle and their responsiveness to cyclic adenosine monophosphate- and calcium-related stimuli. J Anim Sci (2006) 0.79
A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med (2008) 17.19
Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med (2008) 8.88
Withdrawal of inhaled glucocorticoids and exacerbations of COPD. N Engl J Med (2014) 6.29
Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene. Thorax (2009) 4.86
High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med (2012) 3.99
Characteristics of physical activities in daily life in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2005) 3.58
Early exercise in critically ill patients enhances short-term functional recovery. Crit Care Med (2009) 3.43
Office spirometry significantly improves early detection of COPD in general practice: the DIDASCO Study. Chest (2004) 3.09
Mechanical ventilation-induced diaphragmatic atrophy is associated with oxidative injury and increased proteolytic activity. Am J Respir Crit Care Med (2002) 2.99
Cardiovascular safety of tiotropium in patients with COPD. Chest (2009) 2.70
Resistance training prevents deterioration in quadriceps muscle function during acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 2.59
Mortality in the 4-year trial of tiotropium (UPLIFT) in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2009) 2.55
Oxidative stress and disuse muscle atrophy. J Appl Physiol (1985) (2007) 2.53
Mechanisms of disuse muscle atrophy: role of oxidative stress. Am J Physiol Regul Integr Comp Physiol (2005) 2.38
Noninvasive and invasive pulmonary function in mouse models of obstructive and restrictive respiratory diseases. Am J Respir Cell Mol Biol (2009) 2.26
Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness. Crit Care Med (2011) 2.25
Physical activity and hospitalization for exacerbation of COPD. Chest (2006) 2.24
Physical inactivity in patients with COPD, a controlled multi-center pilot-study. Respir Med (2010) 2.06
Preventing COPD exacerbations with macrolides: a review and budget impact analysis. Respir Med (2013) 2.05
Minimal clinically important differences in pharmacological trials. Am J Respir Crit Care Med (2014) 2.00
Intermittent spontaneous breathing protects the rat diaphragm from mechanical ventilation effects. Crit Care Med (2005) 2.00
Pulmonary rehabilitation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2005) 1.97
Xanthine oxidase contributes to mechanical ventilation-induced diaphragmatic oxidative stress and contractile dysfunction. J Appl Physiol (1985) (2008) 1.92
Mechanical ventilation results in progressive contractile dysfunction in the diaphragm. J Appl Physiol (1985) (2002) 1.89
Both high level pressure support ventilation and controlled mechanical ventilation induce diaphragm dysfunction and atrophy. Crit Care Med (2012) 1.87
Trolox attenuates mechanical ventilation-induced diaphragmatic dysfunction and proteolysis. Am J Respir Crit Care Med (2004) 1.85
Increased duration of mechanical ventilation is associated with decreased diaphragmatic force: a prospective observational study. Crit Care (2010) 1.85
Risk factors and comorbidities in the preclinical stages of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2014) 1.78
Leupeptin inhibits ventilator-induced diaphragm dysfunction in rats. Am J Respir Crit Care Med (2007) 1.74
An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2014) 1.73
Caspase-3 regulation of diaphragm myonuclear domain during mechanical ventilation-induced atrophy. Am J Respir Crit Care Med (2006) 1.70
Are patients with COPD more active after pulmonary rehabilitation? Chest (2008) 1.69
Reactive oxygen species are signalling molecules for skeletal muscle adaptation. Exp Physiol (2009) 1.67
Neural deficits contribute to respiratory insufficiency in Pompe disease. Proc Natl Acad Sci U S A (2009) 1.67
Nuclear factor-κB signaling contributes to mechanical ventilation-induced diaphragm weakness*. Crit Care Med (2012) 1.64
Vitamin D beyond bones in chronic obstructive pulmonary disease: time to act. Am J Respir Crit Care Med (2009) 1.63
An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2015) 1.63
Hypogonadism, quadriceps weakness, and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2005) 1.61
N-Acetylcysteine protects the rat diaphragm from the decreased contractility associated with controlled mechanical ventilation. Crit Care Med (2011) 1.54
Mechanical ventilation reduces rat diaphragm blood flow and impairs oxygen delivery and uptake. Crit Care Med (2012) 1.53
Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm. J Appl Physiol (1985) (2010) 1.53
Bortezomib partially protects the rat diaphragm from ventilator-induced diaphragm dysfunction. Crit Care Med (2012) 1.51
Mechanical ventilation depresses protein synthesis in the rat diaphragm. Am J Respir Crit Care Med (2004) 1.50
Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant production. Free Radic Biol Med (2009) 1.50
Mechanical ventilation-induced oxidative stress in the diaphragm. J Appl Physiol (1985) (2003) 1.47
Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy. J Appl Physiol (1985) (2011) 1.46
Prolonged mechanical ventilation alters diaphragmatic structure and function. Crit Care Med (2009) 1.41
Interleukin-6 causes myocardial failure and skeletal muscle atrophy in rats. Circulation (2005) 1.40
Pompe disease gene therapy. Hum Mol Genet (2011) 1.39
Activity monitoring for assessment of physical activities in daily life in patients with chronic obstructive pulmonary disease. Arch Phys Med Rehabil (2005) 1.39
Exacerbation frequency and course of COPD. Int J Chron Obstruct Pulmon Dis (2012) 1.38
Sevoflurane exposure prevents diaphragmatic oxidative stress during mechanical ventilation but reduces force and affects protein metabolism even during spontaneous breathing in a rat model. Anesth Analg (2015) 1.38
Gender differences in the management and experience of Chronic Obstructive Pulmonary Disease. Respir Med (2004) 1.37
The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema. Am J Respir Crit Care Med (2009) 1.36
Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragm. J Appl Physiol (1985) (2004) 1.34
Tiotropium HandiHaler in the treatment of COPD: a safety review. Int J Chron Obstruct Pulmon Dis (2009) 1.32
Exercise-induced cardioprotection against myocardial ischemia-reperfusion injury. Free Radic Biol Med (2007) 1.31
Nitric oxide and AMPK cooperatively regulate PGC-1 in skeletal muscle cells. J Physiol (2010) 1.26
Dietary antioxidants and exercise. J Sports Sci (2004) 1.26
Daily physical activity in subjects with newly diagnosed COPD. Thorax (2013) 1.24
Detrimental effects of short-term mechanical ventilation on diaphragm function and IGF-I mRNA in rats. Intensive Care Med (2003) 1.24
The role of bronchodilator treatment in the prevention of exacerbations of COPD. Eur Respir J (2012) 1.23
Exercise, antioxidants, and HSP72: protection against myocardial ischemia/reperfusion. Free Radic Biol Med (2003) 1.18
Cross-talk between the calpain and caspase-3 proteolytic systems in the diaphragm during prolonged mechanical ventilation. Crit Care Med (2012) 1.18
Ischemia-reperfusion-induced calpain activation and SERCA2a degradation are attenuated by exercise training and calpain inhibition. Am J Physiol Heart Circ Physiol (2005) 1.17
Gel-mediated delivery of AAV1 vectors corrects ventilatory function in Pompe mice with established disease. Mol Ther (2010) 1.17
Diaphragm unloading via controlled mechanical ventilation alters the gene expression profile. Am J Respir Crit Care Med (2005) 1.17
Inhospital management of COPD exacerbations: a systematic review of the literature with regard to adherence to international guidelines. J Eval Clin Pract (2009) 1.16
Rocuronium exacerbates mechanical ventilation-induced diaphragm dysfunction in rats. Crit Care Med (2006) 1.15
Oxidation enhances myofibrillar protein degradation via calpain and caspase-3. Free Radic Biol Med (2010) 1.15
Reactive oxygen species: impact on skeletal muscle. Compr Physiol (2011) 1.14
Loss of exercise-induced cardioprotection after cessation of exercise. J Appl Physiol (1985) (2003) 1.12
Aging impairs skeletal muscle mitochondrial bioenergetic function. J Gerontol A Biol Sci Med Sci (2009) 1.11