Published in FASEB J on February 24, 2009
Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging? Free Radic Biol Med (2009) 2.00
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Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat. Mech Ageing Dev (2005) 1.24
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A novel approach for screening the proteome for changes in protein conformation. Biochemistry (2006) 0.92
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Trends in oxidative aging theories. Free Radic Biol Med (2007) 4.51
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics (2003) 3.84
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One (2010) 3.62
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J Biol Chem (2010) 3.16
Is the oxidative stress theory of aging dead? Biochim Biophys Acta (2009) 2.86
The role of oxidative damage and stress in aging. Mech Ageing Dev (2004) 2.73
Methionine oxidation and aging. Biochim Biophys Acta (2005) 2.37
High oxidative damage levels in the longest-living rodent, the naked mole-rat. Aging Cell (2006) 2.31
The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic Biol Med (2003) 2.30
The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell (2008) 2.25
Genetic mouse models of extended lifespan. Exp Gerontol (2003) 2.15
Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat. Proc Natl Acad Sci U S A (2009) 2.14
Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination. Aging Cell (2011) 2.07
Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging? Free Radic Biol Med (2009) 2.00
Does caloric restriction extend life in wild mice? Aging Cell (2006) 1.99
Lifespan extension in genetically modified mice. Aging Cell (2009) 1.98
Overexpression of Mn superoxide dismutase does not increase life span in mice. J Gerontol A Biol Sci Med Sci (2009) 1.98
Longer life spans and delayed maturation in wild-derived mice. Exp Biol Med (Maywood) (2002) 1.88
Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci (2013) 1.87
Housing density does not influence the longevity effect of calorie restriction. J Gerontol A Biol Sci Med Sci (2005) 1.85
Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration. FASEB J (2009) 1.78
Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production. Am J Physiol Regul Integr Comp Physiol (2007) 1.70
Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms. Aging Cell (2007) 1.69
Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production? J Gerontol A Biol Sci Med Sci (2012) 1.69
Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E. Circ Res (2004) 1.68
Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging. Mech Ageing Dev (2006) 1.67
Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity. J Gerontol A Biol Sci Med Sci (2009) 1.65
Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity. Aging Cell (2007) 1.62
Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. PLoS One (2011) 1.62
Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. J Biol Chem (2004) 1.60
Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice. Am J Physiol Heart Circ Physiol (2008) 1.55
The in vivo gene expression signature of oxidative stress. Physiol Genomics (2008) 1.55
Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis. J Gerontol A Biol Sci Med Sci (2007) 1.47
Caspase-2 deficiency enhances aging-related traits in mice. Mech Ageing Dev (2006) 1.46
Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice. Mech Ageing Dev (2002) 1.46
Biomarkers of aging: from primitive organisms to humans. J Gerontol A Biol Sci Med Sci (2004) 1.44
Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling. Aging Cell (2012) 1.43
Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels. J Gerontol A Biol Sci Med Sci (2005) 1.41
Does reduced IGF-1R signaling in Igf1r+/- mice alter aging? PLoS One (2011) 1.39
Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models? Free Radic Biol Med (2011) 1.35
Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span. FASEB J (2009) 1.34
Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. Free Radic Biol Med (2004) 1.30
Cellular replicative capacity correlates primarily with species body mass not longevity. Mech Ageing Dev (2005) 1.27
Reproducibility, sources of variability, pooling, and sample size: important considerations for the design of high-density oligonucleotide array experiments. J Gerontol A Biol Sci Med Sci (2004) 1.27
Detection of protein carbonyls in aging liver tissue: A fluorescence-based proteomic approach. Mech Ageing Dev (2006) 1.24
Oxidative stress in vascular senescence: lessons from successfully aging species. Front Biosci (2008) 1.24
Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity. Am J Physiol Endocrinol Metab (2009) 1.23
Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress. Free Radic Biol Med (2007) 1.22
Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens. Cancer Res (2003) 1.21
Long-lived ames dwarf mice are resistant to chemical stressors. J Gerontol A Biol Sci Med Sci (2009) 1.18
Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice. Aging Cell (2008) 1.18
A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice. Mech Ageing Dev (2003) 1.18
Characterization of transgenic mice that overexpress both copper zinc superoxide dismutase and catalase. Antioxid Redox Signal (2006) 1.16
Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity. Am J Physiol Cell Physiol (2009) 1.16
Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO Rep (2005) 1.16
Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopus. Am J Physiol Heart Circ Physiol (2009) 1.13
Ageing studies on bats: a review. Biogerontology (2004) 1.12
Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase. Aging Cell (2011) 1.12
Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animal. J Gerontol A Biol Sci Med Sci (2011) 1.11
Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation. FEBS Lett (2007) 1.11
A proposal to sequence genomes of unique interest for research on aging. J Gerontol A Biol Sci Med Sci (2007) 1.10
A new field record for bat longevity. J Gerontol A Biol Sci Med Sci (2005) 1.10
Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate. Cancer Res (2006) 1.08
Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice. J Gerontol A Biol Sci Med Sci (2012) 1.07
Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance. Diabetes (2011) 1.07
Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence. Exp Gerontol (2012) 1.07
Gpx4 protects mitochondrial ATP generation against oxidative damage. Biochem Biophys Res Commun (2007) 1.07
Fat-specific DsbA-L overexpression promotes adiponectin multimerization and protects mice from diet-induced obesity and insulin resistance. Diabetes (2012) 1.07
Genetic modulation of hormone levels and life span in hybrids between laboratory and wild-derived mice. J Gerontol A Biol Sci Med Sci (2006) 1.06
Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity. J Neurosci Res (2006) 1.05
Catalase transgenic mice: characterization and sensitivity to oxidative stress. Arch Biochem Biophys (2004) 1.04
Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD. Aging Cell (2012) 1.03
The age-related failure of adaptive responses to contractile activity in skeletal muscle is mimicked in young mice by deletion of Cu,Zn superoxide dismutase. Aging Cell (2010) 1.03
Lipid peroxidation up-regulates BACE1 expression in vivo: a possible early event of amyloidogenesis in Alzheimer's disease. J Neurochem (2008) 1.02
Hepatic response to oxidative injury in long-lived Ames dwarf mice. FASEB J (2010) 1.01
Skeletal muscle weakness due to deficiency of CuZn-superoxide dismutase is associated with loss of functional innervation. Am J Physiol Regul Integr Comp Physiol (2011) 1.01
Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency. Age (Dordr) (2008) 1.01
Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease. J Neurochem (2012) 1.00
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Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice. J Gerontol A Biol Sci Med Sci (2011) 0.99
Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL. Cell Metab (2010) 0.98
Attenuation of leukocyte-endothelium interaction by antioxidant enzymes. Free Radic Biol Med (2003) 0.98
Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice. FASEB J (2013) 0.98
Embryonic fibroblasts from Gpx4+/- mice: a novel model for studying the role of membrane peroxidation in biological processes. Free Radic Biol Med (2003) 0.98
MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging. Aging Cell (2011) 0.97
Longevity genes: from primitive organisms to humans. J Gerontol A Biol Sci Med Sci (2003) 0.96
Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain. Free Radic Biol Med (2012) 0.95
CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice. FASEB J (2013) 0.95
Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria. Free Radic Biol Med (2009) 0.94
Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels. Biochem Biophys Res Commun (2012) 0.94