Published in Aging Cell on February 01, 2012
mTOR is a key modulator of ageing and age-related disease. Nature (2013) 5.40
Rapamycin extends murine lifespan but has limited effects on aging. J Clin Invest (2013) 2.23
Answering the ultimate question "what is the proximal cause of aging?". Aging (Albany NY) (2012) 2.04
Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci (2013) 1.87
Inflammaging: disturbed interplay between autophagy and inflammasomes. Aging (Albany NY) (2012) 1.58
Rapalogs in cancer prevention: anti-aging or anticancer? Cancer Biol Ther (2012) 1.40
mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies. Aging Cell (2013) 1.24
Longevity and aging. F1000Prime Rep (2013) 1.18
Translating advances from the basic biology of aging into clinical application. Exp Gerontol (2012) 1.16
Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease. J Cereb Blood Flow Metab (2013) 1.13
Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questions. Oncotarget (2012) 1.11
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging. Cell Metab (2016) 1.10
Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging. Aging (Albany NY) (2012) 1.05
Rapamycin suppresses brain aging in senescence-accelerated OXYS rats. Aging (Albany NY) (2013) 1.01
Aging is not programmed: genetic pseudo-program is a shadow of developmental growth. Cell Cycle (2013) 0.98
Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology. Neurobiol Aging (2013) 0.94
mTOR Inhibition: From Aging to Autism and Beyond. Scientifica (Cairo) (2013) 0.94
Longevity, aging and rapamycin. Cell Mol Life Sci (2014) 0.93
Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. Elife (2016) 0.92
The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects. Vet Pathol (2015) 0.91
mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse. J Neurochem (2014) 0.91
Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice. J Gerontol A Biol Sci Med Sci (2016) 0.90
Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life. PLoS One (2015) 0.88
Rapamycin, anti-aging, and avoiding the fate of Tithonus. J Clin Invest (2013) 0.88
Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset. J Gerontol A Biol Sci Med Sci (2014) 0.88
Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment. PLoS One (2013) 0.88
Diet and aging. Oxid Med Cell Longev (2012) 0.86
Rapamycin, Autophagy, and Alzheimer's Disease. J Biochem Pharmacol Res (2013) 0.86
Translational geroscience: emphasizing function to achieve optimal longevity. Aging (Albany NY) (2014) 0.83
Longevity pathways and memory aging. Front Genet (2014) 0.82
Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primate. Pathobiol Aging Age Relat Dis (2016) 0.82
Mitochondrial deficiency: a double-edged sword for aging and neurodegeneration. Front Genet (2012) 0.82
Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes. Oncotarget (2012) 0.82
Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders. Br J Clin Pharmacol (2016) 0.82
Administration of a selective β2 adrenergic receptor antagonist exacerbates neuropathology and cognitive deficits in a mouse model of Alzheimer's disease. Neurobiol Aging (2014) 0.82
The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation. J Neurochem (2015) 0.81
Biochemical Genetic Pathways that Modulate Aging in Multiple Species. Cold Spring Harb Perspect Med (2015) 0.81
Reversal of phenotypes of cellular senescence by pan-mTOR inhibition. Aging (Albany NY) (2016) 0.80
Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island. J Gerontol A Biol Sci Med Sci (2016) 0.80
The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases. Aging Dis (2016) 0.79
Role of the hypothalamus in mediating protective effects of dietary restriction during aging. Front Neuroendocrinol (2012) 0.79
The dog aging project: translational geroscience in companion animals. Mamm Genome (2016) 0.79
Management of anemia of inflammation in the elderly. Anemia (2012) 0.79
Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond. Cold Spring Harb Perspect Med (2016) 0.78
Histone modifications change with age, dietary restriction and rapamycin treatment in mouse brain. Oncotarget (2015) 0.78
DNA methylation and cognitive aging. Oncotarget (2015) 0.78
Genetic suppression of β2-adrenergic receptors ameliorates tau pathology in a mouse model of tauopathies. Hum Mol Genet (2014) 0.77
The Role of Insulin and Insulin-Like Growth Factor-1/FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia. Curr Gerontol Geriatr Res (2012) 0.77
VGF expression by T lymphocytes in patients with Alzheimer's disease. Oncotarget (2015) 0.77
Reduced Incidence of Dementia in Solid Organ Transplant Patients Treated with Calcineurin Inhibitors. J Alzheimers Dis (2015) 0.77
Age-dependent changes in the protein expression levels of Redd1 and mTOR in the gerbil hippocampus during normal aging. Mol Med Rep (2016) 0.77
Effect of Chronic Administration of Low Dose Rapamycin on Development and Immunity in Young Rats. PLoS One (2015) 0.76
Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD. Acta Neuropathol Commun (2016) 0.76
Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways. Aging Cell (2016) 0.75
Neuronal functions of FOXO/DAF-16. Nutr Healthy Aging (2017) 0.75
Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules. F1000Res (2016) 0.75
The beneficial effects of dietary restriction on learning are distinct from its effects on longevity and mediated by depletion of a neuroinhibitory metabolite. PLoS Biol (2017) 0.75
Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency. Front Genet (2017) 0.75
TOR signaling in growth and metabolism. Cell (2006) 35.29
Upstream and downstream of mTOR. Genes Dev (2004) 21.61
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science (2005) 11.31
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol (2004) 9.96
Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci (2005) 9.17
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem (1999) 7.94
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science (2009) 7.80
Genetics: influence of TOR kinase on lifespan in C. elegans. Nature (2003) 7.55
NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol (2001) 6.96
Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev (2006) 6.62
Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med (2008) 5.54
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development (2004) 5.27
Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis. Nat Med (2008) 5.15
Interleukin-1 and neuronal injury. Nat Rev Immunol (2005) 3.85
Immune activation in brain aging and neurodegeneration: too much or too little? Neuron (2009) 3.76
Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum Mol Genet (2005) 3.45
Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav Immun (2010) 3.37
Ageing and neuronal vulnerability. Nat Rev Neurosci (2006) 3.36
Internalization of ionotropic glutamate receptors in response to mGluR activation. Nat Neurosci (2001) 3.34
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J Biol Chem (2010) 3.16
Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit. Nature (1995) 2.91
A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis. Cell (1999) 2.77
The molecular and cellular biology of enhanced cognition. Nat Rev Neurosci (2009) 2.12
Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory. Nat Neurosci (2008) 1.83
Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection. Brain Behav Immun (2008) 1.82
The role of mTOR signaling in controlling mammalian life span: what a fungicide teaches us about longevity. J Gerontol A Biol Sci Med Sci (2010) 1.77
Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling. Nat Neurosci (2009) 1.77
The multifunctional role of mTOR in innate immunity: implications for transplant immunity. Am J Transplant (2009) 1.60
Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress. Neuroimmunomodulation (2008) 1.43
CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2010) 1.37
mTOR inhibitors: an overview. Liver Transpl (2001) 1.32
Genetic variation in the interleukin-1 beta-converting enzyme associates with cognitive function. The PROSPER study. Brain (2008) 1.19
A dual role for interleukin-1 in LTP in mouse hippocampal slices. J Neuroimmunol (2003) 1.17
Interleukin-1 beta released by gp120 drives neural death through tyrosine phosphorylation and trafficking of NMDA receptors. J Biol Chem (2006) 1.16
Rapamycin-sensitive signalling in long-term consolidation of auditory cortex-dependent memory. Eur J Neurosci (2003) 1.16
Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism. J Biol Chem (2011) 1.12
Immune regulation by rapamycin: moving beyond T cells. Sci Signal (2009) 1.01
Glycolytic inhibition as a strategy for developing calorie restriction mimetics. Exp Gerontol (2010) 1.01
The effects of age on lipopolysaccharide-induced cognitive deficits and interleukin-1β expression. Behav Brain Res (2010) 0.90
Age-related impairment in LTP is accompanied by enhanced activity of stress-activated protein kinases: analysis of underlying mechanisms. Eur J Neurosci (2000) 0.87
Cell resilience in species life spans: a link to inflammation? Aging Cell (2010) 0.86
Cytokines and neuronal channels: a molecular basis for age-related decline of neuronal function? Exp Gerontol (2010) 0.84
Time, damage, and aging: what really matters? Rejuvenation Res (2007) 0.78
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron (2003) 14.03
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science (2012) 6.69
Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron (2005) 6.20
Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci (2007) 5.72
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2010) 5.54
Oral topiramate for treatment of alcohol dependence: a randomised controlled trial. Lancet (2003) 4.79
Trends in oxidative aging theories. Free Radic Biol Med (2007) 4.51
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics (2003) 3.84
Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol Aging (2003) 3.83
Rapamycin slows aging in mice. Aging Cell (2012) 3.76
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One (2010) 3.62
Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci (2005) 3.18
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J Biol Chem (2010) 3.16
Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy. Free Radic Biol Med (2006) 3.04
Is the oxidative stress theory of aging dead? Biochim Biophys Acta (2009) 2.86
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest (2004) 2.80
The role of oxidative damage and stress in aging. Mech Ageing Dev (2004) 2.73
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell (2008) 2.65
Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. J Biol Chem (2005) 2.56
An Aging Interventions Testing Program: study design and interim report. Aging Cell (2007) 2.54
Methionine oxidation and aging. Biochim Biophys Acta (2005) 2.37
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell (2014) 2.35
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem (2006) 2.33
Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice. J Neurosci (2006) 2.32
The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic Biol Med (2003) 2.30
The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell (2008) 2.25
Genetic mouse models of extended lifespan. Exp Gerontol (2003) 2.15
Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat. Proc Natl Acad Sci U S A (2009) 2.14
M1 receptors play a central role in modulating AD-like pathology in transgenic mice. Neuron (2006) 2.07
Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging? Free Radic Biol Med (2009) 2.00
Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice. J Neurosci (2007) 2.00
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Sci Transl Med (2012) 1.98
Lifespan extension in genetically modified mice. Aging Cell (2009) 1.98
Overexpression of Mn superoxide dismutase does not increase life span in mice. J Gerontol A Biol Sci Med Sci (2009) 1.98
Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability. J Neurosci (2004) 1.92
Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci (2013) 1.87
Housing density does not influence the longevity effect of calorie restriction. J Gerontol A Biol Sci Med Sci (2005) 1.85
Alzheimer's disease: Abeta, tau and synaptic dysfunction. Trends Mol Med (2005) 1.78
Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration. FASEB J (2009) 1.78
The role of mTOR signaling in controlling mammalian life span: what a fungicide teaches us about longevity. J Gerontol A Biol Sci Med Sci (2010) 1.77
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell (2013) 1.71
Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production. Am J Physiol Regul Integr Comp Physiol (2007) 1.70
Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinking. Am J Psychiatry (2011) 1.69
Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E. Circ Res (2004) 1.68
Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders. Neurobiol Aging (2005) 1.68
Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging. Mech Ageing Dev (2006) 1.67
A dynamic relationship between intracellular and extracellular pools of Abeta. Am J Pathol (2006) 1.66
Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity. J Gerontol A Biol Sci Med Sci (2009) 1.65
Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice. J Neuroinflammation (2005) 1.64
Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease. PLoS One (2008) 1.62
Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. PLoS One (2011) 1.62
Duration of rapamycin treatment has differential effects on metabolism in mice. Cell Metab (2013) 1.61
Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell (2013) 1.60
Use of oral topiramate to promote smoking abstinence among alcohol-dependent smokers: a randomized controlled trial. Arch Intern Med (2005) 1.60
Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. J Biol Chem (2004) 1.60
Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol Dis (2009) 1.60
Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain Res (2008) 1.56
Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. Am J Pathol (2008) 1.55
The in vivo gene expression signature of oxidative stress. Physiol Genomics (2008) 1.55
Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability. J Biol Chem (2009) 1.53
Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease. J Neurochem (2005) 1.52
Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc Natl Acad Sci U S A (2005) 1.51
Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology. J Neurosci (2008) 1.49
Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis. J Gerontol A Biol Sci Med Sci (2007) 1.47
Methylene blue reduces aβ levels and rescues early cognitive deficit by increasing proteasome activity. Brain Pathol (2011) 1.46
Caspase-2 deficiency enhances aging-related traits in mice. Mech Ageing Dev (2006) 1.46
Neural stem cells improve memory in an inducible mouse model of neuronal loss. J Neurosci (2007) 1.46
Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice. Mech Ageing Dev (2002) 1.46
Biomarkers of aging: from primitive organisms to humans. J Gerontol A Biol Sci Med Sci (2004) 1.44
Congo red and thioflavin-T analogs detect Abeta oligomers. J Neurochem (2007) 1.43
WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Eur J Neurosci (2009) 1.42
Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels. J Gerontol A Biol Sci Med Sci (2005) 1.41
Does reduced IGF-1R signaling in Igf1r+/- mice alter aging? PLoS One (2011) 1.39
CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2010) 1.37
Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models? Free Radic Biol Med (2011) 1.35
Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span. FASEB J (2009) 1.34
Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease. J Neurochem (2013) 1.34
Deficits in dopamine clearance and locomotion in hypoinsulinemic rats unmask novel modulation of dopamine transporters by amphetamine. J Neurochem (2005) 1.34
Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice. Neurobiol Dis (2007) 1.30
Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. Free Radic Biol Med (2004) 1.30