Published in Free Radic Biol Med on August 01, 2003
Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cells. Free Radic Biol Med (2009) 1.02
Overexpression of antioxidant enzymes in ApoE-deficient mice suppresses benzo(a)pyrene-accelerated atherosclerosis. Atherosclerosis (2009) 0.97
Nrf2-dependent induction of NQO1 in mouse aortic endothelial cells overexpressing catalase. Free Radic Biol Med (2011) 0.92
Transcriptional regulation of ATP-binding cassette transporter A1 expression by a novel signaling pathway. J Biol Chem (2011) 0.91
Overexpression of catalase delays G0/G1- to S-phase transition during cell cycle progression in mouse aortic endothelial cells. Free Radic Biol Med (2009) 0.87
Overexpression of antioxidant enzymes upregulates aryl hydrocarbon receptor expression via increased Sp1 DNA-binding activity. Free Radic Biol Med (2010) 0.87
Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice. Free Radic Biol Med (2007) 0.86
A Subregion of Reelin Suppresses Lipoprotein-Induced Cholesterol Accumulation in Macrophages. PLoS One (2015) 0.78
High-density lipoprotein-mediated transcellular cholesterol transport in mouse aortic endothelial cells. Biochem Biophys Res Commun (2015) 0.75
Overexpression of Catalase Enhances Benzo(a)pyrene Detoxification in Endothelial Microsomes. PLoS One (2016) 0.75
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science (2012) 6.69
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature (2006) 5.57
Trends in oxidative aging theories. Free Radic Biol Med (2007) 4.51
Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature (2006) 4.00
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics (2003) 3.84
Aging and genome maintenance: lessons from the mouse? Science (2003) 3.72
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One (2010) 3.62
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J Biol Chem (2010) 3.16
Is the oxidative stress theory of aging dead? Biochim Biophys Acta (2009) 2.86
The role of oxidative damage and stress in aging. Mech Ageing Dev (2004) 2.73
DNA damage and ageing: new-age ideas for an age-old problem. Nat Cell Biol (2008) 2.44
Methionine oxidation and aging. Biochim Biophys Acta (2005) 2.37
The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic Biol Med (2003) 2.30
The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell (2008) 2.25
Genetic mouse models of extended lifespan. Exp Gerontol (2003) 2.15
Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat. Proc Natl Acad Sci U S A (2009) 2.14
Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity. Aging Cell (2004) 2.11
Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging? Free Radic Biol Med (2009) 2.00
Lifespan extension in genetically modified mice. Aging Cell (2009) 1.98
Overexpression of Mn superoxide dismutase does not increase life span in mice. J Gerontol A Biol Sci Med Sci (2009) 1.98
Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci (2013) 1.87
Housing density does not influence the longevity effect of calorie restriction. J Gerontol A Biol Sci Med Sci (2005) 1.85
Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration. FASEB J (2009) 1.78
Direct mutation analysis by high-throughput sequencing: from germline to low-abundant, somatic variants. Mutat Res (2011) 1.75
Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production. Am J Physiol Regul Integr Comp Physiol (2007) 1.70
Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E. Circ Res (2004) 1.68
Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging. Mech Ageing Dev (2006) 1.67
Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity. J Gerontol A Biol Sci Med Sci (2009) 1.65
Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. PLoS One (2011) 1.62
Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. J Biol Chem (2004) 1.60
Direct, genome-wide assessment of DNA mutations in single cells. Nucleic Acids Res (2011) 1.56
Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell (2003) 1.55
The in vivo gene expression signature of oxidative stress. Physiol Genomics (2008) 1.55
Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proc Natl Acad Sci U S A (2002) 1.54
Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis. J Gerontol A Biol Sci Med Sci (2007) 1.47
Caspase-2 deficiency enhances aging-related traits in mice. Mech Ageing Dev (2006) 1.46
Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice. Mech Ageing Dev (2002) 1.46
Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations. Hum Mutat (2002) 1.44
Biomarkers of aging: from primitive organisms to humans. J Gerontol A Biol Sci Med Sci (2004) 1.44
Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling. Aging Cell (2012) 1.43
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. Mutat Res (2006) 1.43
SNP discovery in associating genetic variation with human disease phenotypes. Mutat Res (2005) 1.42
Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels. J Gerontol A Biol Sci Med Sci (2005) 1.41
Genome instability, cancer and aging. Biochim Biophys Acta (2009) 1.40
Does reduced IGF-1R signaling in Igf1r+/- mice alter aging? PLoS One (2011) 1.39
Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction. DNA Repair (Amst) (2005) 1.38
Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models? Free Radic Biol Med (2011) 1.35
Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span. FASEB J (2009) 1.34
Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. Free Radic Biol Med (2004) 1.30
Mitochondrial DNA mutations and aging: devils in the details? Trends Genet (2008) 1.30
Reproducibility, sources of variability, pooling, and sample size: important considerations for the design of high-density oligonucleotide array experiments. J Gerontol A Biol Sci Med Sci (2004) 1.27
Detection of protein carbonyls in aging liver tissue: A fluorescence-based proteomic approach. Mech Ageing Dev (2006) 1.24
Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues. Mech Ageing Dev (2008) 1.24
Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity. Am J Physiol Endocrinol Metab (2009) 1.23
Turning anti-ageing genes against cancer. Nat Rev Mol Cell Biol (2008) 1.23
Detection of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis using denaturing gradient gel electrophoresis. Antimicrob Agents Chemother (2005) 1.22
Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress. Free Radic Biol Med (2007) 1.22
The long lifespan of two bat species is correlated with resistance to protein oxidation and enhanced protein homeostasis. FASEB J (2009) 1.22
Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens. Cancer Res (2003) 1.21
Genome dynamics in aging mice. Genome Res (2002) 1.20
Aging alters the apoptotic response to genotoxic stress. Nat Med (2002) 1.18
Long-lived ames dwarf mice are resistant to chemical stressors. J Gerontol A Biol Sci Med Sci (2009) 1.18
Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice. Aging Cell (2008) 1.18
A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice. Mech Ageing Dev (2003) 1.18
Broad segmental progeroid changes in short-lived Ercc1(-/Δ7) mice. Pathobiol Aging Age Relat Dis (2011) 1.17
Characterization of transgenic mice that overexpress both copper zinc superoxide dismutase and catalase. Antioxid Redox Signal (2006) 1.16
Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity. Am J Physiol Cell Physiol (2009) 1.16
Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO Rep (2005) 1.16
Does damage to DNA and other macromolecules play a role in aging? If so, how? J Gerontol A Biol Sci Med Sci (2009) 1.16
Epigenetic factors in aging and longevity. Pflugers Arch (2009) 1.15
Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes. Cancer Res (2008) 1.15
Induction of DNA polymerase beta-dependent base excision repair in response to oxidative stress in vivo. Carcinogenesis (2002) 1.13
Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase. Aging Cell (2011) 1.12
Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice. Cancer Res (2005) 1.12
Intra-organ variation in age-related mutation accumulation in the mouse. PLoS One (2007) 1.11
Detection and analysis of somatic mutations at a lacZ reporter locus in higher organisms: application to Mus musculus and Drosophila melanogaster. Methods Mol Biol (2007) 1.11
Mutational fingerprints of aging. Nucleic Acids Res (2002) 1.08
The demographic and biomedical case for late-life interventions in aging. Sci Transl Med (2010) 1.08
Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate. Cancer Res (2006) 1.08
Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice. J Gerontol A Biol Sci Med Sci (2012) 1.07
Attenuation of DNA polymerase beta-dependent base excision repair and increased DMS-induced mutagenicity in aged mice. Mutat Res (2002) 1.07
Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance. Diabetes (2011) 1.07
Gpx4 protects mitochondrial ATP generation against oxidative damage. Biochem Biophys Res Commun (2007) 1.07
DNA structure-induced genomic instability in vivo. J Natl Cancer Inst (2008) 1.06
Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity. J Neurosci Res (2006) 1.05
Catalase transgenic mice: characterization and sensitivity to oxidative stress. Arch Biochem Biophys (2004) 1.04
Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD. Aging Cell (2012) 1.03
What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? Mech Ageing Dev (2005) 1.03
The age-related failure of adaptive responses to contractile activity in skeletal muscle is mimicked in young mice by deletion of Cu,Zn superoxide dismutase. Aging Cell (2010) 1.03
A model system for analyzing somatic mutations in Drosophila melanogaster. Nat Methods (2007) 1.02
Lipid peroxidation up-regulates BACE1 expression in vivo: a possible early event of amyloidogenesis in Alzheimer's disease. J Neurochem (2008) 1.02
Hepatic response to oxidative injury in long-lived Ames dwarf mice. FASEB J (2010) 1.01
Skeletal muscle weakness due to deficiency of CuZn-superoxide dismutase is associated with loss of functional innervation. Am J Physiol Regul Integr Comp Physiol (2011) 1.01
Chromosome-specific accumulation of aneuploidy in the aging mouse brain. Hum Mol Genet (2012) 1.00