Toll-like receptor polymorphisms and age-related macular degeneration.

Molecular pathology of age-related macular degeneration. Prog Retin Eye Res (2008) 3.35

Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration. Annu Rev Genomics Hum Genet (2009) 2.40

Common variation in the SERPING1 gene is not associated with age-related macular degeneration in two independent groups of subjects. Mol Vis (2009) 1.26

Age-related macular degeneration: genetic and environmental factors of disease. Mol Interv (2010) 1.24

Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. J Biol Chem (2013) 1.22

Progression of geographic atrophy and genotype in age-related macular degeneration. Ophthalmology (2010) 1.18

Multilocus analysis of age-related macular degeneration. Eur J Hum Genet (2009) 1.18

Mediators of ocular angiogenesis. J Genet (2009) 1.17

Genetics of age-related macular degeneration: current concepts, future directions. Semin Ophthalmol (2011) 1.16

Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics. Mol Aspects Med (2012) 1.16

Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice. J Biol Chem (2011) 1.08

Toll-like receptor 2 ligand-induced protection against bacterial endophthalmitis. J Infect Dis (2010) 1.07

Coding variant Met72Thr in the PEDF gene and risk of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. Mol Vis (2009) 1.04

Novel role for the innate immune receptor Toll-like receptor 4 (TLR4) in the regulation of the Wnt signaling pathway and photoreceptor apoptosis. PLoS One (2012) 0.98

Geographic atrophy in age-related macular degeneration and TLR3. N Engl J Med (2009) 0.97

Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: a systems biology based approach. Vision Res (2009) 0.95

Toll-like receptor polymorphisms and age-related macular degeneration: replication in three case-control samples. Invest Ophthalmol Vis Sci (2009) 0.95

Evaluation of clustering and genotype distribution for replication in genome wide association studies: the age-related eye disease study. PLoS One (2008) 0.95

Genome-wide association analyses of genetic, phenotypic, and environmental risks in the age-related eye disease study. Mol Vis (2010) 0.91

The role of TLR4 activation in photoreceptor mitochondrial oxidative stress. Invest Ophthalmol Vis Sci (2011) 0.88

Toll-like receptor 3 (TLR3) protects retinal pigmented epithelium (RPE) cells from oxidative stress through a STAT3-dependent mechanism. Mol Immunol (2012) 0.86

A TRIF-independent branch of TLR3 signaling. J Immunol (2012) 0.86

A novel protective role for the innate immunity Toll-Like Receptor 3 (TLR3) in the retina via Stat3. Mol Cell Neurosci (2014) 0.85

Oxidative stress, innate immunity, and age-related macular degeneration. AIMS Mol Sci (2016) 0.83

Polymorphisms in Toll-like receptor genes influence antibody responses to cytomegalovirus glycoprotein B vaccine. BMC Res Notes (2012) 0.83

Inflammation and Cell Death in Age-Related Macular Degeneration: An Immunopathological and Ultrastructural Model. J Clin Med (2014) 0.82

The Immune System and AMD. Curr Ophthalmol Rep (2014) 0.76

Investigation of associations of ARMS2, CD14, and TLR4 gene polymorphisms with wet age-related macular degeneration in a Greek population. Clin Ophthalmol (2017) 0.75

The Sequence Alignment/Map format and SAMtools. Bioinformatics (2009) 232.39

The variant call format and VCFtools. Bioinformatics (2011) 25.88

Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (2012) 17.12

Replicating genotype-phenotype associations. Nature (2007) 16.11

Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol (2004) 13.78

MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet (2008) 9.50

Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature (2012) 8.91

Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care (2012) 7.83

Renal and retinal effects of enalapril and losartan in type 1 diabetes. N Engl J Med (2009) 6.75

The prevalence of diabetic retinopathy among adults in the United States. Arch Ophthalmol (2004) 6.53

Views of US physicians about controlling health care costs. JAMA (2013) 6.36

Diabetic retinopathy. N Engl J Med (2012) 5.79

Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies. Lancet Oncol (2012) 5.70

Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47

The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat Genet (2006) 5.36

Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med (2014) 4.94

Diabetic retinopathy in a multi-ethnic cohort in the United States. Am J Ophthalmol (2006) 4.68

Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet (2010) 4.51

CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration. Nat Genet (2006) 4.51

FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell (2009) 4.48

The Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS Report No. 17. Arch Ophthalmol (2005) 4.46

Prevalence of diabetic retinopathy in the United States, 2005-2008. JAMA (2010) 4.41

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet (2009) 4.38

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35

Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A (2010) 4.30

Retinopathy in diabetes. Diabetes Care (2004) 4.25

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes (2008) 4.20

Fifteen-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study. Ophthalmology (2007) 3.96

In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse. Hum Mol Genet (2006) 3.90

The impact of hearing loss on quality of life in older adults. Gerontologist (2003) 3.87

A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet (2010) 3.86

Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. JAMA (2012) 3.85

Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81

Ten-year incidence and progression of age-related maculopathy: The Beaver Dam eye study. Ophthalmology (2002) 3.80

Prevalence of cataract and pseudophakia/aphakia among adults in the United States. Arch Ophthalmol (2004) 3.78

A simplified severity scale for age-related macular degeneration: AREDS Report No. 18. Arch Ophthalmol (2005) 3.74

Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin. Nat Genet (2005) 3.55

Risk factors for incident age-related macular degeneration: pooled findings from 3 continents. Ophthalmology (2004) 3.53

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci U S A (2007) 3.50

Revised formulas for summarizing retinal vessel diameters. Curr Eye Res (2003) 3.47

Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans. Kidney Int (2012) 3.46

Prevalence of olfactory impairment in older adults. JAMA (2002) 3.46

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet (2013) 3.42

Relation between fasting glucose and retinopathy for diagnosis of diabetes: three population-based cross-sectional studies. Lancet (2008) 3.42

The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XXII the twenty-five-year progression of retinopathy in persons with type 1 diabetes. Ophthalmology (2008) 3.37

A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies. Nat Genet (2009) 3.36

E2-2 protein and Fuchs's corneal dystrophy. N Engl J Med (2010) 3.31

Risk factors for the incidence of Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study (AREDS) AREDS report no. 19. Ophthalmology (2005) 3.28

Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors. Proc Natl Acad Sci U S A (2006) 3.27

High-resolution imaging with adaptive optics in patients with inherited retinal degeneration. Invest Ophthalmol Vis Sci (2007) 3.21

Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration. Am J Hum Genet (2005) 3.19

Potential public health impact of Age-Related Eye Disease Study results: AREDS report no. 11. Arch Ophthalmol (2003) 3.17

The 5-year incidence and progression of hearing loss: the epidemiology of hearing loss study. Arch Otolaryngol Head Neck Surg (2003) 3.17

Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss. Nat Genet (2011) 3.16

The 30-year natural history of type 1 diabetes complications: the Pittsburgh Epidemiology of Diabetes Complications Study experience. Diabetes (2006) 3.00

Age-related macular degeneration: a high-resolution genome scan for susceptibility loci in a population enriched for late-stage disease. Am J Hum Genet (2004) 2.97

Diabetic retinopathy. Diabetes Care (2004) 2.97

Prevalence of age-related macular degeneration in 4 racial/ethnic groups in the multi-ethnic study of atherosclerosis. Ophthalmology (2006) 2.95

Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration. Am J Hum Genet (2003) 2.92

The economic burden of major adult visual disorders in the United States. Arch Ophthalmol (2006) 2.92

The association among smoking, heavy drinking, and chronic kidney disease. Am J Epidemiol (2006) 2.89

Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial. Lancet (2008) 2.89

Prevalence of age-related macular degeneration in the US population. Arch Ophthalmol (2011) 2.89

Retinal vascular caliber and the development of hypertension: a meta-analysis of individual participant data. J Hypertens (2014) 2.83

Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA). Invest Ophthalmol Vis Sci (2006) 2.79

Retinal arteriolar narrowing and risk of coronary heart disease in men and women. The Atherosclerosis Risk in Communities Study. JAMA (2002) 2.78

Changes in visual acuity in a population over a 15-year period: the Beaver Dam Eye Study. Am J Ophthalmol (2006) 2.77

Cerebral white matter lesions, retinopathy, and incident clinical stroke. JAMA (2002) 2.72

Long-term use of aspirin and age-related macular degeneration. JAMA (2012) 2.72