Published in Cell Adh Migr on January 26, 2009
Gene Atlasing of digestive and reproductive tissues in Schistosoma mansoni. PLoS Negl Trop Dis (2011) 0.98
Age at onset in Huntington's disease: replication study on the associations of ADORA2A, HAP1 and OGG1. Neurogenetics (2010) 0.90
Kalirin, a key player in synapse formation, is implicated in human diseases. Neural Plast (2012) 0.90
Gene-based analysis of regionally enriched cortical genes in GWAS data sets of cognitive traits and psychiatric disorders. PLoS One (2012) 0.88
Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing. J Biol Chem (2011) 0.86
The Joubert syndrome-associated missense mutation (V443D) in the Abelson-helper integration site 1 (AHI1) protein alters its localization and protein-protein interactions. J Biol Chem (2013) 0.85
Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease. Front Mol Neurosci (2013) 0.83
Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation. J Neurosci (2013) 0.82
Huntington's Disease: From Mutant Huntingtin Protein to Neurotrophic Factor Therapy. Int J Biomed Sci (2011) 0.82
Huntingtin-associated protein 1 interacts with breakpoint cluster region protein to regulate neuronal differentiation. PLoS One (2015) 0.78
HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic β cells. Histochem Cell Biol (2015) 0.76
Chromatin plasticity and the pathogenesis of Huntington disease. Proc Natl Acad Sci U S A (2011) 0.76
Exploring Genetic Factors Involved in Huntington Disease Age of Onset: E2F2 as a New Potential Modifier Gene. PLoS One (2015) 0.75
Regulation of L-type Ca2+ Channel Activity and Insulin Secretion by Huntingtin-associated Protein 1. J Biol Chem (2016) 0.75
The molecular motor toolbox for intracellular transport. Cell (2003) 9.97
The WD repeat: a common architecture for diverse functions. Trends Biochem Sci (1999) 8.39
Neuronal calcium signaling. Neuron (1998) 7.03
Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev (2002) 6.54
Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell (2004) 5.67
TBP, a universal eukaryotic transcription factor? Genes Dev (1993) 5.61
Dynactin. Annu Rev Cell Dev Biol (2004) 5.46
SH3 domains: complexity in moderation. J Cell Sci (2001) 4.54
Molecular motors and mechanisms of directional transport in neurons. Nat Rev Neurosci (2005) 4.46
Subunit composition, distribution and function of GABA(A) receptor subtypes. Curr Top Med Chem (2002) 4.45
Dynactin is required for microtubule anchoring at centrosomes. J Cell Biol (1999) 4.19
Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron (2003) 4.04
The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1). Proc Natl Acad Sci U S A (1995) 3.77
14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking. Biochem J (2004) 3.60
Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol (2002) 3.46
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol (2004) 3.45
Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron (2003) 3.25
Evidence that the head of kinesin is sufficient for force generation and motility in vitro. Science (1990) 3.21
Native structure and physical properties of bovine brain kinesin and identification of the ATP-binding subunit polypeptide. Biochemistry (1988) 3.17
Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease. Neuron (2002) 3.15
Identification of globular mechanochemical heads of kinesin. Nature (1989) 2.83
Normal huntingtin function: an alternative approach to Huntington's disease. Nat Rev Neurosci (2005) 2.78
Mitotic spindle poles are organized by structural and motor proteins in addition to centrosomes. J Cell Biol (1997) 2.71
Modular organization of actin crosslinking proteins. Trends Biochem Sci (1991) 2.69
A role for regulated binding of p150(Glued) to microtubule plus ends in organelle transport. J Cell Biol (2002) 2.68
A huntingtin-associated protein enriched in brain with implications for pathology. Nature (1995) 2.67
Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro. Mol Cell Biol (2004) 2.65
FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes. J Cell Sci (2001) 2.48
Constructing inhibitory synapses. Nat Rev Neurosci (2001) 2.43
Monoclonal antibodies to kinesin heavy and light chains stain vesicle-like structures, but not microtubules, in cultured cells. J Cell Biol (1989) 2.38
Kinesin associates with anterogradely transported membranous organelles in vivo. J Cell Biol (1991) 2.32
Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. Hum Mol Genet (1997) 2.28
The quaternary structure of bovine brain kinesin. EMBO J (1988) 2.21
Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes. J Biol Chem (1997) 2.20
NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development (2001) 2.20
Modulation of GABAA receptor activity by phosphorylation and receptor trafficking: implications for the efficacy of synaptic inhibition. Curr Opin Neurobiol (2003) 2.15
Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking. Proc Natl Acad Sci U S A (2004) 2.10
Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J Neurosci (2000) 2.04
Interaction of huntingtin-associated protein with dynactin P150Glued. J Neurosci (1998) 1.98
Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons. J Biol Chem (2005) 1.98
Endosomal signaling of epidermal growth factor receptor stimulates signal transduction pathways leading to cell survival. Mol Cell Biol (2002) 1.98
Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor. J Biol Chem (2000) 1.91
A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor. EMBO J (1998) 1.86
Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior. Nat Med (2006) 1.86
Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways. Exp Neurol (1998) 1.85
Distinct cell cycle-dependent roles for dynactin and dynein at centrosomes. J Cell Biol (2002) 1.70
A concentric circle model of multivesicular body cargo sorting. EMBO Rep (2007) 1.65
BETA2/NeuroD1 null mice: a new model for transcription factor-dependent photoreceptor degeneration. J Neurosci (2003) 1.61
Structural elements, mechanism, and evolutionary convergence of Rho protein-guanine nucleotide exchange factor complexes. Biochemistry (2004) 1.55
Microtubule-dependent movement of late endocytic vesicles in vitro: requirements for Dynein and Kinesin. Mol Biol Cell (2004) 1.50
Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate. Mol Cell Biol (2000) 1.49
Ahi-1, a novel gene encoding a modular protein with WD40-repeat and SH3 domains, is targeted by the Ahi-1 and Mis-2 provirus integrations. J Virol (2002) 1.38
Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease. J Neurosci (2003) 1.35
Trinucleotide repeat polymorphism in the androgen receptor gene (AR). Nucleic Acids Res (1992) 1.34
The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human. J Neurosci (1998) 1.33
Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking. J Biol Chem (2002) 1.27
Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth. J Neurosci (2006) 1.23
Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain. Hum Mol Genet (1997) 1.21
Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease. J Neurobiol (2004) 1.20
Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice. J Clin Invest (2008) 1.19
Huntington's disease. Mol Pathol (2001) 1.16
A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: evidence for a compact beta-sheet structure. Hum Mol Genet (2005) 1.16
Constitutive GABAA receptor endocytosis is dynamin-mediated and dependent on a dileucine AP2 adaptin-binding motif within the beta 2 subunit of the receptor. J Biol Chem (2003) 1.16
Trafficking of signaling modules by kinesin motors. J Cell Sci (2003) 1.16
HAP1 and intracellular trafficking. Trends Pharmacol Sci (2005) 1.12
Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor. J Neurosci Res (1998) 1.11
Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. Hum Mol Genet (2002) 1.10
Brain spectrin: of mice and men. Brain Res Bull (1995) 1.09
Distinct helper virus requirements for Abelson murine leukemia virus-induced pre-B- and T-cell lymphomas. J Virol (1989) 1.08
Analysis of Huntingtin-associated protein 1 in mouse brain and immortalized striatal neurons. J Comp Neurol (1999) 1.07
Sequence homologies between four cytoskeleton-associated proteins. Trends Biochem Sci (1993) 1.06
Huntingtin-associated protein (HAP1): discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase. Proc Natl Acad Sci U S A (1996) 1.05
A human HAP1 homologue. Cloning, expression, and interaction with huntingtin. J Biol Chem (1998) 1.03
Identification of routing determinants in the cytosolic domain of a secretory granule-associated integral membrane protein. J Biol Chem (1996) 1.00
Function of Hrs in endocytic trafficking and signalling. Biochem Soc Trans (2001) 1.00
HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice. FEBS Lett (1998) 0.98
HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca release in primary culture of striatal medium spiny neurons. Eur J Neurosci (2004) 0.95
The expression of Huntingtin-associated protein (HAP1) mRNA in developing, adult and ageing rat CNS: implications for Huntington's disease neuropathology. Eur J Neurosci (1998) 0.95
Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin. J Biol Chem (2000) 0.93
Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2. Proc Natl Acad Sci U S A (2003) 0.92
Expression of the Huntingtin-associated protein 1 gene in the developing and adult mouse. Neurosci Lett (2000) 0.92
Hrs and hbp: possible regulators of endocytosis and exocytosis. Biochem Biophys Res Commun (2001) 0.91
The use of tactile and olfactory cues in neonatal orientation and localization of the nipple. Dev Psychobiol (1984) 0.89
Spinal and bulbar muscular atrophy: ligand-dependent pathogenesis and therapeutic perspectives. J Mol Med (Berl) (2004) 0.88
Gene structure and map location of the murine homolog of the Huntington-associated protein, Hap1. Mamm Genome (1998) 0.87
Association of HAP1 isoforms with a unique cytoplasmic structure. J Neurochem (1998) 0.86
Huntingtin-associated protein 1 (Hap1) mutant mice bypassing the early postnatal lethality are neuroanatomically normal and fertile but display growth retardation. Hum Mol Genet (2004) 0.86
Neuroanatomical distribution of Huntingtin-associated protein 1-mRNA in the male mouse brain. J Comp Neurol (2004) 0.85
Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis. Hum Mol Genet (2006) 0.85
14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking. J Biol Chem (2006) 0.85
An aromatase-associated cytoplasmic inclusion, the "stigmoid body," in the rat brain: II. Ultrastructure (with a review of its history and nomenclature). J Comp Neurol (1993) 0.84
Stigmoid bodies contain type I receptor proteins SorLA/LR11 and sortilin: new perspectives on their function. J Histochem Cytochem (2003) 0.83
An aromatase-associated cytoplasmic inclusion, the "stigmoid body," in the rat brain: I. Distribution in the forebrain. J Comp Neurol (1992) 0.83
HAP1 can sequester a subset of TBP in cytoplasmic inclusions via specific interaction with the conserved TBP(CORE). BMC Mol Biol (2007) 0.81
Suckling dysfunction caused by defects in the olfactory system in genetic arhinencephaly mice. Biol Neonate (2000) 0.80
Hap1 and GABA: thinking about food intake. Cell Metab (2006) 0.79
Anti-human placental antigen complex X-P2 (hPAX-P2) anti-serum recognizes C-terminus of huntingtin-associated protein 1A common to 1B as a determinant marker for the stigmoid body. Histochem Cell Biol (2007) 0.77
A protocol for isolation and biochemical characterization of stigmoid bodies from rat brain. J Neurosci Methods (2003) 0.76
Amyloid beta₁₋₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75(NTR)/RhoA signaling pathway. J Neurochem (2013) 1.46
Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives. Drug Discov Today (2006) 1.28
Isolation and characterization of neural crest progenitors from adult dorsal root ganglia. Stem Cells (2007) 1.24
Suppression of p75NTR does not promote regeneration of injured spinal cord in mice. J Neurosci (2004) 1.18
p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain. J Neurosci (2011) 1.17
Consumption of grape seed extract prevents amyloid-beta deposition and attenuates inflammation in brain of an Alzheimer's disease mouse. Neurotox Res (2009) 1.11
ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA. PLoS One (2012) 1.11
Actions of brain-derived neurotrophic factor on spinal nociceptive transmission during inflammation in the rat. J Physiol (2005) 1.08
Knockout of p75(NTR) impairs re-myelination of injured sciatic nerve in mice. J Neurochem (2005) 1.04
TNF-alpha mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats. J Bone Miner Res (2006) 1.02
Upregulation of blood proBDNF and its receptors in major depression. J Affect Disord (2013) 1.01
Nogo-66 inhibits adhesion and migration of microglia via GTPase Rho pathway in vitro. J Neurochem (2012) 0.96
Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release. J Biol Chem (2009) 0.96
Effect of lumbar 5 ventral root transection on pain behaviors: a novel rat model for neuropathic pain without axotomy of primary sensory neurons. Exp Neurol (2002) 0.95
Primary sensory neuron addition in the adult rat trigeminal ganglion: evidence for neural crest glio-neuronal precursor maturation. J Neurosci (2007) 0.95
Intramuscular delivery of a single chain antibody gene reduces brain Abeta burden in a mouse model of Alzheimer's disease. Neurobiol Aging (2007) 0.95
Peripherally-derived BDNF promotes regeneration of ascending sensory neurons after spinal cord injury. PLoS One (2008) 0.93
Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease. Mutat Res (2008) 0.93
EGF family of growth factors: essential roles and functional redundancy in the nerve system. Front Biosci (2004) 0.91
ProBDNF and its receptors are upregulated in glioma and inhibit the growth of glioma cells in vitro. Neuro Oncol (2013) 0.91
ProBDNF inhibits infiltration of ED1+ macrophages after spinal cord injury. Brain Behav Immun (2010) 0.90
Differential effects of pro-BDNF on sensory neurons after sciatic nerve transection in neonatal rats. Eur J Neurosci (2008) 0.90
Biphasic activation of extracellular signal-regulated kinase in anterior cingulate cortex distinctly regulates the development of pain-related anxiety and mechanical hypersensitivity in rats after incision. Anesthesiology (2011) 0.89
Roles of p75NTR in the pathogenesis of Alzheimer's disease: a novel therapeutic target. Biochem Pharmacol (2011) 0.89
Effects of proNGF on neuronal viability, neurite growth and amyloid-beta metabolism. Neurotox Res (2009) 0.87
Lumbar 5 ventral root transection-induced upregulation of nerve growth factor in sensory neurons and their target tissues: a mechanism in neuropathic pain. Mol Cell Neurosci (2003) 0.87
SNAP25 ameliorates sensory deficit in rats with spinal cord transection. Mol Neurobiol (2014) 0.87
Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing. J Biol Chem (2011) 0.86
Differential expression of microRNA-1 in dorsal root ganglion neurons. Histochem Cell Biol (2010) 0.86
Intramuscular delivery of a single chain antibody gene prevents brain Aβ deposition and cognitive impairment in a mouse model of Alzheimer's disease. Brain Behav Immun (2010) 0.85
The activation of NMDA receptor-ERK pathway in the central amygdala is required for the expression of morphine-conditioned place preference in the rat. Neurotox Res (2011) 0.85
Modified immunotherapies against Alzheimer's disease: toward safer and effective amyloid clearance. J Alzheimers Dis (2010) 0.85
Axonal transport of BDNF precursor in primary sensory neurons. Eur J Neurosci (2006) 0.85
Graft of pre-injured sural nerve promotes regeneration of corticospinal tract and functional recovery in rats with chronic spinal cord injury. Brain Res (2008) 0.84
Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons. J Neurochem (2012) 0.84
Endogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal mice. Eur J Neurosci (2011) 0.84
Surgical incision induces anxiety-like behavior and amygdala sensitization: effects of morphine and gabapentin. Pain Res Treat (2010) 0.83
Deletion of TRIM32 protects mice from anxiety- and depression-like behaviors under mild stress. Eur J Neurosci (2014) 0.82
Macrophage presence is essential for the regeneration of ascending afferent fibres following a conditioning sciatic nerve lesion in adult rats. BMC Neurosci (2011) 0.82
Preconditioning selective ventral root injury promotes plasticity of ascending sensory neurons in the injured spinal cord of adult rats--possible roles of brain-derived neurotrophic factor, TrkB and p75 neurotrophin receptor. Eur J Neurosci (2009) 0.82
Treating skeletal pain: limitations of conventional anti-inflammatory drugs, and anti-neurotrophic factor as a possible alternative. Nat Clin Pract Rheumatol (2009) 0.82
The intracellular domain of sortilin interacts with amyloid precursor protein and regulates its lysosomal and lipid raft trafficking. PLoS One (2013) 0.81
Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sorting. J Clin Invest (2013) 0.81
Upregulation of eIF-5A1 in the paralyzed muscle after spinal cord transection associates with spontaneous hindlimb locomotor recovery in rats by upregulation of the ErbB, MAPK and neurotrophin signal pathways. J Proteomics (2012) 0.81
Sciatic nerve conditioning lesion increases macrophage response but it does not promote the regeneration of injured optic nerves. Brain Res (2010) 0.81
Upregulation of brain-derived neurotrophic factor in the sensory pathway by selective motor nerve injury in adult rats. Neurotox Res (2006) 0.81
p75NTR is mainly responsible for Aβ toxicity but not for its internalization: a primary study. Neurol Sci (2011) 0.80
Anterior cingulate cortical lesion attenuates food foraging in rats. Brain Res Bull (2012) 0.80
Sex-differential modulation of visceral pain by brain derived neurotrophic factor (BDNF) in rats. Neurosci Lett (2010) 0.80
Mature BDNF promotes the growth of glioma cells in vitro. Oncol Rep (2013) 0.80
Clearance of amyloid-beta in Alzheimer's disease: shifting the action site from center to periphery. Mol Neurobiol (2014) 0.80
The relationship between single nucleotide polymorphisms of the NTRK2 gene and sporadic Alzheimer's disease in the Chinese Han population. Neurosci Lett (2013) 0.79
Nerve growth factor, neuropeptides, and mast cells in ultraviolet-B-induced systemic suppression of contact hypersensitivity responses in mice. J Invest Dermatol (2002) 0.79
Huntingtin-associated protein 1 regulates exocytosis, vesicle docking, readily releasable pool size and fusion pore stability in mouse chromaffin cells. J Physiol (2013) 0.78
Associations Between ApoEε4 Carrier Status and Serum BDNF Levels--New Insights into the Molecular Mechanism of ApoEε4 Actions in Alzheimer's Disease. Mol Neurobiol (2014) 0.78
Endogenous TGFβ1 Plays a Crucial Role in Functional Recovery After Traumatic Brain Injury Associated with Smad3 Signal in Rats. Neurochem Res (2015) 0.78
Potential conversion of adult clavicle-derived chondrocytes into neural lineage cells in vitro. J Cell Physiol (2008) 0.77
Reversal of bone cancer pain by HSV-1-mediated silencing of CNTF in an afferent area of the spinal cord associated with AKT-ERK signal inhibition. Curr Gene Ther (2014) 0.77
No association of SORT1 gene polymorphism with sporadic Alzheimer's disease in the Chinese Han population. Neuroreport (2013) 0.77
Deletion of p75NTR impairs regeneration of peripheral nerves in mice. Life Sci (2008) 0.76
Reciprocal induction between α-synuclein and β-amyloid in adult rat neurons. Neurotox Res (2012) 0.76
Treatment of spinal cord injury with co-grafts of genetically modified Schwann cells and fetal spinal cord cell suspension in the rat. Neurotox Res (2005) 0.76
A monoclonal antibody against the extracellular domain of p75 neurotrophin receptor. Monoclon Antib Immunodiagn Immunother (2013) 0.75
Protective effects of adenoviral cardiotrophin-1 gene transfer on rubrospinal neurons after spinal cord injury in adult rats. Neurotox Res (2003) 0.75
[In vitro expansion of the adult human bone marrow mesenchymal stem cells for clinic application in HSCT]. Zhongguo Shi Yan Xue Ye Xue Za Zhi (2008) 0.75