Published in Hum Mol Genet on December 01, 1997
Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron (2003) 3.25
Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis. J Cell Biol (2005) 3.07
Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro. Mol Cell Biol (2004) 2.65
Centriolar satellites: molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis. J Cell Biol (1999) 2.40
Repeat expansion disease: progress and puzzles in disease pathogenesis. Nat Rev Genet (2010) 2.36
Huntingtin facilitates dynein/dynactin-mediated vesicle transport. Proc Natl Acad Sci U S A (2007) 2.16
Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking. Proc Natl Acad Sci U S A (2004) 2.10
Axonal transport deficits and neurodegenerative diseases. Nat Rev Neurosci (2013) 2.05
GABAA receptor trafficking-mediated plasticity of inhibitory synapses. Neuron (2011) 2.05
Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons. EMBO J (2008) 2.03
JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors. J Cell Biol (2013) 2.01
Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. Nat Neurosci (2009) 1.95
Huntingtin as an essential integrator of intracellular vesicular trafficking. Trends Cell Biol (2009) 1.88
Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia. Arch Gen Psychiatry (2006) 1.86
Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease. J Clin Invest (2011) 1.79
Kinesin molecular motors: transport pathways, receptors, and human disease. Proc Natl Acad Sci U S A (2001) 1.59
Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease. J Cell Biol (2006) 1.55
Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin. Neuron (2010) 1.54
The genetics of axonal transport and axonal transport disorders. PLoS Genet (2006) 1.49
In vitro reconstitution of a highly processive recombinant human dynein complex. EMBO J (2014) 1.45
The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium. Mol Biol Cell (2012) 1.44
Knock-in mouse models of Huntington's disease. NeuroRx (2005) 1.40
Physical chemistry of polyglutamine: intriguing tales of a monotonous sequence. J Mol Biol (2012) 1.37
Multiple pathways contribute to the pathogenesis of Huntington disease. Mol Neurodegener (2006) 1.35
Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease. PLoS One (2012) 1.32
Integrated regulation of motor-driven organelle transport by scaffolding proteins. Trends Cell Biol (2014) 1.30
Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease. Proc Natl Acad Sci U S A (2004) 1.29
The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation. J Neurosci (2014) 1.28
Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation. Mol Biol Cell (2005) 1.28
Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment. Proc Natl Acad Sci U S A (2002) 1.24
Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes. Mol Biol Cell (2010) 1.22
Hook is an adapter that coordinates kinesin-3 and dynein cargo attachment on early endosomes. J Cell Biol (2014) 1.21
Does Huntingtin play a role in selective macroautophagy? Cell Cycle (2010) 1.20
Dynactin's pointed-end complex is a cargo-targeting module. Mol Biol Cell (2012) 1.20
Polyglutamine neurodegeneration: expanded glutamines enhance native functions. Curr Opin Genet Dev (2012) 1.13
A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons. J Neurosci (2011) 1.10
Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model. Dis Model Mech (2009) 1.09
Polyglutamine pathogenesis. Philos Trans R Soc Lond B Biol Sci (1999) 1.08
Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity. Mol Cell Biol (2009) 1.05
The role of the cytoskeleton and molecular motors in endosomal dynamics. Semin Cell Dev Biol (2014) 1.04
A role for huntington disease protein in dendritic RNA granules. J Biol Chem (2010) 1.01
pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking. Mol Brain (2010) 1.00
A large number of protein expression changes occur early in life and precede phenotype onset in a mouse model for huntington disease. Mol Cell Proteomics (2008) 0.99
The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus. Hum Mol Genet (2010) 0.97
GABA(A) Receptor Dynamics and Constructing GABAergic Synapses. Front Mol Neurosci (2008) 0.97
Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release. J Biol Chem (2009) 0.96
Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease. Mol Brain (2009) 0.96
Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease. Bioorg Med Chem (2013) 0.94
Autophagosome dynamics in neurodegeneration at a glance. J Cell Sci (2015) 0.94
Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype. Proc Natl Acad Sci U S A (2010) 0.92
Huntingtin associated protein 1 and its functions. Cell Adh Migr (2009) 0.92
PtdIns(4)P regulates retromer-motor interaction to facilitate dynein-cargo dissociation at the trans-Golgi network. Nat Cell Biol (2013) 0.92
Impaired mitochondrial trafficking in Huntington's disease. Biochim Biophys Acta (2009) 0.91
Absence of disturbed axonal transport in spinal and bulbar muscular atrophy. Hum Mol Genet (2011) 0.91
The biological function of the Huntingtin protein and its relevance to Huntington's Disease pathology. Curr Trends Neurol (2011) 0.90
Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin. J Biol Chem (2011) 0.90
BDNF signaling and survival of striatal neurons. Front Cell Neurosci (2014) 0.90
Corticostriatal circuit dysfunction in Huntington's disease: intersection of glutamate, dopamine and calcium. Future Neurol (2010) 0.89
Huntingtin-associated protein-1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mice. J Biol Chem (2010) 0.88
Immunohistochemical localization of huntingtin-associated protein 1 in endocrine system of the rat. J Histochem Cytochem (2005) 0.87
Are there multiple pathways in the pathogenesis of Huntington's disease? Philos Trans R Soc Lond B Biol Sci (1999) 0.87
Axonal transport and neurodegenerative disease: can we see the elephant? Prog Neurobiol (2012) 0.87
Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing. J Biol Chem (2011) 0.86
Palmitoylation and trafficking of GAD65 are impaired in a cellular model of Huntington's disease. Biochem J (2012) 0.85
Huntingtin's function in axonal transport is conserved in Drosophila melanogaster. PLoS One (2013) 0.85
Impaired alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking and function by mutant huntingtin. J Biol Chem (2011) 0.84
Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. J Cell Sci (2014) 0.83
Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders. Int J Mol Sci (2009) 0.82
Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sorting. J Clin Invest (2013) 0.81
Normal dynactin complex function during synapse growth in Drosophila requires membrane binding by Arfaptin. Mol Biol Cell (2013) 0.81
Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease. Neurobiol Dis (2012) 0.80
A multifunctional, multi-pathway intracellular localization signal in Huntingtin. Commun Integr Biol (2013) 0.79
Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells. Cell Mol Life Sci (2011) 0.79
Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo. Hum Mol Genet (2015) 0.78
Primary cilia and autophagic dysfunction in Huntington's disease. Cell Death Differ (2015) 0.78
The localization and interactions of huntingtin. Philos Trans R Soc Lond B Biol Sci (1999) 0.78
Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane. Dis Model Mech (2014) 0.77
Huntington's disease: from gene to potential therapy. Dialogues Clin Neurosci (2001) 0.77
A C. elegans homolog of huntingtin-associated protein 1 is expressed in chemosensory neurons and in a number of other somatic cell types. J Mol Neurosci (2008) 0.77
The Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formation. PLoS One (2012) 0.76
HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic β cells. Histochem Cell Biol (2015) 0.76
Microtubule-dependent formation of the stigmoid body as a cytoplasmic inclusion distinct from pathological aggresomes. Histochem Cell Biol (2009) 0.76
Necrotic cell death and neurodegeneration: The involvement of endocytosis and intracellular trafficking. Worm (2012) 0.76
Integral Characterization of Defective BDNF/TrkB Signalling in Neurological and Psychiatric Disorders Leads the Way to New Therapies. Int J Mol Sci (2017) 0.75
Huntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestine. BMC Evol Biol (2016) 0.75
Glucocorticoid affects dendritic transport of BDNF-containing vesicles. Sci Rep (2015) 0.75
Is Huntingtin Dispensable in the Adult Brain? J Huntingtons Dis (2017) 0.75
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell (1997) 9.57
Detection of Huntington's disease decades before diagnosis: the Predict-HD study. J Neurol Neurosurg Psychiatry (2007) 5.49
Microsatellite evolution--evidence for directionality and variation in rate between species. Nat Genet (1995) 4.77
Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning. Science (1999) 4.56
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med (2001) 4.22
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science (2001) 4.13
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum Mol Genet (1999) 4.06
Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex. J Biol Chem (1995) 3.96
Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatr Scand (2005) 3.96
Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells. Hum Mol Genet (2000) 3.87
Expression and structure of the human NGF receptor. Cell (1986) 3.82
The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1). Proc Natl Acad Sci U S A (1995) 3.77
Cytoplasmic dynein and dynactin in cell division and intracellular transport. Curr Opin Cell Biol (1999) 3.63
jun-D: a third member of the jun gene family. Proc Natl Acad Sci U S A (1989) 3.47
Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel. Science (1988) 3.38
Antigenic relationship of varicella-zoster and herpes simplex. Lancet (1965) 3.33
Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp. Neuron (1999) 3.28
CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion. Neurology (2012) 3.12
Decreased expression of striatal signaling genes in a mouse model of Huntington's disease. Hum Mol Genet (2000) 3.07
Dynein binds to beta-catenin and may tether microtubules at adherens junctions. Nat Cell Biol (2001) 3.06
Characterization of a 50-kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin. J Biol Chem (1993) 2.91
Onset and rate of striatal atrophy in preclinical Huntington disease. Neurology (2004) 2.81
Influenza, respiratory syncytial virus, and pneumonia in Glasgow, 1962-5. Br Med J (1967) 2.76
A huntingtin-associated protein enriched in brain with implications for pathology. Nature (1995) 2.67
Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia. Mol Psychiatry (2007) 2.53
Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. Nat Genet (1999) 2.53
Anticipation in bipolar affective disorder. Am J Hum Genet (1993) 2.44
Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles. J Cell Biol (1996) 2.41
Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture. Hum Mol Genet (1998) 2.39
A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder. Mol Psychiatry (2005) 2.32
The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport. Proc Natl Acad Sci U S A (1997) 2.26
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. J Biol Chem (1998) 2.23
Two-year follow-up of inpatients with dissociative identity disorder. Am J Psychiatry (1997) 2.18
A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem (1996) 2.16
Basic research by medical students. J R Soc Med (1981) 2.15
Clinical markers of early disease in persons near onset of Huntington's disease. Neurology (2001) 2.11
beta III spectrin binds to the Arp1 subunit of dynactin. J Biol Chem (2001) 2.05
The inositol 1,4,5,-trisphosphate receptor in cerebellar Purkinje cells: quantitative immunogold labeling reveals concentration in an ER subcompartment. J Cell Biol (1990) 2.03
Correlation between the onset age of Huntington's disease and length of the trinucleotide repeat in IT-15. Hum Mol Genet (1993) 2.00
The biochemistry and molecular biology of the dihydropyridine-sensitive calcium channel. Trends Neurosci (1988) 1.98
Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length. Neurobiol Dis (1998) 1.96
Millon Clinical Multiaxial Inventory--II. Follow-up of patients with dissociative identity disorder. Psychol Rep (1996) 1.95
Wild-type huntingtin protects from apoptosis upstream of caspase-3. J Neurosci (2000) 1.92
Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor. Science (1996) 1.92
The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias. Proc Natl Acad Sci U S A (1986) 1.91
Dynactin-dependent, dynein-driven vesicle transport in the absence of membrane proteins: a role for spectrin and acidic phospholipids. Mol Cell (2001) 1.89
Endothelin: visualization of mRNAs by in situ hybridization provides evidence for local action. Proc Natl Acad Sci U S A (1989) 1.87
Validity of the Dissociative Experiences Scale in screening for multiple personality disorder: a multicenter study. Am J Psychiatry (1993) 1.87
Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization. Nat Med (1999) 1.86
Inositol 1,4,5-trisphosphate receptors: distinct neuronal and nonneuronal forms derived by alternative splicing differ in phosphorylation. Proc Natl Acad Sci U S A (1991) 1.76
The role of the dynactin complex in intracellular motility. Int Rev Cytol (1998) 1.75
Immediate-early genes and synaptic function. Neurobiol Learn Mem (1998) 1.75
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Hum Mol Genet (2001) 1.74
Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12. Nat Genet (1999) 1.74
Rate of caudate atrophy in presymptomatic and symptomatic stages of Huntington's disease. Mov Disord (2000) 1.67
Structural characterization of the dihydropyridine-sensitive calcium channel alpha 2-subunit and the associated delta peptides. J Biol Chem (1991) 1.63
Secretory leukocyte protease inhibitor (SLPI) in mucosal fluids inhibits HIV-I. Oral Dis (1997) 1.58
Functionally distinct isoforms of dynactin are expressed in human neurons. Mol Biol Cell (1996) 1.57
Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Neurobiol Dis (2001) 1.57
A repeat expansion in the gene encoding junctophilin-3 is associated with Huntington disease-like 2. Nat Genet (2001) 1.56
The involvement of the intermediate chain of cytoplasmic dynein in binding the motor complex to membranous organelles of Xenopus oocytes. Mol Biol Cell (1997) 1.56
Longitudinal change in basal ganglia volume in patients with Huntington's disease. Neurology (1997) 1.56
Endothelin in brain: receptors, mitogenesis, and biosynthesis in glial cells. Proc Natl Acad Sci U S A (1990) 1.55
Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. Mol Cell Neurosci (1998) 1.53
Caveolin transfection results in caveolae formation but not apical sorting of glycosylphosphatidylinositol (GPI)-anchored proteins in epithelial cells. J Cell Biol (1998) 1.51
The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis. Proc Natl Acad Sci U S A (2001) 1.51
Herpes zoster in general practice. J R Coll Gen Pract (1975) 1.51
Activity-regulated cytoskeletal-associated protein is localized to recently activated excitatory synapses. Neuroscience (2004) 1.49
Dentatorubral and pallidoluysian atrophy (DRPLA). Clinical and neuropathological findings in genetically confirmed North American and European pedigrees. Mov Disord (1997) 1.49
Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders. Mol Psychiatry (2010) 1.49
Infective agents and embryopathy in the west of Scotland 1966-1970. Scott Med J (1972) 1.48
Rostral ventrolateral medulla: selective projections to the thoracic autonomic cell column from the region containing C1 adrenaline neurons. J Comp Neurol (1984) 1.48
The active site and mechanism of action of bovine pancreatic ribonuclease. 7. The catalytic mechanism. Biochem J (1962) 1.47
Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms. Genomics (1993) 1.47
Schizophrenia: a disease of heteromodal association cortex? Neuropsychopharmacology (1996) 1.47
Specific IgM antibody in serum of patients with herpes zoster infections. Br Med J (1972) 1.45
The Valsalva DCR bubble test: a new method of assessing lacrimal patency after DCR surgery. Ophthal Plast Reconstr Surg (1994) 1.44
Specific absence of the alpha 1 subunit of the dihydropyridine receptor in mice with muscular dysgenesis. J Biol Chem (1989) 1.44
Developing the accredited postgraduate assessment program for Fellowship of the Australian College of Rural and Remote Medicine. Rural Remote Health (2007) 1.43
Detection of a large CTG/CAG trinucleotide repeat expansion in a Danish schizophrenia kindred. Am J Med Genet (1997) 1.42
Ubiquinone pair in the Qo site central to the primary energy conversion reactions of cytochrome bc1 complex. Biochemistry (1995) 1.42
Herpes simplex and temporal lobe epilepsy. Br Med J (1972) 1.40
Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation. Mol Psychiatry (2011) 1.39
Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site. Neuron (2000) 1.39
Nuclear targeting of mutant Huntingtin increases toxicity. Mol Cell Neurosci (1999) 1.39