Published in Proteins on September 01, 2009
Reproducing crystal binding modes of ligand functional groups using Site-Identification by Ligand Competitive Saturation (SILCS) simulations. J Chem Inf Model (2011) 1.26
The FTMap family of web servers for determining and characterizing ligand-binding hot spots of proteins. Nat Protoc (2015) 1.26
Analysis of binding site hot spots on the surface of Ras GTPase. J Mol Biol (2011) 1.22
Protein flexibility in docking and surface mapping. Q Rev Biophys (2012) 0.96
Relationship between hot spot residues and ligand binding hot spots in protein-protein interfaces. J Chem Inf Model (2012) 0.95
Improving protocols for protein mapping through proper comparison to crystallography data. J Chem Inf Model (2013) 0.86
New Frontiers in Druggability. J Med Chem (2015) 0.77
Thermodynamics and solvent linkage of macromolecule-ligand interactions. Methods (2014) 0.76
Driving Structure-Based Drug Discovery through Cosolvent Molecular Dynamics. J Med Chem (2016) 0.76
Lipase in aqueous-polar organic solvents: activity, structure, and stability. Protein Sci (2013) 0.75
NMR studies on structure and dynamics of the monomeric derivative of BS-RNase: new insights for 3D domain swapping. PLoS One (2012) 0.75
A comprehensive survey of Ras mutations in cancer. Cancer Res (2012) 3.67
Fragment-based identification of druggable 'hot spots' of proteins using Fourier domain correlation techniques. Bioinformatics (2009) 3.00
Allosteric modulation of Ras positions Q61 for a direct role in catalysis. Proc Natl Acad Sci U S A (2010) 1.62
A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis. Biochem J (2009) 1.33
Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf. Structure (2007) 1.26
Analysis of binding site hot spots on the surface of Ras GTPase. J Mol Biol (2011) 1.22
Role of loop bundle hydrogen bonds in the maturation and activity of (Pro)caspase-3. Biochemistry (2006) 1.12
Structural mechanism of oxidative regulation of the phosphatase Cdc25B via an intramolecular disulfide bond. Biochemistry (2005) 1.03
Crystal structures of Ral-GppNHp and Ral-GDP reveal two binding sites that are also present in Ras and Rap. Structure (2004) 0.99
Allosteric modulation of Ras-GTP is linked to signal transduction through RAF kinase. J Biol Chem (2010) 0.98
Organic solvents order the dynamic switch II in Ras crystals. Structure (2003) 0.95
'Pathway drug cocktail': targeting Ras signaling based on structural pathways. Trends Mol Med (2013) 0.89
Allosteric modulation of caspase 3 through mutagenesis. Biosci Rep (2012) 0.84
Rapid folding and unfolding of Apaf-1 CARD. J Mol Biol (2007) 0.83
Shift in the equilibrium between on and off states of the allosteric switch in Ras-GppNHp affected by small molecules and bulk solvent composition. Biochemistry (2012) 0.82
Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3. Arch Biochem Biophys (2011) 0.80
Lengthening the intersubunit linker of procaspase 3 leads to constitutive activation. Biochemistry (2013) 0.80
Modifying caspase-3 activity by altering allosteric networks. Biochemistry (2014) 0.78
Comparative analysis of the 15.5kD box C/D snoRNP core protein in the primitive eukaryote Giardia lamblia reveals unique structural and functional features. Biochemistry (2011) 0.77
The role of T56 in controlling the flexibility of the distal histidine in dehaloperoxidase-hemoglobin from Amphitrite ornata. Biochim Biophys Acta (2013) 0.76
Structurally conserved Nop56/58 N-terminal domain facilitates archaeal box C/D ribonucleoprotein-guided methyltransferase activity. J Biol Chem (2012) 0.75
Commentary: Biochemistry and molecular biology educators launch national network. Biochem Mol Biol Educ (2010) 0.75